Methyltranfer_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3J0_LEIMA

TriTrypDb:

LmjF.34.0180 , LMJLV39_340007100 , LMJSD75_340007100

Length:

770

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q3J0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3J0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	407	411	PF00656	0.467
CLV_C14_Caspase3-7	506	510	PF00656	0.428
CLV_NRD_NRD_1	156	158	PF00675	0.528
CLV_NRD_NRD_1	187	189	PF00675	0.485
CLV_NRD_NRD_1	279	281	PF00675	0.465
CLV_NRD_NRD_1	296	298	PF00675	0.707
CLV_NRD_NRD_1	330	332	PF00675	0.500
CLV_NRD_NRD_1	391	393	PF00675	0.575
CLV_NRD_NRD_1	397	399	PF00675	0.516
CLV_NRD_NRD_1	518	520	PF00675	0.389
CLV_NRD_NRD_1	551	553	PF00675	0.490
CLV_NRD_NRD_1	583	585	PF00675	0.344
CLV_NRD_NRD_1	591	593	PF00675	0.514
CLV_NRD_NRD_1	723	725	PF00675	0.525
CLV_NRD_NRD_1	727	729	PF00675	0.512
CLV_PCSK_FUR_1	327	331	PF00082	0.580
CLV_PCSK_FUR_1	720	724	PF00082	0.526
CLV_PCSK_KEX2_1	155	157	PF00082	0.575
CLV_PCSK_KEX2_1	279	281	PF00082	0.466
CLV_PCSK_KEX2_1	295	297	PF00082	0.712
CLV_PCSK_KEX2_1	327	329	PF00082	0.508
CLV_PCSK_KEX2_1	330	332	PF00082	0.495
CLV_PCSK_KEX2_1	517	519	PF00082	0.380
CLV_PCSK_KEX2_1	551	553	PF00082	0.624
CLV_PCSK_KEX2_1	591	593	PF00082	0.598
CLV_PCSK_KEX2_1	722	724	PF00082	0.524
CLV_PCSK_PC7_1	547	553	PF00082	0.466
CLV_PCSK_PC7_1	587	593	PF00082	0.477
CLV_PCSK_SKI1_1	157	161	PF00082	0.411
CLV_PCSK_SKI1_1	349	353	PF00082	0.487
CLV_PCSK_SKI1_1	658	662	PF00082	0.547
CLV_PCSK_SKI1_1	729	733	PF00082	0.552
CLV_PCSK_SKI1_1	745	749	PF00082	0.401
CLV_TASPASE1	507	513	PF01112	0.474
DEG_APCC_DBOX_1	723	731	PF00400	0.633
DEG_SPOP_SBC_1	214	218	PF00917	0.466
DEG_SPOP_SBC_1	317	321	PF00917	0.662
DOC_CDC14_PxL_1	494	502	PF14671	0.365
DOC_CYCLIN_RxL_1	722	736	PF00134	0.616
DOC_CYCLIN_yCln2_LP_2	413	419	PF00134	0.479
DOC_MAPK_gen_1	722	732	PF00069	0.499
DOC_MAPK_MEF2A_6	536	545	PF00069	0.366
DOC_PP2B_LxvP_1	478	481	PF13499	0.430
DOC_PP4_FxxP_1	159	162	PF00568	0.391
DOC_USP7_MATH_1	21	25	PF00917	0.394
DOC_USP7_MATH_1	214	218	PF00917	0.599
DOC_USP7_MATH_1	433	437	PF00917	0.449
DOC_USP7_MATH_1	456	460	PF00917	0.739
DOC_USP7_MATH_1	526	530	PF00917	0.688
DOC_USP7_MATH_1	531	535	PF00917	0.676
DOC_USP7_MATH_1	630	634	PF00917	0.524
DOC_USP7_MATH_1	96	100	PF00917	0.649
DOC_USP7_MATH_2	345	351	PF00917	0.582
DOC_USP7_UBL2_3	762	766	PF12436	0.484
DOC_WW_Pin1_4	103	108	PF00397	0.521
DOC_WW_Pin1_4	297	302	PF00397	0.638
DOC_WW_Pin1_4	341	346	PF00397	0.503
DOC_WW_Pin1_4	454	459	PF00397	0.679
DOC_WW_Pin1_4	650	655	PF00397	0.580
DOC_WW_Pin1_4	681	686	PF00397	0.723
DOC_WW_Pin1_4	730	735	PF00397	0.552
LIG_14-3-3_CanoR_1	188	194	PF00244	0.588
LIG_14-3-3_CanoR_1	295	301	PF00244	0.693
LIG_14-3-3_CanoR_1	392	396	PF00244	0.536
LIG_14-3-3_CanoR_1	584	590	PF00244	0.485
LIG_APCC_ABBA_1	543	548	PF00400	0.354
LIG_BIR_III_2	101	105	PF00653	0.526
LIG_BIR_III_2	247	251	PF00653	0.435
LIG_BRCT_BRCA1_1	215	219	PF00533	0.458
LIG_BRCT_BRCA1_1	64	68	PF00533	0.389
LIG_BRCT_BRCA1_1	707	711	PF00533	0.583
LIG_deltaCOP1_diTrp_1	77	81	PF00928	0.508
LIG_eIF4E_1	230	236	PF01652	0.303
LIG_eIF4E_1	484	490	PF01652	0.457
LIG_eIF4E_1	741	747	PF01652	0.415
LIG_FHA_1	484	490	PF00498	0.430
LIG_FHA_1	635	641	PF00498	0.507
LIG_FHA_1	695	701	PF00498	0.741
LIG_FHA_2	196	202	PF00498	0.557
LIG_FHA_2	257	263	PF00498	0.390
LIG_GBD_Chelix_1	42	50	PF00786	0.398
LIG_LIR_Apic_2	368	374	PF02991	0.433
LIG_LIR_Apic_2	648	654	PF02991	0.575
LIG_LIR_Apic_2	674	680	PF02991	0.683
LIG_LIR_Gen_1	112	120	PF02991	0.392
LIG_LIR_Gen_1	472	481	PF02991	0.317
LIG_LIR_Gen_1	509	516	PF02991	0.353
LIG_LIR_Gen_1	574	583	PF02991	0.397
LIG_LIR_Gen_1	633	643	PF02991	0.448
LIG_LIR_Gen_1	708	719	PF02991	0.584
LIG_LIR_Gen_1	78	89	PF02991	0.454
LIG_LIR_Nem_3	112	116	PF02991	0.369
LIG_LIR_Nem_3	122	126	PF02991	0.389
LIG_LIR_Nem_3	216	222	PF02991	0.407
LIG_LIR_Nem_3	26	32	PF02991	0.416
LIG_LIR_Nem_3	394	400	PF02991	0.455
LIG_LIR_Nem_3	412	418	PF02991	0.492
LIG_LIR_Nem_3	472	478	PF02991	0.324
LIG_LIR_Nem_3	509	515	PF02991	0.391
LIG_LIR_Nem_3	574	580	PF02991	0.375
LIG_LIR_Nem_3	617	623	PF02991	0.427
LIG_LIR_Nem_3	633	639	PF02991	0.393
LIG_LIR_Nem_3	642	646	PF02991	0.379
LIG_LIR_Nem_3	708	714	PF02991	0.513
LIG_LIR_Nem_3	78	84	PF02991	0.502
LIG_NRBOX	45	51	PF00104	0.375
LIG_Pex14_1	614	618	PF04695	0.537
LIG_Pex14_2	159	163	PF04695	0.396
LIG_Pex14_2	711	715	PF04695	0.535
LIG_PTAP_UEV_1	300	305	PF05743	0.579
LIG_SH2_CRK	339	343	PF00017	0.696
LIG_SH2_CRK	512	516	PF00017	0.406
LIG_SH2_CRK	651	655	PF00017	0.388
LIG_SH2_CRK	677	681	PF00017	0.622
LIG_SH2_PTP2	178	181	PF00017	0.324
LIG_SH2_PTP2	371	374	PF00017	0.451
LIG_SH2_PTP2	475	478	PF00017	0.414
LIG_SH2_SRC	178	181	PF00017	0.438
LIG_SH2_SRC	371	374	PF00017	0.483
LIG_SH2_STAP1	484	488	PF00017	0.460
LIG_SH2_STAP1	512	516	PF00017	0.328
LIG_SH2_STAT5	158	161	PF00017	0.360
LIG_SH2_STAT5	178	181	PF00017	0.203
LIG_SH2_STAT5	230	233	PF00017	0.462
LIG_SH2_STAT5	277	280	PF00017	0.428
LIG_SH2_STAT5	371	374	PF00017	0.483
LIG_SH2_STAT5	417	420	PF00017	0.466
LIG_SH2_STAT5	475	478	PF00017	0.300
LIG_SH2_STAT5	645	648	PF00017	0.410
LIG_SH2_STAT5	741	744	PF00017	0.420
LIG_SH3_2	301	306	PF14604	0.646
LIG_SH3_3	101	107	PF00018	0.690
LIG_SH3_3	208	214	PF00018	0.481
LIG_SH3_3	298	304	PF00018	0.785
LIG_SH3_3	34	40	PF00018	0.438
LIG_SH3_3	413	419	PF00018	0.479
LIG_SH3_3	660	666	PF00018	0.599
LIG_SH3_3	85	91	PF00018	0.571
LIG_SUMO_SIM_anti_2	579	584	PF11976	0.328
LIG_SUMO_SIM_par_1	20	26	PF11976	0.328
LIG_TRAF2_1	332	335	PF00917	0.566
LIG_TRAF2_1	345	348	PF00917	0.510
LIG_TRAF2_1	572	575	PF00917	0.384
LIG_TRFH_1	158	162	PF08558	0.326
LIG_UBA3_1	756	762	PF00899	0.466
LIG_WRC_WIRS_1	110	115	PF05994	0.374
MOD_CDK_SPK_2	681	686	PF00069	0.590
MOD_CDK_SPxxK_3	730	737	PF00069	0.570
MOD_CK1_1	135	141	PF00069	0.529
MOD_CK1_1	215	221	PF00069	0.411
MOD_CK1_1	299	305	PF00069	0.788
MOD_CK1_1	340	346	PF00069	0.733
MOD_CK1_1	376	382	PF00069	0.383
MOD_CK1_1	558	564	PF00069	0.456
MOD_CK1_1	668	674	PF00069	0.591
MOD_CK2_1	109	115	PF00069	0.292
MOD_CK2_1	14	20	PF00069	0.502
MOD_CK2_1	188	194	PF00069	0.634
MOD_CK2_1	195	201	PF00069	0.525
MOD_CK2_1	256	262	PF00069	0.385
MOD_CK2_1	320	326	PF00069	0.640
MOD_CK2_1	341	347	PF00069	0.635
MOD_CK2_1	433	439	PF00069	0.531
MOD_CK2_1	456	462	PF00069	0.678
MOD_CK2_1	569	575	PF00069	0.557
MOD_CK2_1	641	647	PF00069	0.412
MOD_CK2_1	730	736	PF00069	0.524
MOD_CMANNOS	76	79	PF00535	0.489
MOD_DYRK1A_RPxSP_1	297	301	PF00069	0.519
MOD_GlcNHglycan	137	140	PF01048	0.626
MOD_GlcNHglycan	142	145	PF01048	0.627
MOD_GlcNHglycan	227	230	PF01048	0.301
MOD_GlcNHglycan	301	304	PF01048	0.758
MOD_GlcNHglycan	320	323	PF01048	0.501
MOD_GlcNHglycan	339	342	PF01048	0.622
MOD_GlcNHglycan	355	358	PF01048	0.564
MOD_GlcNHglycan	360	365	PF01048	0.558
MOD_GlcNHglycan	375	378	PF01048	0.267
MOD_GlcNHglycan	402	405	PF01048	0.383
MOD_GlcNHglycan	435	438	PF01048	0.431
MOD_GlcNHglycan	451	455	PF01048	0.578
MOD_GlcNHglycan	458	461	PF01048	0.687
MOD_GlcNHglycan	465	468	PF01048	0.528
MOD_GlcNHglycan	526	529	PF01048	0.624
MOD_GlcNHglycan	557	560	PF01048	0.632
MOD_GlcNHglycan	64	67	PF01048	0.602
MOD_GlcNHglycan	654	657	PF01048	0.544
MOD_GlcNHglycan	667	670	PF01048	0.579
MOD_GlcNHglycan	707	710	PF01048	0.574
MOD_GlcNHglycan	749	752	PF01048	0.467
MOD_GSK3_1	140	147	PF00069	0.438
MOD_GSK3_1	189	196	PF00069	0.664
MOD_GSK3_1	225	232	PF00069	0.348
MOD_GSK3_1	295	302	PF00069	0.797
MOD_GSK3_1	316	323	PF00069	0.668
MOD_GSK3_1	337	344	PF00069	0.698
MOD_GSK3_1	450	457	PF00069	0.590
MOD_GSK3_1	625	632	PF00069	0.514
MOD_GSK3_1	701	708	PF00069	0.514
MOD_GSK3_1	718	725	PF00069	0.519
MOD_GSK3_1	80	87	PF00069	0.489
MOD_N-GLC_1	400	405	PF02516	0.421
MOD_NEK2_1	1	6	PF00069	0.491
MOD_NEK2_1	287	292	PF00069	0.458
MOD_NEK2_1	391	396	PF00069	0.482
MOD_NEK2_1	409	414	PF00069	0.446
MOD_NEK2_1	50	55	PF00069	0.427
MOD_NEK2_1	746	751	PF00069	0.524
MOD_PIKK_1	503	509	PF00454	0.333
MOD_PIKK_1	701	707	PF00454	0.541
MOD_PK_1	189	195	PF00069	0.507
MOD_PKA_1	188	194	PF00069	0.687
MOD_PKA_1	295	301	PF00069	0.523
MOD_PKA_1	722	728	PF00069	0.626
MOD_PKA_2	135	141	PF00069	0.629
MOD_PKA_2	285	291	PF00069	0.514
MOD_PKA_2	295	301	PF00069	0.664
MOD_PKA_2	391	397	PF00069	0.445
MOD_PKA_2	569	575	PF00069	0.358
MOD_PKA_2	62	68	PF00069	0.479
MOD_PKA_2	625	631	PF00069	0.578
MOD_PKA_2	722	728	PF00069	0.619
MOD_PKB_1	720	728	PF00069	0.619
MOD_Plk_1	256	262	PF00069	0.385
MOD_Plk_1	347	353	PF00069	0.614
MOD_Plk_1	409	415	PF00069	0.372
MOD_Plk_1	614	620	PF00069	0.405
MOD_Plk_1	701	707	PF00069	0.548
MOD_Plk_2-3	109	115	PF00069	0.333
MOD_Plk_4	376	382	PF00069	0.383
MOD_Plk_4	391	397	PF00069	0.504
MOD_Plk_4	409	415	PF00069	0.568
MOD_Plk_4	465	471	PF00069	0.359
MOD_Plk_4	641	647	PF00069	0.431
MOD_ProDKin_1	103	109	PF00069	0.510
MOD_ProDKin_1	297	303	PF00069	0.638
MOD_ProDKin_1	341	347	PF00069	0.504
MOD_ProDKin_1	454	460	PF00069	0.683
MOD_ProDKin_1	650	656	PF00069	0.584
MOD_ProDKin_1	681	687	PF00069	0.722
MOD_ProDKin_1	730	736	PF00069	0.547
MOD_SUMO_rev_2	65	73	PF00179	0.463
MOD_SUMO_rev_2	739	747	PF00179	0.426
TRG_DiLeu_BaEn_1	115	120	PF01217	0.251
TRG_DiLeu_BaEn_1	28	33	PF01217	0.472
TRG_DiLeu_BaEn_4	347	353	PF01217	0.488
TRG_ENDOCYTIC_2	178	181	PF00928	0.324
TRG_ENDOCYTIC_2	339	342	PF00928	0.698
TRG_ENDOCYTIC_2	475	478	PF00928	0.300
TRG_ENDOCYTIC_2	511	514	PF00928	0.377
TRG_ENDOCYTIC_2	643	646	PF00928	0.426
TRG_ER_diArg_1	154	157	PF00400	0.566
TRG_ER_diArg_1	295	297	PF00400	0.532
TRG_ER_diArg_1	327	330	PF00400	0.504
TRG_ER_diArg_1	516	519	PF00400	0.407
TRG_ER_diArg_1	551	553	PF00400	0.624
TRG_ER_diArg_1	719	722	PF00400	0.496
TRG_NES_CRM1_1	13	28	PF08389	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY62	Leptomonas seymouri	47%	89%
A0A1X0P9D5	Trypanosomatidae	29%	100%
A0A3S7X7D8	Leishmania donovani	91%	100%
A0A422N292	Trypanosoma rangeli	32%	100%
A4HAD6	Leishmania braziliensis	78%	93%
A4I9I8	Leishmania infantum	91%	100%
D0A1U4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	95%
E9B4I6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BM66	Trypanosoma cruzi	28%	100%