Coatomer subunit beta'

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta prime cop protein, putative

Species:

Leishmania major

UniProt:

Q4Q3L5_LEIMA

TriTrypDb:

LmjF.33.3210 , LMJLV39_330045300 , LMJSD75_330044100

Length:

884

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	11
GO:0016020	membrane	2	11
GO:0030117	membrane coat	3	11
GO:0030120	vesicle coat	4	2
GO:0030126	COPI vesicle coat	5	2
GO:0031090	organelle membrane	3	11
GO:0032991	protein-containing complex	1	11
GO:0098588	bounding membrane of organelle	4	11
GO:0098796	membrane protein complex	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0012506	vesicle membrane	4	9
GO:0030659	cytoplasmic vesicle membrane	5	9
GO:0030660	Golgi-associated vesicle membrane	5	9
GO:0030662	coated vesicle membrane	5	9
GO:0030663	COPI-coated vesicle membrane	6	9

Expansion

Sequence features

Q4Q3L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3L5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	2
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	2
GO:0006891	intra-Golgi vesicle-mediated transport	6	2
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016192	vesicle-mediated transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0048193	Golgi vesicle transport	5	2
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.479
CLV_C14_Caspase3-7	335	339	PF00656	0.498
CLV_C14_Caspase3-7	812	816	PF00656	0.569
CLV_C14_Caspase3-7	862	866	PF00656	0.573
CLV_NRD_NRD_1	644	646	PF00675	0.394
CLV_PCSK_KEX2_1	282	284	PF00082	0.435
CLV_PCSK_KEX2_1	644	646	PF00082	0.371
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.494
CLV_PCSK_SKI1_1	305	309	PF00082	0.465
CLV_PCSK_SKI1_1	417	421	PF00082	0.281
CLV_PCSK_SKI1_1	422	426	PF00082	0.280
CLV_PCSK_SKI1_1	581	585	PF00082	0.283
CLV_PCSK_SKI1_1	629	633	PF00082	0.359
CLV_PCSK_SKI1_1	653	657	PF00082	0.217
DEG_APCC_KENBOX_2	569	573	PF00400	0.501
DEG_SCF_FBW7_2	334	340	PF00400	0.508
DEG_SPOP_SBC_1	442	446	PF00917	0.485
DEG_SPOP_SBC_1	481	485	PF00917	0.508
DOC_CKS1_1	175	180	PF01111	0.511
DOC_CKS1_1	334	339	PF01111	0.508
DOC_CYCLIN_RxL_1	650	660	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	788	794	PF00134	0.557
DOC_CYCLIN_yCln2_LP_2	806	809	PF00134	0.684
DOC_MAPK_gen_1	282	289	PF00069	0.383
DOC_MAPK_gen_1	417	427	PF00069	0.467
DOC_MAPK_gen_1	644	652	PF00069	0.574
DOC_MAPK_HePTP_8	626	638	PF00069	0.483
DOC_MAPK_MEF2A_6	433	442	PF00069	0.464
DOC_MAPK_MEF2A_6	629	638	PF00069	0.480
