CARD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3I4_LEIMA

TriTrypDb:

LmjF.34.0240 , LMJLV39_340007700 , LMJSD75_340007700

Length:

1337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3I4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term	Name	Level	Count
GO:0010941	regulation of cell death	4	3
GO:0042981	regulation of apoptotic process	6	3
GO:0043067	regulation of programmed cell death	5	3
GO:0050789	regulation of biological process	2	3
GO:0050794	regulation of cellular process	3	3
GO:0065007	biological regulation	1	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1054	1058	PF00656	0.621
CLV_C14_Caspase3-7	1165	1169	PF00656	0.651
CLV_C14_Caspase3-7	1201	1205	PF00656	0.571
CLV_C14_Caspase3-7	1224	1228	PF00656	0.465
CLV_C14_Caspase3-7	337	341	PF00656	0.535
CLV_C14_Caspase3-7	386	390	PF00656	0.466
CLV_C14_Caspase3-7	461	465	PF00656	0.606
CLV_C14_Caspase3-7	485	489	PF00656	0.693
CLV_NRD_NRD_1	126	128	PF00675	0.458
CLV_NRD_NRD_1	130	132	PF00675	0.441
CLV_NRD_NRD_1	1304	1306	PF00675	0.559
CLV_NRD_NRD_1	296	298	PF00675	0.689
CLV_NRD_NRD_1	313	315	PF00675	0.614
CLV_NRD_NRD_1	346	348	PF00675	0.750
CLV_NRD_NRD_1	382	384	PF00675	0.725
CLV_NRD_NRD_1	477	479	PF00675	0.589
CLV_NRD_NRD_1	580	582	PF00675	0.590
CLV_NRD_NRD_1	654	656	PF00675	0.654
CLV_NRD_NRD_1	664	666	PF00675	0.538
CLV_NRD_NRD_1	670	672	PF00675	0.488
CLV_NRD_NRD_1	82	84	PF00675	0.571
CLV_NRD_NRD_1	952	954	PF00675	0.530
CLV_PCSK_KEX2_1	1075	1077	PF00082	0.728
CLV_PCSK_KEX2_1	1248	1250	PF00082	0.557
CLV_PCSK_KEX2_1	126	128	PF00082	0.499
CLV_PCSK_KEX2_1	130	132	PF00082	0.481
CLV_PCSK_KEX2_1	158	160	PF00082	0.696
CLV_PCSK_KEX2_1	296	298	PF00082	0.689
CLV_PCSK_KEX2_1	313	315	PF00082	0.402
CLV_PCSK_KEX2_1	346	348	PF00082	0.750
CLV_PCSK_KEX2_1	382	384	PF00082	0.725
CLV_PCSK_KEX2_1	477	479	PF00082	0.589
CLV_PCSK_KEX2_1	579	581	PF00082	0.599
CLV_PCSK_KEX2_1	654	656	PF00082	0.708
CLV_PCSK_KEX2_1	81	83	PF00082	0.531
CLV_PCSK_KEX2_1	951	953	PF00082	0.541
CLV_PCSK_PC1ET2_1	1075	1077	PF00082	0.728
CLV_PCSK_PC1ET2_1	1248	1250	PF00082	0.541
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.696
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.527
CLV_PCSK_PC7_1	126	132	PF00082	0.470
CLV_PCSK_PC7_1	575	581	PF00082	0.576
CLV_PCSK_PC7_1	650	656	PF00082	0.712
CLV_PCSK_SKI1_1	1267	1271	PF00082	0.654
CLV_PCSK_SKI1_1	205	209	PF00082	0.683
CLV_PCSK_SKI1_1	319	323	PF00082	0.513
CLV_PCSK_SKI1_1	395	399	PF00082	0.523
CLV_PCSK_SKI1_1	50	54	PF00082	0.607
CLV_PCSK_SKI1_1	537	541	PF00082	0.576
CLV_PCSK_SKI1_1	560	564	PF00082	0.549
