LeishMANIAdb
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Short-chain dehydrogenase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Short-chain dehydrogenase
Gene product:
short chain dehydrogenase, putative
Species:
Leishmania major
UniProt:
Q4Q3K8_LEIMA
TriTrypDb:
LmjF.34.0010 , LMJLV39_340005200 * , LMJSD75_340005200 *
Length:
306

Annotations

LeishMANIAdb annotations

These proteins belong to short-chain dehydrogenases / reductases using NAD or NADP as cofactor. All homologs are used for very long fatty acid biosynthesis.. Expanded in multiple organisms, but especially Strigomonas. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3
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Expansion

Sequence features

Q4Q3K8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3K8

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 3
GO:0016491 oxidoreductase activity 2 3
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 236 238 PF00675 0.365
CLV_NRD_NRD_1 298 300 PF00675 0.344
CLV_NRD_NRD_1 302 304 PF00675 0.358
CLV_NRD_NRD_1 64 66 PF00675 0.263
CLV_PCSK_KEX2_1 170 172 PF00082 0.260
CLV_PCSK_KEX2_1 298 300 PF00082 0.323
CLV_PCSK_KEX2_1 304 306 PF00082 0.387
CLV_PCSK_KEX2_1 36 38 PF00082 0.303
CLV_PCSK_KEX2_1 64 66 PF00082 0.231
CLV_PCSK_PC1ET2_1 170 172 PF00082 0.278
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I6F8 Leptomonas seymouri 82% 99%
A0A0S4IR33 Bodo saltans 54% 90%
A0A0S4IWL0 Bodo saltans 55% 96%
A0A0S4JBE7 Bodo saltans 48% 94%
A0A0S4JSF1 Bodo saltans 31% 76%
A0A140FAN3 Pinus massoniana 27% 86%
A0A1A9TAK5 Narcissus pseudonarcissus 25% 100%
A0A1B2CTA9 Penicillium thymicola 30% 100%
A0A1C9II22 Narcissus aff. pseudonarcissus MK-2014 25% 100%
A0A1X0NWL8 Trypanosomatidae 59% 99%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS