Cleft lip and palate transmembrane protein 1-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cleft lip and palate transmembrane protein 1 (CLPTM1), putative

Species:

Leishmania major

UniProt:

Q4Q3K4_LEIMA

TriTrypDb:

LmjF.34.0050 , LMJLV39_340005500 , LMJSD75_340005500

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q3K4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3K4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	330	332	PF00675	0.266
CLV_PCSK_KEX2_1	289	291	PF00082	0.407
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.407
CLV_PCSK_SKI1_1	159	163	PF00082	0.514
CLV_PCSK_SKI1_1	21	25	PF00082	0.256
CLV_PCSK_SKI1_1	26	30	PF00082	0.312
CLV_PCSK_SKI1_1	260	264	PF00082	0.449
CLV_PCSK_SKI1_1	289	293	PF00082	0.449
CLV_PCSK_SKI1_1	380	384	PF00082	0.301
CLV_PCSK_SKI1_1	386	390	PF00082	0.301
DEG_SPOP_SBC_1	240	244	PF00917	0.227
DOC_CKS1_1	485	490	PF01111	0.323
DOC_CYCLIN_RxL_1	156	166	PF00134	0.301
DOC_CYCLIN_RxL_1	257	265	PF00134	0.262
DOC_CYCLIN_RxL_1	287	297	PF00134	0.262
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.318
DOC_MAPK_FxFP_2	197	200	PF00069	0.262
DOC_MAPK_gen_1	289	295	PF00069	0.262
DOC_MAPK_gen_1	329	339	PF00069	0.449
DOC_MAPK_gen_1	380	390	PF00069	0.462
DOC_MAPK_gen_1	430	439	PF00069	0.424
DOC_MAPK_MEF2A_6	182	191	PF00069	0.207
DOC_MAPK_MEF2A_6	298	305	PF00069	0.309
DOC_PP1_RVXF_1	129	135	PF00149	0.295
DOC_PP2B_LxvP_1	143	146	PF13499	0.175
DOC_PP2B_PxIxI_1	487	493	PF00149	0.455
DOC_PP4_FxxP_1	197	200	PF00568	0.221
DOC_PP4_FxxP_1	218	221	PF00568	0.262
DOC_SPAK_OSR1_1	78	82	PF12202	0.301
DOC_USP7_MATH_1	175	179	PF00917	0.261
DOC_USP7_MATH_1	404	408	PF00917	0.470
DOC_USP7_MATH_1	45	49	PF00917	0.256
DOC_USP7_MATH_1	576	580	PF00917	0.658
DOC_WW_Pin1_4	189	194	PF00397	0.218
DOC_WW_Pin1_4	206	211	PF00397	0.207
DOC_WW_Pin1_4	251	256	PF00397	0.236
DOC_WW_Pin1_4	484	489	PF00397	0.326
DOC_WW_Pin1_4	56	61	PF00397	0.267
LIG_14-3-3_CanoR_1	131	137	PF00244	0.319
LIG_14-3-3_CanoR_1	335	340	PF00244	0.464
LIG_14-3-3_CanoR_1	464	470	PF00244	0.285
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_BRCT_BRCA1_1	33	37	PF00533	0.254
LIG_BRCT_BRCA1_1	344	348	PF00533	0.398
LIG_BRCT_BRCA1_1	349	353	PF00533	0.409
LIG_BRCT_BRCA1_1	479	483	PF00533	0.402
LIG_CaM_NSCaTE_8	466	473	PF13499	0.260
