Putative cation transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cation transporter, putative

Species:

Leishmania major

UniProt:

Q4Q3L6_LEIMA

TriTrypDb:

LmjF.33.3200 , LMJLV39_330045200 , LMJSD75_330044000

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 27
NetGPI	no	yes: 0, no: 27

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	4
GO:0016020	membrane	2	28
GO:0110165	cellular anatomical entity	1	28

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Expansion

Sequence features

Q4Q3L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3L6

Function

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Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	4
GO:0006810	transport	3	4
GO:0006811	monoatomic ion transport	4	4
GO:0006812	monoatomic cation transport	5	4
GO:0006829	zinc ion transport	8	4
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0006882	intracellular zinc ion homeostasis	7	1
GO:0009987	cellular process	1	4
GO:0019725	cellular homeostasis	2	1

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	28
GO:0005381	iron ion transmembrane transporter activity	7	1
GO:0005385	zinc ion transmembrane transporter activity	7	4
GO:0008324	monoatomic cation transmembrane transporter activity	4	28
GO:0015075	monoatomic ion transmembrane transporter activity	3	28
GO:0015093	ferrous iron transmembrane transporter activity	8	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	28
GO:0022857	transmembrane transporter activity	2	28
GO:0022890	inorganic cation transmembrane transporter activity	4	28
GO:0046873	metal ion transmembrane transporter activity	5	28

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	47	49	PF00082	0.287
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.287
CLV_PCSK_SKI1_1	122	126	PF00082	0.342
CLV_PCSK_SKI1_1	310	314	PF00082	0.251
DEG_APCC_DBOX_1	309	317	PF00400	0.505
DOC_PP1_RVXF_1	120	126	PF00149	0.190
DOC_PP2B_LxvP_1	243	246	PF13499	0.439
DOC_PP4_FxxP_1	52	55	PF00568	0.386
DOC_USP7_MATH_1	113	117	PF00917	0.321
DOC_USP7_MATH_1	157	161	PF00917	0.502

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E9	Leptomonas seymouri	34%	100%
A0A0N0P5K7	Leptomonas seymouri	60%	100%
A0A1X0NR51	Trypanosomatidae	41%	90%
A0A1X0NSB9	Trypanosomatidae	35%	82%
A0A1X0NSI7	Trypanosomatidae	35%	88%
A0A3R7LZX6	Trypanosoma rangeli	38%	95%
A0A3S7X1N7	Leishmania donovani	33%	72%
A0A3S7X7B0	Leishmania donovani	90%	100%
A0A422MUI2	Trypanosoma rangeli	33%	90%
A4HGP7	Leishmania braziliensis	35%	95%

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