DOC_MAPK_MEF2A_6	644	652	PF00069	0.443
DOC_PP1_RVXF_1	524	531	PF00149	0.479
DOC_PP1_RVXF_1	60	67	PF00149	0.354
DOC_PP2B_LxvP_1	425	428	PF13499	0.559
DOC_PP2B_LxvP_1	806	809	PF13499	0.581
DOC_PP2B_PxIxI_1	611	617	PF00149	0.553
DOC_PP4_FxxP_1	435	438	PF00568	0.469
DOC_PP4_MxPP_1	855	858	PF00568	0.553
DOC_USP7_MATH_1	153	157	PF00917	0.490
DOC_USP7_MATH_1	160	164	PF00917	0.448
DOC_USP7_MATH_1	687	691	PF00917	0.553
DOC_USP7_MATH_1	782	786	PF00917	0.504
DOC_USP7_MATH_1	809	813	PF00917	0.549
DOC_USP7_MATH_1	825	829	PF00917	0.747
DOC_WW_Pin1_4	174	179	PF00397	0.433
DOC_WW_Pin1_4	333	338	PF00397	0.601
DOC_WW_Pin1_4	462	467	PF00397	0.533
DOC_WW_Pin1_4	787	792	PF00397	0.473
LIG_14-3-3_CanoR_1	263	273	PF00244	0.431
LIG_14-3-3_CanoR_1	275	280	PF00244	0.222
LIG_14-3-3_CanoR_1	385	390	PF00244	0.483
LIG_14-3-3_CanoR_1	422	428	PF00244	0.483
LIG_14-3-3_CanoR_1	443	451	PF00244	0.485
LIG_14-3-3_CanoR_1	69	74	PF00244	0.366
LIG_14-3-3_CanoR_1	775	779	PF00244	0.539
LIG_14-3-3_CanoR_1	783	791	PF00244	0.473
LIG_BIR_II_1	1	5	PF00653	0.564
LIG_BIR_III_4	311	315	PF00653	0.455
LIG_BRCT_BRCA1_1	155	159	PF00533	0.535
LIG_BRCT_BRCA1_1	234	238	PF00533	0.458
LIG_BRCT_BRCA1_1	446	450	PF00533	0.469
LIG_BRCT_BRCA1_1	483	487	PF00533	0.564
LIG_Clathr_ClatBox_1	574	578	PF01394	0.547
LIG_deltaCOP1_diTrp_1	128	133	PF00928	0.378
LIG_deltaCOP1_diTrp_1	527	535	PF00928	0.416
LIG_eIF4E_1	44	50	PF01652	0.525
LIG_FHA_1	209	215	PF00498	0.476
LIG_FHA_1	259	265	PF00498	0.407
LIG_FHA_1	410	416	PF00498	0.483
LIG_FHA_1	44	50	PF00498	0.444
LIG_FHA_1	453	459	PF00498	0.536
LIG_FHA_1	472	478	PF00498	0.525
LIG_FHA_1	582	588	PF00498	0.467
LIG_FHA_1	611	617	PF00498	0.556
LIG_FHA_2	115	121	PF00498	0.475
LIG_FHA_2	318	324	PF00498	0.438
LIG_FHA_2	465	471	PF00498	0.498
LIG_FHA_2	503	509	PF00498	0.472
LIG_FHA_2	638	644	PF00498	0.446
LIG_FHA_2	837	843	PF00498	0.764
LIG_FHA_2	878	884	PF00498	0.570
LIG_GBD_Chelix_1	648	656	PF00786	0.217
LIG_Integrin_isoDGR_2	313	315	PF01839	0.526
LIG_Integrin_RGD_1	197	199	PF01839	0.359
LIG_LIR_Apic_2	842	846	PF02991	0.530
LIG_LIR_Gen_1	373	384	PF02991	0.489
LIG_LIR_Gen_1	401	408	PF02991	0.474
LIG_LIR_Gen_1	512	521	PF02991	0.469
LIG_LIR_Gen_1	533	541	PF02991	0.449
LIG_LIR_Nem_3	259	265	PF02991	0.532
LIG_LIR_Nem_3	373	379	PF02991	0.489
LIG_LIR_Nem_3	401	407	PF02991	0.488
LIG_LIR_Nem_3	452	456	PF02991	0.469
LIG_LIR_Nem_3	512	518	PF02991	0.469
LIG_LIR_Nem_3	669	674	PF02991	0.559
LIG_LIR_Nem_3	696	700	PF02991	0.561
