Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3L9_LEIMA

TriTrypDb:

LmjF.33.3170 , LMJLV39_330044900 , LMJSD75_330043700

Length:

529

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q3L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3L9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.728
CLV_C14_Caspase3-7	310	314	PF00656	0.533
CLV_NRD_NRD_1	120	122	PF00675	0.556
CLV_NRD_NRD_1	259	261	PF00675	0.536
CLV_NRD_NRD_1	512	514	PF00675	0.596
CLV_PCSK_FUR_1	257	261	PF00082	0.424
CLV_PCSK_KEX2_1	120	122	PF00082	0.499
CLV_PCSK_KEX2_1	259	261	PF00082	0.534
CLV_PCSK_KEX2_1	289	291	PF00082	0.570
CLV_PCSK_KEX2_1	296	298	PF00082	0.581
CLV_PCSK_KEX2_1	300	302	PF00082	0.597
CLV_PCSK_KEX2_1	512	514	PF00082	0.618
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.570
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.581
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.597
CLV_PCSK_PC7_1	285	291	PF00082	0.545
CLV_PCSK_SKI1_1	120	124	PF00082	0.574
CLV_PCSK_SKI1_1	230	234	PF00082	0.490
CLV_PCSK_SKI1_1	297	301	PF00082	0.562
CLV_PCSK_SKI1_1	332	336	PF00082	0.444
CLV_PCSK_SKI1_1	343	347	PF00082	0.528
CLV_PCSK_SKI1_1	355	359	PF00082	0.398
CLV_PCSK_SKI1_1	421	425	PF00082	0.630
CLV_PCSK_SKI1_1	73	77	PF00082	0.588
DEG_APCC_DBOX_1	354	362	PF00400	0.443
DEG_MDM2_SWIB_1	28	36	PF02201	0.480
DEG_Nend_UBRbox_1	1	4	PF02207	0.639
DOC_CDC14_PxL_1	515	523	PF14671	0.599
DOC_CYCLIN_RxL_1	117	125	PF00134	0.577
DOC_CYCLIN_yCln2_LP_2	315	321	PF00134	0.615
DOC_MAPK_gen_1	309	317	PF00069	0.547
DOC_MAPK_MEF2A_6	217	224	PF00069	0.507
DOC_PP2B_LxvP_1	315	318	PF13499	0.606
DOC_USP7_MATH_1	103	107	PF00917	0.394
DOC_USP7_MATH_1	187	191	PF00917	0.526
DOC_USP7_MATH_1	349	353	PF00917	0.539
DOC_USP7_MATH_1	35	39	PF00917	0.354
DOC_USP7_MATH_1	430	434	PF00917	0.780
DOC_USP7_MATH_1	464	468	PF00917	0.687
DOC_USP7_MATH_1	486	490	PF00917	0.762
DOC_USP7_MATH_1	504	508	PF00917	0.621
DOC_USP7_MATH_1	59	63	PF00917	0.516
DOC_USP7_MATH_1	87	91	PF00917	0.501
DOC_USP7_UBL2_3	296	300	PF12436	0.546
DOC_WW_Pin1_4	215	220	PF00397	0.582
DOC_WW_Pin1_4	480	485	PF00397	0.735
DOC_WW_Pin1_4	493	498	PF00397	0.468
LIG_14-3-3_CanoR_1	130	134	PF00244	0.570
LIG_14-3-3_CanoR_1	158	168	PF00244	0.602
LIG_14-3-3_CanoR_1	225	229	PF00244	0.546
LIG_14-3-3_CanoR_1	235	240	PF00244	0.467
LIG_14-3-3_CanoR_1	290	298	PF00244	0.437
LIG_14-3-3_CanoR_1	406	412	PF00244	0.713
LIG_14-3-3_CanoR_1	428	437	PF00244	0.728
LIG_14-3-3_CanoR_1	513	519	PF00244	0.649
LIG_Actin_WH2_2	115	132	PF00022	0.518
