Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3J9_LEIMA

TriTrypDb:

LmjF.34.0090 , LMJLV39_340006100 , LMJSD75_340006100

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3J9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3J9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.557
CLV_C14_Caspase3-7	447	451	PF00656	0.533
CLV_NRD_NRD_1	252	254	PF00675	0.741
CLV_NRD_NRD_1	491	493	PF00675	0.553
CLV_NRD_NRD_1	502	504	PF00675	0.465
CLV_NRD_NRD_1	58	60	PF00675	0.600
CLV_NRD_NRD_1	80	82	PF00675	0.662
CLV_PCSK_FUR_1	500	504	PF00082	0.629
CLV_PCSK_KEX2_1	252	254	PF00082	0.741
CLV_PCSK_KEX2_1	491	493	PF00082	0.468
CLV_PCSK_KEX2_1	502	504	PF00082	0.534
CLV_PCSK_KEX2_1	79	81	PF00082	0.670
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.670
CLV_PCSK_SKI1_1	166	170	PF00082	0.645
CLV_PCSK_SKI1_1	290	294	PF00082	0.589
CLV_PCSK_SKI1_1	318	322	PF00082	0.527
CLV_PCSK_SKI1_1	462	466	PF00082	0.464
CLV_PCSK_SKI1_1	484	488	PF00082	0.499
CLV_PCSK_SKI1_1	503	507	PF00082	0.278
CLV_PCSK_SKI1_1	80	84	PF00082	0.613
DEG_APCC_DBOX_1	165	173	PF00400	0.538
DEG_ODPH_VHL_1	402	414	PF01847	0.481
DEG_SCF_TRCP1_1	120	126	PF00400	0.658
DEG_SPOP_SBC_1	376	380	PF00917	0.630
DOC_CYCLIN_RxL_1	312	325	PF00134	0.634
DOC_MAPK_gen_1	428	435	PF00069	0.396
DOC_MAPK_MEF2A_6	222	229	PF00069	0.525
DOC_MAPK_NFAT4_5	222	230	PF00069	0.650
DOC_MIT_MIM_1	573	583	PF04212	0.649
DOC_PP1_RVXF_1	202	208	PF00149	0.569
DOC_PP1_RVXF_1	490	497	PF00149	0.451
DOC_PP1_RVXF_1	568	574	PF00149	0.734
DOC_PP4_FxxP_1	342	345	PF00568	0.679
DOC_USP7_MATH_1	118	122	PF00917	0.682
DOC_USP7_MATH_1	145	149	PF00917	0.738
DOC_USP7_MATH_1	275	279	PF00917	0.713
DOC_USP7_MATH_1	280	284	PF00917	0.682
DOC_USP7_MATH_1	376	380	PF00917	0.656
DOC_USP7_MATH_1	384	388	PF00917	0.621
DOC_USP7_MATH_1	404	408	PF00917	0.620
DOC_USP7_MATH_1	92	96	PF00917	0.499
DOC_WW_Pin1_4	21	26	PF00397	0.635
DOC_WW_Pin1_4	271	276	PF00397	0.709
LIG_14-3-3_CanoR_1	16	22	PF00244	0.710
LIG_14-3-3_CanoR_1	204	208	PF00244	0.693
LIG_14-3-3_CanoR_1	222	228	PF00244	0.409
LIG_14-3-3_CanoR_1	290	296	PF00244	0.663
LIG_14-3-3_CanoR_1	383	391	PF00244	0.641
LIG_14-3-3_CanoR_1	491	495	PF00244	0.565
LIG_14-3-3_CanoR_1	80	89	PF00244	0.683
LIG_Actin_WH2_2	422	438	PF00022	0.548
LIG_AP2alpha_2	139	141	PF02296	0.732
LIG_APCC_ABBA_1	172	177	PF00400	0.537
LIG_BIR_III_2	355	359	PF00653	0.676
LIG_BRCT_BRCA1_1	191	195	PF00533	0.606
LIG_BRCT_BRCA1_1	295	299	PF00533	0.538
LIG_BRCT_BRCA1_1	338	342	PF00533	0.545
LIG_BRCT_BRCA1_1	492	496	PF00533	0.563
LIG_deltaCOP1_diTrp_1	137	143	PF00928	0.751
LIG_deltaCOP1_diTrp_1	187	195	PF00928	0.609
LIG_FHA_1	124	130	PF00498	0.760
LIG_FHA_1	197	203	PF00498	0.568
LIG_FHA_1	266	272	PF00498	0.678
LIG_FHA_1	346	352	PF00498	0.675
LIG_FHA_1	365	371	PF00498	0.541