LIG_LIR_Nem_3	761	766	PF02991	0.517
LIG_LYPXL_yS_3	763	766	PF13949	0.360
LIG_LYPXL_yS_3	794	797	PF13949	0.466
LIG_MYND_1	795	799	PF01753	0.461
LIG_NRBOX	651	657	PF00104	0.417
LIG_Pex14_2	487	491	PF04695	0.469
LIG_SH2_CRK	376	380	PF00017	0.496
LIG_SH2_CRK	704	708	PF00017	0.525
LIG_SH2_GRB2like	537	540	PF00017	0.559
LIG_SH2_NCK_1	376	380	PF00017	0.559
LIG_SH2_STAP1	758	762	PF00017	0.483
LIG_SH2_STAT3	42	45	PF00017	0.490
LIG_SH2_STAT3	499	502	PF00017	0.559
LIG_SH2_STAT3	537	540	PF00017	0.559
LIG_SH2_STAT3	586	589	PF00017	0.547
LIG_SH2_STAT5	102	105	PF00017	0.474
LIG_SH2_STAT5	202	205	PF00017	0.469
LIG_SH2_STAT5	376	379	PF00017	0.491
LIG_SH2_STAT5	499	502	PF00017	0.501
LIG_SH2_STAT5	547	550	PF00017	0.450
LIG_SH2_STAT5	563	566	PF00017	0.469
LIG_SH2_STAT5	567	570	PF00017	0.469
LIG_SH2_STAT5	586	589	PF00017	0.453
LIG_SH2_STAT5	683	686	PF00017	0.531
LIG_SH2_STAT5	704	707	PF00017	0.547
LIG_SH3_3	22	28	PF00018	0.401
LIG_SH3_3	237	243	PF00018	0.369
LIG_SH3_3	300	306	PF00018	0.525
LIG_SH3_3	331	337	PF00018	0.540
LIG_SH3_3	393	399	PF00018	0.483
LIG_SH3_3	819	825	PF00018	0.755
LIG_SH3_3	855	861	PF00018	0.714
LIG_SUMO_SIM_anti_2	455	460	PF11976	0.559
LIG_SUMO_SIM_anti_2	476	485	PF11976	0.466
LIG_SUMO_SIM_anti_2	698	706	PF11976	0.529
LIG_SUMO_SIM_anti_2	741	747	PF11976	0.483
LIG_SUMO_SIM_par_1	112	117	PF11976	0.470
LIG_SUMO_SIM_par_1	438	447	PF11976	0.549
LIG_SUMO_SIM_par_1	476	485	PF11976	0.485
LIG_SUMO_SIM_par_1	612	617	PF11976	0.553
LIG_SUMO_SIM_par_1	698	706	PF11976	0.457
LIG_TRAF2_1	875	878	PF00917	0.706
LIG_TYR_ITIM	702	707	PF00017	0.391
LIG_UBA3_1	378	387	PF00899	0.332
LIG_UBA3_1	564	570	PF00899	0.337
LIG_UBA3_1	574	581	PF00899	0.274
LIG_WRC_WIRS_1	225	230	PF05994	0.495
LIG_WRC_WIRS_1	50	55	PF05994	0.382
LIG_WRC_WIRS_1	70	75	PF05994	0.342
LIG_WW_2	858	861	PF00397	0.552
MOD_CK1_1	2	8	PF00069	0.617
MOD_CK1_1	258	264	PF00069	0.525
MOD_CK1_1	278	284	PF00069	0.446
MOD_CK1_1	380	386	PF00069	0.324
MOD_CK1_1	52	58	PF00069	0.495
MOD_CK1_1	777	783	PF00069	0.566
MOD_CK1_1	866	872	PF00069	0.699
MOD_CK2_1	244	250	PF00069	0.309
MOD_CK2_1	317	323	PF00069	0.527
MOD_CK2_1	423	429	PF00069	0.369
MOD_CK2_1	464	470	PF00069	0.411
MOD_CK2_1	637	643	PF00069	0.348
MOD_CK2_1	762	768	PF00069	0.450
MOD_CK2_1	877	883	PF00069	0.761
MOD_GlcNHglycan	1	4	PF01048	0.634
MOD_GlcNHglycan	160	163	PF01048	0.435
MOD_GlcNHglycan	204	207	PF01048	0.313
MOD_GlcNHglycan	35	38	PF01048	0.358
MOD_GlcNHglycan	400	403	PF01048	0.438
