IFT81_CH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

intraflagellar transport protein 81, putative

Species:

Leishmania major

UniProt:

Q4Q3I5_LEIMA

TriTrypDb:

LmjF.34.0230 , LMJLV39_340007600 , LMJSD75_340007600

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	2
GO:0005815	microtubule organizing center	2	2
GO:0005929	cilium	4	12
GO:0030990	intraciliary transport particle	2	2
GO:0030992	intraciliary transport particle B	2	12
GO:0032991	protein-containing complex	1	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0031514	motile cilium	5	2

Expansion

Sequence features

Q4Q3I5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3I5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006996	organelle organization	4	12
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12
GO:0010970	transport along microtubule	4	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0030030	cell projection organization	4	12
GO:0030031	cell projection assembly	5	12
GO:0030705	cytoskeleton-dependent intracellular transport	4	12
GO:0031503	protein-containing complex localization	2	12
GO:0035721	intraciliary retrograde transport	4	2
GO:0042073	intraciliary transport	3	12
GO:0044782	cilium organization	5	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0060271	cilium assembly	6	12
GO:0070925	organelle assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0099111	microtubule-based transport	4	12
GO:0120031	plasma membrane bounded cell projection assembly	6	12
GO:0120036	plasma membrane bounded cell projection organization	5	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0015631	tubulin binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.386
CLV_C14_Caspase3-7	280	284	PF00656	0.407
CLV_NRD_NRD_1	199	201	PF00675	0.390
CLV_NRD_NRD_1	266	268	PF00675	0.441
CLV_NRD_NRD_1	278	280	PF00675	0.331
CLV_NRD_NRD_1	291	293	PF00675	0.398
CLV_NRD_NRD_1	339	341	PF00675	0.525
CLV_NRD_NRD_1	378	380	PF00675	0.379
CLV_NRD_NRD_1	650	652	PF00675	0.530
CLV_PCSK_KEX2_1	140	142	PF00082	0.240
CLV_PCSK_KEX2_1	199	201	PF00082	0.390
CLV_PCSK_KEX2_1	266	268	PF00082	0.451
CLV_PCSK_KEX2_1	278	280	PF00082	0.331
CLV_PCSK_KEX2_1	291	293	PF00082	0.398
CLV_PCSK_KEX2_1	605	607	PF00082	0.585
CLV_PCSK_KEX2_1	649	651	PF00082	0.525
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.240
CLV_PCSK_PC1ET2_1	605	607	PF00082	0.456
CLV_PCSK_PC1ET2_1	649	651	PF00082	0.506
CLV_PCSK_SKI1_1	165	169	PF00082	0.455
CLV_PCSK_SKI1_1	175	179	PF00082	0.304