LIG_FHA_1	397	403	PF00498	0.562
LIG_FHA_1	408	414	PF00498	0.356
LIG_FHA_1	417	423	PF00498	0.482
LIG_FHA_1	444	450	PF00498	0.556
LIG_FHA_1	46	52	PF00498	0.555
LIG_FHA_1	467	473	PF00498	0.444
LIG_FHA_1	525	531	PF00498	0.514
LIG_FHA_1	73	79	PF00498	0.538
LIG_FHA_2	429	435	PF00498	0.630
LIG_LIR_Apic_2	270	275	PF02991	0.559
LIG_LIR_Apic_2	339	345	PF02991	0.564
LIG_LIR_Gen_1	294	303	PF02991	0.535
LIG_LIR_Gen_1	406	416	PF02991	0.466
LIG_LIR_Gen_1	493	501	PF02991	0.569
LIG_LIR_Gen_1	572	581	PF02991	0.662
LIG_LIR_LC3C_4	409	413	PF02991	0.558
LIG_LIR_Nem_3	157	163	PF02991	0.628
LIG_LIR_Nem_3	185	191	PF02991	0.608
LIG_LIR_Nem_3	294	298	PF02991	0.541
LIG_LIR_Nem_3	393	397	PF02991	0.567
LIG_LIR_Nem_3	406	411	PF02991	0.362
LIG_LIR_Nem_3	493	499	PF02991	0.476
LIG_LIR_Nem_3	572	576	PF02991	0.665
LIG_LYPXL_yS_3	337	340	PF13949	0.730
LIG_MLH1_MIPbox_1	295	299	PF16413	0.538
LIG_MYND_1	372	376	PF01753	0.662
LIG_NRBOX	33	39	PF00104	0.586
LIG_SH2_CRK	14	18	PF00017	0.654
LIG_SH2_CRK	160	164	PF00017	0.711
LIG_SH2_GRB2like	201	204	PF00017	0.583
LIG_SH2_GRB2like	471	474	PF00017	0.559
LIG_SH2_NCK_1	272	276	PF00017	0.561
LIG_SH2_SRC	175	178	PF00017	0.409
LIG_SH2_SRC	305	308	PF00017	0.508
LIG_SH2_SRC	534	537	PF00017	0.442
LIG_SH2_STAP1	295	299	PF00017	0.538
LIG_SH2_STAT5	175	178	PF00017	0.572
LIG_SH2_STAT5	201	204	PF00017	0.566
LIG_SH2_STAT5	305	308	PF00017	0.508
LIG_SH2_STAT5	390	393	PF00017	0.559
LIG_SH2_STAT5	40	43	PF00017	0.526
LIG_SH2_STAT5	471	474	PF00017	0.513
LIG_SH2_STAT5	489	492	PF00017	0.506
LIG_SH2_STAT5	498	501	PF00017	0.448
LIG_SH2_STAT5	534	537	PF00017	0.465
LIG_SH3_3	348	354	PF00018	0.676
LIG_SH3_3	355	361	PF00018	0.790
LIG_SH3_3	370	376	PF00018	0.729
LIG_SH3_3	398	404	PF00018	0.527
LIG_SUMO_SIM_anti_2	167	173	PF11976	0.644
LIG_SUMO_SIM_anti_2	409	415	PF11976	0.459
LIG_SUMO_SIM_par_1	409	415	PF11976	0.451
LIG_TRAF2_1	518	521	PF00917	0.504
LIG_TYR_ITIM	38	43	PF00017	0.555
LIG_UBA3_1	257	264	PF00899	0.643
LIG_WRC_WIRS_1	295	300	PF05994	0.563
LIG_WRC_WIRS_1	445	450	PF05994	0.339
MOD_CK1_1	150	156	PF00069	0.733
MOD_CK1_1	278	284	PF00069	0.615
MOD_CK1_1	294	300	PF00069	0.541
MOD_CK1_1	406	412	PF00069	0.569
MOD_CK1_1	42	48	PF00069	0.538
MOD_CK1_1	443	449	PF00069	0.488
MOD_CK2_1	428	434	PF00069	0.633
MOD_CK2_1	46	52	PF00069	0.633
MOD_CK2_1	515	521	PF00069	0.506
MOD_GlcNHglycan	120	123	PF01048	0.711
MOD_GlcNHglycan	145	148	PF01048	0.634
MOD_GlcNHglycan	17	20	PF01048	0.670
MOD_GlcNHglycan	276	280	PF01048	0.674
MOD_GlcNHglycan	364	367	PF01048	0.695
MOD_GlcNHglycan	384	387	PF01048	0.599
MOD_GlcNHglycan	414	417	PF01048	0.404
MOD_GlcNHglycan	573	576	PF01048	0.684
MOD_GlcNHglycan	583	586	PF01048	0.539
MOD_GSK3_1	139	146	PF00069	0.557
MOD_GSK3_1	150	157	PF00069	0.587
MOD_GSK3_1	17	24	PF00069	0.709
MOD_GSK3_1	214	221	PF00069	0.571
