Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3M0_LEIMA

TriTrypDb:

LmjF.33.3160 , LMJLV39_330044800 , LMJSD75_330043600

Length:

489

Annotations

LeishMANIAdb annotations

A protein with very uncertain structure. However, it does not appear to be transmembrane.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3M0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3M0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.543
CLV_NRD_NRD_1	11	13	PF00675	0.562
CLV_NRD_NRD_1	164	166	PF00675	0.495
CLV_NRD_NRD_1	2	4	PF00675	0.506
CLV_NRD_NRD_1	276	278	PF00675	0.655
CLV_NRD_NRD_1	289	291	PF00675	0.646
CLV_NRD_NRD_1	303	305	PF00675	0.564
CLV_NRD_NRD_1	321	323	PF00675	0.656
CLV_NRD_NRD_1	390	392	PF00675	0.660
CLV_NRD_NRD_1	400	402	PF00675	0.623
CLV_NRD_NRD_1	433	435	PF00675	0.684
CLV_NRD_NRD_1	456	458	PF00675	0.621
CLV_NRD_NRD_1	46	48	PF00675	0.449
CLV_NRD_NRD_1	483	485	PF00675	0.677
CLV_PCSK_FUR_1	431	435	PF00082	0.605
CLV_PCSK_KEX2_1	11	13	PF00082	0.562
CLV_PCSK_KEX2_1	120	122	PF00082	0.439
CLV_PCSK_KEX2_1	163	165	PF00082	0.445
CLV_PCSK_KEX2_1	2	4	PF00082	0.506
CLV_PCSK_KEX2_1	276	278	PF00082	0.612
CLV_PCSK_KEX2_1	289	291	PF00082	0.596
CLV_PCSK_KEX2_1	305	307	PF00082	0.558
CLV_PCSK_KEX2_1	390	392	PF00082	0.658
CLV_PCSK_KEX2_1	400	402	PF00082	0.601
CLV_PCSK_KEX2_1	433	435	PF00082	0.684
CLV_PCSK_KEX2_1	456	458	PF00082	0.621
CLV_PCSK_KEX2_1	46	48	PF00082	0.449
CLV_PCSK_KEX2_1	483	485	PF00082	0.613
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.439
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.445
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.627
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.570
CLV_PCSK_SKI1_1	12	16	PF00082	0.476
CLV_PCSK_SKI1_1	205	209	PF00082	0.392
CLV_PCSK_SKI1_1	235	239	PF00082	0.344
CLV_PCSK_SKI1_1	296	300	PF00082	0.678
CLV_PCSK_SKI1_1	400	404	PF00082	0.653
CLV_PCSK_SKI1_1	456	460	PF00082	0.622
DEG_APCC_DBOX_1	305	313	PF00400	0.476
DEG_Nend_UBRbox_1	1	4	PF02207	0.676
DEG_SPOP_SBC_1	135	139	PF00917	0.715
DOC_CKS1_1	98	103	PF01111	0.703
DOC_CYCLIN_RxL_1	453	464	PF00134	0.420
DOC_MAPK_MEF2A_6	179	187	PF00069	0.605
DOC_MAPK_MEF2A_6	235	243	PF00069	0.396
DOC_PP1_RVXF_1	118	125	PF00149	0.651
DOC_PP4_FxxP_1	124	127	PF00568	0.672
DOC_PP4_FxxP_1	60	63	PF00568	0.707
DOC_USP7_MATH_1	105	109	PF00917	0.762
DOC_USP7_MATH_1	268	272	PF00917	0.285
DOC_USP7_MATH_1	372	376	PF00917	0.558
DOC_USP7_UBL2_3	292	296	PF12436	0.485
DOC_USP7_UBL2_3	31	35	PF12436	0.678
DOC_WW_Pin1_4	153	158	PF00397	0.697
