CS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CS domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q3I7_LEIMA

TriTrypDb:

LmjF.34.0210 , LMJLV39_340007400 , LMJSD75_340007400

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q3I7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3I7

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0043933	protein-containing complex organization	4	2
GO:0051131	chaperone-mediated protein complex assembly	6	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0031072	heat shock protein binding	3	11
GO:0051087	protein-folding chaperone binding	3	2
GO:0051879	Hsp90 protein binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.651
CLV_NRD_NRD_1	83	85	PF00675	0.271
DOC_MAPK_gen_1	108	116	PF00069	0.404
DOC_MAPK_gen_1	75	83	PF00069	0.509
DOC_MAPK_MEF2A_6	108	116	PF00069	0.480
DOC_MAPK_MEF2A_6	16	24	PF00069	0.415
DOC_MAPK_MEF2A_6	75	83	PF00069	0.509
DOC_PIKK_1	126	134	PF02985	0.538
DOC_PP1_RVXF_1	39	46	PF00149	0.417
DOC_PP2B_LxvP_1	7	10	PF13499	0.505
DOC_PP2B_PxIxI_1	111	117	PF00149	0.453
DOC_USP7_MATH_1	165	169	PF00917	0.580
DOC_USP7_UBL2_3	106	110	PF12436	0.568
DOC_USP7_UBL2_3	82	86	PF12436	0.446
DOC_WW_Pin1_4	46	51	PF00397	0.435
LIG_BIR_II_1	1	5	PF00653	0.512
LIG_deltaCOP1_diTrp_1	117	121	PF00928	0.413
LIG_FHA_1	21	27	PF00498	0.471
LIG_FHA_2	193	199	PF00498	0.611
LIG_LIR_Gen_1	146	157	PF02991	0.602
LIG_LIR_Gen_1	18	26	PF02991	0.430
LIG_LIR_Nem_3	109	114	PF02991	0.503
LIG_LIR_Nem_3	18	22	PF02991	0.477
LIG_LIR_Nem_3	58	64	PF02991	0.433
LIG_LIR_Nem_3	98	104	PF02991	0.454
LIG_LYPXL_yS_3	111	114	PF13949	0.454
LIG_MYND_3	202	206	PF01753	0.537
LIG_SH2_CRK	62	66	PF00017	0.463
LIG_SH2_PTP2	19	22	PF00017	0.446
LIG_SH2_STAP1	149	153	PF00017	0.566
LIG_SH2_STAP1	55	59	PF00017	0.509
LIG_SH2_STAT5	19	22	PF00017	0.446
LIG_SH3_3	3	9	PF00018	0.419
LIG_SH3_3	70	76	PF00018	0.457
LIG_SH3_3	96	102	PF00018	0.493
LIG_TRAF2_1	204	207	PF00917	0.571
LIG_TRAF2_1	66	69	PF00917	0.446
MOD_CDK_SPxxK_3	46	53	PF00069	0.435
MOD_CK1_1	192	198	PF00069	0.644
MOD_CK1_1	67	73	PF00069	0.457
MOD_CK2_1	45	51	PF00069	0.520
MOD_CK2_1	63	69	PF00069	0.446
MOD_CMANNOS	118	121	PF00535	0.429
MOD_GlcNHglycan	139	142	PF01048	0.675
MOD_GlcNHglycan	166	170	PF01048	0.678
MOD_GlcNHglycan	180	183	PF01048	0.554
MOD_GlcNHglycan	191	194	PF01048	0.661
MOD_GlcNHglycan	3	6	PF01048	0.484
MOD_GSK3_1	102	109	PF00069	0.329
MOD_GSK3_1	112	119	PF00069	0.510
MOD_GSK3_1	147	154	PF00069	0.548
MOD_GSK3_1	185	192	PF00069	0.634
MOD_GSK3_1	26	33	PF00069	0.516
MOD_GSK3_1	63	70	PF00069	0.456
MOD_N-GLC_1	112	117	PF02516	0.508
MOD_NEK2_1	1	6	PF00069	0.637
MOD_NEK2_1	137	142	PF00069	0.553
MOD_NEK2_1	26	31	PF00069	0.519
MOD_NEK2_1	45	50	PF00069	0.443
MOD_NEK2_2	55	60	PF00069	0.509
MOD_PIKK_1	151	157	PF00454	0.518
MOD_PIKK_1	67	73	PF00454	0.509
MOD_PKA_1	85	91	PF00069	0.472
MOD_PKA_2	102	108	PF00069	0.406
MOD_Plk_1	112	118	PF00069	0.447
MOD_ProDKin_1	46	52	PF00069	0.435
MOD_SUMO_for_1	36	39	PF00179	0.509
TRG_DiLeu_BaEn_4	166	172	PF01217	0.583
TRG_ENDOCYTIC_2	111	114	PF00928	0.544
TRG_ENDOCYTIC_2	149	152	PF00928	0.526
TRG_ENDOCYTIC_2	19	22	PF00928	0.446
TRG_ENDOCYTIC_2	62	65	PF00928	0.463
TRG_ER_diArg_1	74	77	PF00400	0.486
TRG_NLS_MonoExtN_4	82	88	PF00514	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I2	Leptomonas seymouri	65%	100%
A0A0S4JQC8	Bodo saltans	30%	100%
A0A1X0P8I0	Trypanosomatidae	38%	100%
A0A3Q8II57	Leishmania donovani	95%	100%
A0A3S5H807	Leishmania donovani	28%	100%
A0A422N770	Trypanosoma rangeli	39%	100%
A4HAD9	Leishmania braziliensis	85%	100%
A4HNB5	Leishmania braziliensis	27%	100%
A4I9J1	Leishmania infantum	95%	100%
A4IBY7	Leishmania infantum	28%	100%
D0A1U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AFS4	Leishmania major	25%	100%
E9B4I9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B6X6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
G1TGF1	Oryctolagus cuniculus	29%	100%
P28707	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	97%
P83868	Rattus norvegicus	29%	100%
Q11118	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q15185	Homo sapiens	29%	100%
Q3ZBF7	Bos taurus	29%	100%
Q5NVM4	Pongo abelii	29%	100%
Q6PWL5	Macaca fascicularis	29%	100%
Q9FR62	Brassica napus	28%	100%
Q9R0Q7	Mus musculus	29%	100%
V5B2A2	Trypanosoma cruzi	41%	100%