Fuz_longin_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Trafficking protein Mon1, putative

Species:

Leishmania major

UniProt:

Q4Q3H9_LEIMA

TriTrypDb:

LmjF.34.0290 , LMJLV39_340008200 , LMJSD75_340008200

Length:

680

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q3H9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3H9

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	10
GO:0006623	protein targeting to vacuole	5	10
GO:0006810	transport	3	10
GO:0006886	intracellular protein transport	4	10
GO:0007034	vacuolar transport	4	10
GO:0008104	protein localization	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0016192	vesicle-mediated transport	4	10
GO:0033036	macromolecule localization	2	10
GO:0033365	protein localization to organelle	5	10
GO:0045184	establishment of protein localization	3	10
GO:0046907	intracellular transport	3	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0051649	establishment of localization in cell	3	10
GO:0070727	cellular macromolecule localization	3	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10
GO:0072594	establishment of protein localization to organelle	4	10
GO:0072665	protein localization to vacuole	6	10
GO:0072666	establishment of protein localization to vacuole	5	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	257	261	PF00656	0.532
CLV_C14_Caspase3-7	595	599	PF00656	0.500
CLV_NRD_NRD_1	244	246	PF00675	0.380
CLV_NRD_NRD_1	366	368	PF00675	0.384
CLV_NRD_NRD_1	407	409	PF00675	0.342
CLV_NRD_NRD_1	666	668	PF00675	0.613
CLV_PCSK_KEX2_1	243	245	PF00082	0.384
CLV_PCSK_KEX2_1	407	409	PF00082	0.342
CLV_PCSK_KEX2_1	666	668	PF00082	0.613
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.498
CLV_PCSK_SKI1_1	213	217	PF00082	0.559
CLV_PCSK_SKI1_1	249	253	PF00082	0.509
CLV_PCSK_SKI1_1	31	35	PF00082	0.377
CLV_PCSK_SKI1_1	41	45	PF00082	0.411
CLV_PCSK_SKI1_1	510	514	PF00082	0.656
DEG_APCC_DBOX_1	212	220	PF00400	0.547
DEG_SPOP_SBC_1	547	551	PF00917	0.543
DOC_CKS1_1	432	437	PF01111	0.514
DOC_CKS1_1	570	575	PF01111	0.597
DOC_PP1_RVXF_1	508	514	PF00149	0.635
DOC_PP2B_LxvP_1	187	190	PF13499	0.570
DOC_PP2B_LxvP_1	413	416	PF13499	0.489
DOC_PP4_FxxP_1	583	586	PF00568	0.684
DOC_PP4_FxxP_1	590	593	PF00568	0.600
DOC_SPAK_OSR1_1	669	673	PF12202	0.498
DOC_USP7_MATH_1	169	173	PF00917	0.563
DOC_USP7_MATH_1	294	298	PF00917	0.573
DOC_USP7_MATH_1	505	509	PF00917	0.696
DOC_USP7_MATH_1	547	551	PF00917	0.566
DOC_USP7_MATH_1	553	557	PF00917	0.526
DOC_USP7_MATH_1	615	619	PF00917	0.608
DOC_USP7_UBL2_3	368	372	PF12436	0.203
DOC_WW_Pin1_4	196	201	PF00397	0.520
DOC_WW_Pin1_4	431	436	PF00397	0.522
DOC_WW_Pin1_4	51	56	PF00397	0.486
DOC_WW_Pin1_4	569	574	PF00397	0.603
DOC_WW_Pin1_4	582	587	PF00397	0.517
DOC_WW_Pin1_4	644	649	PF00397	0.516
LIG_14-3-3_CanoR_1	324	330	PF00244	0.420
LIG_14-3-3_CanoR_1	345	353	PF00244	0.400