CLV_PCSK_SKI1_1	575	579	PF00082	0.598
CLV_PCSK_SKI1_1	901	905	PF00082	0.679
CLV_Separin_Metazoa	62	66	PF03568	0.464
CLV_Separin_Metazoa	72	76	PF03568	0.465
DEG_APCC_DBOX_1	1173	1181	PF00400	0.578
DEG_APCC_DBOX_1	1325	1333	PF00400	0.567
DEG_APCC_DBOX_1	373	381	PF00400	0.603
DEG_APCC_DBOX_1	712	720	PF00400	0.678
DEG_APCC_KENBOX_2	906	910	PF00400	0.538
DEG_Nend_UBRbox_2	1	3	PF02207	0.519
DEG_SPOP_SBC_1	115	119	PF00917	0.725
DEG_SPOP_SBC_1	13	17	PF00917	0.605
DEG_SPOP_SBC_1	306	310	PF00917	0.711
DOC_CYCLIN_RxL_1	156	166	PF00134	0.699
DOC_MAPK_gen_1	158	165	PF00069	0.662
DOC_MAPK_gen_1	293	303	PF00069	0.604
DOC_MAPK_gen_1	504	511	PF00069	0.502
DOC_MAPK_gen_1	556	564	PF00069	0.577
DOC_MAPK_gen_1	729	738	PF00069	0.543
DOC_MAPK_MEF2A_6	158	165	PF00069	0.662
DOC_MAPK_MEF2A_6	504	511	PF00069	0.532
DOC_MAPK_NFAT4_5	158	166	PF00069	0.662
DOC_USP7_MATH_1	1079	1083	PF00917	0.722
DOC_USP7_MATH_1	115	119	PF00917	0.655
DOC_USP7_MATH_1	1163	1167	PF00917	0.715
DOC_USP7_MATH_1	1240	1244	PF00917	0.684
DOC_USP7_MATH_1	22	26	PF00917	0.570
DOC_USP7_MATH_1	306	310	PF00917	0.711
DOC_USP7_MATH_1	324	328	PF00917	0.417
DOC_USP7_MATH_1	354	358	PF00917	0.651
DOC_USP7_MATH_1	541	545	PF00917	0.720
DOC_USP7_MATH_1	842	846	PF00917	0.635
DOC_USP7_MATH_1	97	101	PF00917	0.618
DOC_USP7_UBL2_3	53	57	PF12436	0.492
DOC_WW_Pin1_4	101	106	PF00397	0.628
DOC_WW_Pin1_4	805	810	PF00397	0.734
LIG_14-3-3_CanoR_1	1222	1230	PF00244	0.552
LIG_14-3-3_CanoR_1	126	130	PF00244	0.574
LIG_14-3-3_CanoR_1	1267	1276	PF00244	0.643
LIG_14-3-3_CanoR_1	21	28	PF00244	0.581
LIG_14-3-3_CanoR_1	319	324	PF00244	0.506
LIG_14-3-3_CanoR_1	597	603	PF00244	0.678
LIG_14-3-3_CanoR_1	616	620	PF00244	0.527
LIG_14-3-3_CanoR_1	644	652	PF00244	0.656
LIG_14-3-3_CanoR_1	65	70	PF00244	0.596
LIG_14-3-3_CanoR_1	803	811	PF00244	0.641
LIG_14-3-3_CanoR_1	891	900	PF00244	0.687
LIG_Actin_WH2_2	1166	1183	PF00022	0.634
LIG_Actin_WH2_2	1234	1250	PF00022	0.691
LIG_Actin_WH2_2	866	884	PF00022	0.402
LIG_Actin_WH2_2	997	1014	PF00022	0.601
LIG_AP2alpha_2	3	5	PF02296	0.444
LIG_BIR_III_4	355	359	PF00653	0.650
LIG_BIR_III_4	488	492	PF00653	0.471
LIG_BIR_III_4	861	865	PF00653	0.608
LIG_CaM_IQ_9	1241	1256	PF13499	0.661
LIG_CaM_NSCaTE_8	1007	1014	PF13499	0.493
LIG_Clathr_ClatBox_1	857	861	PF01394	0.630
LIG_deltaCOP1_diTrp_1	1118	1123	PF00928	0.695
LIG_FHA_1	1017	1023	PF00498	0.560
LIG_FHA_1	1115	1121	PF00498	0.507
LIG_FHA_1	1268	1274	PF00498	0.641
LIG_FHA_1	18	24	PF00498	0.560
LIG_FHA_1	450	456	PF00498	0.692
LIG_FHA_1	471	477	PF00498	0.640
LIG_FHA_1	806	812	PF00498	0.699
