Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PrimPol-like protein 2, putative

Species:

Leishmania major

UniProt:

Q4Q3J8_LEIMA

TriTrypDb:

LmjF.34.0100 , LMJLV39_340006200 , LMJSD75_340006200

Length:

693

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q3J8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3J8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0003887	DNA-directed DNA polymerase activity	5	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0034061	DNA polymerase activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	644	648	PF00656	0.525
CLV_NRD_NRD_1	213	215	PF00675	0.450
CLV_NRD_NRD_1	238	240	PF00675	0.473
CLV_NRD_NRD_1	683	685	PF00675	0.458
CLV_NRD_NRD_1	94	96	PF00675	0.520
CLV_PCSK_FUR_1	303	307	PF00082	0.506
CLV_PCSK_KEX2_1	213	215	PF00082	0.450
CLV_PCSK_KEX2_1	238	240	PF00082	0.534
CLV_PCSK_KEX2_1	305	307	PF00082	0.590
CLV_PCSK_KEX2_1	401	403	PF00082	0.541
CLV_PCSK_KEX2_1	539	541	PF00082	0.393
CLV_PCSK_KEX2_1	683	685	PF00082	0.458
CLV_PCSK_KEX2_1	94	96	PF00082	0.593
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.491
CLV_PCSK_PC1ET2_1	401	403	PF00082	0.545
CLV_PCSK_PC1ET2_1	539	541	PF00082	0.345
CLV_PCSK_PC7_1	397	403	PF00082	0.518
CLV_PCSK_SKI1_1	203	207	PF00082	0.341
CLV_PCSK_SKI1_1	265	269	PF00082	0.494
CLV_PCSK_SKI1_1	397	401	PF00082	0.417
CLV_PCSK_SKI1_1	408	412	PF00082	0.360
CLV_PCSK_SKI1_1	494	498	PF00082	0.608
CLV_PCSK_SKI1_1	539	543	PF00082	0.439
CLV_PCSK_SKI1_1	669	673	PF00082	0.367
CLV_PCSK_SKI1_1	85	89	PF00082	0.483
CLV_Separin_Metazoa	680	684	PF03568	0.490
DEG_APCC_DBOX_1	264	272	PF00400	0.554
DEG_APCC_DBOX_1	396	404	PF00400	0.419
DEG_APCC_DBOX_1	407	415	PF00400	0.285
DEG_Nend_UBRbox_3	1	3	PF02207	0.535
DEG_SPOP_SBC_1	229	233	PF00917	0.346
DOC_CKS1_1	240	245	PF01111	0.483
DOC_CYCLIN_RxL_1	200	210	PF00134	0.442
DOC_CYCLIN_RxL_1	393	404	PF00134	0.371
DOC_MAPK_gen_1	599	607	PF00069	0.433
DOC_MAPK_MEF2A_6	85	92	PF00069	0.504
DOC_PP1_RVXF_1	251	257	PF00149	0.326
DOC_PP1_RVXF_1	316	323	PF00149	0.449
DOC_PP2B_LxvP_1	56	59	PF13499	0.621
DOC_PP2B_LxvP_1	572	575	PF13499	0.474
DOC_PP2B_LxvP_1	672	675	PF13499	0.389
DOC_PP4_FxxP_1	331	334	PF00568	0.326
DOC_PP4_FxxP_1	409	412	PF00568	0.333
DOC_PP4_FxxP_1	428	431	PF00568	0.372
DOC_PP4_FxxP_1	518	521	PF00568	0.568
DOC_USP7_MATH_1	342	346	PF00917	0.631
DOC_USP7_MATH_1	347	351	PF00917	0.615
DOC_USP7_MATH_1	376	380	PF00917	0.467
DOC_USP7_MATH_1	450	454	PF00917	0.411
DOC_USP7_MATH_1	507	511	PF00917	0.632
DOC_WW_Pin1_4	239	244	PF00397	0.531
DOC_WW_Pin1_4	297	302	PF00397	0.536
DOC_WW_Pin1_4	427	432	PF00397	0.479
DOC_WW_Pin1_4	43	48	PF00397	0.679
DOC_WW_Pin1_4	446	451	PF00397	0.486
DOC_WW_Pin1_4	560	565	PF00397	0.623
DOC_WW_Pin1_4	576	581	PF00397	0.325
LIG_14-3-3_CanoR_1	108	116	PF00244	0.512
LIG_14-3-3_CanoR_1	310	316	PF00244	0.385
LIG_14-3-3_CanoR_1	34	43	PF00244	0.605
LIG_14-3-3_CanoR_1	63	69	PF00244	0.510
LIG_Actin_WH2_2	205	223	PF00022	0.499
LIG_APCC_ABBA_1	158	163	PF00400	0.324
LIG_BRCT_BRCA1_1	489	493	PF00533	0.550
LIG_BRCT_BRCA1_1	514	518	PF00533	0.702
LIG_BRCT_BRCA1_1	99	103	PF00533	0.536
LIG_FHA_1	109	115	PF00498	0.447
LIG_FHA_1	229	235	PF00498	0.321
LIG_FHA_1	292	298	PF00498	0.443
LIG_FHA_1	515	521	PF00498	0.568
LIG_FHA_1	676	682	PF00498	0.585
LIG_FHA_1	685	691	PF00498	0.488
LIG_FHA_2	221	227	PF00498	0.479
LIG_FHA_2	69	75	PF00498	0.449
LIG_LIR_Apic_2	427	431	PF02991	0.435
LIG_LIR_Apic_2	515	521	PF02991	0.613
LIG_LIR_Apic_2	552	556	PF02991	0.401
LIG_LIR_Gen_1	100	107	PF02991	0.508
LIG_LIR_Gen_1	567	575	PF02991	0.482
LIG_LIR_Gen_1	6	17	PF02991	0.530
LIG_LIR_Gen_1	614	622	PF02991	0.435
LIG_LIR_Nem_3	100	106	PF02991	0.507
LIG_LIR_Nem_3	13	19	PF02991	0.478
LIG_LIR_Nem_3	159	164	PF02991	0.328
LIG_LIR_Nem_3	321	325	PF02991	0.358
LIG_LIR_Nem_3	326	331	PF02991	0.428
LIG_LIR_Nem_3	404	410	PF02991	0.337
LIG_LIR_Nem_3	490	496	PF02991	0.499
LIG_LIR_Nem_3	544	549	PF02991	0.326
LIG_LIR_Nem_3	567	572	PF02991	0.481
LIG_LIR_Nem_3	6	12	PF02991	0.494
LIG_LIR_Nem_3	614	618	PF02991	0.359
LIG_LIR_Nem_3	621	625	PF02991	0.374
LIG_Pex14_2	162	166	PF04695	0.467
LIG_Pex14_2	256	260	PF04695	0.304
LIG_PTAP_UEV_1	242	247	PF05743	0.404
LIG_PTB_Apo_2	667	674	PF02174	0.445
LIG_RPA_C_Fungi	90	102	PF08784	0.503
LIG_SH2_CRK	553	557	PF00017	0.432
LIG_SH2_GRB2like	630	633	PF00017	0.436
LIG_SH2_NCK_1	149	153	PF00017	0.448
LIG_SH2_SRC	587	590	PF00017	0.419
LIG_SH2_STAP1	587	591	PF00017	0.518
LIG_SH2_STAP1	662	666	PF00017	0.482
LIG_SH2_STAT3	595	598	PF00017	0.343
LIG_SH2_STAT5	161	164	PF00017	0.413
LIG_SH2_STAT5	325	328	PF00017	0.519
LIG_SH2_STAT5	398	401	PF00017	0.468
