Delta-12 fatty acid desaturase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

delta-12 fatty acid desaturase

Species:

Leishmania major

UniProt:

Q4Q3K9_LEIMA

TriTrypDb:

LmjF.33.3270 , LMJLV39_330046000 , LMJSD75_330044800

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

Q4Q3K9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3K9

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	18
GO:0008152	metabolic process	1	18
GO:0044238	primary metabolic process	2	18
GO:0071704	organic substance metabolic process	2	18

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004768	stearoyl-CoA 9-desaturase activity	6	6
GO:0016215	acyl-CoA desaturase activity	5	6
GO:0016491	oxidoreductase activity	2	7
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	6
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.561
CLV_NRD_NRD_1	215	217	PF00675	0.329
CLV_NRD_NRD_1	227	229	PF00675	0.279
CLV_NRD_NRD_1	360	362	PF00675	0.333
CLV_PCSK_KEX2_1	215	217	PF00082	0.329
CLV_PCSK_KEX2_1	360	362	PF00082	0.298
CLV_PCSK_KEX2_1	392	394	PF00082	0.447
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.447
CLV_PCSK_SKI1_1	2	6	PF00082	0.336
CLV_PCSK_SKI1_1	301	305	PF00082	0.198
CLV_PCSK_SKI1_1	349	353	PF00082	0.198
DEG_APCC_DBOX_1	300	308	PF00400	0.398
DEG_COP1_1	12	20	PF00400	0.437
DEG_Nend_UBRbox_1	1	4	PF02207	0.624
DOC_MAPK_gen_1	10	17	PF00069	0.499
DOC_MAPK_gen_1	172	180	PF00069	0.312
DOC_MAPK_MEF2A_6	10	17	PF00069	0.579
DOC_PP4_FxxP_1	198	201	PF00568	0.284
DOC_USP7_MATH_1	126	130	PF00917	0.485
DOC_USP7_MATH_1	145	149	PF00917	0.295
DOC_USP7_MATH_2	379	385	PF00917	0.598
DOC_USP7_UBL2_3	2	6	PF12436	0.547
DOC_WW_Pin1_4	122	127	PF00397	0.434
DOC_WW_Pin1_4	181	186	PF00397	0.286
DOC_WW_Pin1_4	221	226	PF00397	0.509
LIG_APCC_ABBA_1	45	50	PF00400	0.388
LIG_BRCT_BRCA1_1	223	227	PF00533	0.509
LIG_BRCT_BRCA1_2	223	229	PF00533	0.542
LIG_deltaCOP1_diTrp_1	295	299	PF00928	0.435
LIG_EH1_1	345	353	PF00400	0.513
LIG_FHA_1	158	164	PF00498	0.247
LIG_FHA_1	165	171	PF00498	0.243
LIG_FHA_1	182	188	PF00498	0.366
LIG_GBD_Chelix_1	327	335	PF00786	0.268
LIG_LIR_Apic_2	373	379	PF02991	0.483
LIG_LIR_Gen_1	295	305	PF02991	0.422
LIG_LIR_Gen_1	39	48	PF02991	0.510
LIG_LIR_Gen_1	86	95	PF02991	0.404
LIG_LIR_Nem_3	125	130	PF02991	0.513
LIG_LIR_Nem_3	253	259	PF02991	0.305
LIG_LIR_Nem_3	295	300	PF02991	0.431
LIG_LIR_Nem_3	308	314	PF02991	0.461
LIG_LIR_Nem_3	384	389	PF02991	0.581
LIG_LIR_Nem_3	39	45	PF02991	0.549
LIG_LIR_Nem_3	86	90	PF02991	0.384
LIG_LYPXL_SIV_4	268	276	PF13949	0.202
LIG_Pex14_1	42	46	PF04695	0.559
LIG_Pex14_2	196	200	PF04695	0.299
LIG_SH2_CRK	127	131	PF00017	0.540
LIG_SH2_CRK	259	263	PF00017	0.244