LIG_FHA_2	1049	1055	PF00498	0.708
LIG_FHA_2	1177	1183	PF00498	0.619
LIG_FHA_2	1266	1272	PF00498	0.625
LIG_FHA_2	133	139	PF00498	0.639
LIG_FHA_2	242	248	PF00498	0.689
LIG_FHA_2	280	286	PF00498	0.685
LIG_FHA_2	335	341	PF00498	0.432
LIG_FHA_2	459	465	PF00498	0.659
LIG_FHA_2	610	616	PF00498	0.617
LIG_FHA_2	781	787	PF00498	0.596
LIG_FHA_2	831	837	PF00498	0.493
LIG_FHA_2	874	880	PF00498	0.634
LIG_FHA_2	969	975	PF00498	0.572
LIG_GBD_Chelix_1	1215	1223	PF00786	0.636
LIG_GBD_Chelix_1	416	424	PF00786	0.651
LIG_LIR_Gen_1	871	881	PF02991	0.633
LIG_LIR_Nem_3	34	38	PF02991	0.461
LIG_LIR_Nem_3	871	877	PF02991	0.635
LIG_LIR_Nem_3	919	925	PF02991	0.422
LIG_LYPXL_SIV_4	44	52	PF13949	0.516
LIG_LYPXL_yS_3	35	38	PF13949	0.516
LIG_MYND_1	809	813	PF01753	0.718
LIG_NRBOX	1328	1334	PF00104	0.563
LIG_NRBOX	876	882	PF00104	0.630
LIG_PCNA_yPIPBox_3	846	858	PF02747	0.407
LIG_Pex14_1	702	706	PF04695	0.591
LIG_SH2_NCK_1	1070	1074	PF00017	0.647
LIG_SH2_STAP1	1070	1074	PF00017	0.622
LIG_SH2_STAP1	45	49	PF00017	0.462
LIG_SH2_STAT3	1021	1024	PF00017	0.571
LIG_SH2_STAT3	193	196	PF00017	0.591
LIG_SH2_STAT5	1021	1024	PF00017	0.571
LIG_Sin3_3	819	826	PF02671	0.534
LIG_SUMO_SIM_anti_2	586	594	PF11976	0.525
LIG_SUMO_SIM_anti_2	875	883	PF11976	0.630
LIG_SUMO_SIM_par_1	229	235	PF11976	0.537
LIG_SUMO_SIM_par_1	714	721	PF11976	0.684
LIG_TRAF2_1	1051	1054	PF00917	0.706
LIG_TRAF2_1	1062	1065	PF00917	0.543
LIG_TRAF2_1	1150	1153	PF00917	0.704
LIG_TRAF2_1	1162	1165	PF00917	0.668
LIG_TRAF2_1	1243	1246	PF00917	0.565
LIG_TRAF2_1	195	198	PF00917	0.640
LIG_TRAF2_1	361	364	PF00917	0.644
LIG_TRAF2_1	482	485	PF00917	0.660
LIG_TRAF2_1	500	503	PF00917	0.391
LIG_TRAF2_1	775	778	PF00917	0.606
LIG_UBA3_1	716	720	PF00899	0.686
LIG_UBA3_1	73	81	PF00899	0.509
LIG_WRC_WIRS_1	1332	1337	PF05994	0.640
MOD_CDK_SPK_2	101	106	PF00069	0.628
MOD_CDK_SPxxK_3	805	812	PF00069	0.618
MOD_CK1_1	117	123	PF00069	0.626
MOD_CK1_1	1184	1190	PF00069	0.584
MOD_CK1_1	132	138	PF00069	0.528
MOD_CK1_1	1331	1337	PF00069	0.644
MOD_CK1_1	317	323	PF00069	0.676
MOD_CK1_1	544	550	PF00069	0.744
MOD_CK1_1	762	768	PF00069	0.698
MOD_CK1_1	805	811	PF00069	0.730
MOD_CK1_1	890	896	PF00069	0.685
MOD_CK2_1	101	107	PF00069	0.653
MOD_CK2_1	1048	1054	PF00069	0.706
MOD_CK2_1	1079	1085	PF00069	0.722
MOD_CK2_1	1176	1182	PF00069	0.633
MOD_CK2_1	118	124	PF00069	0.377
MOD_CK2_1	1240	1246	PF00069	0.457
MOD_CK2_1	1265	1271	PF00069	0.631
MOD_CK2_1	132	138	PF00069	0.585
MOD_CK2_1	1331	1337	PF00069	0.543
MOD_CK2_1	241	247	PF00069	0.682
MOD_CK2_1	279	285	PF00069	0.653
MOD_CK2_1	65	71	PF00069	0.599
MOD_CK2_1	661	667	PF00069	0.697
MOD_CK2_1	690	696	PF00069	0.589
MOD_CK2_1	706	712	PF00069	0.607
MOD_CK2_1	734	740	PF00069	0.730
MOD_CK2_1	780	786	PF00069	0.594
MOD_CK2_1	830	836	PF00069	0.485
MOD_CK2_1	968	974	PF00069	0.559
MOD_GlcNHglycan	1001	1004	PF01048	0.576
MOD_GlcNHglycan	1165	1168	PF01048	0.734
MOD_GlcNHglycan	255	258	PF01048	0.725
MOD_GlcNHglycan	355	359	PF01048	0.659
MOD_GlcNHglycan	497	500	PF01048	0.598
MOD_GlcNHglycan	630	633	PF01048	0.655
MOD_GlcNHglycan	672	675	PF01048	0.588
MOD_GlcNHglycan	805	808	PF01048	0.753
MOD_GlcNHglycan	813	816	PF01048	0.587
MOD_GlcNHglycan	819	822	PF01048	0.502
MOD_GlcNHglycan	861	865	PF01048	0.454
MOD_GlcNHglycan	893	896	PF01048	0.686
MOD_GlcNHglycan	97	100	PF01048	0.682
MOD_GSK3_1	1064	1071	PF00069	0.708
MOD_GSK3_1	1079	1086	PF00069	0.515
MOD_GSK3_1	1114	1121	PF00069	0.433
MOD_GSK3_1	114	121	PF00069	0.593
MOD_GSK3_1	1172	1179	PF00069	0.616
MOD_GSK3_1	1180	1187	PF00069	0.557
MOD_GSK3_1	12	19	PF00069	0.519
MOD_GSK3_1	1222	1229	PF00069	0.569
MOD_GSK3_1	1236	1243	PF00069	0.471
MOD_GSK3_1	125	132	PF00069	0.499
MOD_GSK3_1	1289	1296	PF00069	0.674
MOD_GSK3_1	174	181	PF00069	0.673
MOD_GSK3_1	264	271	PF00069	0.528
MOD_GSK3_1	279	286	PF00069	0.647
MOD_GSK3_1	334	341	PF00069	0.586
MOD_GSK3_1	537	544	PF00069	0.679
MOD_GSK3_1	690	697	PF00069	0.466
MOD_GSK3_1	734	741	PF00069	0.642
MOD_GSK3_1	887	894	PF00069	0.675
MOD_GSK3_1	97	104	PF00069	0.611
MOD_GSK3_1	982	989	PF00069	0.668
MOD_N-GLC_1	1307	1312	PF02516	0.546
MOD_N-GLC_1	817	822	PF02516	0.432
MOD_NEK2_1	1180	1185	PF00069	0.613
MOD_NEK2_1	1289	1294	PF00069	0.633
MOD_NEK2_1	148	153	PF00069	0.616
MOD_NEK2_1	165	170	PF00069	0.584
MOD_NEK2_1	241	246	PF00069	0.592
MOD_NEK2_1	265	270	PF00069	0.683
MOD_NEK2_1	283	288	PF00069	0.400
MOD_NEK2_1	333	338	PF00069	0.633
MOD_NEK2_1	734	739	PF00069	0.619
MOD_NEK2_1	759	764	PF00069	0.713
MOD_NEK2_1	780	785	PF00069	0.632
MOD_NEK2_1	873	878	PF00069	0.515
MOD_PIKK_1	1011	1017	PF00454	0.454
MOD_PIKK_1	1040	1046	PF00454	0.606
MOD_PIKK_1	1156	1162	PF00454	0.768
MOD_PIKK_1	1172	1178	PF00454	0.440
MOD_PIKK_1	1193	1199	PF00454	0.597
MOD_PIKK_1	153	159	PF00454	0.507
MOD_PIKK_1	241	247	PF00454	0.682
MOD_PIKK_1	314	320	PF00454	0.677
MOD_PIKK_1	596	602	PF00454	0.674
MOD_PIKK_1	644	650	PF00454	0.650
MOD_PK_1	1211	1217	PF00069	0.607
MOD_PK_1	65	71	PF00069	0.599
MOD_PK_1	694	700	PF00069	0.629
MOD_PK_1	907	913	PF00069	0.532
MOD_PKA_1	952	958	PF00069	0.556
MOD_PKA_2	1011	1017	PF00069	0.454
MOD_PKA_2	1079	1085	PF00069	0.535
MOD_PKA_2	1093	1099	PF00069	0.551