MOD_GlcNHglycan	662	665	PF01048	0.373
MOD_GlcNHglycan	696	700	PF01048	0.407
MOD_GlcNHglycan	827	830	PF01048	0.698
MOD_GlcNHglycan	867	871	PF01048	0.725
MOD_GSK3_1	127	134	PF00069	0.449
MOD_GSK3_1	154	161	PF00069	0.313
MOD_GSK3_1	204	211	PF00069	0.441
MOD_GSK3_1	244	251	PF00069	0.446
MOD_GSK3_1	264	271	PF00069	0.243
MOD_GSK3_1	278	285	PF00069	0.497
MOD_GSK3_1	348	355	PF00069	0.367
MOD_GSK3_1	374	381	PF00069	0.293
MOD_GSK3_1	5	12	PF00069	0.471
MOD_GSK3_1	610	617	PF00069	0.351
MOD_GSK3_1	758	765	PF00069	0.386
MOD_GSK3_1	827	834	PF00069	0.729
MOD_GSK3_1	86	93	PF00069	0.392
MOD_N-GLC_1	268	273	PF02516	0.496
MOD_N-GLC_1	471	476	PF02516	0.431
MOD_N-GLC_1	502	507	PF02516	0.431
MOD_N-GLC_1	581	586	PF02516	0.295
MOD_NEK2_1	11	16	PF00069	0.511
MOD_NEK2_1	114	119	PF00069	0.438
MOD_NEK2_1	164	169	PF00069	0.316
MOD_NEK2_1	264	269	PF00069	0.527
MOD_NEK2_1	317	322	PF00069	0.518
MOD_NEK2_1	407	412	PF00069	0.362
MOD_NEK2_1	480	485	PF00069	0.474
MOD_NEK2_1	625	630	PF00069	0.391
MOD_NEK2_1	702	707	PF00069	0.290
MOD_NEK2_1	728	733	PF00069	0.378
MOD_NEK2_1	746	751	PF00069	0.207
MOD_NEK2_1	831	836	PF00069	0.682
MOD_NEK2_1	90	95	PF00069	0.399
MOD_NEK2_2	409	414	PF00069	0.422
MOD_NEK2_2	827	832	PF00069	0.691
MOD_PIKK_1	12	18	PF00454	0.523
MOD_PIKK_1	43	49	PF00454	0.392
MOD_PIKK_1	733	739	PF00454	0.431
MOD_PIKK_1	782	788	PF00454	0.565
MOD_PKA_1	282	288	PF00069	0.433
MOD_PKA_2	282	288	PF00069	0.433
MOD_PKA_2	442	448	PF00069	0.422
MOD_PKA_2	774	780	PF00069	0.534
MOD_PKA_2	782	788	PF00069	0.488
MOD_Plk_1	120	126	PF00069	0.313
MOD_Plk_1	154	160	PF00069	0.357
MOD_Plk_1	164	170	PF00069	0.265
MOD_Plk_1	208	214	PF00069	0.313
MOD_Plk_1	322	328	PF00069	0.350
MOD_Plk_1	372	378	PF00069	0.315
MOD_Plk_1	511	517	PF00069	0.412
MOD_Plk_1	581	587	PF00069	0.312
MOD_Plk_1	614	620	PF00069	0.431
MOD_Plk_1	877	883	PF00069	0.571
MOD_Plk_2-3	348	354	PF00069	0.422
MOD_Plk_2-3	637	643	PF00069	0.301
MOD_Plk_2-3	877	883	PF00069	0.571
MOD_Plk_4	232	238	PF00069	0.458
MOD_Plk_4	374	380	PF00069	0.332
MOD_Plk_4	391	397	PF00069	0.309
MOD_Plk_4	444	450	PF00069	0.369
MOD_Plk_4	482	488	PF00069	0.371
MOD_Plk_4	582	588	PF00069	0.309
MOD_Plk_4	69	75	PF00069	0.381
MOD_Plk_4	762	768	PF00069	0.483
MOD_ProDKin_1	174	180	PF00069	0.429
MOD_ProDKin_1	333	339	PF00069	0.497
MOD_ProDKin_1	462	468	PF00069	0.402
MOD_ProDKin_1	787	793	PF00069	0.478
MOD_SUMO_rev_2	323	332	PF00179	0.313
MOD_SUMO_rev_2	516	525	PF00179	0.438
TRG_DiLeu_BaEn_1	260	265	PF01217	0.493