LIG_CtBP_PxDLS_1	552	556	PF00389	0.611
LIG_eIF4E_1	30	36	PF01652	0.341
LIG_FHA_1	111	117	PF00498	0.240
LIG_FHA_1	125	131	PF00498	0.209
LIG_FHA_1	138	144	PF00498	0.274
LIG_FHA_1	207	213	PF00498	0.301
LIG_FHA_1	248	254	PF00498	0.239
LIG_FHA_1	304	310	PF00498	0.283
LIG_FHA_1	382	388	PF00498	0.462
LIG_FHA_1	393	399	PF00498	0.439
LIG_FHA_1	4	10	PF00498	0.693
LIG_FHA_1	485	491	PF00498	0.362
LIG_FHA_1	50	56	PF00498	0.317
LIG_FHA_2	263	269	PF00498	0.301
LIG_FHA_2	394	400	PF00498	0.518
LIG_FHA_2	512	518	PF00498	0.450
LIG_GBD_Chelix_1	304	312	PF00786	0.320
LIG_LIR_Apic_2	198	202	PF02991	0.245
LIG_LIR_Gen_1	314	321	PF02991	0.255
LIG_LIR_Gen_1	34	45	PF02991	0.254
LIG_LIR_Gen_1	345	356	PF02991	0.295
LIG_LIR_Gen_1	361	372	PF02991	0.216
LIG_LIR_Gen_1	454	460	PF02991	0.243
LIG_LIR_Gen_1	480	491	PF02991	0.402
LIG_LIR_Gen_1	517	527	PF02991	0.477
LIG_LIR_Gen_1	538	546	PF02991	0.460
LIG_LIR_Gen_1	77	87	PF02991	0.239
LIG_LIR_Nem_3	178	184	PF02991	0.259
LIG_LIR_Nem_3	207	211	PF02991	0.230
LIG_LIR_Nem_3	314	319	PF02991	0.272
LIG_LIR_Nem_3	333	337	PF02991	0.380
LIG_LIR_Nem_3	34	40	PF02991	0.254
LIG_LIR_Nem_3	345	351	PF02991	0.316
LIG_LIR_Nem_3	361	367	PF02991	0.216
LIG_LIR_Nem_3	377	381	PF02991	0.317
LIG_LIR_Nem_3	451	456	PF02991	0.313
LIG_LIR_Nem_3	506	512	PF02991	0.455
LIG_LIR_Nem_3	517	523	PF02991	0.405
LIG_LIR_Nem_3	538	544	PF02991	0.472
LIG_LIR_Nem_3	77	82	PF02991	0.247
LIG_MLH1_MIPbox_1	344	348	PF16413	0.357
LIG_PCNA_yPIPBox_3	510	520	PF02747	0.454
LIG_Pex14_2	37	41	PF04695	0.363
LIG_Pex14_2	375	379	PF04695	0.272
LIG_Pex14_2	477	481	PF04695	0.253
LIG_PTB_Apo_2	135	142	PF02174	0.264
LIG_PTB_Apo_2	94	101	PF02174	0.279
LIG_REV1ctd_RIR_1	148	156	PF16727	0.288
LIG_SH2_CRK	30	34	PF00017	0.329
LIG_SH2_CRK	444	448	PF00017	0.315
LIG_SH2_CRK	456	460	PF00017	0.199
LIG_SH2_CRK	467	471	PF00017	0.178
LIG_SH2_CRK	509	513	PF00017	0.453
LIG_SH2_GRB2like	224	227	PF00017	0.207
LIG_SH2_SRC	419	422	PF00017	0.462
LIG_SH2_STAP1	139	143	PF00017	0.254
LIG_SH2_STAP1	444	448	PF00017	0.325
LIG_SH2_STAP1	456	460	PF00017	0.257
LIG_SH2_STAP1	467	471	PF00017	0.241
LIG_SH2_STAT5	139	142	PF00017	0.235
LIG_SH2_STAT5	160	163	PF00017	0.270
LIG_SH2_STAT5	184	187	PF00017	0.236
LIG_SH2_STAT5	224	227	PF00017	0.262
LIG_SH2_STAT5	264	267	PF00017	0.221
