Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3H8_LEIMA

TriTrypDb:

LmjF.34.0300 , LMJLV39_340008300 , LMJLV39_340008400 , LMJSD75_340008300

Length:

757

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030684	preribosome	3	2
GO:0032040	small-subunit processome	4	2
GO:0032991	protein-containing complex	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q3H8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3H8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0030515	snoRNA binding	5	11
GO:0034511	U3 snoRNA binding	6	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.477
CLV_C14_Caspase3-7	641	645	PF00656	0.664
CLV_C14_Caspase3-7	65	69	PF00656	0.586
CLV_NRD_NRD_1	112	114	PF00675	0.613
CLV_NRD_NRD_1	18	20	PF00675	0.516
CLV_NRD_NRD_1	205	207	PF00675	0.488
CLV_NRD_NRD_1	276	278	PF00675	0.311
CLV_NRD_NRD_1	328	330	PF00675	0.450
CLV_NRD_NRD_1	410	412	PF00675	0.419
CLV_NRD_NRD_1	465	467	PF00675	0.516
CLV_NRD_NRD_1	564	566	PF00675	0.487
CLV_NRD_NRD_1	587	589	PF00675	0.412
CLV_NRD_NRD_1	687	689	PF00675	0.732
CLV_PCSK_KEX2_1	112	114	PF00082	0.613
CLV_PCSK_KEX2_1	18	20	PF00082	0.499
CLV_PCSK_KEX2_1	204	206	PF00082	0.575
CLV_PCSK_KEX2_1	410	412	PF00082	0.419
CLV_PCSK_KEX2_1	465	467	PF00082	0.516
CLV_PCSK_KEX2_1	509	511	PF00082	0.720
CLV_PCSK_KEX2_1	564	566	PF00082	0.448
CLV_PCSK_KEX2_1	687	689	PF00082	0.705
CLV_PCSK_KEX2_1	729	731	PF00082	0.680
CLV_PCSK_KEX2_1	753	755	PF00082	0.697
CLV_PCSK_KEX2_1	9	11	PF00082	0.491
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.649
CLV_PCSK_PC1ET2_1	687	689	PF00082	0.694
CLV_PCSK_PC1ET2_1	729	731	PF00082	0.640
CLV_PCSK_PC1ET2_1	753	755	PF00082	0.689
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.540
CLV_PCSK_SKI1_1	206	210	PF00082	0.370
CLV_PCSK_SKI1_1	234	238	PF00082	0.489
CLV_PCSK_SKI1_1	270	274	PF00082	0.487
CLV_PCSK_SKI1_1	278	282	PF00082	0.329
CLV_PCSK_SKI1_1	365	369	PF00082	0.644
CLV_PCSK_SKI1_1	6	10	PF00082	0.600
CLV_PCSK_SKI1_1	61	65	PF00082	0.682
CLV_PCSK_SKI1_1	720	724	PF00082	0.655
CLV_PCSK_SKI1_1	726	730	PF00082	0.640
CLV_PCSK_SKI1_1	750	754	PF00082	0.670
DEG_APCC_DBOX_1	410	418	PF00400	0.419
DEG_APCC_DBOX_1	587	595	PF00400	0.640
DEG_Nend_Nbox_1	1	3	PF02207	0.535
DOC_CKS1_1	34	39	PF01111	0.497
DOC_CYCLIN_RxL_1	204	211	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	209	215	PF00134	0.413
DOC_MAPK_gen_1	176	185	PF00069	0.440
DOC_MAPK_gen_1	204	210	PF00069	0.529
DOC_MAPK_gen_1	277	285	PF00069	0.538
DOC_MAPK_gen_1	329	336	PF00069	0.313
DOC_MAPK_gen_1	410	417	PF00069	0.366
DOC_MAPK_gen_1	670	677	PF00069	0.666
DOC_MAPK_gen_1	700	710	PF00069	0.636
DOC_MAPK_MEF2A_6	179	187	PF00069	0.460
DOC_MAPK_MEF2A_6	410	417	PF00069	0.427
DOC_MAPK_MEF2A_6	465	474	PF00069	0.302
DOC_MAPK_MEF2A_6	525	533	PF00069	0.556
DOC_MAPK_MEF2A_6	575	583	PF00069	0.477
DOC_PP1_RVXF_1	268	275	PF00149	0.456
