HGWP repeat containing protein-like

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HPP family, putative

Species:

Leishmania major

UniProt:

Q4Q3K0_LEIMA

TriTrypDb:

LmjF.34.0085 , LMJLV39_340006000 , LMJSD75_340006000

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q3K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3K0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	45	47	PF00675	0.517
CLV_PCSK_KEX2_1	45	47	PF00082	0.517
CLV_PCSK_SKI1_1	4	8	PF00082	0.480
DEG_Nend_Nbox_1	1	3	PF02207	0.546
DOC_CKS1_1	154	159	PF01111	0.329
DOC_MAPK_gen_1	45	52	PF00069	0.313
DOC_USP7_MATH_1	129	133	PF00917	0.463
DOC_WW_Pin1_4	153	158	PF00397	0.337
LIG_14-3-3_CanoR_1	14	24	PF00244	0.636
LIG_APCC_ABBA_1	164	169	PF00400	0.225
LIG_deltaCOP1_diTrp_1	169	172	PF00928	0.225
LIG_FHA_1	122	128	PF00498	0.301
LIG_FHA_1	132	138	PF00498	0.407
LIG_FHA_1	157	163	PF00498	0.336
LIG_FHA_1	31	37	PF00498	0.246
LIG_FHA_1	65	71	PF00498	0.317
LIG_FHA_1	76	82	PF00498	0.504
LIG_FHA_1	95	101	PF00498	0.148
LIG_LIR_Gen_1	169	177	PF02991	0.225
LIG_LIR_Gen_1	27	37	PF02991	0.289
LIG_LIR_Gen_1	62	71	PF02991	0.225
LIG_LIR_Nem_3	169	175	PF02991	0.225
LIG_LIR_Nem_3	27	32	PF02991	0.274
LIG_LIR_Nem_3	62	66	PF02991	0.225
LIG_NRBOX	65	71	PF00104	0.225
LIG_PDZ_Class_2	181	186	PF00595	0.407
LIG_Pex14_1	178	182	PF04695	0.202
LIG_SH2_CRK	63	67	PF00017	0.225
LIG_SH2_SRC	55	58	PF00017	0.214
LIG_SH2_STAT5	2	5	PF00017	0.535
LIG_SH2_STAT5	55	58	PF00017	0.214
LIG_SH2_STAT5	63	66	PF00017	0.214
LIG_SH2_STAT5	68	71	PF00017	0.116
LIG_SH3_4	102	109	PF00018	0.232
LIG_SUMO_SIM_anti_2	30	36	PF11976	0.276
LIG_SUMO_SIM_par_1	119	124	PF11976	0.225
LIG_SUMO_SIM_par_1	35	43	PF11976	0.281
LIG_WRC_WIRS_1	56	61	PF05994	0.236
MOD_CK1_1	132	138	PF00069	0.402
MOD_CK1_1	27	33	PF00069	0.343
MOD_CK1_1	96	102	PF00069	0.194
MOD_Cter_Amidation	43	46	PF01082	0.500
MOD_GlcNHglycan	129	132	PF01048	0.190
MOD_GlcNHglycan	26	29	PF01048	0.343
MOD_GlcNHglycan	41	45	PF01048	0.562
MOD_GlcNHglycan	85	88	PF01048	0.402
MOD_GSK3_1	12	19	PF00069	0.631
MOD_GSK3_1	123	130	PF00069	0.237
MOD_GSK3_1	152	159	PF00069	0.371
MOD_GSK3_1	51	58	PF00069	0.316
MOD_GSK3_1	75	82	PF00069	0.450
MOD_NEK2_1	121	126	PF00069	0.246
MOD_NEK2_1	152	157	PF00069	0.338
MOD_NEK2_1	17	22	PF00069	0.571
MOD_NEK2_1	59	64	PF00069	0.199
MOD_NEK2_1	81	86	PF00069	0.223
MOD_PIKK_1	102	108	PF00454	0.311
MOD_Plk_1	12	18	PF00069	0.533
MOD_Plk_1	30	36	PF00069	0.269
MOD_Plk_4	30	36	PF00069	0.269
MOD_Plk_4	51	57	PF00069	0.325
MOD_Plk_4	64	70	PF00069	0.116
MOD_ProDKin_1	153	159	PF00069	0.337
TRG_DiLeu_BaLyEn_6	1	6	PF01217	0.697
TRG_DiLeu_BaLyEn_6	117	122	PF01217	0.369
TRG_ENDOCYTIC_2	181	184	PF00928	0.444
TRG_ENDOCYTIC_2	2	5	PF00928	0.699
TRG_ENDOCYTIC_2	63	66	PF00928	0.433
TRG_ER_diArg_1	45	47	PF00400	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDQ3	Leptomonas seymouri	49%	72%
A0A1X0P8H0	Trypanosomatidae	28%	70%
A0A1X0P8I7	Trypanosomatidae	38%	72%
A0A3R7M3A0	Trypanosoma rangeli	32%	71%
V5CZW2	Trypanosoma cruzi	34%	74%