LIG_Actin_WH2_2	244	261	PF00022	0.400
LIG_APCC_Cbox_2	97	103	PF00515	0.525
LIG_BRCT_BRCA1_1	243	247	PF00533	0.550
LIG_CaM_IQ_9	277	292	PF13499	0.619
LIG_Clathr_ClatBox_1	13	17	PF01394	0.604
LIG_FHA_1	135	141	PF00498	0.557
LIG_FHA_1	16	22	PF00498	0.559
LIG_FHA_1	170	176	PF00498	0.569
LIG_FHA_1	192	198	PF00498	0.788
LIG_FHA_1	231	237	PF00498	0.528
LIG_FHA_1	90	96	PF00498	0.567
LIG_FHA_2	308	314	PF00498	0.535
LIG_FHA_2	325	331	PF00498	0.613
LIG_FHA_2	336	342	PF00498	0.405
LIG_FHA_2	455	461	PF00498	0.766
LIG_LIR_Apic_2	459	464	PF02991	0.716
LIG_LIR_Gen_1	172	182	PF02991	0.436
LIG_LIR_Gen_1	302	312	PF02991	0.553
LIG_LIR_Gen_1	66	75	PF02991	0.418
LIG_LIR_Nem_3	302	307	PF02991	0.551
LIG_LIR_Nem_3	352	357	PF02991	0.464
LIG_LIR_Nem_3	66	70	PF02991	0.396
LIG_Pex14_2	28	32	PF04695	0.483
LIG_SH2_CRK	437	441	PF00017	0.654
LIG_SH2_CRK	461	465	PF00017	0.657
LIG_SH2_CRK	67	71	PF00017	0.406
LIG_SH2_GRB2like	67	70	PF00017	0.389
LIG_SH2_STAP1	502	506	PF00017	0.548
LIG_SH2_STAT5	267	270	PF00017	0.672
LIG_SH3_2	414	419	PF14604	0.587
LIG_SH3_3	408	414	PF00018	0.683
LIG_SH3_3	516	522	PF00018	0.527
LIG_SUMO_SIM_par_1	218	223	PF11976	0.554
LIG_TRAF2_1	376	379	PF00917	0.643
LIG_TYR_ITIM	65	70	PF00017	0.358
LIG_WRC_WIRS_1	221	226	PF05994	0.482
LIG_WRC_WIRS_1	60	65	PF05994	0.500
MOD_CDK_SPK_2	480	485	PF00069	0.668
MOD_CK1_1	106	112	PF00069	0.600
MOD_CK1_1	132	138	PF00069	0.610
MOD_CK1_1	141	147	PF00069	0.540
MOD_CK1_1	201	207	PF00069	0.596
MOD_CK1_1	210	216	PF00069	0.582
MOD_CK1_1	443	449	PF00069	0.780
MOD_CK1_1	5	11	PF00069	0.662
MOD_CK2_1	16	22	PF00069	0.476
MOD_CK2_1	324	330	PF00069	0.510
MOD_CK2_1	335	341	PF00069	0.497
MOD_CK2_1	373	379	PF00069	0.676
MOD_CK2_1	454	460	PF00069	0.730
MOD_CK2_1	5	11	PF00069	0.685
MOD_GlcNHglycan	105	108	PF01048	0.654
MOD_GlcNHglycan	134	137	PF01048	0.549
MOD_GlcNHglycan	164	167	PF01048	0.504
MOD_GlcNHglycan	188	192	PF01048	0.646
MOD_GlcNHglycan	198	201	PF01048	0.563
MOD_GlcNHglycan	203	206	PF01048	0.579
MOD_GlcNHglycan	4	7	PF01048	0.665
MOD_GlcNHglycan	430	433	PF01048	0.677
MOD_GlcNHglycan	445	448	PF01048	0.664
MOD_GlcNHglycan	89	92	PF01048	0.566
MOD_GSK3_1	1	8	PF00069	0.714
MOD_GSK3_1	101	108	PF00069	0.535
MOD_GSK3_1	134	141	PF00069	0.553
MOD_GSK3_1	158	165	PF00069	0.553
MOD_GSK3_1	16	23	PF00069	0.404
MOD_GSK3_1	187	194	PF00069	0.635
MOD_GSK3_1	220	227	PF00069	0.555
MOD_GSK3_1	230	237	PF00069	0.435
MOD_GSK3_1	285	292	PF00069	0.648
MOD_GSK3_1	307	314	PF00069	0.560
MOD_GSK3_1	31	38	PF00069	0.590
MOD_GSK3_1	357	364	PF00069	0.552
MOD_GSK3_1	424	431	PF00069	0.628