TRG_DiLeu_BaEn_1	476	481	PF01217	0.422
TRG_DiLeu_BaEn_1	627	632	PF01217	0.438
TRG_DiLeu_BaEn_1	741	746	PF01217	0.438
TRG_DiLeu_BaLyEn_6	435	440	PF01217	0.332
TRG_DiLeu_LyEn_5	260	265	PF01217	0.493
TRG_ENDOCYTIC_2	376	379	PF00928	0.361
TRG_ENDOCYTIC_2	404	407	PF00928	0.329
TRG_ENDOCYTIC_2	683	686	PF00928	0.399
TRG_ENDOCYTIC_2	704	707	PF00928	0.357
TRG_ENDOCYTIC_2	763	766	PF00928	0.360
TRG_ENDOCYTIC_2	794	797	PF00928	0.466
TRG_ENDOCYTIC_2	87	90	PF00928	0.388
TRG_ER_diArg_1	644	646	PF00400	0.367
TRG_NES_CRM1_1	647	660	PF08389	0.295
TRG_Pf-PMV_PEXEL_1	460	464	PF00026	0.313
TRG_Pf-PMV_PEXEL_1	629	633	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R6	Leptomonas seymouri	23%	74%
A0A0N1HWQ8	Leptomonas seymouri	79%	98%
A0A0S4IPS1	Bodo saltans	23%	73%
A0A0S4J4T7	Bodo saltans	41%	89%
A0A1X0NT50	Trypanosomatidae	61%	92%
A0A3Q8IGV8	Leishmania donovani	95%	100%
A0A3S7X8J8	Leishmania donovani	22%	74%
A0A422N6J5	Trypanosoma rangeli	61%	96%
A4HBF3	Leishmania braziliensis	23%	74%
A4HM28	Leishmania braziliensis	84%	98%
A4I9G2	Leishmania infantum	95%	100%
A4IAK2	Leishmania infantum	22%	74%
C9ZJT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9B4G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B5M6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	74%
O35142	Rattus norvegicus	41%	98%
O42937	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
O55029	Mus musculus	42%	98%
O62621	Drosophila melanogaster	41%	97%
P35605	Bos taurus	41%	98%
P35606	Homo sapiens	41%	98%
P41811	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	99%
P53621	Homo sapiens	24%	72%
P53622	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	74%
Q0J3D9	Oryza sativa subsp. japonica	25%	73%
Q20168	Caenorhabditis elegans	38%	88%
Q27954	Bos taurus	24%	72%
Q4Q2B0	Leishmania major	23%	74%
Q4R4I8	Macaca fascicularis	41%	98%
Q54YD8	Dictyostelium discoideum	42%	88%
Q5R664	Pongo abelii	41%	98%
Q5VQ78	Oryza sativa subsp. japonica	44%	97%
Q6H8D5	Oryza sativa subsp. japonica	42%	97%
Q6H8D6	Oryza sativa subsp. japonica	44%	97%
Q8CIE6	Mus musculus	24%	72%
Q8L828	Arabidopsis thaliana	43%	97%
Q94A40	Arabidopsis thaliana	26%	73%
Q96WV5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	73%
Q9AUR7	Oryza sativa subsp. japonica	25%	73%
Q9AUR8	Oryza sativa subsp. japonica	26%	73%
Q9C827	Arabidopsis thaliana	43%	95%
Q9CAA0	Arabidopsis thaliana	43%	96%
Q9SJT9	Arabidopsis thaliana	26%	73%
V5AUU0	Trypanosoma cruzi	58%	97%