Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3L8_LEIMA

TriTrypDb:

LmjF.33.3180 , LMJLV39_330045000 , LMJSD75_330043800

Length:

612

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 4
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q3L8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3L8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	525	529	PF00656	0.712
CLV_NRD_NRD_1	212	214	PF00675	0.520
CLV_NRD_NRD_1	346	348	PF00675	0.457
CLV_PCSK_KEX2_1	345	347	PF00082	0.461
CLV_PCSK_SKI1_1	2	6	PF00082	0.563
DEG_Kelch_Keap1_1	469	474	PF01344	0.717
DEG_Kelch_Keap1_1	515	520	PF01344	0.708
DEG_Nend_UBRbox_1	1	4	PF02207	0.703
DEG_SPOP_SBC_1	264	268	PF00917	0.377
DEG_SPOP_SBC_1	31	35	PF00917	0.451
DOC_CKS1_1	420	425	PF01111	0.695
DOC_MAPK_gen_1	213	220	PF00069	0.320
DOC_MAPK_gen_1	279	288	PF00069	0.450
DOC_MAPK_MEF2A_6	213	220	PF00069	0.417
DOC_PP1_RVXF_1	328	335	PF00149	0.485
DOC_USP7_MATH_1	112	116	PF00917	0.422
DOC_USP7_MATH_1	263	267	PF00917	0.524
DOC_USP7_MATH_1	30	34	PF00917	0.412
DOC_USP7_MATH_1	39	43	PF00917	0.380
DOC_USP7_MATH_1	493	497	PF00917	0.735
DOC_USP7_MATH_1	506	510	PF00917	0.652
DOC_WW_Pin1_4	222	227	PF00397	0.404
DOC_WW_Pin1_4	384	389	PF00397	0.628
DOC_WW_Pin1_4	419	424	PF00397	0.720
DOC_WW_Pin1_4	6	11	PF00397	0.564
LIG_14-3-3_CanoR_1	137	146	PF00244	0.403
LIG_14-3-3_CanoR_1	165	173	PF00244	0.494
LIG_14-3-3_CanoR_1	2	7	PF00244	0.692
LIG_14-3-3_CanoR_1	295	305	PF00244	0.543
LIG_14-3-3_CanoR_1	93	101	PF00244	0.403
LIG_BIR_III_4	364	368	PF00653	0.770
LIG_BIR_III_4	438	442	PF00653	0.714
LIG_EVH1_2	372	376	PF00568	0.778
LIG_FHA_1	114	120	PF00498	0.388
LIG_FHA_1	183	189	PF00498	0.373
LIG_FHA_1	266	272	PF00498	0.355
LIG_FHA_1	3	9	PF00498	0.654
LIG_FHA_1	35	41	PF00498	0.552
LIG_FHA_1	590	596	PF00498	0.775
LIG_FHA_1	60	66	PF00498	0.412
LIG_FHA_1	67	73	PF00498	0.330
LIG_FHA_1	96	102	PF00498	0.419
LIG_FHA_2	205	211	PF00498	0.411
LIG_FHA_2	510	516	PF00498	0.745
LIG_FHA_2	523	529	PF00498	0.751
LIG_FHA_2	562	568	PF00498	0.745
LIG_LIR_Apic_2	157	163	PF02991	0.379
LIG_LIR_Apic_2	466	470	PF02991	0.732
LIG_LIR_Apic_2	512	516	PF02991	0.723
LIG_LIR_Apic_2	546	552	PF02991	0.769
LIG_LIR_Apic_2	559	563	PF02991	0.666
LIG_LIR_Apic_2	606	610	PF02991	0.741
LIG_LIR_Gen_1	167	178	PF02991	0.518
LIG_LIR_Gen_1	224	235	PF02991	0.401
LIG_LIR_Gen_1	521	531	PF02991	0.710
LIG_LIR_Gen_1	535	542	PF02991	0.628
LIG_LIR_Nem_3	115	120	PF02991	0.404
LIG_LIR_Nem_3	167	173	PF02991	0.505
LIG_LIR_Nem_3	224	230	PF02991	0.402
LIG_LIR_Nem_3	310	316	PF02991	0.429
LIG_LIR_Nem_3	508	513	PF02991	0.733
LIG_LIR_Nem_3	521	527	PF02991	0.730
LIG_LIR_Nem_3	535	539	PF02991	0.628