DOC_PP2B_LxvP_1	579	582	PF13499	0.472
DOC_PP2B_PxIxI_1	469	475	PF00149	0.195
DOC_PP4_FxxP_1	54	57	PF00568	0.561
DOC_USP7_MATH_1	192	196	PF00917	0.572
DOC_USP7_MATH_1	363	367	PF00917	0.650
DOC_USP7_MATH_1	42	46	PF00917	0.650
DOC_USP7_MATH_1	453	457	PF00917	0.699
DOC_USP7_MATH_1	484	488	PF00917	0.451
DOC_USP7_MATH_1	57	61	PF00917	0.471
DOC_USP7_MATH_1	627	631	PF00917	0.734
DOC_USP7_MATH_1	682	686	PF00917	0.799
DOC_USP7_MATH_1	711	715	PF00917	0.732
DOC_USP7_MATH_1	72	76	PF00917	0.438
DOC_USP7_MATH_1	8	12	PF00917	0.531
DOC_USP7_UBL2_3	5	9	PF12436	0.568
DOC_USP7_UBL2_3	686	690	PF12436	0.574
DOC_USP7_UBL2_3	749	753	PF12436	0.627
DOC_WW_Pin1_4	33	38	PF00397	0.497
DOC_WW_Pin1_4	371	376	PF00397	0.631
LIG_BIR_III_2	518	522	PF00653	0.602
LIG_BIR_III_4	616	620	PF00653	0.762
LIG_BRCT_BRCA1_1	544	548	PF00533	0.303
LIG_Clathr_ClatBox_1	605	609	PF01394	0.683
LIG_FHA_1	166	172	PF00498	0.510
LIG_FHA_1	287	293	PF00498	0.530
LIG_FHA_1	298	304	PF00498	0.474
LIG_FHA_2	230	236	PF00498	0.563
LIG_FHA_2	238	244	PF00498	0.553
LIG_FHA_2	333	339	PF00498	0.325
LIG_FHA_2	428	434	PF00498	0.465
LIG_LIR_Apic_2	52	57	PF02991	0.564
LIG_LIR_Apic_2	523	529	PF02991	0.452
LIG_LIR_Gen_1	260	268	PF02991	0.446
LIG_LIR_Nem_3	260	265	PF02991	0.461
LIG_LIR_Nem_3	485	491	PF02991	0.454
LIG_MAD2	207	215	PF02301	0.504
LIG_PCNA_PIPBox_1	309	318	PF02747	0.480
LIG_Rb_pABgroove_1	655	663	PF01858	0.586
LIG_RPA_C_Fungi	116	128	PF08784	0.588
LIG_SH2_CRK	423	427	PF00017	0.379
LIG_SH2_CRK	488	492	PF00017	0.311
LIG_SH2_SRC	357	360	PF00017	0.506
LIG_SH2_SRC	479	482	PF00017	0.402
LIG_SH2_STAP1	479	483	PF00017	0.335
LIG_SH2_STAT5	138	141	PF00017	0.457
LIG_SH2_STAT5	181	184	PF00017	0.399
LIG_SH2_STAT5	249	252	PF00017	0.308
LIG_SH3_3	209	215	PF00018	0.428
LIG_SH3_3	372	378	PF00018	0.650
LIG_SH3_3	412	418	PF00018	0.546
LIG_SUMO_SIM_anti_2	553	558	PF11976	0.379
LIG_SUMO_SIM_par_1	181	186	PF11976	0.476
LIG_SUMO_SIM_par_1	308	313	PF11976	0.422
LIG_SUMO_SIM_par_1	530	536	PF11976	0.388
LIG_TRAF2_1	612	615	PF00917	0.710
LIG_TRAF2_1	618	621	PF00917	0.762
LIG_TYR_ITIM	477	482	PF00017	0.311
LIG_UBA3_1	272	278	PF00899	0.498
LIG_ULM_U2AF65_1	564	569	PF00076	0.512
MOD_CDK_SPxK_1	33	39	PF00069	0.491
MOD_CDK_SPxxK_3	33	40	PF00069	0.495
MOD_CK1_1	11	17	PF00069	0.393
MOD_CK1_1	186	192	PF00069	0.572
MOD_CK1_1	224	230	PF00069	0.483
MOD_CK1_1	245	251	PF00069	0.372
MOD_CK1_1	366	372	PF00069	0.503
MOD_CK1_1	45	51	PF00069	0.649
MOD_CK1_1	457	463	PF00069	0.660
MOD_CK1_1	706	712	PF00069	0.644
MOD_CK2_1	257	263	PF00069	0.445
MOD_CK2_1	291	297	PF00069	0.343
MOD_CK2_1	332	338	PF00069	0.337
MOD_CK2_1	427	433	PF00069	0.451
MOD_CK2_1	633	639	PF00069	0.665
MOD_Cter_Amidation	507	510	PF01082	0.639
MOD_Cter_Amidation	586	589	PF01082	0.512
MOD_GlcNHglycan	10	13	PF01048	0.541
MOD_GlcNHglycan	175	179	PF01048	0.355
