LeishMANIAdb
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Malate dehydrogenase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Malate dehydrogenase
Gene product:
malate dehydrogenase, putative
Species:
Leishmania major
UniProt:
Q4Q3J5_LEIMA
TriTrypDb:
LmjF.34.0130 , LMJLV39_340006500 , LMJSD75_340006500
Length:
342

Annotations

LeishMANIAdb annotations

A group of metabolic enzymes without any likely TM segment. Very conserved in Eukaryota.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 19
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 3
GO:0110165 cellular anatomical entity 1 3
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

Q4Q3J5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3J5

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 20
GO:0006099 tricarboxylic acid cycle 3 18
GO:0006108 malate metabolic process 7 18
GO:0008152 metabolic process 1 20
GO:0009987 cellular process 1 20
GO:0019752 carboxylic acid metabolic process 5 20
GO:0043436 oxoacid metabolic process 4 20
GO:0043648 dicarboxylic acid metabolic process 6 18
GO:0044237 cellular metabolic process 2 20
GO:0044238 primary metabolic process 2 18
GO:0044281 small molecule metabolic process 2 20
GO:0071704 organic substance metabolic process 2 20
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 20
GO:0016491 oxidoreductase activity 2 20
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 20
GO:0016615 malate dehydrogenase activity 4 19
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 20
GO:0030060 L-malate dehydrogenase activity 5 19

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 118 120 PF00675 0.399
CLV_NRD_NRD_1 159 161 PF00675 0.286
CLV_NRD_NRD_1 173 175 PF00675 0.286
CLV_NRD_NRD_1 6 8 PF00675 0.508
CLV_PCSK_KEX2_1 118 120 PF00082 0.399
CLV_PCSK_KEX2_1 6 8 PF00082 0.508
CLV_PCSK_SKI1_1 16 20 PF00082 0.373
CLV_PCSK_SKI1_1 160 164 PF00082 0.330
CLV_PCSK_SKI1_1 7 11 PF00082 0.573
CLV_Separin_Metazoa 327 331 PF03568 0.241
DEG_APCC_DBOX_1 210 218 PF00400 0.305
DEG_APCC_DBOX_1 5 13 PF00400 0.365
DEG_COP1_1 319 328 PF00400 0.403
DOC_MAPK_gen_1 13 20 PF00069 0.354
DOC_MAPK_gen_1 268 276 PF00069 0.417
DOC_MAPK_MEF2A_6 86 95 PF00069 0.417
DOC_PP1_RVXF_1 14 21 PF00149 0.302
DOC_PP2B_LxvP_1 210 213 PF13499 0.321
DOC_USP7_MATH_1 123 127 PF00917 0.397
DOC_USP7_MATH_1 134 138 PF00917 0.327
DOC_USP7_MATH_1 312 316 PF00917 0.356
DOC_USP7_UBL2_3 152 156 PF12436 0.417
DOC_WW_Pin1_4 135 140 PF00397 0.333
DOC_WW_Pin1_4 141 146 PF00397 0.338
DOC_WW_Pin1_4 287 292 PF00397 0.298
LIG_14-3-3_CanoR_1 6 10 PF00244 0.604
LIG_Actin_WH2_2 136 154 PF00022 0.314
LIG_Actin_WH2_2 95 113 PF00022 0.241
LIG_APCC_ABBA_1 36 41 PF00400 0.305
LIG_BRCT_BRCA1_1 153 157 PF00533 0.417
LIG_FHA_1 128 134 PF00498 0.375
LIG_FHA_1 165 171 PF00498 0.300
LIG_FHA_1 262 268 PF00498 0.471
LIG_FHA_2 164 170 PF00498 0.294
LIG_FHA_2 312 318 PF00498 0.286
LIG_FHA_2 46 52 PF00498 0.380
LIG_IBAR_NPY_1 184 186 PF08397 0.345