MOD_PKA_2	1180	1186	PF00069	0.636
MOD_PKA_2	1221	1227	PF00069	0.683
MOD_PKA_2	125	131	PF00069	0.512
MOD_PKA_2	222	228	PF00069	0.670
MOD_PKA_2	596	602	PF00069	0.674
MOD_PKA_2	607	613	PF00069	0.525
MOD_PKA_2	615	621	PF00069	0.527
MOD_PKA_2	670	676	PF00069	0.549
MOD_PKA_2	795	801	PF00069	0.595
MOD_PKA_2	802	808	PF00069	0.658
MOD_PKA_2	811	817	PF00069	0.650
MOD_PKA_2	890	896	PF00069	0.637
MOD_PKA_2	952	958	PF00069	0.533
MOD_PKB_1	801	809	PF00069	0.700
MOD_Plk_1	1226	1232	PF00069	0.718
MOD_Plk_1	1307	1313	PF00069	0.548
MOD_Plk_1	457	463	PF00069	0.570
MOD_Plk_1	550	556	PF00069	0.588
MOD_Plk_1	6	12	PF00069	0.657
MOD_Plk_1	694	700	PF00069	0.707
MOD_Plk_1	817	823	PF00069	0.546
MOD_Plk_1	907	913	PF00069	0.638
MOD_Plk_2-3	1182	1188	PF00069	0.479
MOD_Plk_2-3	1265	1271	PF00069	0.660
MOD_Plk_2-3	458	464	PF00069	0.689
MOD_Plk_4	1211	1217	PF00069	0.548
MOD_Plk_4	1328	1334	PF00069	0.664
MOD_Plk_4	222	228	PF00069	0.670
MOD_Plk_4	338	344	PF00069	0.649
MOD_Plk_4	7	13	PF00069	0.651
MOD_Plk_4	873	879	PF00069	0.634
MOD_ProDKin_1	101	107	PF00069	0.630
MOD_ProDKin_1	805	811	PF00069	0.730
MOD_SUMO_for_1	903	906	PF00179	0.688
MOD_SUMO_rev_2	1131	1137	PF00179	0.779
MOD_SUMO_rev_2	1243	1250	PF00179	0.563
MOD_SUMO_rev_2	174	179	PF00179	0.494
MOD_SUMO_rev_2	488	497	PF00179	0.534
MOD_SUMO_rev_2	908	917	PF00179	0.751
TRG_DiLeu_BaEn_1	712	717	PF01217	0.672
TRG_DiLeu_BaEn_4	124	130	PF01217	0.476
TRG_DiLeu_BaEn_4	368	374	PF01217	0.590
TRG_DiLeu_BaEn_4	457	463	PF01217	0.686
TRG_DiLeu_BaLyEn_6	392	397	PF01217	0.467
TRG_ENDOCYTIC_2	35	38	PF00928	0.458
TRG_ENDOCYTIC_2	39	42	PF00928	0.462
TRG_ER_diArg_1	1230	1233	PF00400	0.730
TRG_ER_diArg_1	129	131	PF00400	0.567
TRG_ER_diArg_1	290	293	PF00400	0.671
TRG_ER_diArg_1	373	376	PF00400	0.623
TRG_ER_diArg_1	476	478	PF00400	0.583
TRG_ER_diArg_1	578	581	PF00400	0.604
TRG_ER_diArg_1	654	656	PF00400	0.708
TRG_ER_diArg_1	846	849	PF00400	0.510
TRG_ER_diArg_1	951	953	PF00400	0.536
TRG_Pf-PMV_PEXEL_1	1267	1271	PF00026	0.654
TRG_Pf-PMV_PEXEL_1	210	214	PF00026	0.710
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.707
TRG_Pf-PMV_PEXEL_1	281	285	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	422	426	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	937	941	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	944	948	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6H4	Leptomonas seymouri	41%	94%
A0A3Q8IF73	Leishmania donovani	91%	100%
A4HAE2	Leishmania braziliensis	74%	100%
A4I9J4	Leishmania infantum	91%	100%
E9B4J2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%