Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine-protein kinase NAK, putative

Species:

Leishmania major

UniProt:

Q4Q3K6_LEIMA

TriTrypDb:

LmjF.34.0030 , LMJLV39_340005300 , LMJSD75_340005300

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q3K6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3K6

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0004674	protein serine/threonine kinase activity	4	10
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.424
CLV_C14_Caspase3-7	204	208	PF00656	0.424
CLV_PCSK_KEX2_1	123	125	PF00082	0.312
CLV_PCSK_KEX2_1	327	329	PF00082	0.384
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.312
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.454
CLV_PCSK_PC7_1	119	125	PF00082	0.424
CLV_PCSK_SKI1_1	119	123	PF00082	0.345
CLV_PCSK_SKI1_1	124	128	PF00082	0.315
CLV_PCSK_SKI1_1	200	204	PF00082	0.454
CLV_PCSK_SKI1_1	33	37	PF00082	0.457
CLV_PCSK_SKI1_1	351	355	PF00082	0.424
DEG_Nend_UBRbox_4	1	3	PF02207	0.370
DOC_MAPK_gen_1	339	347	PF00069	0.192
DOC_PP1_RVXF_1	48	54	PF00149	0.618
DOC_PP4_FxxP_1	253	256	PF00568	0.390
DOC_USP7_MATH_1	264	268	PF00917	0.367
DOC_USP7_UBL2_3	351	355	PF12436	0.366
DOC_WW_Pin1_4	18	23	PF00397	0.352
DOC_WW_Pin1_4	190	195	PF00397	0.454
DOC_WW_Pin1_4	217	222	PF00397	0.312
LIG_14-3-3_CanoR_1	272	276	PF00244	0.355
LIG_14-3-3_CanoR_1	37	45	PF00244	0.365
LIG_14-3-3_CanoR_1	50	54	PF00244	0.599
LIG_14-3-3_CanoR_1	76	84	PF00244	0.477
LIG_Actin_WH2_2	20	35	PF00022	0.332
LIG_APCC_ABBA_1	140	145	PF00400	0.424
LIG_APCC_ABBA_1	306	311	PF00400	0.331
LIG_APCC_ABBAyCdc20_2	123	129	PF00400	0.454
LIG_BIR_III_2	315	319	PF00653	0.367
LIG_BRCT_BRCA1_1	20	24	PF00533	0.340
LIG_deltaCOP1_diTrp_1	170	177	PF00928	0.384
LIG_eIF4E_1	94	100	PF01652	0.331
LIG_FHA_1	236	242	PF00498	0.459
LIG_FHA_1	348	354	PF00498	0.356
LIG_FHA_2	152	158	PF00498	0.381
LIG_FHA_2	255	261	PF00498	0.432
LIG_FHA_2	291	297	PF00498	0.312
LIG_LIR_Apic_2	250	256	PF02991	0.316
LIG_LIR_Apic_2	274	280	PF02991	0.296
LIG_LIR_Gen_1	102	112	PF02991	0.357
LIG_LIR_Gen_1	170	177	PF02991	0.312
LIG_LIR_Gen_1	201	210	PF02991	0.417
LIG_LIR_Gen_1	21	32	PF02991	0.297
LIG_LIR_Gen_1	52	60	PF02991	0.383
LIG_LIR_Gen_1	7	16	PF02991	0.338
LIG_LIR_Gen_1	92	100	PF02991	0.403
LIG_LIR_Nem_3	102	108	PF02991	0.357
LIG_LIR_Nem_3	201	206	PF02991	0.386
LIG_LIR_Nem_3	21	27	PF02991	0.307
LIG_LIR_Nem_3	340	344	PF02991	0.355
LIG_LIR_Nem_3	65	70	PF02991	0.625
LIG_LIR_Nem_3	7	12	PF02991	0.339
LIG_LIR_Nem_3	92	97	PF02991	0.383
LIG_Pex14_2	36	40	PF04695	0.356
LIG_SH2_CRK	105	109	PF00017	0.349
LIG_SH2_CRK	94	98	PF00017	0.405
LIG_SH2_GRB2like	112	115	PF00017	0.192
LIG_SH2_GRB2like	186	189	PF00017	0.331
LIG_SH2_NCK_1	112	116	PF00017	0.424
LIG_SH2_PTP2	305	308	PF00017	0.424
LIG_SH2_SRC	155	158	PF00017	0.424
LIG_SH2_STAP1	105	109	PF00017	0.384