LIG_Integrin_RGD_1 271 273 PF01839 0.294
LIG_LIR_Gen_1 97 105 PF02991 0.241
LIG_LIR_Nem_3 226 230 PF02991 0.387
LIG_LIR_Nem_3 78 84 PF02991 0.417
LIG_LIR_Nem_3 97 102 PF02991 0.209
LIG_PDZ_Class_1 337 342 PF00595 0.378
LIG_Pex14_2 95 99 PF04695 0.305
LIG_REV1ctd_RIR_1 290 300 PF16727 0.302
LIG_SH2_CRK 227 231 PF00017 0.417
LIG_SH2_STAP1 186 190 PF00017 0.322
LIG_SH2_STAP1 316 320 PF00017 0.353
LIG_SH3_3 133 139 PF00018 0.286
LIG_SH3_3 185 191 PF00018 0.345
LIG_SH3_3 23 29 PF00018 0.371
LIG_SH3_3 244 250 PF00018 0.356
LIG_SUMO_SIM_anti_2 166 173 PF11976 0.297
MOD_CK1_1 126 132 PF00069 0.425
MOD_CK2_1 292 298 PF00069 0.351
MOD_CK2_1 311 317 PF00069 0.168
MOD_DYRK1A_RPxSP_1 287 291 PF00069 0.262
MOD_GlcNHglycan 153 156 PF01048 0.464
MOD_GlcNHglycan 220 223 PF01048 0.416
MOD_GlcNHglycan 56 59 PF01048 0.447
MOD_GSK3_1 123 130 PF00069 0.450
MOD_GSK3_1 281 288 PF00069 0.253
MOD_GSK3_1 61 68 PF00069 0.308
MOD_NEK2_1 151 156 PF00069 0.324
MOD_NEK2_1 163 168 PF00069 0.270
MOD_NEK2_1 20 25 PF00069 0.297
MOD_NEK2_1 262 267 PF00069 0.306
MOD_NEK2_1 281 286 PF00069 0.145
MOD_NEK2_1 292 297 PF00069 0.249
MOD_NEK2_1 320 325 PF00069 0.266
MOD_NEK2_1 5 10 PF00069 0.583
MOD_PKA_2 218 224 PF00069 0.417
MOD_PKA_2 5 11 PF00069 0.376
MOD_Plk_1 282 288 PF00069 0.264
MOD_Plk_1 61 67 PF00069 0.301
MOD_Plk_4 262 268 PF00069 0.265
MOD_Plk_4 28 34 PF00069 0.320
MOD_ProDKin_1 135 141 PF00069 0.333
MOD_ProDKin_1 287 293 PF00069 0.298
TRG_DiLeu_BaLyEn_6 200 205 PF01217 0.325
TRG_ENDOCYTIC_2 227 230 PF00928 0.177
TRG_ER_diArg_1 117 119 PF00400 0.401
TRG_ER_diArg_1 171 174 PF00400 0.303
TRG_ER_diArg_1 5 7 PF00400 0.523
TRG_NES_CRM1_1 89 105 PF08389 0.241

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6H7 Leptomonas seymouri 33% 100%
A0A0N0P6W7 Leptomonas seymouri 36% 100%
A0A0N1HYD1 Leptomonas seymouri 29% 100%
A0A0N1I818 Leptomonas seymouri 76% 100%
A0A0N1ILF3 Leptomonas seymouri 37% 100%
A0A0S4IRQ1 Bodo saltans 39% 84%
A0A0S4ITJ4 Bodo saltans 27% 100%
A0A1X0P752 Trypanosomatidae 30% 100%
A0A1X0P9G5 Trypanosomatidae 53% 94%
A0A1X0P9V7 Trypanosomatidae 37% 100%
A0A3Q8IGW8 Leishmania donovani 95% 100%
A0A3Q8IKK8 Leishmania donovani 32% 100%
A0A3R7M519 Trypanosoma rangeli 38% 70%
A0A3S7WVE3 Leishmania donovani 31% 100%
A0A3S7X7B8 Leishmania donovani 34% 100%
A0A3S7X7D4 Leishmania donovani 39% 100%
A0A422N293 Trypanosoma rangeli 53% 96%
A0A422NMV1 Trypanosoma rangeli 27% 100%
A0KG16 Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049) 34% 100%
A0L113 Shewanella sp. (strain ANA-3) 32% 100%
A1AGC9 Escherichia coli O1:K1 / APEC 33% 100%
A1JIV0 Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) 31% 100%
A1RFX8 Shewanella sp. (strain W3-18-1) 31% 100%
A1S3C4 Shewanella amazonensis (strain ATCC BAA-1098 / SB2B) 32% 100%
A1SRP8 Psychromonas ingrahamii (strain 37) 33% 100%
A3D075 Shewanella baltica (strain OS155 / ATCC BAA-1091) 32% 100%
A3N1U6 Actinobacillus pleuropneumoniae serotype 5b (strain L20) 32% 100%
A3QB91 Shewanella loihica (strain ATCC BAA-1088 / PV-4) 32% 100%
A4HA28 Leishmania braziliensis 30% 100%
A4HAB8 Leishmania braziliensis 38% 100%
A4HAB9 Leishmania braziliensis 33% 100%
A4HAC0 Leishmania braziliensis 35% 100%
A4HAC1 Leishmania braziliensis 83% 100%
A4HY91 Leishmania infantum 32% 100%
A4I9I2 Leishmania infantum 94% 100%
A4I9I3 Leishmania infantum 35% 100%
A4I9I4 Leishmania infantum 32% 100%
A4I9I5 Leishmania infantum 39% 100%
A4SIV0 Aeromonas salmonicida (strain A449) 34% 100%
A4TRK3 Yersinia pestis (strain Pestoides F) 31% 100%
A4WF48 Enterobacter sp. (strain 638) 33% 100%
A4YAE8 Shewanella putrefaciens (strain CN-32 / ATCC BAA-453) 31% 100%
A5UCQ1 Haemophilus influenzae (strain PittEE) 35% 100%
A5UIX3 Haemophilus influenzae (strain PittGG) 34% 100%
A6TEQ3 Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) 33% 100%
A6WSM1 Shewanella baltica (strain OS185) 32% 100%
A7FMU2 Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) 31% 100%
A7MNR3 Cronobacter sakazakii (strain ATCC BAA-894) 33% 100%
A7MWD3 Vibrio campbellii (strain ATCC BAA-1116) 35% 100%
A7ZSD0 Escherichia coli O139:H28 (strain E24377A / ETEC) 33% 100%
A8A545 Escherichia coli O9:H4 (strain HS) 33% 100%
A8AQC8 Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) 33% 100%
A8FRU0 Shewanella sediminis (strain HAW-EB3) 31% 100%
A8G8Y7 Serratia proteamaculans (strain 568) 33% 100%
A8H0U0 Shewanella pealeana (strain ATCC 700345 / ANG-SQ1) 33% 100%
A9L340 Shewanella baltica (strain OS195) 32% 100%
A9MNX5 Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) 33% 100%
A9N855 Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) 33% 100%
A9R584 Yersinia pestis bv. Antiqua (strain Angola) 31% 100%
B0BQN0 Actinobacillus pleuropneumoniae serotype 3 (strain JL03) 32% 100%
B0TUH8 Shewanella halifaxensis (strain HAW-EB4) 33% 100%
B0UUR6 Histophilus somni (strain 2336) 34% 100%
B1IQP3 Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks) 33% 100%
B1JMK1 Yersinia pseudotuberculosis serotype O:3 (strain YPIII) 31% 100%
B1KGG7 Shewanella woodyi (strain ATCC 51908 / MS32) 32% 100%
B1LGK2 Escherichia coli (strain SMS-3-5 / SECEC) 33% 100%
B1XHK9 Escherichia coli (strain K12 / DH10B) 33% 100%
B2K2N5 Yersinia pseudotuberculosis serotype IB (strain PB1/+) 31% 100%
B2U1U9 Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) 33% 100%
B2VGW7 Erwinia tasmaniensis (strain DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB 4357 / Et1/99) 32% 100%
B3H269 Actinobacillus pleuropneumoniae serotype 7 (strain AP76) 32% 100%
B4F2A1 Proteus mirabilis (strain HI4320) 33% 100%
B4T769 Salmonella newport (strain SL254) 33% 100%
B4TJT3 Salmonella heidelberg (strain SL476) 33% 100%
B4TWK9 Salmonella schwarzengrund (strain CVM19633) 33% 100%
B5BGR3 Salmonella paratyphi A (strain AKU_12601) 33% 100%
B5F7L9 Salmonella agona (strain SL483) 33% 100%
B5FGF5 Aliivibrio fischeri (strain MJ11) 33% 100%
B5FIT7 Salmonella dublin (strain CT_02021853) 33% 100%
B5R0N2 Salmonella enteritidis PT4 (strain P125109) 33% 100%
B5REV7 Salmonella gallinarum (strain 287/91 / NCTC 13346) 33% 100%
B5XSQ7 Klebsiella pneumoniae (strain 342) 33% 100%
B5YSW2 Escherichia coli O157:H7 (strain EC4115 / EHEC) 33% 100%
B6EL39 Aliivibrio salmonicida (strain LFI1238) 33% 100%
B6I1V4 Escherichia coli (strain SE11) 33% 100%
B7LHU4 Escherichia coli (strain 55989 / EAEC) 33% 100%
B7LRL0 Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73) 33% 100%
B7M0U8 Escherichia coli O8 (strain IAI1) 33% 100%
B7MBZ7 Escherichia coli O45:K1 (strain S88 / ExPEC) 33% 100%
B7N0M1 Escherichia coli O81 (strain ED1a) 33% 100%
B7NDL4 Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) 33% 100%
B7NKU9 Escherichia coli O7:K1 (strain IAI39 / ExPEC) 33% 100%
B7UJW8 Escherichia coli O127:H6 (strain E2348/69 / EPEC) 33% 100%
B7VID0 Vibrio atlanticus (strain LGP32) 34% 100%
B8CSY7 Shewanella piezotolerans (strain WP3 / JCM 13877) 32% 100%
B8EB55 Shewanella baltica (strain OS223) 32% 100%
B8F5K4 Glaesserella parasuis serovar 5 (strain SH0165) 35% 100%
C0PZQ4 Salmonella paratyphi C (strain RKS4594) 33% 100%
C4ZSX4 Escherichia coli (strain K12 / MC4100 / BW2952) 33% 100%
C5BF98 Edwardsiella ictaluri (strain 93-146) 33% 100%
C6DKH1 Pectobacterium carotovorum subsp. carotovorum (strain PC1) 33% 100%
D0A0M1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
D0A1U0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 96%
D0A1U1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9AS23 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B4I0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9B4I1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9B4I2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B4I3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
K0J107 Felis catus 34% 100%
O02640 Caenorhabditis elegans 33% 100%
O82399 Arabidopsis thaliana 36% 97%
P00346 Sus scrofa 33% 100%
P04636 Rattus norvegicus 34% 100%
P08249 Mus musculus 34% 100%
P0C7R5 Yersinia pseudotuberculosis serotype I (strain IP32953) 31% 100%
P17505 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 32% 100%
P17783 Citrullus lanatus 35% 99%
P19446 Citrullus lanatus 36% 96%
P22133 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 91%
P25077 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 33% 100%
P32419 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 100%
P37226 Photobacterium profundum (strain SS9) 33% 100%
P37228 Glycine max 37% 97%
P40926 Homo sapiens 34% 100%
P44427 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 35% 100%
P46487 Eucalyptus gunnii 34% 99%
P46488 Cucumis sativus 36% 96%
P48364 Moritella sp. (strain 5710) 33% 100%
P61889 Escherichia coli (strain K12) 33% 100%
P61890 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 33% 100%
P61891 Escherichia coli O157:H7 33% 100%
P61892 Yersinia pestis 31% 100%
P61896 Klebsiella variicola 34% 100%
P82177 Shewanella oneidensis (strain MR-1) 31% 100%
P83373 Fragaria ananassa 35% 100%