CLV_PCSK_SKI1_1	229	233	PF00082	0.396
CLV_PCSK_SKI1_1	291	295	PF00082	0.475
CLV_PCSK_SKI1_1	434	438	PF00082	0.417
CLV_PCSK_SKI1_1	671	675	PF00082	0.391
DEG_APCC_DBOX_1	440	448	PF00400	0.410
DEG_APCC_DBOX_1	526	534	PF00400	0.394
DEG_APCC_DBOX_1	57	65	PF00400	0.305
DEG_SCF_FBW7_2	80	87	PF00400	0.218
DOC_ANK_TNKS_1	278	285	PF00023	0.410
DOC_CKS1_1	81	86	PF01111	0.218
DOC_MAPK_gen_1	592	600	PF00069	0.516
DOC_PP1_RVXF_1	660	667	PF00149	0.458
DOC_PP1_RVXF_1	89	96	PF00149	0.300
DOC_PP1_SILK_1	364	369	PF00149	0.425
DOC_PP2B_LxvP_1	151	154	PF13499	0.397
DOC_PP4_FxxP_1	147	150	PF00568	0.386
DOC_USP7_MATH_1	235	239	PF00917	0.433
DOC_USP7_MATH_1	259	263	PF00917	0.598
DOC_USP7_MATH_1	553	557	PF00917	0.389
DOC_USP7_MATH_2	20	26	PF00917	0.592
DOC_USP7_MATH_2	309	315	PF00917	0.462
DOC_WW_Pin1_4	1	6	PF00397	0.627
DOC_WW_Pin1_4	80	85	PF00397	0.268
LIG_14-3-3_CanoR_1	266	274	PF00244	0.430
LIG_14-3-3_CanoR_1	46	51	PF00244	0.240
LIG_14-3-3_CanoR_1	541	547	PF00244	0.384
LIG_14-3-3_CanoR_1	592	600	PF00244	0.498
LIG_14-3-3_CanoR_1	617	622	PF00244	0.620
LIG_Actin_WH2_2	160	177	PF00022	0.420
LIG_Actin_WH2_2	394	409	PF00022	0.517
LIG_Actin_WH2_2	657	673	PF00022	0.405
LIG_BIR_II_1	1	5	PF00653	0.798
LIG_BIR_III_4	54	58	PF00653	0.355
LIG_BRCT_BRCA1_1	419	423	PF00533	0.547
LIG_Clathr_ClatBox_1	50	54	PF01394	0.240
LIG_CtBP_PxDLS_1	329	333	PF00389	0.535
LIG_deltaCOP1_diTrp_1	450	456	PF00928	0.395
LIG_FAT_LD_1	93	101	PF03623	0.386
LIG_FHA_1	12	18	PF00498	0.695
LIG_FHA_1	413	419	PF00498	0.552
LIG_FHA_1	518	524	PF00498	0.383
LIG_FHA_1	564	570	PF00498	0.507
LIG_FHA_1	593	599	PF00498	0.450
LIG_FHA_1	634	640	PF00498	0.452
LIG_FHA_1	709	715	PF00498	0.543
LIG_FHA_2	131	137	PF00498	0.386
LIG_FHA_2	334	340	PF00498	0.502
LIG_FHA_2	453	459	PF00498	0.399
LIG_FHA_2	506	512	PF00498	0.433
LIG_FHA_2	541	547	PF00498	0.433
LIG_FHA_2	582	588	PF00498	0.577
LIG_FHA_2	625	631	PF00498	0.528
LIG_FHA_2	693	699	PF00498	0.729
LIG_FHA_2	81	87	PF00498	0.218
LIG_GBD_Chelix_1	64	72	PF00786	0.334
LIG_LIR_Gen_1	45	56	PF02991	0.240
LIG_LIR_Gen_1	463	472	PF02991	0.478
LIG_LIR_Gen_1	587	598	PF02991	0.385
LIG_LIR_Gen_1	665	674	PF02991	0.412
LIG_LIR_Gen_1	67	76	PF02991	0.334
LIG_LIR_LC3C_4	120	124	PF02991	0.305
LIG_LIR_Nem_3	127	132	PF02991	0.274
LIG_LIR_Nem_3	166	171	PF02991	0.491
LIG_LIR_Nem_3	420	426	PF02991	0.435
LIG_LIR_Nem_3	449	454	PF02991	0.371
LIG_LIR_Nem_3	45	51	PF02991	0.240
LIG_LIR_Nem_3	463	468	PF02991	0.374
LIG_LIR_Nem_3	52	56	PF02991	0.240
LIG_LIR_Nem_3	587	593	PF02991	0.419