MOD_GlcNHglycan	189	192	PF01048	0.512
MOD_GlcNHglycan	215	218	PF01048	0.436
MOD_GlcNHglycan	43	47	PF01048	0.519
MOD_GlcNHglycan	457	460	PF01048	0.689
MOD_GlcNHglycan	522	525	PF01048	0.719
MOD_GlcNHglycan	572	575	PF01048	0.378
MOD_GlcNHglycan	585	588	PF01048	0.390
MOD_GlcNHglycan	635	639	PF01048	0.683
MOD_GlcNHglycan	65	68	PF01048	0.630
MOD_GlcNHglycan	692	695	PF01048	0.732
MOD_GlcNHglycan	713	716	PF01048	0.681
MOD_GlcNHglycan	723	726	PF01048	0.554
MOD_GlcNHglycan	74	77	PF01048	0.510
MOD_GSK3_1	183	190	PF00069	0.505
MOD_GSK3_1	213	220	PF00069	0.371
MOD_GSK3_1	238	245	PF00069	0.484
MOD_GSK3_1	257	264	PF00069	0.392
MOD_GSK3_1	288	295	PF00069	0.336
MOD_GSK3_1	38	45	PF00069	0.581
MOD_GSK3_1	451	458	PF00069	0.702
MOD_GSK3_1	520	527	PF00069	0.618
MOD_GSK3_1	59	66	PF00069	0.639
MOD_GSK3_1	699	706	PF00069	0.662
MOD_GSK3_1	72	79	PF00069	0.494
MOD_GSK3_1	740	747	PF00069	0.609
MOD_LATS_1	276	282	PF00433	0.402
MOD_N-GLC_1	389	394	PF02516	0.387
MOD_N-GLC_1	76	81	PF02516	0.407
MOD_NEK2_1	131	136	PF00069	0.454
MOD_NEK2_1	187	192	PF00069	0.547
MOD_NEK2_1	237	242	PF00069	0.495
MOD_NEK2_1	255	260	PF00069	0.322
MOD_NEK2_1	389	394	PF00069	0.387
MOD_NEK2_1	583	588	PF00069	0.489
MOD_NEK2_1	738	743	PF00069	0.612
MOD_NEK2_1	83	88	PF00069	0.435
MOD_OFUCOSY	157	162	PF10250	0.398
MOD_PIKK_1	25	31	PF00454	0.551
MOD_PIKK_1	348	354	PF00454	0.379
MOD_PKA_1	329	335	PF00069	0.480
MOD_PKA_2	229	235	PF00069	0.477
MOD_PKA_2	699	705	PF00069	0.682
MOD_PKA_2	711	717	PF00069	0.623
MOD_Plk_1	183	189	PF00069	0.463
MOD_Plk_1	237	243	PF00069	0.499
MOD_Plk_1	363	369	PF00069	0.547
MOD_Plk_1	389	395	PF00069	0.383
MOD_Plk_1	706	712	PF00069	0.636
MOD_Plk_2-3	238	244	PF00069	0.528
MOD_Plk_4	245	251	PF00069	0.361
MOD_Plk_4	288	294	PF00069	0.253
MOD_Plk_4	389	395	PF00069	0.368
MOD_Plk_4	740	746	PF00069	0.498
MOD_ProDKin_1	33	39	PF00069	0.503
MOD_ProDKin_1	371	377	PF00069	0.629
TRG_ENDOCYTIC_2	423	426	PF00928	0.384
TRG_ENDOCYTIC_2	479	482	PF00928	0.297
TRG_ENDOCYTIC_2	488	491	PF00928	0.271
TRG_ER_diArg_1	17	19	PF00400	0.619
TRG_ER_diArg_1	204	206	PF00400	0.575
TRG_ER_diArg_1	563	565	PF00400	0.475
TRG_NLS_Bipartite_1	736	757	PF00514	0.685
TRG_NLS_MonoCore_2	685	690	PF00514	0.611
TRG_NLS_MonoExtC_3	685	690	PF00514	0.570
TRG_NLS_MonoExtC_3	725	730	PF00514	0.648
TRG_NLS_MonoExtN_4	57	62	PF00514	0.595
TRG_NLS_MonoExtN_4	686	693	PF00514	0.594
TRG_NLS_MonoExtN_4	750	757	PF00514	0.577
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A4	Leptomonas seymouri	68%	99%
A0A1X0P8I5	Trypanosomatidae	43%	100%
A0A3S5IQN4	Trypanosoma rangeli	44%	100%
A0A3S7X7G1	Leishmania donovani	91%	99%
A4H7E0	Leishmania braziliensis	80%	100%
A4I9K0	Leishmania infantum	91%	99%
D0A1V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B4J8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BRS0	Trypanosoma cruzi	42%	100%