Pyr_redox_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pyridine nucleotide-disulphide oxidoreductase, putative

Species:

Leishmania major

UniProt:

Q4Q3I1_LEIMA

TriTrypDb:

LmjF.34.0270 , LMJLV39_340008000 , LMJSD75_340008000

Length:

792

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	5
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4Q3I1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3I1

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0019418	sulfide oxidation	4	2
GO:0044237	cellular metabolic process	2	2
GO:0070221	sulfide oxidation, using sulfide:quinone oxidoreductase	5	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	2
GO:0016491	oxidoreductase activity	2	7
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	2
GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0050660	flavin adenine dinucleotide binding	4	2
GO:0070224	sulfide:quinone oxidoreductase activity	5	2
GO:0071949	FAD binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.282
CLV_C14_Caspase3-7	266	270	PF00656	0.477
CLV_NRD_NRD_1	198	200	PF00675	0.577
CLV_NRD_NRD_1	2	4	PF00675	0.755
CLV_NRD_NRD_1	546	548	PF00675	0.654
CLV_NRD_NRD_1	558	560	PF00675	0.649
CLV_NRD_NRD_1	563	565	PF00675	0.651
CLV_NRD_NRD_1	67	69	PF00675	0.509
CLV_PCSK_KEX2_1	198	200	PF00082	0.577
CLV_PCSK_KEX2_1	2	4	PF00082	0.755
CLV_PCSK_KEX2_1	546	548	PF00082	0.654
CLV_PCSK_KEX2_1	558	560	PF00082	0.638
CLV_PCSK_KEX2_1	69	71	PF00082	0.510
CLV_PCSK_KEX2_1	713	715	PF00082	0.714
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.468
CLV_PCSK_PC1ET2_1	713	715	PF00082	0.714
CLV_PCSK_SKI1_1	163	167	PF00082	0.597
CLV_PCSK_SKI1_1	171	175	PF00082	0.547
CLV_PCSK_SKI1_1	297	301	PF00082	0.608
CLV_PCSK_SKI1_1	64	68	PF00082	0.520
CLV_PCSK_SKI1_1	739	743	PF00082	0.629
CLV_Separin_Metazoa	154	158	PF03568	0.346
CLV_Separin_Metazoa	644	648	PF03568	0.511
CLV_Separin_Metazoa	65	69	PF03568	0.766
DEG_APCC_DBOX_1	2	10	PF00400	0.560
DEG_APCC_DBOX_1	267	275	PF00400	0.472
DEG_APCC_DBOX_1	738	746	PF00400	0.504
DEG_COP1_1	767	776	PF00400	0.443
DEG_Nend_UBRbox_1	1	4	PF02207	0.554
DEG_SPOP_SBC_1	298	302	PF00917	0.372
DOC_ANK_TNKS_1	33	40	PF00023	0.252
DOC_CKS1_1	324	329	PF01111	0.635
DOC_CYCLIN_yCln2_LP_2	516	522	PF00134	0.377
DOC_MAPK_gen_1	105	112	PF00069	0.419
DOC_MAPK_gen_1	188	196	PF00069	0.349
DOC_MAPK_gen_1	198	206	PF00069	0.287
DOC_MAPK_gen_1	2	11	PF00069	0.561
DOC_MAPK_gen_1	68	77	PF00069	0.633
DOC_MAPK_HePTP_8	196	208	PF00069	0.363
DOC_MAPK_MEF2A_6	198	206	PF00069	0.363
DOC_PP2B_LxvP_1	516	519	PF13499	0.373
DOC_PP2B_LxvP_1	520	523	PF13499	0.380
DOC_PP4_FxxP_1	345	348	PF00568	0.577
DOC_PP4_FxxP_1	771	774	PF00568	0.396
DOC_USP7_MATH_1	239	243	PF00917	0.419
DOC_USP7_MATH_1	306	310	PF00917	0.560
DOC_USP7_MATH_1	331	335	PF00917	0.596