LIG_SH2_CRK	311	315	PF00017	0.468
LIG_SH2_CRK	62	66	PF00017	0.330
LIG_SH2_NCK_1	77	81	PF00017	0.268
LIG_SH2_PTP2	265	268	PF00017	0.423
LIG_SH2_PTP2	376	379	PF00017	0.484
LIG_SH2_SRC	254	257	PF00017	0.456
LIG_SH2_STAT5	203	206	PF00017	0.377
LIG_SH2_STAT5	265	268	PF00017	0.289
LIG_SH2_STAT5	278	281	PF00017	0.282
LIG_SH2_STAT5	35	38	PF00017	0.517
LIG_SH2_STAT5	356	359	PF00017	0.498
LIG_SH2_STAT5	376	379	PF00017	0.382
LIG_SH2_STAT5	46	49	PF00017	0.469
LIG_SH2_STAT5	58	61	PF00017	0.356
LIG_SH3_3	12	18	PF00018	0.489
LIG_SH3_3	139	145	PF00018	0.362
LIG_SH3_3	165	171	PF00018	0.232
LIG_SH3_3	219	225	PF00018	0.443
LIG_SUMO_SIM_par_1	174	184	PF11976	0.242
LIG_SUMO_SIM_par_1	185	190	PF11976	0.342
LIG_TYR_ITIM	267	272	PF00017	0.231
LIG_TYR_ITIM	60	65	PF00017	0.344
LIG_UBA3_1	363	372	PF00899	0.582
MOD_CDC14_SPxK_1	125	128	PF00782	0.421
MOD_CDK_SPxK_1	122	128	PF00069	0.421
MOD_CDK_SPxxK_3	221	228	PF00069	0.455
MOD_CK1_1	88	94	PF00069	0.390
MOD_CK2_1	367	373	PF00069	0.504
MOD_CMANNOS	84	87	PF00535	0.462
MOD_Cter_Amidation	213	216	PF01082	0.342
MOD_GlcNHglycan	18	21	PF01048	0.353
MOD_GlcNHglycan	37	41	PF01048	0.337
MOD_GlcNHglycan	90	93	PF01048	0.555
MOD_GSK3_1	122	129	PF00069	0.474
MOD_GSK3_1	145	152	PF00069	0.303
MOD_GSK3_1	157	164	PF00069	0.252
MOD_GSK3_1	16	23	PF00069	0.485
MOD_GSK3_1	36	43	PF00069	0.463
MOD_GSK3_1	377	384	PF00069	0.564
MOD_N-GLC_1	107	112	PF02516	0.217
MOD_NEK2_1	107	112	PF00069	0.249
MOD_NEK2_1	137	142	PF00069	0.398
MOD_NEK2_1	277	282	PF00069	0.417
MOD_NEK2_1	36	41	PF00069	0.508
MOD_NEK2_1	367	372	PF00069	0.531
MOD_NEK2_2	20	25	PF00069	0.503
MOD_NEK2_2	40	45	PF00069	0.545
MOD_PIKK_1	207	213	PF00454	0.542
MOD_PIKK_1	330	336	PF00454	0.486
MOD_PKA_1	172	178	PF00069	0.300
MOD_PKA_2	149	155	PF00069	0.243
MOD_PKA_2	214	220	PF00069	0.497
MOD_Plk_1	20	26	PF00069	0.565
MOD_Plk_1	36	42	PF00069	0.559
MOD_Plk_4	138	144	PF00069	0.268
MOD_Plk_4	164	170	PF00069	0.285
MOD_Plk_4	244	250	PF00069	0.256
MOD_Plk_4	381	387	PF00069	0.547
MOD_ProDKin_1	122	128	PF00069	0.434
MOD_ProDKin_1	181	187	PF00069	0.286
MOD_ProDKin_1	221	227	PF00069	0.509
TRG_DiLeu_BaEn_2	294	300	PF01217	0.476
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.549
TRG_ENDOCYTIC_2	127	130	PF00928	0.542
TRG_ENDOCYTIC_2	203	206	PF00928	0.410
TRG_ENDOCYTIC_2	259	262	PF00928	0.272
TRG_ENDOCYTIC_2	269	272	PF00928	0.240
TRG_ENDOCYTIC_2	311	314	PF00928	0.468
TRG_ENDOCYTIC_2	338	341	PF00928	0.443
TRG_ENDOCYTIC_2	58	61	PF00928	0.246
TRG_ENDOCYTIC_2	62	65	PF00928	0.227
TRG_ER_diArg_1	360	362	PF00400	0.608
TRG_ER_diLys_1	391	394	PF00400	0.636
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.254

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L0	Leptomonas seymouri	78%	100%
A0A0S4IVK0	Bodo saltans	56%	94%
A0A1X0NKF1	Trypanosomatidae	47%	85%
A0A3Q8I8P6	Leishmania donovani	75%	100%
A0A3S7X797	Leishmania donovani	96%	100%
A0A422MYL0	Trypanosoma rangeli	60%	94%
A3F5L2	Sorghum bicolor	37%	100%
A3F5L3	Sorghum bicolor	38%	100%
A4H5Y3	Leishmania braziliensis	75%	100%
A4H6C4	Leishmania braziliensis	74%	100%
A4HM35	Leishmania braziliensis	83%	100%
A4HUP7	Leishmania infantum	75%	100%
A4I9G8	Leishmania infantum	96%	100%
B4YQU1	Claviceps purpurea	36%	83%
C9ZJ57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	97%
E9ANE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
E9B4G6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
G5EGA5	Caenorhabditis elegans	29%	100%
O81931	Crepis alpina	36%	100%
P32291	Vigna radiata var. radiata	35%	100%
P46310	Arabidopsis thaliana	34%	88%
P46313	Arabidopsis thaliana	39%	100%
P48618	Brassica napus	39%	98%
P48619	Ricinus communis	33%	86%
P48620	Sesamum indicum	34%	88%
P48621	Glycine max	37%	87%
P48622	Arabidopsis thaliana	33%	91%
P48623	Arabidopsis thaliana	33%	100%
P48624	Brassica napus	33%	100%
P48625	Glycine max	38%	100%
P48626	Nicotiana tabacum	32%	100%
P48627	Brassica napus	23%	89%
P48630	Glycine max	40%	100%
P48631	Glycine max	39%	100%
P59668	Mortierella isabellina	43%	98%
Q39287	Brassica juncea	39%	100%
Q41131	Ricinus communis	39%	100%
Q4QH80	Leishmania major	75%	100%
Q56VS4	Helianthus annuus	37%	89%
Q594P3	Sorghum bicolor	38%	100%
Q59J82	Mortierella alpina	36%	98%
Q6RS95	Dimorphotheca sinuata	36%	100%
Q6RS96	Dimorphotheca sinuata	33%	100%
Q84UB8	Punica granatum	37%	100%
Q84UB9	Trichosanthes kirilowii	38%	100%
Q84UC0	Trichosanthes kirilowii	38%	100%
Q84VT2	Punica granatum	40%	100%
Q8GZC2	Vernicia fordii	40%	100%
Q8GZC3	Vernicia fordii	39%	100%
Q9AT72	Calendula officinalis	39%	100%
Q9FPP7	Calendula officinalis	35%	100%
Q9FPP8	Calendula officinalis	34%	100%
Q9NEQ0	Caenorhabditis elegans	31%	98%
Q9SCG2	Calendula officinalis	38%	100%
Q9SP61	Momordica charantia	35%	99%
Q9SP62	Impatiens balsamina	34%	100%
Q9Y8H5	Mortierella alpina	43%	98%
V5BA48	Trypanosoma cruzi	59%	96%