GOLD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

emp24/gp25L/p24 family/GOLD, putative

Species:

Leishmania major

UniProt:

Q4Q3I6_LEIMA

TriTrypDb:

LmjF.34.0220 , LMJLV39_340007500 , LMJSD75_340007500

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 1
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	2
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	7
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	2
GO:0030135	coated vesicle	7	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q3I6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3I6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	2
GO:0006996	organelle organization	4	2
GO:0007030	Golgi organization	5	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0016192	vesicle-mediated transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0048193	Golgi vesicle transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.673
CLV_NRD_NRD_1	124	126	PF00675	0.473
CLV_NRD_NRD_1	246	248	PF00675	0.345
CLV_NRD_NRD_1	290	292	PF00675	0.269
CLV_PCSK_FUR_1	288	292	PF00082	0.269
CLV_PCSK_KEX2_1	124	126	PF00082	0.473
CLV_PCSK_KEX2_1	290	292	PF00082	0.269
CLV_PCSK_SKI1_1	235	239	PF00082	0.269
CLV_PCSK_SKI1_1	247	251	PF00082	0.269
CLV_PCSK_SKI1_1	8	12	PF00082	0.604
DEG_MDM2_SWIB_1	300	308	PF02201	0.469
DEG_Nend_Nbox_1	1	3	PF02207	0.533
DOC_CYCLIN_RxL_1	232	242	PF00134	0.516
DOC_USP7_MATH_1	74	78	PF00917	0.589
DOC_USP7_MATH_1	95	99	PF00917	0.645
DOC_USP7_UBL2_3	42	46	PF12436	0.469
LIG_14-3-3_CanoR_1	116	122	PF00244	0.623
LIG_14-3-3_CanoR_1	136	144	PF00244	0.490
LIG_14-3-3_CanoR_1	168	176	PF00244	0.422
LIG_14-3-3_CanoR_1	195	200	PF00244	0.516
LIG_14-3-3_CanoR_1	239	249	PF00244	0.516
LIG_14-3-3_CanoR_1	291	300	PF00244	0.469
LIG_14-3-3_CanoR_1	72	82	PF00244	0.575
LIG_Clathr_ClatBox_1	60	64	PF01394	0.304
LIG_FHA_1	221	227	PF00498	0.422
LIG_FHA_1	241	247	PF00498	0.451
LIG_FHA_1	308	314	PF00498	0.285
LIG_FHA_1	323	329	PF00498	0.327
LIG_FHA_1	4	10	PF00498	0.489
LIG_LIR_Gen_1	178	189	PF02991	0.517
LIG_LIR_Gen_1	197	205	PF02991	0.389
LIG_LIR_Gen_1	229	238	PF02991	0.473
LIG_LIR_Gen_1	297	308	PF02991	0.505
LIG_LIR_Gen_1	45	52	PF02991	0.477
LIG_LIR_Nem_3	178	184	PF02991	0.517
LIG_LIR_Nem_3	197	202	PF02991	0.389
LIG_LIR_Nem_3	273	279	PF02991	0.452
LIG_LIR_Nem_3	297	303	PF02991	0.474
LIG_LIR_Nem_3	316	322	PF02991	0.495
LIG_LIR_Nem_3	32	38	PF02991	0.495
LIG_LIR_Nem_3	45	51	PF02991	0.434
LIG_NRBOX	11	17	PF00104	0.542
LIG_NRBOX	245	251	PF00104	0.469
LIG_PCNA_PIPBox_1	272	281	PF02747	0.469
LIG_PCNA_yPIPBox_3	269	279	PF02747	0.469
LIG_Pex14_2	300	304	PF04695	0.469
LIG_PTB_Apo_2	278	285	PF02174	0.469
LIG_PTB_Phospho_1	278	284	PF10480	0.469
LIG_RPA_C_Fungi	131	143	PF08784	0.588
LIG_RPA_C_Fungi	223	235	PF08784	0.303
LIG_SH2_CRK	48	52	PF00017	0.624
LIG_SH2_SRC	181	184	PF00017	0.325
LIG_SH2_SRC	284	287	PF00017	0.356
LIG_SH2_STAP1	160	164	PF00017	0.304
LIG_SH2_STAP1	230	234	PF00017	0.304
LIG_SH2_STAP1	324	328	PF00017	0.303
LIG_SH2_STAP1	75	79	PF00017	0.444
LIG_SH2_STAT5	201	204	PF00017	0.304
LIG_SH2_STAT5	284	287	PF00017	0.347
LIG_SH2_STAT5	324	327	PF00017	0.369
LIG_SH3_3	30	36	PF00018	0.566
LIG_SH3_3	76	82	PF00018	0.617
LIG_SH3_3	94	100	PF00018	0.474
LIG_SUMO_SIM_anti_2	101	106	PF11976	0.568
LIG_SUMO_SIM_anti_2	310	317	PF11976	0.285
LIG_SUMO_SIM_par_1	59	64	PF11976	0.304
LIG_TRAF2_1	118	121	PF00917	0.663
LIG_TRAF2_1	257	260	PF00917	0.304
LIG_TRAF2_1	270	273	PF00917	0.304
MOD_CK1_1	135	141	PF00069	0.653
MOD_CK1_1	169	175	PF00069	0.237
MOD_CK1_1	197	203	PF00069	0.292
MOD_CK1_1	77	83	PF00069	0.527
MOD_CK1_1	98	104	PF00069	0.556
MOD_CK2_1	115	121	PF00069	0.584
MOD_CK2_1	254	260	PF00069	0.304
MOD_CK2_1	41	47	PF00069	0.632
MOD_GlcNHglycan	117	120	PF01048	0.538
MOD_GlcNHglycan	19	22	PF01048	0.506
MOD_GSK3_1	111	118	PF00069	0.573
MOD_GSK3_1	134	141	PF00069	0.640
MOD_GSK3_1	190	197	PF00069	0.304
MOD_GSK3_1	292	299	PF00069	0.304
MOD_GSK3_1	314	321	PF00069	0.371
MOD_GSK3_1	73	80	PF00069	0.467
MOD_GSK3_1	89	96	PF00069	0.400
MOD_N-GLC_1	77	82	PF02516	0.521
MOD_N-GLC_2	56	58	PF02516	0.259
MOD_NEK2_1	1	6	PF00069	0.510
MOD_NEK2_1	11	16	PF00069	0.503
MOD_NEK2_1	166	171	PF00069	0.369
MOD_NEK2_1	233	238	PF00069	0.328
MOD_NEK2_1	307	312	PF00069	0.283
MOD_NEK2_1	314	319	PF00069	0.331
MOD_NEK2_1	322	327	PF00069	0.362
MOD_NEK2_1	73	78	PF00069	0.467
MOD_NEK2_1	89	94	PF00069	0.567
MOD_PIKK_1	111	117	PF00454	0.485
MOD_PIKK_1	3	9	PF00454	0.490
MOD_PKA_2	115	121	PF00069	0.497
MOD_PKA_2	135	141	PF00069	0.795
MOD_PKA_2	194	200	PF00069	0.369
MOD_PKA_2	238	244	PF00069	0.304
MOD_PKA_2	292	298	PF00069	0.328
MOD_Plk_1	296	302	PF00069	0.304
MOD_Plk_4	11	17	PF00069	0.640
MOD_Plk_4	314	320	PF00069	0.310
MOD_Plk_4	324	330	PF00069	0.352
MOD_SUMO_rev_2	177	186	PF00179	0.325
MOD_SUMO_rev_2	254	263	PF00179	0.347
MOD_SUMO_rev_2	34	44	PF00179	0.606
TRG_DiLeu_BaEn_4	266	272	PF01217	0.303
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.272
TRG_ENDOCYTIC_2	181	184	PF00928	0.369
TRG_ENDOCYTIC_2	230	233	PF00928	0.304
TRG_ENDOCYTIC_2	279	282	PF00928	0.477
TRG_ENDOCYTIC_2	48	51	PF00928	0.628
TRG_ER_diArg_1	124	127	PF00400	0.592
TRG_ER_diArg_1	289	291	PF00400	0.315
TRG_ER_diLys_1	331	335	PF00400	0.475
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.304
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCV9	Leptomonas seymouri	51%	100%
A0A3S7X7B6	Leishmania donovani	91%	100%
A4HAE0	Leishmania braziliensis	72%	95%
A4I9J2	Leishmania infantum	91%	100%
E9B4J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	95%