MOD_GSK3_1	439	446	PF00069	0.681
MOD_GSK3_1	449	456	PF00069	0.650
MOD_GSK3_1	464	471	PF00069	0.608
MOD_GSK3_1	504	511	PF00069	0.609
MOD_GSK3_1	59	66	PF00069	0.485
MOD_LATS_1	426	432	PF00433	0.588
MOD_N-GLC_1	169	174	PF02516	0.441
MOD_N-GLC_1	406	411	PF02516	0.669
MOD_NEK2_1	1	6	PF00069	0.736
MOD_NEK2_1	16	21	PF00069	0.466
MOD_NEK2_1	196	201	PF00069	0.769
MOD_NEK2_1	220	225	PF00069	0.523
MOD_NEK2_1	247	252	PF00069	0.562
MOD_NEK2_1	280	285	PF00069	0.597
MOD_NEK2_1	307	312	PF00069	0.520
MOD_NEK2_1	357	362	PF00069	0.561
MOD_NEK2_1	440	445	PF00069	0.766
MOD_NEK2_1	453	458	PF00069	0.616
MOD_NEK2_1	63	68	PF00069	0.545
MOD_NEK2_2	35	40	PF00069	0.356
MOD_PIKK_1	159	165	PF00454	0.519
MOD_PIKK_1	361	367	PF00454	0.636
MOD_PIKK_1	430	436	PF00454	0.639
MOD_PIKK_1	454	460	PF00454	0.775
MOD_PIKK_1	468	474	PF00454	0.635
MOD_PIKK_1	495	501	PF00454	0.542
MOD_PIKK_1	89	95	PF00454	0.592
MOD_PK_1	235	241	PF00069	0.546
MOD_PKA_1	289	295	PF00069	0.402
MOD_PKA_2	1	7	PF00069	0.623
MOD_PKA_2	129	135	PF00069	0.537
MOD_PKA_2	224	230	PF00069	0.520
MOD_PKA_2	234	240	PF00069	0.438
MOD_PKA_2	289	295	PF00069	0.437
MOD_PKA_2	335	341	PF00069	0.552
MOD_PKA_2	393	399	PF00069	0.761
MOD_Plk_1	109	115	PF00069	0.423
MOD_Plk_1	16	22	PF00069	0.559
MOD_Plk_1	169	175	PF00069	0.378
MOD_Plk_1	486	492	PF00069	0.629
MOD_Plk_2-3	207	213	PF00069	0.653
MOD_Plk_4	16	22	PF00069	0.514
MOD_Plk_4	192	198	PF00069	0.777
MOD_Plk_4	210	216	PF00069	0.363
MOD_Plk_4	224	230	PF00069	0.441
MOD_Plk_4	235	241	PF00069	0.505
MOD_Plk_4	311	317	PF00069	0.607
MOD_Plk_4	393	399	PF00069	0.747
MOD_Plk_4	486	492	PF00069	0.722
MOD_Plk_4	59	65	PF00069	0.579
MOD_ProDKin_1	215	221	PF00069	0.577
MOD_ProDKin_1	480	486	PF00069	0.731
MOD_ProDKin_1	493	499	PF00069	0.462
TRG_DiLeu_BaEn_1	303	308	PF01217	0.491
TRG_DiLeu_BaEn_1	353	358	PF01217	0.549
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.506
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.574
TRG_ENDOCYTIC_2	437	440	PF00928	0.656
TRG_ENDOCYTIC_2	502	505	PF00928	0.569
TRG_ENDOCYTIC_2	67	70	PF00928	0.402
TRG_ER_diArg_1	120	122	PF00400	0.556
TRG_ER_diArg_1	257	260	PF00400	0.417
TRG_NES_CRM1_1	169	184	PF08389	0.536
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5K5	Leptomonas seymouri	46%	96%
A0A0S4J1S4	Bodo saltans	25%	68%
A0A3Q8IMT0	Leishmania donovani	89%	100%
A4HM24	Leishmania braziliensis	65%	99%
A4I9F8	Leishmania infantum	89%	100%
C9ZJT2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B4F6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%