LIG_SH2_STAT5	347	350	PF00017	0.251
LIG_SH2_STAT5	355	358	PF00017	0.234
LIG_SH2_STAT5	441	444	PF00017	0.244
LIG_SH2_STAT5	453	456	PF00017	0.244
LIG_SH3_3	109	115	PF00018	0.262
LIG_SH3_3	363	369	PF00018	0.376
LIG_SH3_3	54	60	PF00018	0.258
LIG_SUMO_SIM_par_1	291	297	PF11976	0.297
LIG_SUMO_SIM_par_1	300	306	PF11976	0.214
LIG_TRAF2_1	397	400	PF00917	0.434
LIG_TYR_ITIM	28	33	PF00017	0.341
LIG_TYR_ITIM	442	447	PF00017	0.376
LIG_UBA3_1	89	94	PF00899	0.262
LIG_ULM_U2AF65_1	410	415	PF00076	0.427
LIG_WRC_WIRS_1	20	25	PF05994	0.444
LIG_WRC_WIRS_1	478	483	PF05994	0.376
MOD_CDK_SPxxK_3	251	258	PF00069	0.262
MOD_CK1_1	241	247	PF00069	0.338
MOD_CK1_1	280	286	PF00069	0.238
MOD_CK1_1	338	344	PF00069	0.244
MOD_CK1_1	359	365	PF00069	0.301
MOD_CK1_1	426	432	PF00069	0.509
MOD_CK1_1	511	517	PF00069	0.543
MOD_CK1_1	64	70	PF00069	0.294
MOD_CK2_1	163	169	PF00069	0.215
MOD_CK2_1	262	268	PF00069	0.284
MOD_CK2_1	280	286	PF00069	0.212
MOD_CK2_1	311	317	PF00069	0.376
MOD_CK2_1	393	399	PF00069	0.518
MOD_Cter_Amidation	329	332	PF01082	0.301
MOD_Cter_Amidation	408	411	PF01082	0.175
MOD_GlcNHglycan	169	172	PF01048	0.525
MOD_GlcNHglycan	369	372	PF01048	0.263
MOD_GlcNHglycan	406	409	PF01048	0.318
MOD_GlcNHglycan	456	459	PF01048	0.257
MOD_GlcNHglycan	561	564	PF01048	0.463
MOD_GSK3_1	120	127	PF00069	0.240
MOD_GSK3_1	137	144	PF00069	0.284
MOD_GSK3_1	163	170	PF00069	0.288
MOD_GSK3_1	247	254	PF00069	0.246
MOD_GSK3_1	273	280	PF00069	0.301
MOD_GSK3_1	303	310	PF00069	0.244
MOD_GSK3_1	338	345	PF00069	0.357
MOD_GSK3_1	356	363	PF00069	0.357
MOD_GSK3_1	45	52	PF00069	0.266
MOD_GSK3_1	465	472	PF00069	0.262
MOD_GSK3_1	61	68	PF00069	0.289
MOD_N-GLC_1	108	113	PF02516	0.467
MOD_N-GLC_1	124	129	PF02516	0.360
MOD_N-GLC_1	137	142	PF02516	0.407
MOD_N-GLC_1	163	168	PF02516	0.456
MOD_N-GLC_1	238	243	PF02516	0.407
MOD_N-GLC_1	247	252	PF02516	0.407
MOD_NEK2_1	110	115	PF00069	0.279
MOD_NEK2_1	141	146	PF00069	0.326
MOD_NEK2_1	151	156	PF00069	0.323
MOD_NEK2_1	238	243	PF00069	0.226
MOD_NEK2_1	247	252	PF00069	0.186
MOD_NEK2_1	262	267	PF00069	0.219
MOD_NEK2_1	293	298	PF00069	0.229
MOD_NEK2_1	303	308	PF00069	0.246
MOD_NEK2_1	381	386	PF00069	0.407
MOD_NEK2_1	459	464	PF00069	0.397
MOD_NEK2_1	469	474	PF00069	0.274
MOD_NEK2_1	477	482	PF00069	0.115
MOD_NEK2_2	126	131	PF00069	0.251
MOD_PIKK_1	241	247	PF00454	0.262
