Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3I3_LEIMA

TriTrypDb:

LmjF.34.0250 , LMJLV39_340007800 , LMJSD75_340007800

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3I3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3I3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.527
CLV_C14_Caspase3-7	308	312	PF00656	0.601
CLV_NRD_NRD_1	137	139	PF00675	0.496
CLV_NRD_NRD_1	173	175	PF00675	0.411
CLV_NRD_NRD_1	301	303	PF00675	0.694
CLV_NRD_NRD_1	366	368	PF00675	0.539
CLV_NRD_NRD_1	38	40	PF00675	0.670
CLV_PCSK_KEX2_1	141	143	PF00082	0.475
CLV_PCSK_KEX2_1	173	175	PF00082	0.434
CLV_PCSK_KEX2_1	211	213	PF00082	0.669
CLV_PCSK_KEX2_1	301	303	PF00082	0.669
CLV_PCSK_KEX2_1	316	318	PF00082	0.430
CLV_PCSK_KEX2_1	366	368	PF00082	0.519
CLV_PCSK_KEX2_1	38	40	PF00082	0.732
CLV_PCSK_KEX2_1	54	56	PF00082	0.419
CLV_PCSK_KEX2_1	72	74	PF00082	0.489
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.475
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.669
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.620
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.504
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.489
CLV_PCSK_SKI1_1	138	142	PF00082	0.604
CLV_PCSK_SKI1_1	81	85	PF00082	0.568
DEG_SPOP_SBC_1	125	129	PF00917	0.540
DOC_CKS1_1	101	106	PF01111	0.663
DOC_CKS1_1	108	113	PF01111	0.699
DOC_CKS1_1	249	254	PF01111	0.519
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.600
DOC_USP7_MATH_1	324	328	PF00917	0.650
DOC_USP7_MATH_2	2	8	PF00917	0.654
DOC_WW_Pin1_4	10	15	PF00397	0.662
DOC_WW_Pin1_4	100	105	PF00397	0.622
DOC_WW_Pin1_4	107	112	PF00397	0.630
DOC_WW_Pin1_4	197	202	PF00397	0.594
DOC_WW_Pin1_4	248	253	PF00397	0.663
DOC_WW_Pin1_4	276	281	PF00397	0.620
DOC_WW_Pin1_4	28	33	PF00397	0.476
LIG_14-3-3_CanoR_1	19	25	PF00244	0.648
LIG_14-3-3_CanoR_1	244	248	PF00244	0.678
LIG_14-3-3_CanoR_1	325	333	PF00244	0.586
LIG_14-3-3_CanoR_1	349	356	PF00244	0.512
LIG_14-3-3_CanoR_1	378	383	PF00244	0.544
LIG_BRCT_BRCA1_1	126	130	PF00533	0.669
LIG_Clathr_ClatBox_1	295	299	PF01394	0.631
LIG_CtBP_PxDLS_1	345	349	PF00389	0.544
LIG_eIF4E_1	290	296	PF01652	0.630
LIG_EVH1_1	277	281	PF00568	0.536
LIG_FHA_1	150	156	PF00498	0.380
LIG_FHA_1	198	204	PF00498	0.621
LIG_FHA_1	231	237	PF00498	0.557
LIG_LIR_Apic_2	275	280	PF02991	0.473
LIG_LIR_Apic_2	99	104	PF02991	0.645
LIG_LIR_Gen_1	161	168	PF02991	0.495
LIG_LIR_Nem_3	161	165	PF02991	0.532
LIG_LIR_Nem_3	99	105	PF02991	0.651
LIG_RPA_C_Fungi	314	326	PF08784	0.537
LIG_SH2_CRK	102	106	PF00017	0.663
LIG_SH2_CRK	162	166	PF00017	0.504
LIG_SH2_CRK	261	265	PF00017	0.454
LIG_SH2_CRK	290	294	PF00017	0.659
LIG_SH2_NCK_1	162	166	PF00017	0.620
LIG_SH2_NCK_1	290	294	PF00017	0.629
LIG_SH2_SRC	180	183	PF00017	0.643
LIG_SH2_STAP1	147	151	PF00017	0.525
LIG_SH2_STAP1	267	271	PF00017	0.645
LIG_SH2_STAT5	102	105	PF00017	0.667
LIG_SH2_STAT5	96	99	PF00017	0.633
LIG_SH3_2	111	116	PF14604	0.695
LIG_SH3_2	249	254	PF14604	0.607
LIG_SH3_3	108	114	PF00018	0.687
LIG_SH3_3	246	252	PF00018	0.526
LIG_SH3_3	275	281	PF00018	0.545
LIG_SH3_3	340	346	PF00018	0.552
LIG_SH3_3	82	88	PF00018	0.648
LIG_SH3_CIN85_PxpxPR_1	111	116	PF14604	0.672
LIG_SH3_CIN85_PxpxPR_1	339	344	PF14604	0.579
LIG_TRAF2_1	106	109	PF00917	0.537
LIG_TRAF2_1	176	179	PF00917	0.602
LIG_TRAF2_1	326	329	PF00917	0.646
LIG_WW_3	113	117	PF00397	0.625
LIG_WW_3	222	226	PF00397	0.591
MOD_CDK_SPK_2	10	15	PF00069	0.589
MOD_CDK_SPK_2	28	33	PF00069	0.473
MOD_CDK_SPxK_1	248	254	PF00069	0.520
MOD_CDK_SPxxK_3	100	107	PF00069	0.663
MOD_CDK_SPxxK_3	109	116	PF00069	0.702
MOD_CK1_1	163	169	PF00069	0.487
MOD_CK1_1	231	237	PF00069	0.700
MOD_CK1_1	376	382	PF00069	0.598
MOD_CK2_1	103	109	PF00069	0.528
MOD_Cter_Amidation	36	39	PF01082	0.609
MOD_GlcNHglycan	272	275	PF01048	0.748
MOD_GlcNHglycan	321	324	PF01048	0.578
MOD_GSK3_1	10	17	PF00069	0.576
MOD_GSK3_1	160	167	PF00069	0.506
MOD_GSK3_1	266	273	PF00069	0.645
MOD_GSK3_1	373	380	PF00069	0.542
MOD_GSK3_1	77	84	PF00069	0.654
MOD_GSK3_1	96	103	PF00069	0.540
MOD_N-GLC_1	47	52	PF02516	0.580
MOD_NEK2_1	230	235	PF00069	0.527
MOD_PIKK_1	225	231	PF00454	0.628
MOD_PIKK_1	324	330	PF00454	0.684
MOD_PKA_2	115	121	PF00069	0.730
MOD_PKA_2	14	20	PF00069	0.710
MOD_PKA_2	243	249	PF00069	0.626
MOD_PKA_2	324	330	PF00069	0.688
MOD_PKA_2	365	371	PF00069	0.537
MOD_PKA_2	377	383	PF00069	0.569
MOD_PKB_1	317	325	PF00069	0.652
MOD_Plk_1	160	166	PF00069	0.540
MOD_Plk_4	160	166	PF00069	0.485
MOD_Plk_4	291	297	PF00069	0.631
MOD_Plk_4	96	102	PF00069	0.711
MOD_ProDKin_1	10	16	PF00069	0.662
MOD_ProDKin_1	100	106	PF00069	0.625
MOD_ProDKin_1	107	113	PF00069	0.628
MOD_ProDKin_1	197	203	PF00069	0.593
MOD_ProDKin_1	248	254	PF00069	0.659
MOD_ProDKin_1	276	282	PF00069	0.614
MOD_ProDKin_1	28	34	PF00069	0.477
MOD_SUMO_for_1	140	143	PF00179	0.511
MOD_SUMO_rev_2	163	172	PF00179	0.458
MOD_SUMO_rev_2	51	56	PF00179	0.593
TRG_DiLeu_BaEn_2	328	334	PF01217	0.657
TRG_ENDOCYTIC_2	102	105	PF00928	0.660
TRG_ENDOCYTIC_2	162	165	PF00928	0.530
TRG_ER_diArg_1	173	175	PF00400	0.434
TRG_ER_diArg_1	255	258	PF00400	0.643
TRG_ER_diArg_1	301	304	PF00400	0.699
TRG_NLS_Bipartite_1	301	320	PF00514	0.608
TRG_NLS_MonoExtC_3	137	142	PF00514	0.501
TRG_NLS_MonoExtN_4	136	142	PF00514	0.505
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	370	375	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK05	Leptomonas seymouri	60%	92%
A0A1X0P9W7	Trypanosomatidae	37%	100%
A0A3R7K419	Trypanosoma rangeli	35%	98%
A0A3S5H7V7	Leishmania donovani	95%	100%
A4HAE3	Leishmania braziliensis	80%	100%
A4I9J5	Leishmania infantum	95%	100%
E9B4J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5B266	Trypanosoma cruzi	34%	100%