MOD_GSK3_1	271	278	PF00069	0.613
MOD_GSK3_1	294	301	PF00069	0.564
MOD_GSK3_1	360	367	PF00069	0.759
MOD_GSK3_1	403	410	PF00069	0.491
MOD_GSK3_1	412	419	PF00069	0.326
MOD_GSK3_1	42	49	PF00069	0.641
MOD_GSK3_1	424	431	PF00069	0.595
MOD_GSK3_1	440	447	PF00069	0.383
MOD_GSK3_1	524	531	PF00069	0.518
MOD_GSK3_1	99	106	PF00069	0.658
MOD_N-GLC_1	46	51	PF02516	0.549
MOD_NEK2_1	143	148	PF00069	0.645
MOD_NEK2_1	17	22	PF00069	0.615
MOD_NEK2_1	218	223	PF00069	0.543
MOD_NEK2_1	225	230	PF00069	0.542
MOD_NEK2_1	291	296	PF00069	0.517
MOD_NEK2_1	298	303	PF00069	0.454
MOD_NEK2_1	571	576	PF00069	0.583
MOD_PIKK_1	147	153	PF00454	0.699
MOD_PIKK_1	27	33	PF00454	0.685
MOD_PIKK_1	80	86	PF00454	0.665
MOD_PK_1	336	342	PF00069	0.542
MOD_PKA_1	80	86	PF00069	0.665
MOD_PKA_2	104	110	PF00069	0.679
MOD_PKA_2	15	21	PF00069	0.704
MOD_PKA_2	203	209	PF00069	0.585
MOD_PKA_2	265	271	PF00069	0.783
MOD_PKA_2	382	388	PF00069	0.734
MOD_PKA_2	490	496	PF00069	0.560
MOD_PKA_2	501	507	PF00069	0.424
MOD_PKA_2	80	86	PF00069	0.665
MOD_PKB_1	85	93	PF00069	0.681
MOD_Plk_1	196	202	PF00069	0.482
MOD_Plk_1	218	224	PF00069	0.622
MOD_Plk_1	443	449	PF00069	0.572
MOD_Plk_1	563	569	PF00069	0.662
MOD_Plk_1	72	78	PF00069	0.600
MOD_Plk_2-3	444	450	PF00069	0.502
MOD_Plk_4	125	131	PF00069	0.649
MOD_Plk_4	167	173	PF00069	0.567
MOD_Plk_4	17	23	PF00069	0.669
MOD_Plk_4	197	203	PF00069	0.529
MOD_Plk_4	294	300	PF00069	0.524
MOD_Plk_4	32	38	PF00069	0.568
MOD_Plk_4	366	372	PF00069	0.692
MOD_Plk_4	407	413	PF00069	0.565
MOD_Plk_4	444	450	PF00069	0.457
MOD_Plk_4	478	484	PF00069	0.450
MOD_ProDKin_1	21	27	PF00069	0.632
MOD_ProDKin_1	271	277	PF00069	0.708
MOD_SUMO_for_1	561	564	PF00179	0.744
MOD_SUMO_rev_2	555	563	PF00179	0.751
TRG_DiLeu_BaEn_1	167	172	PF01217	0.646
TRG_DiLeu_BaEn_2	443	449	PF01217	0.338
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.603
TRG_ENDOCYTIC_2	14	17	PF00928	0.658
TRG_ENDOCYTIC_2	160	163	PF00928	0.637
TRG_ENDOCYTIC_2	175	178	PF00928	0.502
TRG_ENDOCYTIC_2	288	291	PF00928	0.586
TRG_ENDOCYTIC_2	295	298	PF00928	0.540
TRG_ENDOCYTIC_2	337	340	PF00928	0.730
TRG_ENDOCYTIC_2	40	43	PF00928	0.550
TRG_ENDOCYTIC_2	498	501	PF00928	0.583
TRG_ER_diArg_1	251	253	PF00400	0.744
TRG_ER_diArg_1	490	492	PF00400	0.549
TRG_ER_diArg_1	499	502	PF00400	0.484
TRG_ER_diArg_1	80	82	PF00400	0.662
TRG_ER_diArg_1	85	88	PF00400	0.562
TRG_NLS_Bipartite_1	68	83	PF00514	0.602
TRG_NLS_MonoExtC_3	58	64	PF00514	0.458
TRG_Pf-PMV_PEXEL_1	470	475	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.693

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEU5	Leptomonas seymouri	43%	99%
A0A3Q8IF64	Leishmania donovani	93%	100%
A4HAC5	Leishmania braziliensis	79%	100%
A4I9H8	Leishmania infantum	93%	100%
E9B4H6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%