LIG_SH2_STAT5	125	128	PF00017	0.411
LIG_SH2_STAT5	151	154	PF00017	0.424
LIG_SH2_STAT5	155	158	PF00017	0.424
LIG_SH2_STAT5	186	189	PF00017	0.331
LIG_SH2_STAT5	305	308	PF00017	0.312
LIG_SH2_STAT5	34	37	PF00017	0.349
LIG_SH3_3	158	164	PF00018	0.342
LIG_TRAF2_1	136	139	PF00917	0.408
LIG_TRAF2_1	182	185	PF00917	0.454
LIG_TRAF2_1	258	261	PF00917	0.454
LIG_TRFH_1	60	64	PF08558	0.657
LIG_TYR_ITIM	303	308	PF00017	0.331
LIG_UBA3_1	344	351	PF00899	0.408
MOD_CK1_1	113	119	PF00069	0.413
MOD_CK1_1	271	277	PF00069	0.403
MOD_CK1_1	78	84	PF00069	0.558
MOD_CK2_1	179	185	PF00069	0.443
MOD_CK2_1	195	201	PF00069	0.222
MOD_CK2_1	254	260	PF00069	0.335
MOD_GlcNHglycan	247	250	PF01048	0.310
MOD_GlcNHglycan	257	260	PF01048	0.299
MOD_GlcNHglycan	261	265	PF01048	0.278
MOD_GlcNHglycan	387	390	PF01048	0.548
MOD_GlcNHglycan	46	49	PF01048	0.380
MOD_GlcNHglycan	84	87	PF01048	0.485
MOD_GlcNHglycan	92	97	PF01048	0.349
MOD_GSK3_1	151	158	PF00069	0.380
MOD_GSK3_1	217	224	PF00069	0.312
MOD_GSK3_1	260	267	PF00069	0.397
MOD_GSK3_1	347	354	PF00069	0.388
MOD_GSK3_1	75	82	PF00069	0.593
MOD_N-GLC_1	113	118	PF02516	0.424
MOD_NEK2_1	235	240	PF00069	0.331
MOD_NEK2_1	70	75	PF00069	0.595
MOD_PIKK_1	215	221	PF00454	0.355
MOD_PIKK_1	330	336	PF00454	0.367
MOD_PKA_2	271	277	PF00069	0.346
MOD_PKA_2	49	55	PF00069	0.391
MOD_PKA_2	75	81	PF00069	0.428
MOD_Plk_1	138	144	PF00069	0.379
MOD_Plk_1	92	98	PF00069	0.384
MOD_Plk_2-3	179	185	PF00069	0.424
MOD_Plk_4	103	109	PF00069	0.385
MOD_Plk_4	151	157	PF00069	0.304
MOD_Plk_4	271	277	PF00069	0.312
MOD_ProDKin_1	18	24	PF00069	0.349
MOD_ProDKin_1	190	196	PF00069	0.454
MOD_ProDKin_1	217	223	PF00069	0.312
MOD_SUMO_for_1	89	92	PF00179	0.325
MOD_SUMO_rev_2	224	230	PF00179	0.312
MOD_SUMO_rev_2	287	295	PF00179	0.384
TRG_DiLeu_BaEn_1	340	345	PF01217	0.367
TRG_ENDOCYTIC_2	105	108	PF00928	0.349
TRG_ENDOCYTIC_2	305	308	PF00928	0.300
TRG_ENDOCYTIC_2	94	97	PF00928	0.405
TRG_ER_diArg_1	381	384	PF00400	0.520
TRG_ER_diArg_1	391	394	PF00400	0.484
TRG_NLS_MonoExtN_4	326	331	PF00514	0.454
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S2	Leptomonas seymouri	24%	71%
A0A0N1I6T8	Leptomonas seymouri	25%	100%
A0A0N1IHM7	Leptomonas seymouri	29%	67%
A0A0N1ILF6	Leptomonas seymouri	77%	100%
A0A0N1PD05	Leptomonas seymouri	25%	88%
A0A0N1PEV2	Leptomonas seymouri	26%	73%
A0A0S4IHW4	Bodo saltans	24%	88%
A0A0S4IQ75	Bodo saltans	25%	78%
A0A0S4IRU8	Bodo saltans	25%	91%
A0A0S4IRZ7	Bodo saltans	27%	80%
A0A0S4IXR9	Bodo saltans	28%	85%
A0A0S4J3Y5	Bodo saltans	25%	92%
A0A0S4J9Y8	Bodo saltans	25%	74%
A0A0S4JBY0	Bodo saltans	44%	100%
A0A0S4JCG2	Bodo saltans	26%	88%
A0A0S4JF22	Bodo saltans	24%	100%
A0A0S4JNA1	Bodo saltans	26%	80%
A0A0S4JPZ1	Bodo saltans	27%	88%
A0A0S4JUJ2	Bodo saltans	26%	100%
A0A1X0NQ63	Trypanosomatidae	26%	100%
A0A1X0NRZ9	Trypanosomatidae	25%	100%
A0A1X0NTP1	Trypanosomatidae	26%	68%
A0A1X0P246	Trypanosomatidae	26%	91%
A0A1X0P549	Trypanosomatidae	28%	83%
A0A1X0P5U3	Trypanosomatidae	25%	77%
A0A1X0P6V1	Trypanosomatidae	26%	100%
A0A1X0P963	Trypanosomatidae	29%	82%
A0A1X0P9C1	Trypanosomatidae	56%	100%
A0A3Q8IAQ1	Leishmania donovani	27%	100%
A0A3Q8IC87	Leishmania donovani	25%	100%
A0A3Q8IFK8	Leishmania donovani	27%	90%
A0A3Q8IIG1	Leishmania donovani	26%	100%
A0A3Q8IIH5	Leishmania donovani	26%	71%
A0A3R7K1T4	Trypanosoma rangeli	26%	78%
A0A3R7KRP1	Trypanosoma rangeli	24%	83%
A0A3R7KZ44	Trypanosoma rangeli	25%	67%
A0A3R7M5C7	Trypanosoma rangeli	25%	100%
A0A3R7N5S4	Trypanosoma rangeli	26%	100%
A0A3R7NKI8	Trypanosoma rangeli	28%	100%
A0A3R7NLI6	Trypanosoma rangeli	28%	100%
A0A3R7R6T1	Trypanosoma rangeli	54%	100%
A0A3S5H606	Leishmania donovani	26%	100%
A0A3S7X6T8	Leishmania donovani	26%	88%
A0A3S7X7D5	Leishmania donovani	95%	100%
A2XFF4	Oryza sativa subsp. indica	28%	78%
A4H539	Leishmania braziliensis	25%	100%
A4H7W1	Leishmania braziliensis	24%	72%
A4HAC8	Leishmania braziliensis	82%	100%
A4HCE6	Leishmania braziliensis	28%	100%
A4HJT5	Leishmania braziliensis	26%	90%
A4HTB4	Leishmania infantum	26%	100%
A4HW88	Leishmania infantum	26%	71%
A4HZV1	Leishmania infantum	25%	100%
A4HZW8	Leishmania infantum	27%	100%
A4I435	Leishmania infantum	26%	100%
A4I7A1	Leishmania infantum	27%	90%
A4I960	Leishmania infantum	26%	88%
A4I9H1	Leishmania infantum	95%	100%
A4K2S1	Lemur catta	28%	81%
A8XJW8	Caenorhabditis briggsae	27%	80%
B8BBT7	Oryza sativa subsp. indica	28%	78%
C9ZKZ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	84%
C9ZUK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
C9ZW46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	84%
C9ZW68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
C9ZWI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	92%
C9ZWK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	90%
D0A2Z1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	81%
D0A2Z6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	80%
D0A8X3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9ALA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9APY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	71%
E9AVS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B0C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B296	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	90%
E9B436	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	88%
E9B4G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O14047	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
O22971	Arabidopsis thaliana	30%	79%
O54748	Rattus norvegicus	28%	80%
O61125	Dictyostelium discoideum	27%	86%
O75716	Homo sapiens	26%	100%
O88697	Mus musculus	27%	100%
O96013	Homo sapiens	29%	67%
P08458	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	81%
P12965	Xenopus laevis	26%	100%
P17157	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P32491	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	78%
P45894	Caenorhabditis elegans	25%	67%
P45985	Homo sapiens	26%	99%
P47809	Mus musculus	26%	99%
P57760	Rattus norvegicus	27%	100%
P83104	Drosophila melanogaster	23%	100%
P9WI62	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	26%	99%
P9WI63	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	99%
Q02723	Secale cereale	27%	79%
Q03428	Trypanosoma brucei brucei	25%	92%
Q07192	Xenopus laevis	26%	89%
Q08942	Trypanosoma brucei brucei	27%	92%
Q0JI49	Oryza sativa subsp. japonica	27%	79%
Q10SC8	Oryza sativa subsp. japonica	25%	87%
Q12003	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
Q13188	Homo sapiens	28%	80%
Q32PP3	Danio rerio	26%	100%
Q4Q3Y9	Leishmania major	26%	88%
Q4Q5W2	Leishmania major	27%	90%
Q4Q7W2	Leishmania major	26%	100%
Q4QBQ2	Leishmania major	27%	100%
Q4QBR6	Leishmania major	25%	100%
Q4QFJ2	Leishmania major	25%	71%
Q4QIJ7	Leishmania major	26%	100%
Q54JG7	Dictyostelium discoideum	25%	81%
Q55BN8	Dictyostelium discoideum	24%	94%
Q5E9L6	Bos taurus	28%	81%
Q5JLQ9	Oryza sativa subsp. japonica	28%	83%
Q5Z6X0	Oryza sativa subsp. japonica	29%	77%
Q5ZJK4	Gallus gallus	27%	81%
Q66H84	Rattus norvegicus	30%	100%
Q68Y49	Oryza sativa subsp. japonica	27%	78%
Q6DE87	Xenopus laevis	26%	83%
Q6H7U5	Oryza sativa subsp. japonica	26%	80%
Q6IP06	Xenopus laevis	28%	80%
Q6NU47	Xenopus laevis	26%	100%
Q6NU98	Xenopus laevis	27%	100%
Q6ZLP5	Oryza sativa subsp. japonica	25%	88%
Q7TYY6	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	26%	99%
Q7XJR9	Arabidopsis thaliana	27%	69%
Q7ZUQ3	Danio rerio	27%	80%
Q80ZW0	Mus musculus	25%	73%
Q852Q0	Oryza sativa subsp. japonica	28%	78%
Q852Q1	Oryza sativa subsp. japonica	28%	78%
Q8BTW9	Mus musculus	30%	67%
Q8C0N0	Mus musculus	25%	79%
Q8C1R0	Mus musculus	26%	100%
Q8QGV6	Xenopus laevis	26%	88%
Q8TDR2	Homo sapiens	26%	74%
Q965G5	Caenorhabditis elegans	29%	100%
Q99JT2	Mus musculus	25%	95%
Q9C562	Arabidopsis thaliana	28%	82%
Q9ESG9	Mus musculus	27%	81%
Q9FJ55	Arabidopsis thaliana	28%	82%
Q9JI10	Mus musculus	28%	79%
Q9JI11	Mus musculus	28%	81%
Q9LDI3	Arabidopsis thaliana	27%	89%
Q9LP51	Arabidopsis thaliana	29%	76%
Q9LYQ8	Arabidopsis thaliana	27%	87%
Q9NB31	Caenorhabditis elegans	27%	79%
Q9P289	Homo sapiens	25%	95%
Q9S2C0	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	24%	71%
Q9SN43	Arabidopsis thaliana	28%	81%
Q9YHZ5	Danio rerio	27%	100%
V5B472	Trypanosoma cruzi	52%	100%
V5BAZ8	Trypanosoma cruzi	24%	100%
V5BMH5	Trypanosoma cruzi	28%	100%
V5BNV8	Trypanosoma cruzi	25%	100%
V5BWC2	Trypanosoma cruzi	25%	100%
V5C234	Trypanosoma cruzi	28%	73%
V5DC27	Trypanosoma cruzi	26%	67%