DOC_USP7_MATH_1	444	448	PF00917	0.336
DOC_USP7_MATH_1	82	86	PF00917	0.513
DOC_USP7_UBL2_3	661	665	PF12436	0.493
DOC_WW_Pin1_4	135	140	PF00397	0.346
DOC_WW_Pin1_4	299	304	PF00397	0.528
DOC_WW_Pin1_4	318	323	PF00397	0.570
DOC_WW_Pin1_4	347	352	PF00397	0.497
DOC_WW_Pin1_4	361	366	PF00397	0.604
DOC_WW_Pin1_4	389	394	PF00397	0.515
DOC_WW_Pin1_4	700	705	PF00397	0.591
DOC_WW_Pin1_4	764	769	PF00397	0.468
DOC_WW_Pin1_4	774	779	PF00397	0.507
LIG_14-3-3_CanoR_1	205	213	PF00244	0.336
LIG_14-3-3_CanoR_1	297	303	PF00244	0.507
LIG_14-3-3_CanoR_1	336	345	PF00244	0.552
LIG_14-3-3_CanoR_1	58	67	PF00244	0.696
LIG_14-3-3_CanoR_1	696	704	PF00244	0.542
LIG_Actin_WH2_2	37	55	PF00022	0.416
LIG_Actin_WH2_2	83	101	PF00022	0.513
LIG_APCC_Cbox_2	639	645	PF00515	0.376
LIG_BRCT_BRCA1_1	28	32	PF00533	0.482
LIG_Clathr_ClatBox_1	513	517	PF01394	0.328
LIG_EVH1_2	285	289	PF00568	0.395
LIG_FHA_1	208	214	PF00498	0.404
LIG_FHA_1	255	261	PF00498	0.541
LIG_FHA_1	33	39	PF00498	0.359
LIG_FHA_1	41	47	PF00498	0.345
LIG_FHA_1	532	538	PF00498	0.384
LIG_FHA_1	780	786	PF00498	0.524
LIG_FHA_2	129	135	PF00498	0.385
LIG_FHA_2	264	270	PF00498	0.453
LIG_FHA_2	495	501	PF00498	0.415
LIG_FHA_2	564	570	PF00498	0.433
LIG_FHA_2	721	727	PF00498	0.397
LIG_FHA_2	785	791	PF00498	0.522
LIG_FHA_2	99	105	PF00498	0.346
LIG_LIR_Apic_2	342	348	PF02991	0.574
LIG_LIR_Apic_2	685	691	PF02991	0.572
LIG_LIR_Apic_2	769	774	PF02991	0.447
LIG_LIR_Gen_1	229	237	PF02991	0.346
LIG_LIR_Gen_1	353	363	PF02991	0.435
LIG_LIR_Gen_1	47	55	PF02991	0.436
LIG_LIR_Gen_1	476	486	PF02991	0.454
LIG_LIR_Gen_1	577	588	PF02991	0.392
LIG_LIR_Gen_1	667	676	PF02991	0.437
LIG_LIR_LC3C_4	231	235	PF02991	0.419
LIG_LIR_Nem_3	229	233	PF02991	0.346
LIG_LIR_Nem_3	353	358	PF02991	0.459
LIG_LIR_Nem_3	419	424	PF02991	0.403
LIG_LIR_Nem_3	47	52	PF02991	0.513
LIG_LIR_Nem_3	476	481	PF02991	0.465
LIG_LIR_Nem_3	577	583	PF02991	0.386
LIG_LIR_Nem_3	610	614	PF02991	0.410
LIG_LIR_Nem_3	667	672	PF02991	0.427
LIG_LIR_Nem_3	753	759	PF02991	0.448
LIG_LIR_Nem_3	767	773	PF02991	0.450
LIG_LIR_Nem_3	775	779	PF02991	0.437
LIG_LIR_Nem_3	787	791	PF02991	0.318
LIG_NRBOX	86	92	PF00104	0.358
LIG_PCNA_TLS_4	567	574	PF02747	0.461
LIG_PCNA_yPIPBox_3	450	460	PF02747	0.437
LIG_PDZ_Class_3	787	792	PF00595	0.562
LIG_Pex14_1	400	404	PF04695	0.430
LIG_Pex14_2	478	482	PF04695	0.437
LIG_PTB_Apo_2	740	747	PF02174	0.430
LIG_Rb_pABgroove_1	493	501	PF01858	0.459
LIG_SH2_CRK	230	234	PF00017	0.346
LIG_SH2_CRK	427	431	PF00017	0.430
LIG_SH2_CRK	511	515	PF00017	0.419
LIG_SH2_CRK	611	615	PF00017	0.413
LIG_SH2_CRK	688	692	PF00017	0.464
LIG_SH2_GRB2like	426	429	PF00017	0.514
LIG_SH2_NCK_1	125	129	PF00017	0.419
LIG_SH2_NCK_1	593	597	PF00017	0.376
LIG_SH2_NCK_1	688	692	PF00017	0.575
LIG_SH2_NCK_1	776	780	PF00017	0.508
LIG_SH2_SRC	125	128	PF00017	0.419
LIG_SH2_SRC	593	596	PF00017	0.453
LIG_SH2_STAP1	230	234	PF00017	0.346
LIG_SH2_STAP1	593	597	PF00017	0.376
LIG_SH2_STAP1	752	756	PF00017	0.434
LIG_SH2_STAT5	10	13	PF00017	0.567
LIG_SH2_STAT5	423	426	PF00017	0.411
LIG_SH2_STAT5	485	488	PF00017	0.376
LIG_SH2_STAT5	536	539	PF00017	0.405
LIG_SH2_STAT5	641	644	PF00017	0.381
LIG_SH2_STAT5	666	669	PF00017	0.418
LIG_SH2_STAT5	756	759	PF00017	0.451
LIG_SH2_STAT5	772	775	PF00017	0.517
LIG_SH3_2	12	17	PF14604	0.558
LIG_SH3_3	133	139	PF00018	0.346
LIG_SH3_3	279	285	PF00018	0.456
LIG_SH3_3	321	327	PF00018	0.558
LIG_SH3_3	345	351	PF00018	0.479
LIG_SH3_3	359	365	PF00018	0.436
LIG_SH3_3	368	374	PF00018	0.396
LIG_SH3_3	504	510	PF00018	0.391
LIG_SH3_3	654	660	PF00018	0.572
LIG_SH3_3	715	721	PF00018	0.480
LIG_SH3_3	780	786	PF00018	0.444
LIG_SH3_3	9	15	PF00018	0.563
LIG_SUMO_SIM_anti_2	129	138	PF11976	0.419
LIG_SUMO_SIM_par_1	209	215	PF11976	0.336
LIG_SUMO_SIM_par_1	42	47	PF11976	0.436
LIG_SUMO_SIM_par_1	512	517	PF11976	0.353
LIG_TYR_ITIM	509	514	PF00017	0.456
LIG_TYR_ITIM	754	759	PF00017	0.445
LIG_WRC_WIRS_1	669	674	PF05994	0.440
MOD_CDK_SPK_2	779	784	PF00069	0.439
MOD_CDK_SPxxK_3	318	325	PF00069	0.548
MOD_CK1_1	209	215	PF00069	0.394
MOD_CK1_1	222	228	PF00069	0.282
MOD_CK1_1	242	248	PF00069	0.419
MOD_CK1_1	339	345	PF00069	0.580
MOD_CK1_1	346	352	PF00069	0.531
MOD_CK1_1	416	422	PF00069	0.381
MOD_CK1_1	59	65	PF00069	0.707
MOD_CK1_1	607	613	PF00069	0.486
MOD_CK1_1	648	654	PF00069	0.515
MOD_CK1_1	699	705	PF00069	0.567
MOD_CK2_1	335	341	PF00069	0.599
MOD_CK2_1	563	569	PF00069	0.521
MOD_CK2_1	59	65	PF00069	0.707
MOD_CK2_1	98	104	PF00069	0.346
MOD_GlcNHglycan	180	183	PF01048	0.510
MOD_GlcNHglycan	275	278	PF01048	0.621
MOD_GlcNHglycan	306	309	PF01048	0.762
MOD_GlcNHglycan	338	341	PF01048	0.820
MOD_GlcNHglycan	384	387	PF01048	0.800
MOD_GlcNHglycan	446	449	PF01048	0.552
MOD_GlcNHglycan	470	473	PF01048	0.716
MOD_GlcNHglycan	528	531	PF01048	0.596
MOD_GlcNHglycan	614	617	PF01048	0.624
MOD_GlcNHglycan	649	653	PF01048	0.741
MOD_GlcNHglycan	84	87	PF01048	0.513
MOD_GlcNHglycan	93	96	PF01048	0.513
MOD_GSK3_1	215	222	PF00069	0.389
MOD_GSK3_1	306	313	PF00069	0.493
MOD_GSK3_1	331	338	PF00069	0.541
MOD_GSK3_1	339	346	PF00069	0.479
MOD_GSK3_1	350	357	PF00069	0.521
MOD_GSK3_1	382	389	PF00069	0.508
MOD_GSK3_1	40	47	PF00069	0.467
MOD_GSK3_1	408	415	PF00069	0.400
MOD_GSK3_1	481	488	PF00069	0.419
MOD_GSK3_1	664	671	PF00069	0.404
MOD_GSK3_1	696	703	PF00069	0.562
MOD_GSK3_1	82	89	PF00069	0.280
MOD_N-GLC_1	142	147	PF02516	0.546
MOD_N-GLC_1	183	188	PF02516	0.452
MOD_N-GLC_1	215	220	PF02516	0.550
MOD_NEK2_1	1	6	PF00069	0.556
MOD_NEK2_1	166	171	PF00069	0.363
MOD_NEK2_1	206	211	PF00069	0.363
MOD_NEK2_1	32	37	PF00069	0.346
MOD_NEK2_1	354	359	PF00069	0.436
MOD_NEK2_1	402	407	PF00069	0.410
MOD_NEK2_1	413	418	PF00069	0.355
MOD_NEK2_1	481	486	PF00069	0.347
MOD_NEK2_1	531	536	PF00069	0.378
MOD_NEK2_1	563	568	PF00069	0.443
MOD_NEK2_1	758	763	PF00069	0.468
MOD_NEK2_1	91	96	PF00069	0.459
MOD_NEK2_1	98	103	PF00069	0.375
MOD_NEK2_2	668	673	PF00069	0.432
MOD_PIKK_1	26	32	PF00454	0.525
MOD_PIKK_1	628	634	PF00454	0.478
MOD_PIKK_1	696	702	PF00454	0.548
MOD_PKA_2	1	7	PF00069	0.554
MOD_PKA_2	167	173	PF00069	0.419
MOD_PKA_2	335	341	PF00069	0.515
MOD_PKA_2	526	532	PF00069	0.393
MOD_PKA_2	563	569	PF00069	0.458
MOD_PKA_2	59	65	PF00069	0.711
MOD_PKB_1	380	388	PF00069	0.550
MOD_Plk_1	409	415	PF00069	0.384
MOD_Plk_1	576	582	PF00069	0.391
MOD_Plk_2-3	576	582	PF00069	0.391
MOD_Plk_4	223	229	PF00069	0.339
MOD_Plk_4	285	291	PF00069	0.453
MOD_Plk_4	350	356	PF00069	0.456
MOD_Plk_4	40	46	PF00069	0.436
MOD_Plk_4	409	415	PF00069	0.371
MOD_Plk_4	416	422	PF00069	0.360
MOD_Plk_4	481	487	PF00069	0.338
MOD_Plk_4	494	500	PF00069	0.318
MOD_Plk_4	521	527	PF00069	0.427
MOD_Plk_4	576	582	PF00069	0.391
MOD_Plk_4	766	772	PF00069	0.454
MOD_Plk_4	86	92	PF00069	0.386
MOD_ProDKin_1	135	141	PF00069	0.346
MOD_ProDKin_1	299	305	PF00069	0.532
MOD_ProDKin_1	318	324	PF00069	0.571
MOD_ProDKin_1	347	353	PF00069	0.495
MOD_ProDKin_1	361	367	PF00069	0.606
MOD_ProDKin_1	389	395	PF00069	0.508
MOD_ProDKin_1	700	706	PF00069	0.589
MOD_ProDKin_1	764	770	PF00069	0.466
MOD_ProDKin_1	774	780	PF00069	0.509
MOD_SUMO_rev_2	159	165	PF00179	0.330
MOD_SUMO_rev_2	94	101	PF00179	0.363
TRG_DiLeu_BaEn_1	476	481	PF01217	0.465
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.453
TRG_DiLeu_BaLyEn_6	558	563	PF01217	0.425
TRG_ENDOCYTIC_2	230	233	PF00928	0.346
TRG_ENDOCYTIC_2	427	430	PF00928	0.429
TRG_ENDOCYTIC_2	511	514	PF00928	0.421
TRG_ENDOCYTIC_2	593	596	PF00928	0.380
TRG_ENDOCYTIC_2	611	614	PF00928	0.412
TRG_ENDOCYTIC_2	669	672	PF00928	0.430
TRG_ENDOCYTIC_2	752	755	PF00928	0.437
TRG_ENDOCYTIC_2	756	759	PF00928	0.451
TRG_ENDOCYTIC_2	776	779	PF00928	0.505
TRG_ER_diArg_1	1	3	PF00400	0.556
TRG_ER_diArg_1	197	199	PF00400	0.381
TRG_ER_diArg_1	380	383	PF00400	0.468
TRG_ER_diArg_1	533	536	PF00400	0.417
TRG_ER_diArg_1	545	547	PF00400	0.437
TRG_ER_diArg_1	557	559	PF00400	0.440
TRG_ER_diArg_1	58	61	PF00400	0.711
TRG_ER_diArg_1	67	70	PF00400	0.687
TRG_NLS_Bipartite_1	546	568	PF00514	0.465
TRG_NLS_MonoExtC_3	563	568	PF00514	0.460
TRG_NLS_MonoExtN_4	561	568	PF00514	0.457
TRG_Pf-PMV_PEXEL_1	463	468	PF00026	0.700
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.668
TRG_Pf-PMV_PEXEL_1	640	644	PF00026	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A2	Leptomonas seymouri	56%	95%
A0A3Q8IMW0	Leishmania donovani	93%	100%
A4HAE5	Leishmania braziliensis	81%	100%
A4I9J7	Leishmania infantum	93%	100%
E9B4J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%