Nucleolar protein 12

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 12 (25kDa), putative

Species:

Leishmania major

UniProt:

Q4Q3J1_LEIMA

TriTrypDb:

LmjF.34.0170 , LMJLV39_340006900 , LMJSD75_340006900

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q3J1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3J1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.592
CLV_C14_Caspase3-7	42	46	PF00656	0.707
CLV_NRD_NRD_1	105	107	PF00675	0.144
CLV_NRD_NRD_1	189	191	PF00675	0.535
CLV_NRD_NRD_1	19	21	PF00675	0.626
CLV_NRD_NRD_1	307	309	PF00675	0.490
CLV_NRD_NRD_1	310	312	PF00675	0.504
CLV_NRD_NRD_1	314	316	PF00675	0.556
CLV_NRD_NRD_1	321	323	PF00675	0.609
CLV_NRD_NRD_1	326	328	PF00675	0.599
CLV_NRD_NRD_1	329	331	PF00675	0.500
CLV_NRD_NRD_1	63	65	PF00675	0.339
CLV_NRD_NRD_1	77	79	PF00675	0.328
CLV_NRD_NRD_1	86	88	PF00675	0.340
CLV_NRD_NRD_1	89	91	PF00675	0.337
CLV_NRD_NRD_1	97	99	PF00675	0.144
CLV_PCSK_FUR_1	187	191	PF00082	0.654
CLV_PCSK_KEX2_1	105	107	PF00082	0.365
CLV_PCSK_KEX2_1	177	179	PF00082	0.629
CLV_PCSK_KEX2_1	187	189	PF00082	0.510
CLV_PCSK_KEX2_1	192	194	PF00082	0.505
CLV_PCSK_KEX2_1	32	34	PF00082	0.587
CLV_PCSK_KEX2_1	320	322	PF00082	0.658
CLV_PCSK_KEX2_1	326	328	PF00082	0.610
CLV_PCSK_KEX2_1	63	65	PF00082	0.366
CLV_PCSK_KEX2_1	77	79	PF00082	0.328
CLV_PCSK_KEX2_1	86	88	PF00082	0.340
CLV_PCSK_KEX2_1	97	99	PF00082	0.144
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.672
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.597
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.620
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.658
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.610
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.416
CLV_PCSK_PC7_1	101	107	PF00082	0.430
CLV_PCSK_PC7_1	188	194	PF00082	0.662
CLV_PCSK_PC7_1	322	328	PF00082	0.559
CLV_PCSK_SKI1_1	193	197	PF00082	0.602
CLV_PCSK_SKI1_1	21	25	PF00082	0.554
CLV_PCSK_SKI1_1	241	245	PF00082	0.565
CLV_PCSK_SKI1_1	299	303	PF00082	0.535
CLV_PCSK_SKI1_1	32	36	PF00082	0.525
CLV_PCSK_SKI1_1	54	58	PF00082	0.336
DEG_APCC_DBOX_1	277	285	PF00400	0.638
DEG_APCC_DBOX_1	63	71	PF00400	0.348
DEG_SPOP_SBC_1	225	229	PF00917	0.737
DOC_CDC14_PxL_1	111	119	PF14671	0.328
DOC_CYCLIN_RxL_1	51	62	PF00134	0.440
DOC_MAPK_gen_1	63	70	PF00069	0.400
DOC_MAPK_JIP1_4	52	58	PF00069	0.440
DOC_PP1_RVXF_1	52	59	PF00149	0.314
DOC_PP2B_PxIxI_1	161	167	PF00149	0.745
DOC_USP7_MATH_1	176	180	PF00917	0.695
DOC_USP7_MATH_1	182	186	PF00917	0.622
DOC_USP7_MATH_1	225	229	PF00917	0.665
DOC_USP7_MATH_1	264	268	PF00917	0.585
DOC_USP7_UBL2_3	17	21	PF12436	0.574
DOC_USP7_UBL2_3	289	293	PF12436	0.595
DOC_USP7_UBL2_3	302	306	PF12436	0.522
DOC_USP7_UBL2_3	312	316	PF12436	0.556
DOC_USP7_UBL2_3	328	332	PF12436	0.629
DOC_USP7_UBL2_3	37	41	PF12436	0.383
DOC_USP7_UBL2_3	91	95	PF12436	0.410
DOC_WW_Pin1_4	47	52	PF00397	0.665
LIG_14-3-3_CanoR_1	193	198	PF00244	0.686
LIG_BRCT_BRCA1_1	266	270	PF00533	0.560
LIG_FHA_1	119	125	PF00498	0.318
LIG_FHA_1	235	241	PF00498	0.554
LIG_FHA_1	260	266	PF00498	0.635
LIG_FHA_2	40	46	PF00498	0.694
LIG_FHA_2	5	11	PF00498	0.647
LIG_FHA_2	55	61	PF00498	0.174
LIG_FHA_2	94	100	PF00498	0.365
LIG_LIR_Apic_2	119	125	PF02991	0.335
LIG_LIR_Gen_1	160	171	PF02991	0.720
LIG_LIR_Gen_1	232	243	PF02991	0.551
LIG_LIR_Gen_1	267	277	PF02991	0.447
LIG_LIR_LC3C_4	272	277	PF02991	0.629
LIG_LIR_Nem_3	160	166	PF02991	0.685
LIG_LIR_Nem_3	232	238	PF02991	0.562
LIG_LIR_Nem_3	267	273	PF02991	0.457
LIG_SH2_CRK	111	115	PF00017	0.377
LIG_SH2_CRK	122	126	PF00017	0.270
LIG_SH2_NCK_1	111	115	PF00017	0.440
LIG_SH2_PTP2	235	238	PF00017	0.683
LIG_SH2_STAP1	120	124	PF00017	0.440
LIG_SH2_STAT3	147	150	PF00017	0.469
LIG_SH2_STAT5	120	123	PF00017	0.440
LIG_SH2_STAT5	235	238	PF00017	0.644
LIG_SH2_STAT5	4	7	PF00017	0.685
LIG_SH2_STAT5	66	69	PF00017	0.348
LIG_SH3_3	112	118	PF00018	0.314
LIG_SH3_3	163	169	PF00018	0.757
LIG_SH3_3	219	225	PF00018	0.745
LIG_TRAF2_2	125	130	PF00917	0.469
LIG_UBA3_1	300	309	PF00899	0.548
LIG_UBA3_1	67	74	PF00899	0.348
MOD_CDK_SPK_2	47	52	PF00069	0.517
MOD_CDK_SPxxK_3	47	54	PF00069	0.633
MOD_CK1_1	148	154	PF00069	0.484
MOD_CK1_1	226	232	PF00069	0.678
MOD_CK1_1	245	251	PF00069	0.644
MOD_CK1_1	93	99	PF00069	0.425
MOD_CK2_1	224	230	PF00069	0.667
MOD_CK2_1	93	99	PF00069	0.382
MOD_Cter_Amidation	318	321	PF01082	0.612
MOD_Cter_Amidation	324	327	PF01082	0.614
MOD_GlcNHglycan	150	153	PF01048	0.484
MOD_GlcNHglycan	199	202	PF01048	0.715
MOD_GlcNHglycan	247	250	PF01048	0.630
MOD_GlcNHglycan	323	326	PF01048	0.692
MOD_GlcNHglycan	92	95	PF01048	0.440
MOD_GSK3_1	193	200	PF00069	0.662
MOD_GSK3_1	226	233	PF00069	0.687
MOD_GSK3_1	4	11	PF00069	0.663
MOD_GSK3_1	54	61	PF00069	0.414
MOD_NEK2_1	197	202	PF00069	0.688
MOD_NEK2_1	243	248	PF00069	0.674
MOD_NEK2_1	58	63	PF00069	0.410
MOD_NEK2_2	251	256	PF00069	0.544
MOD_NEK2_2	66	71	PF00069	0.371
MOD_PIKK_1	146	152	PF00454	0.455
MOD_PIKK_1	182	188	PF00454	0.576
MOD_PKA_1	311	317	PF00069	0.553
MOD_PKA_1	321	327	PF00069	0.619
MOD_PKA_1	90	96	PF00069	0.425
MOD_PKA_2	321	327	PF00069	0.559
MOD_PKB_1	283	291	PF00069	0.629
MOD_Plk_1	118	124	PF00069	0.328
MOD_Plk_2-3	234	240	PF00069	0.570
MOD_ProDKin_1	47	53	PF00069	0.661
MOD_SUMO_rev_2	233	243	PF00179	0.563
TRG_ENDOCYTIC_2	111	114	PF00928	0.339
TRG_ENDOCYTIC_2	235	238	PF00928	0.644
TRG_ENDOCYTIC_2	31	34	PF00928	0.637
TRG_ER_diArg_1	187	190	PF00400	0.596
TRG_ER_diArg_1	296	299	PF00400	0.616
TRG_ER_diArg_1	77	79	PF00400	0.328
TRG_NLS_Bipartite_1	308	330	PF00514	0.584
TRG_NLS_Bipartite_1	72	91	PF00514	0.440
TRG_NLS_MonoExtC_3	16	21	PF00514	0.679
TRG_NLS_MonoExtC_3	307	312	PF00514	0.513
TRG_NLS_MonoExtC_3	325	330	PF00514	0.619
TRG_NLS_MonoExtC_3	85	90	PF00514	0.440
TRG_NLS_MonoExtN_4	306	312	PF00514	0.511
TRG_NLS_MonoExtN_4	326	331	PF00514	0.436
TRG_NLS_MonoExtN_4	86	91	PF00514	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ5	Leptomonas seymouri	66%	99%
A0A1X0P8J9	Trypanosomatidae	45%	100%
A0A3Q8IH68	Leishmania donovani	90%	100%
A0A422N280	Trypanosoma rangeli	43%	100%
A4I9I6	Leishmania infantum	88%	100%
D0A1U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B4I4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5DIL2	Trypanosoma cruzi	46%	94%