LIG_LIR_Nem_3	627	631	PF02991	0.546
LIG_LIR_Nem_3	665	670	PF02991	0.402
LIG_LIR_Nem_3	67	72	PF02991	0.240
LIG_LYPXL_S_1	124	128	PF13949	0.240
LIG_LYPXL_yS_3	125	128	PF13949	0.240
LIG_NRBOX	92	98	PF00104	0.386
LIG_PALB2_WD40_1	662	670	PF16756	0.386
LIG_PCNA_PIPBox_1	89	98	PF02747	0.305
LIG_PCNA_yPIPBox_3	316	326	PF02747	0.388
LIG_Pex14_2	112	116	PF04695	0.251
LIG_PTB_Apo_2	63	70	PF02174	0.274
LIG_RPA_C_Fungi	238	250	PF08784	0.524
LIG_SH2_CRK	102	106	PF00017	0.240
LIG_SH2_CRK	171	175	PF00017	0.434
LIG_SH2_CRK	590	594	PF00017	0.434
LIG_SH2_NCK_1	48	52	PF00017	0.288
LIG_SH2_SRC	215	218	PF00017	0.504
LIG_SH2_SRC	560	563	PF00017	0.429
LIG_SH2_STAP1	484	488	PF00017	0.427
LIG_SH2_STAT3	558	561	PF00017	0.369
LIG_SH2_STAT5	143	146	PF00017	0.254
LIG_SH2_STAT5	215	218	PF00017	0.374
LIG_SH2_STAT5	631	634	PF00017	0.566
LIG_SH3_3	120	126	PF00018	0.255
LIG_SH3_3	14	20	PF00018	0.653
LIG_SH3_3	2	8	PF00018	0.749
LIG_SH3_3	323	329	PF00018	0.540
LIG_SUMO_SIM_par_1	149	156	PF11976	0.530
LIG_SUMO_SIM_par_1	518	525	PF11976	0.476
LIG_SUMO_SIM_par_1	711	718	PF11976	0.556
LIG_TRAF2_1	242	245	PF00917	0.375
LIG_TRAF2_1	460	463	PF00917	0.511
LIG_TRAF2_1	500	503	PF00917	0.448
LIG_TRAF2_1	508	511	PF00917	0.399
LIG_TRAF2_1	607	610	PF00917	0.472
LIG_TRAF2_1	84	87	PF00917	0.311
LIG_UBA3_1	131	140	PF00899	0.343
LIG_UBA3_1	289	294	PF00899	0.540
LIG_UBA3_1	68	77	PF00899	0.367
LIG_UBA3_1	92	98	PF00899	0.243
MOD_CK1_1	25	31	PF00069	0.528
MOD_CK1_1	563	569	PF00069	0.425
MOD_CK2_1	130	136	PF00069	0.373
MOD_CK2_1	452	458	PF00069	0.374
MOD_CK2_1	46	52	PF00069	0.252
MOD_CK2_1	505	511	PF00069	0.437
MOD_CK2_1	540	546	PF00069	0.434
MOD_CK2_1	553	559	PF00069	0.432
MOD_CK2_1	581	587	PF00069	0.478
MOD_CK2_1	80	86	PF00069	0.251
MOD_Cter_Amidation	647	650	PF01082	0.443
MOD_GlcNHglycan	1	4	PF01048	0.679
MOD_GlcNHglycan	189	192	PF01048	0.489
MOD_GlcNHglycan	27	30	PF01048	0.465
MOD_GlcNHglycan	412	415	PF01048	0.550
MOD_GlcNHglycan	550	554	PF01048	0.395
MOD_GSK3_1	108	115	PF00069	0.334
MOD_GSK3_1	265	272	PF00069	0.513
MOD_GSK3_1	406	413	PF00069	0.525
MOD_GSK3_1	446	453	PF00069	0.470
MOD_GSK3_1	549	556	PF00069	0.458
MOD_GSK3_1	581	588	PF00069	0.462
MOD_GSK3_1	653	660	PF00069	0.458
MOD_GSK3_1	689	696	PF00069	0.711
MOD_GSK3_1	9	16	PF00069	0.667
MOD_N-GLC_1	617	622	PF02516	0.462
MOD_NEK2_1	178	183	PF00069	0.376
MOD_NEK2_1	233	238	PF00069	0.501
MOD_NEK2_1	406	411	PF00069	0.482
MOD_NEK2_2	235	240	PF00069	0.410
MOD_PIKK_1	22	28	PF00454	0.580
MOD_PIKK_1	406	412	PF00454	0.471