DOC_WW_Pin1_4	330	335	PF00397	0.504
DOC_WW_Pin1_4	97	102	PF00397	0.682
LIG_14-3-3_CanoR_1	11	19	PF00244	0.751
LIG_14-3-3_CanoR_1	2	6	PF00244	0.679
LIG_14-3-3_CanoR_1	20	26	PF00244	0.709
LIG_14-3-3_CanoR_1	253	259	PF00244	0.463
LIG_14-3-3_CanoR_1	407	415	PF00244	0.478
LIG_14-3-3_CanoR_1	53	63	PF00244	0.701
LIG_Actin_WH2_2	442	458	PF00022	0.355
LIG_BRCT_BRCA1_1	56	60	PF00533	0.724
LIG_Clathr_ClatBox_1	184	188	PF01394	0.571
LIG_deltaCOP1_diTrp_1	221	228	PF00928	0.656
LIG_deltaCOP1_diTrp_1	412	419	PF00928	0.513
LIG_FHA_1	11	17	PF00498	0.744
LIG_FHA_1	136	142	PF00498	0.775
LIG_FHA_1	228	234	PF00498	0.344
LIG_FHA_1	236	242	PF00498	0.320
LIG_FHA_1	94	100	PF00498	0.694
LIG_FHA_2	197	203	PF00498	0.587
LIG_FHA_2	379	385	PF00498	0.460
LIG_FHA_2	81	87	PF00498	0.675
LIG_LIR_Apic_2	57	63	PF02991	0.734
LIG_LIR_Gen_1	180	189	PF02991	0.582
LIG_LIR_Gen_1	238	246	PF02991	0.336
LIG_LIR_Gen_1	257	266	PF02991	0.264
LIG_LIR_Gen_1	341	349	PF02991	0.530
LIG_LIR_Gen_1	412	422	PF02991	0.449
LIG_LIR_Gen_1	92	101	PF02991	0.750
LIG_LIR_Nem_3	180	185	PF02991	0.584
LIG_LIR_Nem_3	223	229	PF02991	0.492
LIG_LIR_Nem_3	257	262	PF02991	0.420
LIG_LIR_Nem_3	294	298	PF02991	0.377
LIG_LIR_Nem_3	341	347	PF02991	0.530
LIG_LIR_Nem_3	412	418	PF02991	0.444
LIG_LIR_Nem_3	441	445	PF02991	0.380
LIG_LIR_Nem_3	82	88	PF02991	0.672
LIG_LIR_Nem_3	92	98	PF02991	0.667
LIG_NRBOX	232	238	PF00104	0.475
LIG_NRBOX	338	344	PF00104	0.479
LIG_PCNA_PIPBox_1	243	252	PF02747	0.454
LIG_Pex14_1	222	226	PF04695	0.658
LIG_SH2_CRK	229	233	PF00017	0.344
LIG_SH2_CRK	442	446	PF00017	0.365
LIG_SH2_SRC	485	488	PF00017	0.548
LIG_SH2_STAP1	229	233	PF00017	0.396
LIG_SH2_STAP1	250	254	PF00017	0.360
LIG_SH2_STAP1	259	263	PF00017	0.354
LIG_SH2_STAT5	227	230	PF00017	0.349
LIG_SH3_3	124	130	PF00018	0.703
LIG_SH3_4	292	299	PF00018	0.481
LIG_SUMO_SIM_anti_2	297	303	PF11976	0.301
LIG_SUMO_SIM_par_1	183	188	PF11976	0.577
LIG_SxIP_EBH_1	442	456	PF03271	0.522
LIG_TRAF2_1	199	202	PF00917	0.621
LIG_TRAF2_1	284	287	PF00917	0.442
LIG_TRAF2_1	316	319	PF00917	0.480
LIG_TRAF2_1	381	384	PF00917	0.513
LIG_UBA3_1	183	191	PF00899	0.608
LIG_WRC_WIRS_1	16	21	PF05994	0.738
MOD_CK1_1	406	412	PF00069	0.478
MOD_CK1_1	448	454	PF00069	0.414
MOD_CK1_1	97	103	PF00069	0.701
MOD_CK2_1	174	180	PF00069	0.597
MOD_CK2_1	196	202	PF00069	0.601
MOD_CK2_1	21	27	PF00069	0.689
MOD_CK2_1	268	274	PF00069	0.339
MOD_CK2_1	294	300	PF00069	0.456
MOD_CK2_1	378	384	PF00069	0.457
MOD_GlcNHglycan	107	110	PF01048	0.548
MOD_GlcNHglycan	176	179	PF01048	0.471
MOD_GlcNHglycan	269	273	PF01048	0.586
MOD_GlcNHglycan	364	367	PF01048	0.705
MOD_GlcNHglycan	372	375	PF01048	0.690
MOD_GlcNHglycan	408	411	PF01048	0.731
MOD_GlcNHglycan	66	69	PF01048	0.434
MOD_GSK3_1	15	22	PF00069	0.735
MOD_GSK3_1	167	174	PF00069	0.622
MOD_GSK3_1	444	451	PF00069	0.424
MOD_GSK3_1	6	13	PF00069	0.744
MOD_GSK3_1	89	96	PF00069	0.663
MOD_N-GLC_1	174	179	PF02516	0.400
MOD_N-GLC_1	205	210	PF02516	0.363
MOD_NEK2_1	1	6	PF00069	0.684
MOD_NEK2_1	10	15	PF00069	0.738
MOD_NEK2_1	19	24	PF00069	0.722
MOD_NEK2_1	228	233	PF00069	0.385
MOD_NEK2_1	254	259	PF00069	0.411
MOD_NEK2_1	378	383	PF00069	0.461
MOD_NEK2_1	405	410	PF00069	0.518
MOD_NEK2_2	352	357	PF00069	0.402
MOD_PIKK_1	54	60	PF00454	0.715
MOD_PKA_1	400	406	PF00069	0.531
MOD_PKA_2	1	7	PF00069	0.677
MOD_PKA_2	10	16	PF00069	0.760
MOD_PKA_2	19	25	PF00069	0.688
MOD_PKA_2	400	406	PF00069	0.490
MOD_PKA_2	79	85	PF00069	0.745
MOD_Plk_1	151	157	PF00069	0.723
MOD_Plk_1	268	274	PF00069	0.293
MOD_Plk_1	378	384	PF00069	0.563
MOD_Plk_1	93	99	PF00069	0.750
MOD_Plk_2-3	294	300	PF00069	0.451
MOD_Plk_2-3	325	331	PF00069	0.533
MOD_Plk_4	136	142	PF00069	0.671
MOD_Plk_4	228	234	PF00069	0.341
MOD_Plk_4	235	241	PF00069	0.330
MOD_Plk_4	254	260	PF00069	0.307
MOD_Plk_4	294	300	PF00069	0.462
MOD_Plk_4	94	100	PF00069	0.755
MOD_ProDKin_1	153	159	PF00069	0.694
MOD_ProDKin_1	330	336	PF00069	0.504
MOD_ProDKin_1	97	103	PF00069	0.682
MOD_SUMO_for_1	30	33	PF00179	0.703
MOD_SUMO_for_1	356	359	PF00179	0.404
MOD_SUMO_rev_2	22	30	PF00179	0.726
MOD_SUMO_rev_2	365	372	PF00179	0.559
TRG_DiLeu_BaEn_1	180	185	PF01217	0.584
TRG_ENDOCYTIC_2	229	232	PF00928	0.328
TRG_ENDOCYTIC_2	259	262	PF00928	0.367
TRG_ENDOCYTIC_2	442	445	PF00928	0.442
TRG_ER_diArg_1	1	3	PF00400	0.707
TRG_ER_diArg_1	10	12	PF00400	0.762
TRG_ER_diArg_1	125	128	PF00400	0.675
TRG_ER_diArg_1	288	290	PF00400	0.477
TRG_ER_diArg_1	304	307	PF00400	0.343
TRG_ER_diArg_1	399	401	PF00400	0.456
TRG_ER_diArg_1	431	434	PF00400	0.484
TRG_ER_diArg_1	455	457	PF00400	0.413
TRG_ER_diArg_1	483	485	PF00400	0.481
TRG_NLS_Bipartite_1	289	308	PF00514	0.310
TRG_Pf-PMV_PEXEL_1	53	58	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE42	Leptomonas seymouri	64%	100%
A0A0S4JAR7	Bodo saltans	38%	87%
A0A1X0NS34	Trypanosomatidae	47%	92%
A0A3R7N841	Trypanosoma rangeli	48%	95%
A0A3S5H7V5	Leishmania donovani	93%	100%
A4HM23	Leishmania braziliensis	80%	100%
A4I9F7	Leishmania infantum	93%	100%
C9ZJT1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	93%
E9B4F5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B2X5	Trypanosoma cruzi	44%	100%