LIG_14-3-3_CanoR_1	559	566	PF00244	0.531
LIG_Actin_WH2_2	528	546	PF00022	0.532
LIG_APCC_ABBA_1	64	69	PF00400	0.447
LIG_BIR_II_1	1	5	PF00653	0.704
LIG_BIR_III_4	598	602	PF00653	0.503
LIG_CaM_IQ_9	661	676	PF13499	0.435
LIG_CSL_BTD_1	337	340	PF09270	0.360
LIG_deltaCOP1_diTrp_1	374	379	PF00928	0.215
LIG_EABR_CEP55_1	282	291	PF12180	0.560
LIG_EH_1	587	591	PF12763	0.616
LIG_EH1_1	653	661	PF00400	0.573
LIG_EH1_1	669	677	PF00400	0.636
LIG_eIF4E_1	133	139	PF01652	0.401
LIG_eIF4E_1	275	281	PF01652	0.421
LIG_FHA_1	226	232	PF00498	0.585
LIG_FHA_1	234	240	PF00498	0.551
LIG_FHA_1	347	353	PF00498	0.310
LIG_FHA_1	437	443	PF00498	0.629
LIG_FHA_1	459	465	PF00498	0.697
LIG_FHA_1	497	503	PF00498	0.644
LIG_FHA_1	592	598	PF00498	0.486
LIG_FHA_1	623	629	PF00498	0.601
LIG_FHA_2	207	213	PF00498	0.563
LIG_FHA_2	381	387	PF00498	0.407
LIG_FHA_2	576	582	PF00498	0.592
LIG_GBD_Chelix_1	656	664	PF00786	0.397
LIG_LIR_Apic_2	429	435	PF02991	0.475
LIG_LIR_Apic_2	581	586	PF02991	0.586
LIG_LIR_Gen_1	272	281	PF02991	0.444
LIG_LIR_Gen_1	406	417	PF02991	0.411
LIG_LIR_Nem_3	129	134	PF02991	0.347
LIG_LIR_Nem_3	272	276	PF02991	0.358
LIG_LIR_Nem_3	336	341	PF02991	0.293
LIG_LIR_Nem_3	373	378	PF02991	0.404
LIG_LIR_Nem_3	397	402	PF02991	0.308
LIG_LIR_Nem_3	406	412	PF02991	0.308
LIG_LIR_Nem_3	420	426	PF02991	0.418
LIG_LIR_Nem_3	531	535	PF02991	0.549
LIG_NRBOX	59	65	PF00104	0.446
LIG_NRP_CendR_1	679	680	PF00754	0.601
LIG_SH2_CRK	432	436	PF00017	0.493
LIG_SH2_CRK	468	472	PF00017	0.653
LIG_SH2_NCK_1	208	212	PF00017	0.527
LIG_SH2_STAP1	325	329	PF00017	0.400
LIG_SH2_STAP1	355	359	PF00017	0.400
LIG_SH2_STAP1	362	366	PF00017	0.400
LIG_SH2_STAP1	624	628	PF00017	0.534
LIG_SH2_STAT3	539	542	PF00017	0.575
LIG_SH2_STAT5	133	136	PF00017	0.356
LIG_SH2_STAT5	140	143	PF00017	0.337
LIG_SH2_STAT5	173	176	PF00017	0.474
LIG_SH2_STAT5	208	211	PF00017	0.570
LIG_SH2_STAT5	275	278	PF00017	0.499
LIG_SH2_STAT5	279	282	PF00017	0.482
LIG_SH2_STAT5	351	354	PF00017	0.284
LIG_SH2_STAT5	460	463	PF00017	0.589
LIG_SH2_STAT5	624	627	PF00017	0.508
LIG_SH3_3	146	152	PF00018	0.582
LIG_SH3_3	260	266	PF00018	0.656
LIG_SH3_3	281	287	PF00018	0.493
LIG_SH3_3	295	301	PF00018	0.434
LIG_SH3_3	338	344	PF00018	0.344
LIG_SH3_3	583	589	PF00018	0.592
LIG_SH3_3	77	83	PF00018	0.649
LIG_SUMO_SIM_anti_2	383	389	PF11976	0.347
LIG_SUMO_SIM_anti_2	637	643	PF11976	0.500
LIG_SUMO_SIM_par_1	185	191	PF11976	0.550
LIG_SUMO_SIM_par_1	235	240	PF11976	0.536
LIG_SUMO_SIM_par_1	32	37	PF11976	0.384
LIG_TYR_ITIM	466	471	PF00017	0.646
LIG_UBA3_1	270	277	PF00899	0.404
LIG_UBA3_1	63	70	PF00899	0.452
LIG_WRC_WIRS_1	270	275	PF05994	0.347
MOD_CDK_SPK_2	582	587	PF00069	0.587
MOD_CK1_1	143	149	PF00069	0.442
MOD_CK1_1	222	228	PF00069	0.590
MOD_CK1_1	328	334	PF00069	0.402
MOD_CK1_1	403	409	PF00069	0.400
MOD_CK1_1	444	450	PF00069	0.574
MOD_CK1_1	458	464	PF00069	0.662
MOD_CK1_1	515	521	PF00069	0.487
MOD_CK1_1	87	93	PF00069	0.556
MOD_CK2_1	11	17	PF00069	0.516
MOD_CK2_1	156	162	PF00069	0.694
MOD_CK2_1	575	581	PF00069	0.481
MOD_GlcNHglycan	109	112	PF01048	0.417
MOD_GlcNHglycan	209	212	PF01048	0.518
MOD_GlcNHglycan	298	301	PF01048	0.585
MOD_GlcNHglycan	392	395	PF01048	0.400
MOD_GlcNHglycan	456	460	PF01048	0.534
MOD_GlcNHglycan	505	508	PF01048	0.643
MOD_GlcNHglycan	550	553	PF01048	0.592
MOD_GlcNHglycan	561	564	PF01048	0.585
MOD_GlcNHglycan	612	615	PF01048	0.617
MOD_GlcNHglycan	92	95	PF01048	0.741
MOD_GSK3_1	105	112	PF00069	0.578
MOD_GSK3_1	143	150	PF00069	0.571
MOD_GSK3_1	233	240	PF00069	0.515
MOD_GSK3_1	441	448	PF00069	0.571
MOD_GSK3_1	451	458	PF00069	0.737
MOD_GSK3_1	74	81	PF00069	0.739
MOD_N-GLC_1	346	351	PF02516	0.284
MOD_N-GLC_1	357	362	PF02516	0.284
MOD_NEK2_1	1	6	PF00069	0.642
MOD_NEK2_1	219	224	PF00069	0.491
MOD_NEK2_1	34	39	PF00069	0.439
MOD_NEK2_1	346	351	PF00069	0.380
MOD_NEK2_1	390	395	PF00069	0.400
MOD_NEK2_1	402	407	PF00069	0.400
MOD_NEK2_1	512	517	PF00069	0.516
MOD_NEK2_2	140	145	PF00069	0.426
MOD_NEK2_2	505	510	PF00069	0.698
MOD_OFUCOSY	253	258	PF10250	0.416
MOD_PIKK_1	392	398	PF00454	0.308
MOD_PIKK_1	42	48	PF00454	0.617
MOD_PIKK_1	512	518	PF00454	0.597
MOD_PIKK_1	78	84	PF00454	0.698
MOD_PKA_2	403	409	PF00069	0.400
MOD_PKA_2	558	564	PF00069	0.455
MOD_PKA_2	610	616	PF00069	0.571
MOD_PKA_2	665	671	PF00069	0.523
MOD_Plk_1	225	231	PF00069	0.636
MOD_Plk_1	357	363	PF00069	0.308
MOD_Plk_1	637	643	PF00069	0.587
MOD_Plk_2-3	380	386	PF00069	0.423
MOD_Plk_4	126	132	PF00069	0.398
MOD_Plk_4	191	197	PF00069	0.422
MOD_Plk_4	515	521	PF00069	0.439
MOD_Plk_4	553	559	PF00069	0.455
MOD_Plk_4	637	643	PF00069	0.586
MOD_ProDKin_1	196	202	PF00069	0.519
MOD_ProDKin_1	431	437	PF00069	0.530
MOD_ProDKin_1	51	57	PF00069	0.476
MOD_ProDKin_1	569	575	PF00069	0.599
MOD_ProDKin_1	582	588	PF00069	0.521
MOD_ProDKin_1	644	650	PF00069	0.517
MOD_SUMO_for_1	96	99	PF00179	0.494
MOD_SUMO_rev_2	288	297	PF00179	0.560
MOD_SUMO_rev_2	486	491	PF00179	0.602
TRG_DiLeu_BaEn_1	30	35	PF01217	0.457
TRG_DiLeu_BaEn_1	531	536	PF01217	0.468
TRG_DiLeu_BaEn_4	380	386	PF01217	0.360
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.653
TRG_ENDOCYTIC_2	423	426	PF00928	0.407
TRG_ENDOCYTIC_2	468	471	PF00928	0.651
TRG_ER_diArg_1	244	246	PF00400	0.399
TRG_ER_diArg_1	407	409	PF00400	0.342
TRG_ER_diArg_1	666	669	PF00400	0.545
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	364	369	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	673	678	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKG6	Leptomonas seymouri	53%	96%
A0A1X0P9E4	Trypanosomatidae	27%	94%
A0A3S7X7E3	Leishmania donovani	89%	100%
A0A422N7B5	Trypanosoma rangeli	25%	96%
A4H7E1	Leishmania braziliensis	77%	100%
A4I9J9	Leishmania infantum	90%	100%
E9B4J7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BM77	Trypanosoma cruzi	27%	93%