Calx-beta domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Antimony resistance marker of 58 kDa

Species:

Leishmania major

UniProt:

Q4Q3I8_LEIMA

TriTrypDb:

LmjF.34.0200 , LMJLV39_340007300 , LMJSD75_340007300

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q3I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3I8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	384	388	PF00656	0.734
CLV_NRD_NRD_1	133	135	PF00675	0.366
CLV_NRD_NRD_1	442	444	PF00675	0.383
CLV_PCSK_KEX2_1	133	135	PF00082	0.366
CLV_PCSK_KEX2_1	442	444	PF00082	0.382
CLV_PCSK_SKI1_1	144	148	PF00082	0.322
CLV_PCSK_SKI1_1	270	274	PF00082	0.349
CLV_PCSK_SKI1_1	31	35	PF00082	0.388
CLV_PCSK_SKI1_1	423	427	PF00082	0.296
CLV_PCSK_SKI1_1	443	447	PF00082	0.363
CLV_PCSK_SKI1_1	59	63	PF00082	0.378
DEG_APCC_DBOX_1	30	38	PF00400	0.401
DEG_SCF_FBW7_1	365	371	PF00400	0.583
DEG_SCF_FBW7_2	241	247	PF00400	0.514
DOC_CDC14_PxL_1	341	349	PF14671	0.288
DOC_CKS1_1	241	246	PF01111	0.492
DOC_CKS1_1	365	370	PF01111	0.786
DOC_CYCLIN_yCln2_LP_2	246	252	PF00134	0.384
DOC_CYCLIN_yCln2_LP_2	4	7	PF00134	0.350
DOC_MAPK_gen_1	144	154	PF00069	0.281
DOC_MAPK_MEF2A_6	171	179	PF00069	0.285
DOC_MAPK_MEF2A_6	315	322	PF00069	0.381
DOC_PP1_RVXF_1	124	131	PF00149	0.463
DOC_PP1_RVXF_1	29	36	PF00149	0.288
DOC_PP1_RVXF_1	456	462	PF00149	0.361
DOC_PP2B_LxvP_1	195	198	PF13499	0.475
DOC_PP2B_LxvP_1	212	215	PF13499	0.252
DOC_PP2B_LxvP_1	396	399	PF13499	0.490
DOC_PP2B_LxvP_1	4	7	PF13499	0.350
DOC_USP7_MATH_1	309	313	PF00917	0.401
DOC_USP7_MATH_1	374	378	PF00917	0.708
DOC_WW_Pin1_4	240	245	PF00397	0.520
DOC_WW_Pin1_4	253	258	PF00397	0.259
DOC_WW_Pin1_4	294	299	PF00397	0.294
DOC_WW_Pin1_4	347	352	PF00397	0.356
DOC_WW_Pin1_4	358	363	PF00397	0.600
DOC_WW_Pin1_4	364	369	PF00397	0.759
DOC_WW_Pin1_4	370	375	PF00397	0.682
DOC_WW_Pin1_4	459	464	PF00397	0.398
LIG_14-3-3_CanoR_1	307	316	PF00244	0.474
LIG_BRCT_BRCA1_1	177	181	PF00533	0.366
LIG_Clathr_ClatBox_1	37	41	PF01394	0.288
LIG_FHA_1	123	129	PF00498	0.543
LIG_FHA_1	168	174	PF00498	0.365
LIG_FHA_1	208	214	PF00498	0.378
LIG_FHA_1	226	232	PF00498	0.194
LIG_FHA_1	241	247	PF00498	0.570
LIG_FHA_1	309	315	PF00498	0.402
LIG_FHA_1	448	454	PF00498	0.345
LIG_FHA_1	506	512	PF00498	0.348
LIG_FHA_1	87	93	PF00498	0.365
LIG_FHA_2	200	206	PF00498	0.431
LIG_FHA_2	370	376	PF00498	0.726
LIG_LIR_Apic_2	131	135	PF02991	0.498
LIG_LIR_Gen_1	206	215	PF02991	0.431
LIG_LIR_Nem_3	140	146	PF02991	0.327
LIG_LIR_Nem_3	206	212	PF02991	0.431
LIG_LIR_Nem_3	23	28	PF02991	0.333
LIG_LIR_Nem_3	266	272	PF02991	0.265
LIG_LIR_Nem_3	289	294	PF02991	0.288
LIG_LIR_Nem_3	32	38	PF02991	0.301
LIG_LIR_Nem_3	419	425	PF02991	0.336
LIG_PCNA_yPIPBox_3	144	157	PF02747	0.301
LIG_PCNA_yPIPBox_3	270	284	PF02747	0.415
LIG_PCNA_yPIPBox_3	423	437	PF02747	0.285
LIG_Pex14_2	102	106	PF04695	0.373
LIG_Pex14_2	114	118	PF04695	0.294
LIG_Pex14_2	506	510	PF04695	0.344
LIG_SH2_CRK	132	136	PF00017	0.323
LIG_SH2_CRK	139	143	PF00017	0.305
LIG_SH2_CRK	209	213	PF00017	0.401
LIG_SH2_NCK_1	139	143	PF00017	0.344
LIG_SH2_NCK_1	354	358	PF00017	0.380
LIG_SH2_SRC	252	255	PF00017	0.527
LIG_SH2_STAP1	139	143	PF00017	0.324
LIG_SH2_STAP1	209	213	PF00017	0.288