MOD_PIKK_1	262	268	PF00454	0.301
MOD_PIKK_1	270	276	PF00454	0.301
MOD_PIKK_1	356	362	PF00454	0.406
MOD_PIKK_1	428	434	PF00454	0.501
MOD_PIKK_1	470	476	PF00454	0.244
MOD_PIKK_1	82	88	PF00454	0.331
MOD_PK_1	335	341	PF00069	0.464
MOD_PK_1	495	501	PF00069	0.507
MOD_PKA_2	151	157	PF00069	0.272
MOD_PKA_2	404	410	PF00069	0.514
MOD_Plk_1	108	114	PF00069	0.281
MOD_Plk_1	124	130	PF00069	0.158
MOD_Plk_1	137	143	PF00069	0.221
MOD_Plk_1	173	179	PF00069	0.247
MOD_Plk_1	187	193	PF00069	0.301
MOD_Plk_1	247	253	PF00069	0.219
MOD_Plk_1	267	273	PF00069	0.149
MOD_Plk_1	360	366	PF00069	0.212
MOD_Plk_1	553	559	PF00069	0.620
MOD_Plk_4	219	225	PF00069	0.345
MOD_Plk_4	307	313	PF00069	0.272
MOD_Plk_4	31	37	PF00069	0.358
MOD_Plk_4	347	353	PF00069	0.244
MOD_Plk_4	451	457	PF00069	0.245
MOD_Plk_4	465	471	PF00069	0.228
MOD_Plk_4	511	517	PF00069	0.462
MOD_ProDKin_1	189	195	PF00069	0.218
MOD_ProDKin_1	206	212	PF00069	0.207
MOD_ProDKin_1	251	257	PF00069	0.236
MOD_ProDKin_1	484	490	PF00069	0.322
MOD_ProDKin_1	56	62	PF00069	0.267
MOD_SUMO_for_1	388	391	PF00179	0.462
MOD_SUMO_for_1	93	96	PF00179	0.262
MOD_SUMO_rev_2	111	120	PF00179	0.345
MOD_SUMO_rev_2	283	291	PF00179	0.207
MOD_SUMO_rev_2	322	327	PF00179	0.421
TRG_AP2beta_CARGO_1	538	548	PF09066	0.460
TRG_DiLeu_BaEn_3	286	292	PF01217	0.227
TRG_ENDOCYTIC_2	264	267	PF00928	0.221
TRG_ENDOCYTIC_2	30	33	PF00928	0.315
TRG_ENDOCYTIC_2	444	447	PF00928	0.321
TRG_ENDOCYTIC_2	456	459	PF00928	0.251
TRG_ENDOCYTIC_2	467	470	PF00928	0.232
TRG_ENDOCYTIC_2	509	512	PF00928	0.457
TRG_ER_diLys_1	581	584	PF00400	0.678
TRG_NLS_MonoCore_2	409	414	PF00514	0.455
TRG_NLS_MonoExtC_3	410	415	PF00514	0.375
TRG_NLS_MonoExtN_4	410	416	PF00514	0.375
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I8	Leptomonas seymouri	66%	97%
A0A1X0P8S5	Trypanosomatidae	45%	100%
A0A3S7X7A7	Leishmania donovani	95%	100%
A0A422MZT4	Trypanosoma rangeli	45%	99%
A4HAD0	Leishmania braziliensis	84%	100%
A4I9H3	Leishmania infantum	95%	100%
D0A1S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B4H1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q54RJ1	Dictyostelium discoideum	40%	94%
Q5R7B1	Pongo abelii	35%	100%
Q5ZKJ0	Gallus gallus	36%	100%
Q8BXA5	Mus musculus	37%	100%
Q96KA5	Homo sapiens	34%	100%
V5DIK4	Trypanosoma cruzi	43%	99%