LeishMANIAdb
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ABC transporter family-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ABC transporter family-like protein
Gene product:
ATP-binding cassette half-transporter I4
Species:
Leishmania major
UniProt:
Q4Q3L0_LEIMA
TriTrypDb:
LmjF.33.3260 , LMJLV39_330045900 * , LMJSD75_330044700 *
Length:
949

Annotations

LeishMANIAdb annotations

Publication identifier(s): 23716044
ABC superfamily protein. Involved in the efflux of toxic antimony species and porphyrin derivatives. Dimeric.. Most closely related to bacterial ABC transporters (e.g. A0A557ZZI4_9PSEU, A0A2Z6DZW4_HYDTE, G6XIG1_9PROT) with lipid flippase activity. Localization: Cell surface (experimental) / Mitochondrial (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 2
GO:0005886 plasma membrane 3 2
GO:0016020 membrane 2 7
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

Q4Q3L0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3L0

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0006811 monoatomic ion transport 4 2
GO:0006812 monoatomic cation transport 5 2
GO:0009987 cellular process 1 2
GO:0030001 metal ion transport 6 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 8
GO:0005215 transporter activity 1 2
GO:0005488 binding 1 8
GO:0005524 ATP binding 5 8
GO:0008324 monoatomic cation transmembrane transporter activity 4 2
GO:0015075 monoatomic ion transmembrane transporter activity 3 2
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 2
GO:0015399 primary active transmembrane transporter activity 4 2
GO:0017076 purine nucleotide binding 4 8
GO:0022804 active transmembrane transporter activity 3 2
GO:0022857 transmembrane transporter activity 2 2
GO:0022890 inorganic cation transmembrane transporter activity 4 2
GO:0030554 adenyl nucleotide binding 5 8
GO:0032553 ribonucleotide binding 3 8
GO:0032555 purine ribonucleotide binding 4 8
GO:0032559 adenyl ribonucleotide binding 5 8
GO:0035639 purine ribonucleoside triphosphate binding 4 8
GO:0036094 small molecule binding 2 8
GO:0042626 ATPase-coupled transmembrane transporter activity 2 2
GO:0043167 ion binding 2 8
GO:0043168 anion binding 3 8
GO:0046873 metal ion transmembrane transporter activity 5 2
GO:0097159 organic cyclic compound binding 2 8
GO:0097367 carbohydrate derivative binding 2 8
GO:0140657 ATP-dependent activity 1 2
GO:1901265 nucleoside phosphate binding 3 8
GO:1901363 heterocyclic compound binding 2 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 114 118 PF00656 0.614
CLV_C14_Caspase3-7 48 52 PF00656 0.619
CLV_C14_Caspase3-7 499 503 PF00656 0.479
CLV_MEL_PAP_1 34 40 PF00089 0.356
CLV_NRD_NRD_1 164 166 PF00675 0.407
CLV_NRD_NRD_1 195 197 PF00675 0.466
CLV_NRD_NRD_1 276 278 PF00675 0.621
CLV_NRD_NRD_1 31 33 PF00675 0.424
CLV_NRD_NRD_1 317 319 PF00675 0.593
CLV_NRD_NRD_1 539 541 PF00675 0.705
CLV_NRD_NRD_1 777 779 PF00675 0.261
CLV_NRD_NRD_1 83 85 PF00675 0.440
CLV_NRD_NRD_1 892 894 PF00675 0.324
CLV_PCSK_KEX2_1 164 166 PF00082 0.477
CLV_PCSK_KEX2_1 276 278 PF00082 0.621
CLV_PCSK_KEX2_1 31 33 PF00082 0.473
CLV_PCSK_KEX2_1 317 319 PF00082 0.593
CLV_PCSK_KEX2_1 539 541 PF00082 0.737
CLV_PCSK_KEX2_1 776 778 PF00082 0.261
CLV_PCSK_KEX2_1 83 85 PF00082 0.440
CLV_PCSK_KEX2_1 891 893 PF00082 0.379
CLV_PCSK_PC7_1 773 779 PF00082 0.261
CLV_PCSK_PC7_1 887 893 PF00082 0.322
CLV_PCSK_SKI1_1 180 184 PF00082 0.476
CLV_PCSK_SKI1_1 188 192 PF00082 0.429
CLV_PCSK_SKI1_1 20 24 PF00082 0.371
CLV_PCSK_SKI1_1 224 228 PF00082 0.348
CLV_PCSK_SKI1_1 492 496 PF00082 0.634
CLV_PCSK_SKI1_1 716 720 PF00082 0.466
CLV_PCSK_SKI1_1 83 87 PF00082 0.345
CLV_PCSK_SKI1_1 850 854 PF00082 0.376
CLV_PCSK_SKI1_1 893 897 PF00082 0.355
CLV_Separin_Metazoa 506 510 PF03568 0.462
CLV_Separin_Metazoa 836 840 PF03568 0.512
DEG_APCC_DBOX_1 393 401 PF00400 0.453
DEG_APCC_DBOX_1 405 413 PF00400 0.368
DEG_APCC_DBOX_1 715 723 PF00400 0.212
DEG_APCC_DBOX_1 88 96 PF00400 0.514
DEG_COP1_1 244 253 PF00400 0.466
DEG_Nend_UBRbox_1 1 4 PF02207 0.441
DEG_SPOP_SBC_1 575 579 PF00917 0.504
DOC_ANK_TNKS_1 539 546 PF00023 0.504
DOC_CKS1_1 183 188 PF01111 0.642
DOC_CKS1_1 683 688 PF01111 0.465
DOC_CYCLIN_RxL_1 185 193 PF00134 0.669
DOC_MAPK_FxFP_2 709 712 PF00069 0.360
DOC_MAPK_gen_1 31 38 PF00069 0.590
DOC_MAPK_gen_1 317 323 PF00069 0.357
DOC_MAPK_gen_1 376 385 PF00069 0.437
DOC_MAPK_gen_1 891 900 PF00069 0.538
DOC_MAPK_MEF2A_6 31 38 PF00069 0.590
DOC_MAPK_MEF2A_6 317 325 PF00069 0.356
DOC_MAPK_MEF2A_6 406 414 PF00069 0.354
DOC_MAPK_MEF2A_6 445 454 PF00069 0.413
DOC_MAPK_MEF2A_6 742 749 PF00069 0.357
DOC_MAPK_NFAT4_5 31 39 PF00069 0.562
DOC_MAPK_NFAT4_5 318 326 PF00069 0.356
DOC_MAPK_NFAT4_5 742 750 PF00069 0.357
DOC_PP1_RVXF_1 699 705 PF00149 0.274
DOC_PP2B_LxvP_1 172 175 PF13499 0.644
DOC_PP2B_LxvP_1 439 442 PF13499 0.438
DOC_PP2B_LxvP_1 546 549 PF13499 0.458
DOC_PP4_FxxP_1 547 550 PF00568 0.469
DOC_PP4_FxxP_1 626 629 PF00568 0.449
DOC_PP4_FxxP_1 709 712 PF00568 0.360
DOC_PP4_FxxP_1 857 860 PF00568 0.479
DOC_PP4_FxxP_1 9 12 PF00568 0.369
DOC_USP7_MATH_1 137 141 PF00917 0.698
DOC_USP7_MATH_1 146 150 PF00917 0.626
DOC_USP7_MATH_1 175 179 PF00917 0.731
DOC_USP7_MATH_1 298 302 PF00917 0.432
DOC_USP7_MATH_1 464 468 PF00917 0.460
DOC_USP7_MATH_1 740 744 PF00917 0.357
DOC_USP7_MATH_1 829 833 PF00917 0.487
DOC_WW_Pin1_4 182 187 PF00397 0.677
DOC_WW_Pin1_4 217 222 PF00397 0.560
DOC_WW_Pin1_4 456 461 PF00397 0.534
DOC_WW_Pin1_4 480 485 PF00397 0.468
DOC_WW_Pin1_4 518 523 PF00397 0.510
DOC_WW_Pin1_4 682 687 PF00397 0.475
LIG_14-3-3_CanoR_1 180 186 PF00244 0.725
LIG_14-3-3_CanoR_1 2 9 PF00244 0.455
LIG_14-3-3_CanoR_1 20 28 PF00244 0.369
LIG_14-3-3_CanoR_1 240 250 PF00244 0.477
LIG_14-3-3_CanoR_1 280 290 PF00244 0.426
LIG_14-3-3_CanoR_1 318 324 PF00244 0.356
LIG_14-3-3_CanoR_1 347 355 PF00244 0.455
LIG_14-3-3_CanoR_1 376 381 PF00244 0.456
LIG_14-3-3_CanoR_1 438 442 PF00244 0.465
LIG_14-3-3_CanoR_1 496 505 PF00244 0.485
LIG_14-3-3_CanoR_1 632 637 PF00244 0.455
LIG_14-3-3_CanoR_1 701 705 PF00244 0.284
LIG_14-3-3_CanoR_1 897 907 PF00244 0.529
LIG_14-3-3_CanoR_1 91 96 PF00244 0.601
LIG_Actin_WH2_2 21 39 PF00022 0.529
LIG_APCC_ABBA_1 866 871 PF00400 0.504
LIG_BIR_III_4 51 55 PF00653 0.559
LIG_BRCT_BRCA1_1 300 304 PF00533 0.429
LIG_BRCT_BRCA1_1 638 642 PF00533 0.495
LIG_deltaCOP1_diTrp_1 398 404 PF00928 0.483
LIG_DLG_GKlike_1 91 99 PF00625 0.615
LIG_eIF4E_1 448 454 PF01652 0.460
LIG_FHA_1 167 173 PF00498 0.590
LIG_FHA_1 21 27 PF00498 0.339
LIG_FHA_1 255 261 PF00498 0.437
LIG_FHA_1 409 415 PF00498 0.456
LIG_FHA_1 489 495 PF00498 0.566
LIG_FHA_1 533 539 PF00498 0.475
LIG_FHA_1 599 605 PF00498 0.506
LIG_FHA_1 644 650 PF00498 0.490
LIG_FHA_1 656 662 PF00498 0.360
LIG_FHA_1 70 76 PF00498 0.677
LIG_FHA_1 721 727 PF00498 0.334
LIG_FHA_1 742 748 PF00498 0.299
LIG_FHA_1 787 793 PF00498 0.504
LIG_FHA_1 813 819 PF00498 0.512
LIG_FHA_1 871 877 PF00498 0.461
LIG_FHA_2 112 118 PF00498 0.617
LIG_FHA_2 330 336 PF00498 0.431
LIG_FHA_2 712 718 PF00498 0.395
LIG_FHA_2 72 78 PF00498 0.592
LIG_LIR_Apic_2 339 345 PF02991 0.459
LIG_LIR_Apic_2 379 384 PF02991 0.462
LIG_LIR_Apic_2 544 550 PF02991 0.551
LIG_LIR_Gen_1 122 131 PF02991 0.528
LIG_LIR_Gen_1 332 340 PF02991 0.497
LIG_LIR_Gen_1 359 367 PF02991 0.517
LIG_LIR_Gen_1 703 712 PF02991 0.347
LIG_LIR_Gen_1 926 931 PF02991 0.520
LIG_LIR_Gen_1 936 947 PF02991 0.522
LIG_LIR_Nem_3 122 127 PF02991 0.525
LIG_LIR_Nem_3 274 278 PF02991 0.469
LIG_LIR_Nem_3 332 337 PF02991 0.497
LIG_LIR_Nem_3 359 363 PF02991 0.519
LIG_LIR_Nem_3 5 11 PF02991 0.257
LIG_LIR_Nem_3 557 563 PF02991 0.579
LIG_LIR_Nem_3 703 707 PF02991 0.297
LIG_LIR_Nem_3 926 930 PF02991 0.519
LIG_LIR_Nem_3 936 942 PF02991 0.508
LIG_NRBOX 225 231 PF00104 0.369
LIG_NRBOX 449 455 PF00104 0.451
LIG_NRBOX 744 750 PF00104 0.357
LIG_Pex14_1 700 704 PF04695 0.291
LIG_Pex14_2 704 708 PF04695 0.280
LIG_PTB_Apo_2 231 238 PF02174 0.573
LIG_PTB_Apo_2 354 361 PF02174 0.458
LIG_PTB_Apo_2 570 577 PF02174 0.439
LIG_PTB_Phospho_1 231 237 PF10480 0.574
LIG_Rb_pABgroove_1 97 105 PF01858 0.616
LIG_REV1ctd_RIR_1 706 711 PF16727 0.289
LIG_SH2_CRK 349 353 PF00017 0.463
LIG_SH2_CRK 512 516 PF00017 0.487
LIG_SH2_CRK 683 687 PF00017 0.454
LIG_SH2_CRK 803 807 PF00017 0.487
LIG_SH2_NCK_1 683 687 PF00017 0.454
LIG_SH2_SRC 651 654 PF00017 0.449
LIG_SH2_STAP1 256 260 PF00017 0.452
LIG_SH2_STAP1 657 661 PF00017 0.481
LIG_SH2_STAT3 448 451 PF00017 0.462
LIG_SH2_STAT3 943 946 PF00017 0.571
LIG_SH2_STAT5 138 141 PF00017 0.636
LIG_SH2_STAT5 237 240 PF00017 0.551
LIG_SH2_STAT5 256 259 PF00017 0.323
LIG_SH2_STAT5 657 660 PF00017 0.407
LIG_SH3_3 478 484 PF00018 0.432
LIG_SH3_3 547 553 PF00018 0.481
LIG_SH3_3 624 630 PF00018 0.498
LIG_SH3_3 749 755 PF00018 0.504
LIG_SUMO_SIM_anti_2 257 263 PF11976 0.444
LIG_SUMO_SIM_anti_2 743 750 PF11976 0.357
LIG_SUMO_SIM_anti_2 911 917 PF11976 0.488
LIG_SUMO_SIM_par_1 326 332 PF11976 0.407
LIG_SUMO_SIM_par_1 74 81 PF11976 0.567
LIG_SUMO_SIM_par_1 743 750 PF11976 0.357
LIG_TYR_ITIM 510 515 PF00017 0.386
LIG_TYR_ITIM 801 806 PF00017 0.504
LIG_WRC_WIRS_1 637 642 PF05994 0.493
LIG_WW_3 185 189 PF00397 0.670
LIG_WW_3 770 774 PF00397 0.504
MOD_CDK_SPK_2 480 485 PF00069 0.453
MOD_CDK_SPxK_1 182 188 PF00069 0.678
MOD_CDK_SPxxK_3 217 224 PF00069 0.479
MOD_CK1_1 246 252 PF00069 0.466
MOD_CK1_1 465 471 PF00069 0.487
MOD_CK1_1 551 557 PF00069 0.508
MOD_CK1_1 660 666 PF00069 0.481
MOD_CK1_1 841 847 PF00069 0.512
MOD_CK2_1 303 309 PF00069 0.419
MOD_CK2_1 518 524 PF00069 0.529
MOD_CK2_1 841 847 PF00069 0.439
MOD_CK2_1 875 881 PF00069 0.583
MOD_GlcNHglycan 139 142 PF01048 0.476
MOD_GlcNHglycan 246 249 PF01048 0.672
MOD_GlcNHglycan 251 254 PF01048 0.717
MOD_GlcNHglycan 284 287 PF01048 0.659
MOD_GlcNHglycan 292 295 PF01048 0.630
MOD_GlcNHglycan 305 308 PF01048 0.586
MOD_GlcNHglycan 349 352 PF01048 0.638
MOD_GlcNHglycan 464 467 PF01048 0.673
MOD_GlcNHglycan 541 544 PF01048 0.701
MOD_GlcNHglycan 621 624 PF01048 0.724
MOD_GlcNHglycan 695 699 PF01048 0.682
MOD_GlcNHglycan 737 740 PF01048 0.321
MOD_GlcNHglycan 806 809 PF01048 0.335
MOD_GlcNHglycan 831 834 PF01048 0.305
MOD_GlcNHglycan 842 846 PF01048 0.249
MOD_GSK3_1 146 153 PF00069 0.636
MOD_GSK3_1 242 249 PF00069 0.458
MOD_GSK3_1 456 463 PF00069 0.492
MOD_GSK3_1 528 535 PF00069 0.569
MOD_GSK3_1 548 555 PF00069 0.366
MOD_GSK3_1 588 595 PF00069 0.477
MOD_GSK3_1 632 639 PF00069 0.483
MOD_GSK3_1 65 72 PF00069 0.727
MOD_GSK3_1 667 674 PF00069 0.402
MOD_GSK3_1 934 941 PF00069 0.571
MOD_N-GLC_1 146 151 PF02516 0.427
MOD_N-GLC_1 233 238 PF02516 0.684
MOD_N-GLC_1 26 31 PF02516 0.453
MOD_N-GLC_1 356 361 PF02516 0.665
MOD_N-GLC_1 693 698 PF02516 0.626
MOD_N-GLC_1 78 83 PF02516 0.498
MOD_N-GLC_1 804 809 PF02516 0.212
MOD_N-GLC_1 893 898 PF02516 0.364
MOD_N-GLC_2 217 219 PF02516 0.279
MOD_NEK2_1 176 181 PF00069 0.667
MOD_NEK2_1 241 246 PF00069 0.487
MOD_NEK2_1 290 295 PF00069 0.470
MOD_NEK2_1 303 308 PF00069 0.361
MOD_NEK2_1 319 324 PF00069 0.467
MOD_NEK2_1 329 334 PF00069 0.447
MOD_NEK2_1 488 493 PF00069 0.490
MOD_NEK2_1 532 537 PF00069 0.507
MOD_NEK2_1 576 581 PF00069 0.480
MOD_NEK2_1 636 641 PF00069 0.496
MOD_NEK2_1 747 752 PF00069 0.301
MOD_NEK2_1 78 83 PF00069 0.627
MOD_NEK2_1 938 943 PF00069 0.555
MOD_NEK2_2 408 413 PF00069 0.388
MOD_NEK2_2 534 539 PF00069 0.494
MOD_NEK2_2 934 939 PF00069 0.554
MOD_OFUCOSY 785 790 PF10250 0.212
MOD_PIKK_1 655 661 PF00454 0.382
MOD_PIKK_1 753 759 PF00454 0.412
MOD_PK_1 903 909 PF00069 0.575
MOD_PKA_1 539 545 PF00069 0.470
MOD_PKA_2 1 7 PF00069 0.440
MOD_PKA_2 254 260 PF00069 0.438
MOD_PKA_2 437 443 PF00069 0.545
MOD_PKA_2 488 494 PF00069 0.453
MOD_PKA_2 539 545 PF00069 0.539
MOD_PKA_2 671 677 PF00069 0.385
MOD_PKA_2 700 706 PF00069 0.287
MOD_PKA_2 786 792 PF00069 0.512
MOD_PKA_2 829 835 PF00069 0.497
MOD_PKA_2 838 844 PF00069 0.514
MOD_PKA_2 923 929 PF00069 0.560
MOD_PKB_1 35 43 PF00069 0.622
MOD_PKB_1 89 97 PF00069 0.564
MOD_PKB_1 891 899 PF00069 0.541
MOD_Plk_1 233 239 PF00069 0.683
MOD_Plk_1 356 362 PF00069 0.451
MOD_Plk_1 720 726 PF00069 0.290
MOD_Plk_1 846 852 PF00069 0.412
MOD_Plk_1 893 899 PF00069 0.573
MOD_Plk_1 934 940 PF00069 0.565
MOD_Plk_2-3 45 51 PF00069 0.581
MOD_Plk_2-3 793 799 PF00069 0.512
MOD_Plk_4 233 239 PF00069 0.500
MOD_Plk_4 324 330 PF00069 0.435
MOD_Plk_4 408 414 PF00069 0.419
MOD_Plk_4 45 51 PF00069 0.602
MOD_Plk_4 660 666 PF00069 0.481
MOD_Plk_4 685 691 PF00069 0.442
MOD_Plk_4 71 77 PF00069 0.623
MOD_Plk_4 741 747 PF00069 0.297
MOD_Plk_4 934 940 PF00069 0.557
MOD_ProDKin_1 182 188 PF00069 0.678
MOD_ProDKin_1 217 223 PF00069 0.560
MOD_ProDKin_1 456 462 PF00069 0.534
MOD_ProDKin_1 480 486 PF00069 0.466
MOD_ProDKin_1 518 524 PF00069 0.511
MOD_ProDKin_1 682 688 PF00069 0.472
MOD_SUMO_rev_2 877 885 PF00179 0.585
TRG_DiLeu_BaEn_1 847 852 PF01217 0.512
TRG_DiLeu_BaLyEn_6 177 182 PF01217 0.651
TRG_DiLeu_BaLyEn_6 210 215 PF01217 0.596
TRG_DiLeu_BaLyEn_6 362 367 PF01217 0.442
TRG_ENDOCYTIC_2 349 352 PF00928 0.466
TRG_ENDOCYTIC_2 512 515 PF00928 0.521
TRG_ENDOCYTIC_2 803 806 PF00928 0.504
TRG_ER_diArg_1 164 166 PF00400 0.607
TRG_ER_diArg_1 275 277 PF00400 0.436
TRG_ER_diArg_1 316 318 PF00400 0.386
TRG_ER_diArg_1 34 37 PF00400 0.651
TRG_ER_diArg_1 508 511 PF00400 0.475
TRG_ER_diArg_1 538 540 PF00400 0.508
TRG_ER_diArg_1 775 778 PF00400 0.461
TRG_ER_diArg_1 83 85 PF00400 0.635
TRG_ER_diArg_1 89 92 PF00400 0.579
TRG_ER_diArg_1 891 893 PF00400 0.547
TRG_Pf-PMV_PEXEL_1 188 193 PF00026 0.471

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I508 Leptomonas seymouri 45% 99%
A0A1X0NRF7 Trypanosomatidae 25% 94%
A0A3S7X7B4 Leishmania donovani 92% 100%
A4HM34 Leishmania braziliensis 77% 100%
A4I9G7 Leishmania infantum 92% 100%
E9B4G5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS