Leucine-rich repeat protein (LRRP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q3K7_LEIMA

TriTrypDb:

LmjF.34.0020 , LMJLV39_360060100 , LMJSD75_360059800

Length:

344

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	2
GO:0005929	cilium	4	14
GO:0019005	SCF ubiquitin ligase complex	5	2
GO:0031461	cullin-RING ubiquitin ligase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0042995	cell projection	2	14
GO:0043226	organelle	2	14
GO:0043227	membrane-bounded organelle	3	14
GO:0110165	cellular anatomical entity	1	14
GO:0120025	plasma membrane bounded cell projection	3	14
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2
GO:0005743	mitochondrial inner membrane	5	2
GO:0016020	membrane	2	2
GO:0019866	organelle inner membrane	4	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2

Expansion

Sequence features

Q4Q3K7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3K7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	8
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	8
GO:0010498	proteasomal protein catabolic process	5	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0030163	protein catabolic process	4	2
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0016310	phosphorylation	5	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	298	302	PF00656	0.507
CLV_NRD_NRD_1	150	152	PF00675	0.492
CLV_PCSK_KEX2_1	150	152	PF00082	0.492
CLV_PCSK_SKI1_1	105	109	PF00082	0.516
CLV_PCSK_SKI1_1	150	154	PF00082	0.472
CLV_PCSK_SKI1_1	197	201	PF00082	0.464
CLV_PCSK_SKI1_1	21	25	PF00082	0.554
CLV_PCSK_SKI1_1	303	307	PF00082	0.522
DEG_APCC_DBOX_1	20	28	PF00400	0.503
DEG_Nend_UBRbox_4	1	3	PF02207	0.384
DEG_ODPH_VHL_1	49	61	PF01847	0.545
DEG_SCF_FBW7_1	154	161	PF00400	0.480
DOC_CYCLIN_RxL_1	148	157	PF00134	0.477
DOC_CYCLIN_RxL_1	194	205	PF00134	0.457
DOC_USP7_MATH_1	158	162	PF00917	0.514
DOC_USP7_UBL2_3	165	169	PF12436	0.287
DOC_USP7_UBL2_3	41	45	PF12436	0.509
DOC_WW_Pin1_4	154	159	PF00397	0.480
LIG_14-3-3_CanoR_1	142	149	PF00244	0.495
LIG_14-3-3_CanoR_1	277	284	PF00244	0.489
LIG_14-3-3_CanoR_1	291	296	PF00244	0.494
LIG_Actin_WH2_2	126	144	PF00022	0.262
LIG_Actin_WH2_2	160	176	PF00022	0.357
LIG_Actin_WH2_2	22	40	PF00022	0.302
LIG_BIR_III_4	301	305	PF00653	0.475
LIG_BRCT_BRCA1_1	84	88	PF00533	0.479
LIG_FHA_1	113	119	PF00498	0.484
LIG_FHA_1	122	128	PF00498	0.454
LIG_FHA_1	277	283	PF00498	0.439
LIG_FHA_1	314	320	PF00498	0.503
LIG_FHA_1	98	104	PF00498	0.545
LIG_FHA_2	296	302	PF00498	0.482
LIG_FHA_2	3	9	PF00498	0.545
LIG_FHA_2	75	81	PF00498	0.507
LIG_GBD_Chelix_1	240	248	PF00786	0.488
LIG_LIR_Gen_1	289	300	PF02991	0.457
LIG_LIR_Gen_1	92	103	PF02991	0.569
LIG_LIR_Nem_3	144	149	PF02991	0.398
LIG_LIR_Nem_3	289	295	PF02991	0.433
LIG_NBox_RRM_1	71	81	PF00076	0.281
LIG_NRBOX	148	154	PF00104	0.479
LIG_NRBOX	239	245	PF00104	0.502
LIG_SH2_STAT5	339	342	PF00017	0.552
LIG_SH3_3	48	54	PF00018	0.531
LIG_SUMO_SIM_anti_2	129	134	PF11976	0.478
LIG_SUMO_SIM_anti_2	22	28	PF11976	0.441
LIG_SUMO_SIM_par_1	128	134	PF11976	0.476
LIG_SUMO_SIM_par_1	80	86	PF11976	0.505
LIG_Vh1_VBS_1	261	279	PF01044	0.489
MOD_CK1_1	126	132	PF00069	0.483
MOD_CK1_1	263	269	PF00069	0.449
MOD_CK1_1	60	66	PF00069	0.422
MOD_CK1_1	73	79	PF00069	0.529
MOD_CK1_1	97	103	PF00069	0.491
MOD_CK2_1	113	119	PF00069	0.528
MOD_CK2_1	2	8	PF00069	0.600
MOD_CK2_1	253	259	PF00069	0.495
MOD_CK2_1	263	269	PF00069	0.456
MOD_CK2_1	74	80	PF00069	0.477
MOD_GlcNHglycan	143	146	PF01048	0.434
MOD_GlcNHglycan	255	258	PF01048	0.426
MOD_GlcNHglycan	72	75	PF01048	0.513
MOD_GSK3_1	108	115	PF00069	0.357
MOD_GSK3_1	154	161	PF00069	0.426
MOD_GSK3_1	247	254	PF00069	0.491
MOD_GSK3_1	291	298	PF00069	0.481
MOD_GSK3_1	70	77	PF00069	0.497
MOD_GSK3_1	94	101	PF00069	0.431
MOD_NEK2_1	108	113	PF00069	0.459
MOD_NEK2_1	121	126	PF00069	0.384
MOD_NEK2_1	141	146	PF00069	0.392
MOD_NEK2_1	201	206	PF00069	0.423
MOD_NEK2_1	248	253	PF00069	0.421
MOD_NEK2_1	319	324	PF00069	0.498
MOD_NEK2_1	55	60	PF00069	0.385
MOD_NEK2_1	94	99	PF00069	0.496
MOD_NEK2_2	160	165	PF00069	0.273
MOD_NEK2_2	286	291	PF00069	0.495
MOD_PKA_2	141	147	PF00069	0.264
MOD_PKA_2	2	8	PF00069	0.572
MOD_PKA_2	276	282	PF00069	0.501
MOD_Plk_1	202	208	PF00069	0.472
MOD_Plk_2-3	8	14	PF00069	0.559
MOD_Plk_4	113	119	PF00069	0.531
MOD_Plk_4	128	134	PF00069	0.446
MOD_Plk_4	236	242	PF00069	0.340
MOD_Plk_4	263	269	PF00069	0.477
MOD_Plk_4	291	297	PF00069	0.505
MOD_ProDKin_1	154	160	PF00069	0.480
TRG_DiLeu_BaEn_1	102	107	PF01217	0.473
TRG_DiLeu_BaEn_1	148	153	PF01217	0.313
TRG_DiLeu_LyEn_5	148	153	PF01217	0.313
TRG_ER_diArg_1	149	151	PF00400	0.491
TRG_NES_CRM1_1	33	48	PF08389	0.455
TRG_NES_CRM1_1	80	92	PF08389	0.500
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2F4	Leptomonas seymouri	27%	71%
A0A0S4IPS9	Bodo saltans	26%	94%
A0A0S4IRL6	Bodo saltans	28%	94%
A0A0S4ITQ8	Bodo saltans	26%	70%
A0A0S4J6G8	Bodo saltans	25%	89%
A0A0S4JR29	Bodo saltans	27%	67%
A0A0S4JTM8	Bodo saltans	25%	83%
A0A1X0NJ14	Trypanosomatidae	29%	100%
A0A3S7X7D2	Leishmania donovani	86%	77%
A4I9H0	Leishmania infantum	86%	77%
C9ZXN7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	70%
E9B4G8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	82%