P83778 Candida albicans (strain SC5314 / ATCC MYA-2876) 30% 100%
Q07YA5 Shewanella frigidimarina (strain NCIMB 400) 33% 100%
Q0HEW2 Shewanella sp. (strain MR-4) 32% 100%
Q0HZ38 Shewanella sp. (strain MR-7) 32% 100%
Q0I491 Haemophilus somnus (strain 129Pt) 34% 100%
Q0T052 Shigella flexneri serotype 5b (strain 8401) 33% 100%
Q0TCN0 Escherichia coli O6:K15:H31 (strain 536 / UPEC) 33% 100%
Q12R11 Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013) 33% 100%
Q15YH0 Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087) 33% 100%
Q1CBY7 Yersinia pestis bv. Antiqua (strain Antiqua) 31% 100%
Q1CEJ3 Yersinia pestis bv. Antiqua (strain Nepal516) 31% 100%
Q1R6A3 Escherichia coli (strain UTI89 / UPEC) 33% 100%
Q31WA4 Shigella boydii serotype 4 (strain Sb227) 33% 100%
Q32BA3 Shigella dysenteriae serotype 1 (strain Sd197) 33% 100%
Q32LG3 Bos taurus 34% 100%
Q3IFH4 Pseudoalteromonas translucida (strain TAC 125) 30% 100%
Q3YX11 Shigella sonnei (strain Ss046) 33% 100%
Q42686 Chlamydomonas reinhardtii 34% 92%
Q42972 Oryza sativa subsp. japonica 37% 96%
Q43743 Brassica napus 36% 96%
Q43744 Brassica napus 33% 100%
Q47VL0 Colwellia psychrerythraea (strain 34H / ATCC BAA-681) 32% 100%
Q4Q3J2 Leishmania major 39% 98%
Q4Q3J3 Leishmania major 32% 100%
Q4Q3J4 Leishmania major 36% 97%
Q4QDF0 Leishmania major 31% 100%
Q4QL89 Haemophilus influenzae (strain 86-028NP) 35% 100%
Q4R568 Macaca fascicularis 34% 100%
Q57JA9 Salmonella choleraesuis (strain SC-B67) 33% 100%
Q59838 Salmonella muenchen 33% 100%
Q5E875 Aliivibrio fischeri (strain ATCC 700601 / ES114) 33% 100%
Q5NVR2 Pongo abelii 34% 100%
Q5R030 Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR) 33% 100%
Q5U907 Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / CCUG 43843 / 130Z) 33% 100%
Q65T37 Mannheimia succiniciproducens (strain MBEL55E) 31% 100%
Q6AW21 Moritella japonica 34% 100%
Q6AW23 Moritella marina 33% 100%
Q6D9D1 Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 33% 100%
Q7MP97 Vibrio vulnificus (strain YJ016) 34% 100%
Q7MYW9 Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) 32% 100%
Q7VP41 Haemophilus ducreyi (strain 35000HP / ATCC 700724) 31% 100%
Q7WS85 Salmonella paratyphi A (strain ATCC 9150 / SARB42) 33% 100%
Q7X3X5 Moritella sp. (strain 2D2) 33% 100%
Q83Q04 Shigella flexneri 33% 100%
Q87SU7 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) 33% 100%
Q8DEC2 Vibrio vulnificus (strain CMCP6) 34% 100%
Q8Z3E0 Salmonella typhi 33% 100%
Q9CN86 Pasteurella multocida (strain Pm70) 34% 100%
Q9KUT3 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 34% 100%
Q9LKA3 Arabidopsis thaliana 36% 100%
Q9SN86 Arabidopsis thaliana 35% 85%
Q9XFW3 Brassica napus 36% 96%
Q9Y7R8 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 32% 100%
Q9ZP05 Arabidopsis thaliana 36% 97%
Q9ZP06 Arabidopsis thaliana 34% 100%
V5BHN5 Trypanosoma cruzi 38% 100%
V5BRQ9 Trypanosoma cruzi 54% 91%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS