Agglutinin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF1935), putative

Species:

Leishmania major

UniProt:

Q4Q3I9_LEIMA

TriTrypDb:

LmjF.34.0190 , LMJLV39_340007200 , LMJSD75_340007200

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q3I9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3I9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.288
CLV_MEL_PAP_1	61	67	PF00089	0.327
CLV_NRD_NRD_1	382	384	PF00675	0.327
CLV_NRD_NRD_1	483	485	PF00675	0.547
CLV_PCSK_KEX2_1	482	484	PF00082	0.617
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.617
CLV_PCSK_SKI1_1	148	152	PF00082	0.364
CLV_PCSK_SKI1_1	272	276	PF00082	0.372
CLV_PCSK_SKI1_1	292	296	PF00082	0.212
CLV_PCSK_SKI1_1	352	356	PF00082	0.327
CLV_PCSK_SKI1_1	47	51	PF00082	0.304
CLV_PCSK_SKI1_1	473	477	PF00082	0.327
DEG_APCC_KENBOX_2	274	278	PF00400	0.327
DEG_SIAH_1	319	327	PF03145	0.288
DOC_MAPK_gen_1	30	38	PF00069	0.327
DOC_MAPK_gen_1	352	360	PF00069	0.327
DOC_MAPK_gen_1	76	84	PF00069	0.421
DOC_PP1_RVXF_1	305	311	PF00149	0.367
DOC_USP7_MATH_1	182	186	PF00917	0.391
DOC_USP7_MATH_1	258	262	PF00917	0.377
DOC_WW_Pin1_4	322	327	PF00397	0.360
DOC_WW_Pin1_4	370	375	PF00397	0.516
DOC_WW_Pin1_4	486	491	PF00397	0.579
DOC_WW_Pin1_4	63	68	PF00397	0.351
LIG_14-3-3_CanoR_1	179	185	PF00244	0.469
LIG_14-3-3_CanoR_1	428	432	PF00244	0.428
LIG_14-3-3_CanoR_1	483	488	PF00244	0.577
LIG_BIR_III_4	432	436	PF00653	0.421
LIG_BRCT_BRCA1_1	372	376	PF00533	0.607
LIG_CaM_IQ_9	465	480	PF13499	0.421
LIG_FHA_1	121	127	PF00498	0.545
LIG_FHA_1	179	185	PF00498	0.370
LIG_FHA_1	196	202	PF00498	0.317
LIG_FHA_1	331	337	PF00498	0.318
LIG_FHA_1	418	424	PF00498	0.368
LIG_FHA_1	451	457	PF00498	0.407
LIG_FHA_1	460	466	PF00498	0.379
LIG_FHA_1	96	102	PF00498	0.378
LIG_FHA_2	366	372	PF00498	0.585
LIG_FHA_2	441	447	PF00498	0.308
LIG_LIR_Gen_1	19	29	PF02991	0.367
LIG_LIR_Gen_1	389	399	PF02991	0.421
LIG_LIR_Gen_1	91	101	PF02991	0.288
LIG_LIR_Nem_3	144	150	PF02991	0.343
LIG_LIR_Nem_3	166	172	PF02991	0.318
LIG_LIR_Nem_3	19	25	PF02991	0.356
LIG_LIR_Nem_3	389	395	PF02991	0.353
LIG_LIR_Nem_3	91	96	PF02991	0.310
LIG_PCNA_yPIPBox_3	272	286	PF02747	0.492
LIG_PCNA_yPIPBox_3	30	41	PF02747	0.336
LIG_PDZ_Class_1	486	491	PF00595	0.579
LIG_Pex14_2	117	121	PF04695	0.317
LIG_Pex14_2	425	429	PF04695	0.421
LIG_Pex14_2	475	479	PF04695	0.367
LIG_REV1ctd_RIR_1	156	164	PF16727	0.401
LIG_REV1ctd_RIR_1	422	432	PF16727	0.327
LIG_SH2_CRK	143	147	PF00017	0.328
LIG_SH2_CRK	388	392	PF00017	0.367
LIG_SH2_GRB2like	171	174	PF00017	0.367
LIG_SH2_GRB2like	253	256	PF00017	0.555
LIG_SH2_NCK_1	143	147	PF00017	0.367
LIG_SH2_NCK_1	22	26	PF00017	0.367
LIG_SH2_NCK_1	388	392	PF00017	0.367
LIG_SH2_SRC	22	25	PF00017	0.388
LIG_SH2_SRC	253	256	PF00017	0.555
LIG_SH2_STAP1	143	147	PF00017	0.348
LIG_SH2_STAP1	22	26	PF00017	0.367
LIG_SH2_STAP1	356	360	PF00017	0.421
LIG_SH2_STAP1	388	392	PF00017	0.332
LIG_SH2_STAT5	253	256	PF00017	0.577
LIG_SH2_STAT5	302	305	PF00017	0.421
LIG_SH2_STAT5	455	458	PF00017	0.367
LIG_SH3_3	181	187	PF00018	0.412
LIG_SH3_3	259	265	PF00018	0.312
LIG_SH3_3	314	320	PF00018	0.419
LIG_SH3_3	335	341	PF00018	0.430
LIG_SH3_3	454	460	PF00018	0.327
LIG_SH3_3	484	490	PF00018	0.560
LIG_SH3_3	5	11	PF00018	0.651
LIG_SUMO_SIM_anti_2	357	364	PF11976	0.421
LIG_SUMO_SIM_par_1	329	337	PF11976	0.308
LIG_SUMO_SIM_par_1	94	100	PF11976	0.356
LIG_TRAF2_1	328	331	PF00917	0.327
LIG_TRAF2_1	369	372	PF00917	0.460
LIG_TRAF2_2	202	207	PF00917	0.249
LIG_TYR_ITIM	386	391	PF00017	0.401
LIG_UBA3_1	157	165	PF00899	0.367
LIG_UBA3_1	281	289	PF00899	0.424
LIG_UBA3_1	36	44	PF00899	0.331
MOD_CDK_SPxxK_3	63	70	PF00069	0.327
MOD_CK1_1	185	191	PF00069	0.496
MOD_CK1_1	477	483	PF00069	0.424
MOD_CK2_1	185	191	PF00069	0.378
MOD_CK2_1	365	371	PF00069	0.590
MOD_CK2_1	440	446	PF00069	0.314
MOD_Cter_Amidation	480	483	PF01082	0.503
MOD_GlcNHglycan	187	190	PF01048	0.435
MOD_GSK3_1	178	185	PF00069	0.347
MOD_GSK3_1	228	235	PF00069	0.318
MOD_GSK3_1	330	337	PF00069	0.392
MOD_GSK3_1	361	368	PF00069	0.575
MOD_GSK3_1	446	453	PF00069	0.363
MOD_GSK3_1	455	462	PF00069	0.296
MOD_GSK3_1	482	489	PF00069	0.635
MOD_N-GLC_1	172	177	PF02516	0.348
MOD_N-GLC_1	296	301	PF02516	0.332
MOD_N-GLC_1	417	422	PF02516	0.348
MOD_N-GLC_1	450	455	PF02516	0.405
MOD_N-GLC_1	51	56	PF02516	0.329
MOD_NEK2_1	178	183	PF00069	0.410
MOD_NEK2_1	40	45	PF00069	0.464
MOD_NEK2_1	406	411	PF00069	0.391
MOD_NEK2_1	92	97	PF00069	0.396
MOD_PIKK_1	263	269	PF00454	0.327
MOD_PIKK_1	474	480	PF00454	0.327
MOD_PK_1	483	489	PF00069	0.526
MOD_PKA_1	482	488	PF00069	0.566
MOD_PKA_2	178	184	PF00069	0.327
MOD_PKA_2	427	433	PF00069	0.421
MOD_PKA_2	482	488	PF00069	0.529
MOD_PKA_2	77	83	PF00069	0.427
MOD_Plk_1	258	264	PF00069	0.258
MOD_Plk_1	330	336	PF00069	0.451
MOD_Plk_1	356	362	PF00069	0.434
MOD_Plk_2-3	446	452	PF00069	0.327
MOD_Plk_4	258	264	PF00069	0.307
MOD_Plk_4	330	336	PF00069	0.479
MOD_Plk_4	356	362	PF00069	0.339
MOD_Plk_4	54	60	PF00069	0.361
MOD_Plk_4	92	98	PF00069	0.382
MOD_ProDKin_1	322	328	PF00069	0.360
MOD_ProDKin_1	370	376	PF00069	0.507
MOD_ProDKin_1	63	69	PF00069	0.351
MOD_SUMO_for_1	150	153	PF00179	0.396
MOD_SUMO_for_1	354	357	PF00179	0.327
MOD_SUMO_rev_2	124	134	PF00179	0.631
MOD_SUMO_rev_2	185	195	PF00179	0.457
MOD_SUMO_rev_2	242	251	PF00179	0.564
MOD_SUMO_rev_2	380	386	PF00179	0.327
MOD_SUMO_rev_2	432	437	PF00179	0.421
MOD_SUMO_rev_2	66	71	PF00179	0.431
TRG_DiLeu_BaEn_1	452	457	PF01217	0.288
TRG_DiLeu_BaEn_2	343	349	PF01217	0.327
TRG_DiLeu_BaEn_2	462	468	PF01217	0.450
TRG_DiLeu_BaEn_3	371	377	PF01217	0.469
TRG_ENDOCYTIC_2	143	146	PF00928	0.339
TRG_ENDOCYTIC_2	147	150	PF00928	0.340
TRG_ENDOCYTIC_2	22	25	PF00928	0.368
TRG_ENDOCYTIC_2	271	274	PF00928	0.344
TRG_ENDOCYTIC_2	388	391	PF00928	0.363
TRG_ENDOCYTIC_2	392	395	PF00928	0.372
TRG_ER_diArg_1	136	139	PF00400	0.593
TRG_ER_diArg_1	61	64	PF00400	0.288
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I505	Leptomonas seymouri	39%	91%
A0A0N1PDX2	Leptomonas seymouri	58%	100%
A0A1X0P8U8	Trypanosomatidae	41%	100%
A0A3Q8IE32	Leishmania donovani	40%	95%
A0A3S7X7C8	Leishmania donovani	97%	100%
A4HAD7	Leishmania braziliensis	85%	100%
A4HAD8	Leishmania braziliensis	38%	95%
A4I9I9	Leishmania infantum	98%	100%
A4I9J0	Leishmania infantum	40%	95%
C9ZT01	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0A1U7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B4I7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B4I8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	95%
Q4Q3I8	Leishmania major	40%	100%
V5B262	Trypanosoma cruzi	41%	100%