Putative cation transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cation transporter, putative

Species:

Leishmania major

UniProt:

Q4Q3L6_LEIMA

TriTrypDb:

LmjF.33.3200 , LMJLV39_330045200 , LMJSD75_330044000

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 27
NetGPI	no	yes: 0, no: 27

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	4
GO:0016020	membrane	2	28
GO:0110165	cellular anatomical entity	1	28
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

Q4Q3L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3L6

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	4
GO:0006810	transport	3	4
GO:0006811	monoatomic ion transport	4	4
GO:0006812	monoatomic cation transport	5	4
GO:0006829	zinc ion transport	8	4
GO:0009987	cellular process	1	4
GO:0030001	metal ion transport	6	4
GO:0034220	monoatomic ion transmembrane transport	3	4
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0055085	transmembrane transport	2	4
GO:0071577	zinc ion transmembrane transport	6	4
GO:0098655	monoatomic cation transmembrane transport	4	4
GO:0098660	inorganic ion transmembrane transport	4	4
GO:0098662	inorganic cation transmembrane transport	5	4
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0006882	intracellular zinc ion homeostasis	7	1
GO:0019725	cellular homeostasis	2	1
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0042592	homeostatic process	3	1
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055069	obsolete zinc ion homeostasis	8	1
GO:0055076	obsolete transition metal ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	1
GO:0072507	obsolete divalent inorganic cation homeostasis	7	1
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	28
GO:0005385	zinc ion transmembrane transporter activity	7	4
GO:0008324	monoatomic cation transmembrane transporter activity	4	28
GO:0015075	monoatomic ion transmembrane transporter activity	3	28
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	28
GO:0022857	transmembrane transporter activity	2	28
GO:0022890	inorganic cation transmembrane transporter activity	4	28
GO:0046873	metal ion transmembrane transporter activity	5	28
GO:0046915	transition metal ion transmembrane transporter activity	6	4
GO:0005381	iron ion transmembrane transporter activity	7	1
GO:0015093	ferrous iron transmembrane transporter activity	8	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	47	49	PF00082	0.287
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.287
CLV_PCSK_SKI1_1	122	126	PF00082	0.342
CLV_PCSK_SKI1_1	310	314	PF00082	0.251
DEG_APCC_DBOX_1	309	317	PF00400	0.505
DOC_PP1_RVXF_1	120	126	PF00149	0.190
DOC_PP2B_LxvP_1	243	246	PF13499	0.439
DOC_PP4_FxxP_1	52	55	PF00568	0.386
DOC_USP7_MATH_1	113	117	PF00917	0.321
DOC_USP7_MATH_1	157	161	PF00917	0.502
DOC_USP7_MATH_1	219	223	PF00917	0.299
DOC_USP7_MATH_1	322	326	PF00917	0.210
DOC_USP7_MATH_1	7	11	PF00917	0.333
DOC_USP7_MATH_1	82	86	PF00917	0.300
DOC_WW_Pin1_4	3	8	PF00397	0.389
DOC_WW_Pin1_4	305	310	PF00397	0.378
LIG_Actin_WH2_2	66	82	PF00022	0.210
LIG_AP2alpha_1	124	128	PF02296	0.360
LIG_APCC_ABBA_1	121	126	PF00400	0.378
LIG_eIF4E_1	285	291	PF01652	0.279
LIG_FHA_1	191	197	PF00498	0.196
LIG_FHA_1	231	237	PF00498	0.554
LIG_FHA_1	269	275	PF00498	0.246
LIG_FHA_1	65	71	PF00498	0.333
LIG_FHA_2	13	19	PF00498	0.415
LIG_LIR_Gen_1	18	28	PF02991	0.259
LIG_LIR_Gen_1	201	211	PF02991	0.324
LIG_LIR_Gen_1	234	245	PF02991	0.273
LIG_LIR_Gen_1	294	303	PF02991	0.491
LIG_LIR_Nem_3	126	131	PF02991	0.399
LIG_LIR_Nem_3	18	23	PF02991	0.277
LIG_LIR_Nem_3	187	192	PF02991	0.313
LIG_LIR_Nem_3	210	214	PF02991	0.304
LIG_LIR_Nem_3	234	240	PF02991	0.280
LIG_PCNA_PIPBox_1	289	298	PF02747	0.210
LIG_Pex14_2	124	128	PF04695	0.367
LIG_Pex14_2	211	215	PF04695	0.335
LIG_Pex14_2	237	241	PF04695	0.232
LIG_SH2_SRC	57	60	PF00017	0.531
LIG_SH2_STAP1	20	24	PF00017	0.337
LIG_SH2_STAP1	57	61	PF00017	0.386
LIG_SH2_STAT5	104	107	PF00017	0.343
LIG_SH2_STAT5	203	206	PF00017	0.293
LIG_SH2_STAT5	235	238	PF00017	0.422
LIG_SH2_STAT5	268	271	PF00017	0.287
LIG_SH2_STAT5	285	288	PF00017	0.250
LIG_SH3_3	128	134	PF00018	0.437
LIG_SH3_3	303	309	PF00018	0.475
LIG_SUMO_SIM_anti_2	325	330	PF11976	0.170
LIG_UBA3_1	75	80	PF00899	0.422
MOD_CDK_SPK_2	305	310	PF00069	0.364
MOD_CK1_1	168	174	PF00069	0.563
MOD_CK1_1	184	190	PF00069	0.303
MOD_CK1_1	64	70	PF00069	0.370
MOD_CK1_1	8	14	PF00069	0.431
MOD_CK1_1	85	91	PF00069	0.260
MOD_CK2_1	7	13	PF00069	0.454
MOD_Cter_Amidation	45	48	PF01082	0.286
MOD_GlcNHglycan	145	148	PF01048	0.281
MOD_GlcNHglycan	157	160	PF01048	0.214
MOD_GlcNHglycan	174	177	PF01048	0.259
MOD_GlcNHglycan	243	246	PF01048	0.309
MOD_GlcNHglycan	3	6	PF01048	0.664
MOD_GlcNHglycan	92	95	PF01048	0.542
MOD_GSK3_1	1	8	PF00069	0.447
MOD_GSK3_1	157	164	PF00069	0.472
MOD_GSK3_1	168	175	PF00069	0.526
MOD_GSK3_1	33	40	PF00069	0.264
MOD_N-GLC_1	18	23	PF02516	0.432
MOD_N-GLC_1	82	87	PF02516	0.445
MOD_N-GLC_1	96	101	PF02516	0.422
MOD_NEK2_1	1	6	PF00069	0.356
MOD_NEK2_1	145	150	PF00069	0.534
MOD_NEK2_1	181	186	PF00069	0.288
MOD_NEK2_1	241	246	PF00069	0.291
MOD_NEK2_1	260	265	PF00069	0.249
MOD_NEK2_1	299	304	PF00069	0.522
MOD_NEK2_1	33	38	PF00069	0.301
MOD_NEK2_1	98	103	PF00069	0.255
MOD_NEK2_2	207	212	PF00069	0.448
MOD_NEK2_2	227	232	PF00069	0.397
MOD_PIKK_1	138	144	PF00454	0.528
MOD_PIKK_1	145	151	PF00454	0.556
MOD_PIKK_1	168	174	PF00454	0.342
MOD_PIKK_1	268	274	PF00454	0.240
MOD_PK_1	165	171	PF00069	0.342
MOD_Plk_1	18	24	PF00069	0.336
MOD_Plk_1	82	88	PF00069	0.268
MOD_Plk_4	18	24	PF00069	0.358
MOD_Plk_4	184	190	PF00069	0.277
MOD_Plk_4	201	207	PF00069	0.230
MOD_Plk_4	263	269	PF00069	0.270
MOD_Plk_4	322	328	PF00069	0.382
MOD_Plk_4	33	39	PF00069	0.301
MOD_ProDKin_1	3	9	PF00069	0.388
MOD_ProDKin_1	305	311	PF00069	0.378
TRG_DiLeu_BaEn_1	140	145	PF01217	0.386
TRG_DiLeu_BaEn_1	18	23	PF01217	0.219
TRG_DiLeu_BaEn_1	201	206	PF01217	0.200
TRG_ENDOCYTIC_2	20	23	PF00928	0.195
TRG_ENDOCYTIC_2	203	206	PF00928	0.286
TRG_ENDOCYTIC_2	285	288	PF00928	0.259
TRG_ENDOCYTIC_2	296	299	PF00928	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E9	Leptomonas seymouri	34%	100%
A0A0N0P5K7	Leptomonas seymouri	60%	100%
A0A1X0NR51	Trypanosomatidae	41%	90%
A0A1X0NSB9	Trypanosomatidae	35%	82%
A0A1X0NSI7	Trypanosomatidae	35%	88%
A0A3R7LZX6	Trypanosoma rangeli	38%	95%
A0A3S7X1N7	Leishmania donovani	33%	72%
A0A3S7X7B0	Leishmania donovani	90%	100%
A0A422MUI2	Trypanosoma rangeli	33%	90%
A4HGP7	Leishmania braziliensis	35%	95%
A4HM27	Leishmania braziliensis	74%	100%
A4I3R9	Leishmania infantum	33%	72%
A4I9G1	Leishmania infantum	90%	100%
D0A885	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	85%
D0A886	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	85%
D0A887	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	85%
D0A888	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	85%
D0A889	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	87%
E9B012	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	74%
E9B2A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B2A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	77%
E9B4F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
O23039	Arabidopsis thaliana	25%	93%
O64738	Arabidopsis thaliana	26%	98%
O81123	Arabidopsis thaliana	28%	94%
O81850	Arabidopsis thaliana	25%	95%
O82643	Arabidopsis thaliana	26%	97%
O94639	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	82%
P32804	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	89%
Q38856	Arabidopsis thaliana	28%	96%
Q4Q5V1	Leishmania major	34%	77%
Q4Q873	Leishmania major	34%	100%
Q6L8G0	Oryza sativa subsp. japonica	32%	95%
Q6L8G1	Oryza sativa subsp. japonica	28%	90%
Q6ZJ91	Oryza sativa subsp. japonica	25%	84%
Q75HB1	Oryza sativa subsp. japonica	26%	89%
Q7XLD4	Oryza sativa subsp. japonica	27%	92%
Q852F6	Oryza sativa subsp. japonica	26%	93%
Q8S3W4	Arabidopsis thaliana	25%	96%
Q8W245	Arabidopsis thaliana	28%	92%
Q8W246	Arabidopsis thaliana	24%	92%
Q94EG9	Arabidopsis thaliana	23%	100%
Q9FIS2	Arabidopsis thaliana	25%	94%
Q9SLG3	Arabidopsis thaliana	25%	99%
V5AWN3	Trypanosoma cruzi	36%	90%
V5BC34	Trypanosoma cruzi	34%	90%
V5DCU2	Trypanosoma cruzi	41%	90%