LIG_SH2_STAP1	229	233	PF00017	0.162
LIG_SH2_STAP1	354	358	PF00017	0.401
LIG_SH2_STAT5	209	212	PF00017	0.457
LIG_SH2_STAT5	229	232	PF00017	0.162
LIG_SH2_STAT5	252	255	PF00017	0.552
LIG_SH2_STAT5	300	303	PF00017	0.401
LIG_SH2_STAT5	405	408	PF00017	0.597
LIG_SH3_1	132	138	PF00018	0.244
LIG_SH3_3	132	138	PF00018	0.244
LIG_SH3_3	235	241	PF00018	0.500
LIG_SH3_3	345	351	PF00018	0.402
LIG_SH3_3	359	365	PF00018	0.596
LIG_SH3_3	373	379	PF00018	0.627
LIG_SH3_3	391	397	PF00018	0.548
LIG_SH3_3	58	64	PF00018	0.399
LIG_SUMO_SIM_anti_2	258	263	PF11976	0.259
LIG_SUMO_SIM_anti_2	411	416	PF11976	0.402
LIG_SUMO_SIM_anti_2	449	458	PF11976	0.288
LIG_TRAF2_2	379	384	PF00917	0.529
LIG_TRAF2_2	70	75	PF00917	0.274
LIG_TYR_ITIM	137	142	PF00017	0.344
LIG_TYR_ITIM	207	212	PF00017	0.288
LIG_UBA3_1	33	42	PF00899	0.308
MOD_CK1_1	369	375	PF00069	0.707
MOD_CK2_1	102	108	PF00069	0.398
MOD_CK2_1	199	205	PF00069	0.456
MOD_CK2_1	323	329	PF00069	0.391
MOD_CK2_1	369	375	PF00069	0.735
MOD_GlcNHglycan	183	186	PF01048	0.426
MOD_GlcNHglycan	407	410	PF01048	0.454
MOD_GlcNHglycan	480	483	PF01048	0.267
MOD_GSK3_1	177	184	PF00069	0.324
MOD_GSK3_1	199	206	PF00069	0.389
MOD_GSK3_1	364	371	PF00069	0.672
MOD_GSK3_1	88	95	PF00069	0.380
MOD_N-GLC_1	167	172	PF02516	0.324
MOD_N-GLC_1	294	299	PF02516	0.309
MOD_N-GLC_1	447	452	PF02516	0.324
MOD_N-GLC_1	48	53	PF02516	0.306
MOD_NEK2_1	102	107	PF00069	0.470
MOD_NEK2_1	175	180	PF00069	0.383
MOD_NEK2_1	190	195	PF00069	0.255
MOD_NEK2_1	470	475	PF00069	0.338
MOD_Plk_1	410	416	PF00069	0.501
MOD_Plk_1	92	98	PF00069	0.291
MOD_Plk_2-3	88	94	PF00069	0.401
MOD_Plk_4	102	108	PF00069	0.354
MOD_Plk_4	203	209	PF00069	0.384
MOD_Plk_4	286	292	PF00069	0.288
MOD_Plk_4	410	416	PF00069	0.490
MOD_Plk_4	470	476	PF00069	0.288
MOD_Plk_4	480	486	PF00069	0.418
MOD_Plk_4	63	69	PF00069	0.413
MOD_ProDKin_1	240	246	PF00069	0.521
MOD_ProDKin_1	253	259	PF00069	0.259
MOD_ProDKin_1	294	300	PF00069	0.294
MOD_ProDKin_1	347	353	PF00069	0.356
MOD_ProDKin_1	358	364	PF00069	0.608
MOD_ProDKin_1	366	372	PF00069	0.525
MOD_ProDKin_1	375	381	PF00069	0.562
MOD_ProDKin_1	459	465	PF00069	0.398
MOD_SUMO_rev_2	104	114	PF00179	0.412
TRG_DiLeu_BaEn_2	493	499	PF01217	0.435
TRG_ENDOCYTIC_2	139	142	PF00928	0.315
TRG_ENDOCYTIC_2	143	146	PF00928	0.317
TRG_ENDOCYTIC_2	209	212	PF00928	0.401
TRG_ENDOCYTIC_2	25	28	PF00928	0.356
TRG_ENDOCYTIC_2	422	425	PF00928	0.349
TRG_ER_diArg_1	132	134	PF00400	0.550
TRG_ER_diArg_1	442	444	PF00400	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I505	Leptomonas seymouri	64%	96%
A0A0N1PDX2	Leptomonas seymouri	38%	100%
A0A1X0P8U8	Trypanosomatidae	41%	100%
A0A3Q8IE32	Leishmania donovani	96%	100%
A0A3S7X7C8	Leishmania donovani	40%	100%
A4HAD7	Leishmania braziliensis	40%	100%
A4HAD8	Leishmania braziliensis	81%	100%
A4I9I9	Leishmania infantum	40%	100%
A4I9J0	Leishmania infantum	96%	100%
C9ZT01	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A1U7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B4I7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B4I8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q3I9	Leishmania major	40%	100%
V5B262	Trypanosoma cruzi	38%	100%