LIG_SH2_STAT5	595	598	PF00017	0.396
LIG_SH2_STAT5	603	606	PF00017	0.372
LIG_SH2_STAT5	619	622	PF00017	0.278
LIG_SH3_1	44	50	PF00018	0.597
LIG_SH3_3	154	160	PF00018	0.459
LIG_SH3_3	16	22	PF00018	0.511
LIG_SH3_3	237	243	PF00018	0.565
LIG_SH3_3	409	415	PF00018	0.311
LIG_SH3_3	428	434	PF00018	0.515
LIG_SH3_3	44	50	PF00018	0.657
LIG_SH3_3	444	450	PF00018	0.492
LIG_SH3_3	517	523	PF00018	0.570
LIG_SH3_3	55	61	PF00018	0.606
LIG_SH3_3	643	649	PF00018	0.488
LIG_SUMO_SIM_anti_2	293	300	PF11976	0.455
LIG_SUMO_SIM_par_1	88	93	PF11976	0.488
LIG_TRAF2_1	483	486	PF00917	0.619
LIG_TRAF2_1	677	680	PF00917	0.466
LIG_WRC_WIRS_1	619	624	PF05994	0.487
MOD_CDC14_SPxK_1	300	303	PF00782	0.540
MOD_CDK_SPxK_1	297	303	PF00069	0.556
MOD_CDK_SPxK_1	576	582	PF00069	0.477
MOD_CK1_1	445	451	PF00069	0.618
MOD_CK1_1	487	493	PF00069	0.649
MOD_CK1_1	49	55	PF00069	0.624
MOD_CK2_1	180	186	PF00069	0.445
MOD_CK2_1	220	226	PF00069	0.500
MOD_CK2_1	267	273	PF00069	0.467
MOD_CK2_1	674	680	PF00069	0.493
MOD_CK2_1	68	74	PF00069	0.547
MOD_Cter_Amidation	236	239	PF01082	0.409
MOD_DYRK1A_RPxSP_1	239	243	PF00069	0.477
MOD_DYRK1A_RPxSP_1	446	450	PF00069	0.424
MOD_GlcNHglycan	122	126	PF01048	0.638
MOD_GlcNHglycan	130	133	PF01048	0.370
MOD_GlcNHglycan	137	140	PF01048	0.420
MOD_GlcNHglycan	196	199	PF01048	0.436
MOD_GlcNHglycan	243	246	PF01048	0.509
MOD_GlcNHglycan	345	348	PF01048	0.598
MOD_GlcNHglycan	349	352	PF01048	0.568
MOD_GlcNHglycan	37	40	PF01048	0.706
MOD_GlcNHglycan	421	424	PF01048	0.513
MOD_GlcNHglycan	452	455	PF01048	0.484
MOD_GlcNHglycan	458	461	PF01048	0.425
MOD_GlcNHglycan	503	506	PF01048	0.573
MOD_GlcNHglycan	509	512	PF01048	0.618
MOD_GlcNHglycan	572	575	PF01048	0.573
MOD_GlcNHglycan	650	653	PF01048	0.679
MOD_GlcNHglycan	95	98	PF01048	0.498
MOD_GSK3_1	215	222	PF00069	0.506
MOD_GSK3_1	241	248	PF00069	0.480
MOD_GSK3_1	276	283	PF00069	0.525
MOD_GSK3_1	293	300	PF00069	0.455
MOD_GSK3_1	343	350	PF00069	0.619
MOD_GSK3_1	415	422	PF00069	0.475
MOD_GSK3_1	442	449	PF00069	0.555
MOD_GSK3_1	45	52	PF00069	0.613
MOD_GSK3_1	471	478	PF00069	0.573
MOD_GSK3_1	484	491	PF00069	0.542
MOD_GSK3_1	507	514	PF00069	0.588
MOD_GSK3_1	570	577	PF00069	0.422
MOD_GSK3_1	64	71	PF00069	0.346
MOD_GSK3_1	93	100	PF00069	0.569
MOD_LATS_1	32	38	PF00433	0.617
MOD_N-GLC_2	632	634	PF02516	0.436