LIG_Pex14_1	314	318	PF04695	0.312
LIG_Pex14_2	329	333	PF04695	0.575
LIG_SH2_CRK	160	164	PF00017	0.404
LIG_SH2_CRK	170	174	PF00017	0.458
LIG_SH2_CRK	227	231	PF00017	0.357
LIG_SH2_CRK	549	553	PF00017	0.692
LIG_SH2_GRB2like	467	470	PF00017	0.709
LIG_SH2_GRB2like	549	552	PF00017	0.707
LIG_SH2_NCK_1	227	231	PF00017	0.340
LIG_SH2_NCK_1	524	528	PF00017	0.765
LIG_SH2_NCK_1	549	553	PF00017	0.692
LIG_SH2_NCK_1	607	611	PF00017	0.730
LIG_SH2_PTP2	420	423	PF00017	0.691
LIG_SH2_PTP2	467	470	PF00017	0.715
LIG_SH2_PTP2	513	516	PF00017	0.722
LIG_SH2_PTP2	560	563	PF00017	0.711
LIG_SH2_PTP2	596	599	PF00017	0.746
LIG_SH2_SRC	172	175	PF00017	0.510
LIG_SH2_SRC	467	470	PF00017	0.732
LIG_SH2_SRC	513	516	PF00017	0.722
LIG_SH2_SRC	536	539	PF00017	0.797
LIG_SH2_SRC	547	550	PF00017	0.730
LIG_SH2_SRC	558	561	PF00017	0.704
LIG_SH2_SRC	596	599	PF00017	0.746
LIG_SH2_STAP1	399	403	PF00017	0.690
LIG_SH2_STAP1	571	575	PF00017	0.765
LIG_SH2_STAP1	605	609	PF00017	0.669
LIG_SH2_STAT5	118	121	PF00017	0.377
LIG_SH2_STAT5	172	175	PF00017	0.528
LIG_SH2_STAT5	187	190	PF00017	0.403
LIG_SH2_STAT5	198	201	PF00017	0.336
LIG_SH2_STAT5	202	205	PF00017	0.332
LIG_SH2_STAT5	227	230	PF00017	0.448
LIG_SH2_STAT5	245	248	PF00017	0.274
LIG_SH2_STAT5	331	334	PF00017	0.570
LIG_SH2_STAT5	420	423	PF00017	0.765
LIG_SH2_STAT5	431	434	PF00017	0.718
LIG_SH2_STAT5	467	470	PF00017	0.723
LIG_SH2_STAT5	478	481	PF00017	0.762
LIG_SH2_STAT5	513	516	PF00017	0.736
LIG_SH2_STAT5	524	527	PF00017	0.756
LIG_SH2_STAT5	538	541	PF00017	0.640
LIG_SH2_STAT5	560	563	PF00017	0.728
LIG_SH2_STAT5	571	574	PF00017	0.762
LIG_SH2_STAT5	596	599	PF00017	0.746
LIG_SH3_3	215	221	PF00018	0.480
LIG_SUMO_SIM_par_1	41	48	PF11976	0.301
LIG_TRAF2_1	485	488	PF00917	0.777
LIG_TRAF2_1	583	586	PF00917	0.726
LIG_TRFH_1	187	191	PF08558	0.399
MOD_CK1_1	104	110	PF00069	0.423
MOD_CK1_1	149	155	PF00069	0.415
MOD_CK1_1	222	228	PF00069	0.486
MOD_CK1_1	298	304	PF00069	0.521
MOD_CK1_1	34	40	PF00069	0.458
MOD_CK1_1	448	454	PF00069	0.780
MOD_CK1_1	509	515	PF00069	0.652
MOD_CK1_1	66	72	PF00069	0.373
MOD_CK1_1	78	84	PF00069	0.410
MOD_CK1_1	95	101	PF00069	0.424
MOD_CK2_1	148	154	PF00069	0.306
MOD_CK2_1	204	210	PF00069	0.404
MOD_CK2_1	286	292	PF00069	0.490
MOD_CK2_1	514	520	PF00069	0.708
MOD_CK2_1	561	567	PF00069	0.743
MOD_GlcNHglycan	11	14	PF01048	0.403
MOD_GlcNHglycan	139	142	PF01048	0.590
MOD_GlcNHglycan	199	202	PF01048	0.599
MOD_GlcNHglycan	369	372	PF01048	0.563
MOD_GlcNHglycan	49	52	PF01048	0.579
MOD_GlcNHglycan	77	80	PF01048	0.638
MOD_GlcNHglycan	81	84	PF01048	0.651
MOD_GSK3_1	101	108	PF00069	0.459
MOD_GSK3_1	125	132	PF00069	0.464
MOD_GSK3_1	133	140	PF00069	0.374
MOD_GSK3_1	141	148	PF00069	0.325
MOD_GSK3_1	164	171	PF00069	0.430
MOD_GSK3_1	2	9	PF00069	0.727
MOD_GSK3_1	204	211	PF00069	0.418
MOD_GSK3_1	221	228	PF00069	0.384
MOD_GSK3_1	265	272	PF00069	0.510
MOD_GSK3_1	287	294	PF00069	0.454
MOD_GSK3_1	297	304	PF00069	0.550
MOD_GSK3_1	30	37	PF00069	0.531
MOD_GSK3_1	378	385	PF00069	0.654
MOD_GSK3_1	39	46	PF00069	0.331
MOD_GSK3_1	451	458	PF00069	0.728
MOD_GSK3_1	472	479	PF00069	0.741
MOD_GSK3_1	514	521	PF00069	0.718
MOD_GSK3_1	53	60	PF00069	0.400
MOD_GSK3_1	561	568	PF00069	0.709
MOD_GSK3_1	63	70	PF00069	0.395
MOD_GSK3_1	71	78	PF00069	0.368
MOD_N-GLC_1	113	118	PF02516	0.631
MOD_N-GLC_1	126	131	PF02516	0.509
MOD_N-GLC_1	230	235	PF02516	0.522
MOD_N-GLC_1	455	460	PF02516	0.498
MOD_N-GLC_1	577	582	PF02516	0.611
MOD_N-GLC_1	72	77	PF02516	0.596
MOD_NEK2_1	101	106	PF00069	0.439
MOD_NEK2_1	146	151	PF00069	0.433
MOD_NEK2_1	376	381	PF00069	0.856
MOD_NEK2_1	45	50	PF00069	0.380
MOD_NEK2_2	182	187	PF00069	0.467
MOD_NEK2_2	208	213	PF00069	0.396
MOD_PIKK_1	118	124	PF00454	0.405
MOD_PIKK_1	445	451	PF00454	0.783
MOD_PIKK_1	522	528	PF00454	0.727
MOD_PKA_2	136	142	PF00069	0.402
MOD_PKA_2	164	170	PF00069	0.504
MOD_PKA_2	212	218	PF00069	0.380
MOD_PKA_2	301	307	PF00069	0.596
MOD_PKA_2	92	98	PF00069	0.416
MOD_PKB_1	335	343	PF00069	0.633
MOD_Plk_1	113	119	PF00069	0.494
MOD_Plk_1	126	132	PF00069	0.328
MOD_Plk_1	291	297	PF00069	0.504
MOD_Plk_1	376	382	PF00069	0.740
MOD_Plk_1	493	499	PF00069	0.735
MOD_Plk_1	72	78	PF00069	0.402
MOD_Plk_1	95	101	PF00069	0.363
MOD_Plk_4	101	107	PF00069	0.395
MOD_Plk_4	113	119	PF00069	0.295
MOD_Plk_4	168	174	PF00069	0.495
MOD_Plk_4	182	188	PF00069	0.345
MOD_Plk_4	212	218	PF00069	0.476
MOD_Plk_4	225	231	PF00069	0.385
MOD_Plk_4	463	469	PF00069	0.721
MOD_Plk_4	509	515	PF00069	0.727
MOD_ProDKin_1	222	228	PF00069	0.396
MOD_ProDKin_1	384	390	PF00069	0.626
MOD_ProDKin_1	419	425	PF00069	0.719
MOD_ProDKin_1	6	12	PF00069	0.564
TRG_ENDOCYTIC_2	117	120	PF00928	0.406
TRG_ENDOCYTIC_2	170	173	PF00928	0.528
TRG_ENDOCYTIC_2	227	230	PF00928	0.379
TRG_ENDOCYTIC_2	280	283	PF00928	0.473
TRG_ENDOCYTIC_2	313	316	PF00928	0.409
TRG_ENDOCYTIC_2	331	334	PF00928	0.507
TRG_ENDOCYTIC_2	524	527	PF00928	0.723
TRG_ENDOCYTIC_2	536	539	PF00928	0.706
TRG_ENDOCYTIC_2	558	561	PF00928	0.731
TRG_ER_diArg_1	334	337	PF00400	0.679
TRG_ER_diArg_1	345	347	PF00400	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Z7	Leptomonas seymouri	42%	100%
A0A3S7X786	Leishmania donovani	88%	100%
A4HM25	Leishmania braziliensis	62%	100%
A4I9F9	Leishmania infantum	88%	100%
E9B4F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	76%
V5AI59	Trypanosoma cruzi	29%	100%