MOD_PIKK_1	553	559	PF00454	0.402
MOD_PIKK_1	592	598	PF00454	0.467
MOD_PK_1	677	683	PF00069	0.525
MOD_PKA_2	265	271	PF00069	0.403
MOD_PKA_2	406	412	PF00069	0.431
MOD_PKA_2	540	546	PF00069	0.509
MOD_PKA_2	692	698	PF00069	0.593
MOD_PKB_1	691	699	PF00069	0.580
MOD_Plk_1	22	28	PF00069	0.499
MOD_Plk_1	385	391	PF00069	0.525
MOD_Plk_1	457	463	PF00069	0.510
MOD_Plk_1	510	516	PF00069	0.401
MOD_Plk_1	517	523	PF00069	0.377
MOD_Plk_1	574	580	PF00069	0.439
MOD_Plk_1	609	615	PF00069	0.429
MOD_Plk_1	617	623	PF00069	0.649
MOD_Plk_1	657	663	PF00069	0.538
MOD_Plk_1	693	699	PF00069	0.528
MOD_Plk_4	124	130	PF00069	0.260
MOD_Plk_4	362	368	PF00069	0.581
MOD_Plk_4	46	52	PF00069	0.240
MOD_Plk_4	560	566	PF00069	0.433
MOD_Plk_4	585	591	PF00069	0.392
MOD_ProDKin_1	1	7	PF00069	0.625
MOD_ProDKin_1	80	86	PF00069	0.268
MOD_SUMO_for_1	293	296	PF00179	0.543
MOD_SUMO_for_1	315	318	PF00179	0.409
MOD_SUMO_for_1	579	582	PF00179	0.492
MOD_SUMO_rev_2	474	479	PF00179	0.436
TRG_DiLeu_BaEn_1	228	233	PF01217	0.524
TRG_DiLeu_BaEn_1	321	326	PF01217	0.408
TRG_DiLeu_BaEn_4	244	250	PF01217	0.385
TRG_DiLeu_BaLyEn_6	529	534	PF01217	0.423
TRG_ENDOCYTIC_2	125	128	PF00928	0.240
TRG_ENDOCYTIC_2	129	132	PF00928	0.240
TRG_ENDOCYTIC_2	171	174	PF00928	0.344
TRG_ENDOCYTIC_2	465	468	PF00928	0.527
TRG_ENDOCYTIC_2	48	51	PF00928	0.240
TRG_ENDOCYTIC_2	590	593	PF00928	0.436
TRG_ER_diArg_1	277	279	PF00400	0.398
TRG_ER_diArg_1	290	292	PF00400	0.397
TRG_ER_diArg_1	440	443	PF00400	0.528
TRG_ER_diArg_1	527	530	PF00400	0.554
TRG_NES_CRM1_1	510	525	PF08389	0.389
TRG_NES_CRM1_1	54	67	PF08389	0.386
TRG_NES_CRM1_1	94	109	PF08389	0.377
TRG_Pf-PMV_PEXEL_1	165	170	PF00026	0.353
TRG_Pf-PMV_PEXEL_1	340	344	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	507	511	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	651	655	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	671	675	PF00026	0.255

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W4	Leptomonas seymouri	82%	100%
A0A0S4ITV8	Bodo saltans	48%	95%
A0A1X0P8Q2	Trypanosomatidae	53%	92%
A0A3Q8IHU5	Leishmania donovani	98%	100%
A0A3R7NE32	Trypanosoma rangeli	53%	88%
A4HAE1	Leishmania braziliensis	90%	100%
A4I9J3	Leishmania infantum	98%	100%
D0A1V1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	94%
E9B4J1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O35594	Mus musculus	30%	100%
P83829	Rattus norvegicus	30%	100%
Q68RJ5	Chlamydomonas reinhardtii	26%	100%
Q8WYA0	Homo sapiens	29%	100%
V5BM72	Trypanosoma cruzi	54%	89%