MOD_NEK2_1	180	185	PF00069	0.445
MOD_NEK2_1	220	225	PF00069	0.414
MOD_NEK2_1	228	233	PF00069	0.284
MOD_NEK2_1	252	257	PF00069	0.467
MOD_NEK2_1	618	623	PF00069	0.355
MOD_NEK2_1	64	69	PF00069	0.488
MOD_NEK2_2	587	592	PF00069	0.515
MOD_PIKK_1	140	146	PF00454	0.333
MOD_PIKK_1	27	33	PF00454	0.543
MOD_PKA_2	107	113	PF00069	0.404
MOD_PKA_2	27	33	PF00069	0.530
MOD_PKA_2	343	349	PF00069	0.594
MOD_PKA_2	445	451	PF00069	0.414
MOD_PKA_2	93	99	PF00069	0.645
MOD_Plk_1	4	10	PF00069	0.505
MOD_Plk_1	470	476	PF00069	0.611
MOD_Plk_1	498	504	PF00069	0.523
MOD_Plk_1	587	593	PF00069	0.506
MOD_Plk_4	204	210	PF00069	0.445
MOD_Plk_4	293	299	PF00069	0.460
MOD_Plk_4	311	317	PF00069	0.221
MOD_Plk_4	376	382	PF00069	0.390
MOD_Plk_4	4	10	PF00069	0.555
MOD_Plk_4	49	55	PF00069	0.643
MOD_Plk_4	64	70	PF00069	0.449
MOD_Plk_4	685	691	PF00069	0.497
MOD_ProDKin_1	239	245	PF00069	0.527
MOD_ProDKin_1	297	303	PF00069	0.532
MOD_ProDKin_1	427	433	PF00069	0.475
MOD_ProDKin_1	43	49	PF00069	0.676
MOD_ProDKin_1	446	452	PF00069	0.484
MOD_ProDKin_1	560	566	PF00069	0.621
MOD_ProDKin_1	576	582	PF00069	0.331
MOD_SUMO_rev_2	183	190	PF00179	0.457
MOD_SUMO_rev_2	215	223	PF00179	0.464
MOD_SUMO_rev_2	534	541	PF00179	0.469
TRG_DiLeu_BaEn_1	537	542	PF01217	0.457
TRG_DiLeu_BaEn_2	272	278	PF01217	0.357
TRG_DiLeu_BaLyEn_6	491	496	PF01217	0.534
TRG_DiLeu_LyEn_5	537	542	PF01217	0.403
TRG_ENDOCYTIC_2	149	152	PF00928	0.370
TRG_ENDOCYTIC_2	161	164	PF00928	0.334
TRG_ENDOCYTIC_2	594	597	PF00928	0.458
TRG_ENDOCYTIC_2	619	622	PF00928	0.379
TRG_ENDOCYTIC_2	662	665	PF00928	0.372
TRG_ER_diArg_1	212	214	PF00400	0.438
TRG_ER_diArg_1	238	240	PF00400	0.439
TRG_ER_diArg_1	281	284	PF00400	0.476
TRG_ER_diArg_1	529	532	PF00400	0.608
TRG_ER_diArg_1	682	684	PF00400	0.452
TRG_NES_CRM1_1	250	264	PF08389	0.404
TRG_NES_CRM1_1	355	370	PF08389	0.514
TRG_Pf-PMV_PEXEL_1	494	498	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	540	544	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZS4	Leptomonas seymouri	53%	89%
A0A1X0P8G3	Trypanosomatidae	33%	93%
A0A3R7N6P4	Trypanosoma rangeli	37%	94%
A0A3S7X7B7	Leishmania donovani	93%	100%
A4HAC4	Leishmania braziliensis	80%	91%
A4I9H9	Leishmania infantum	93%	100%
D0A1T6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	95%
E9B4H7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%