START domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3H6_LEIMA

TriTrypDb:

LmjF.34.0320 , LMJLV39_340008600 , LMJSD75_340008500

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q3H6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3H6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0008289	lipid binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	7	11	PF00656	0.650
CLV_NRD_NRD_1	247	249	PF00675	0.527
CLV_NRD_NRD_1	284	286	PF00675	0.416
CLV_NRD_NRD_1	346	348	PF00675	0.732
CLV_PCSK_KEX2_1	201	203	PF00082	0.451
CLV_PCSK_KEX2_1	284	286	PF00082	0.416
CLV_PCSK_KEX2_1	346	348	PF00082	0.712
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.487
CLV_PCSK_SKI1_1	122	126	PF00082	0.511
CLV_PCSK_SKI1_1	284	288	PF00082	0.407
CLV_PCSK_SKI1_1	305	309	PF00082	0.704
CLV_PCSK_SKI1_1	346	350	PF00082	0.718
CLV_PCSK_SKI1_1	60	64	PF00082	0.316
CLV_PCSK_SKI1_1	81	85	PF00082	0.629
CLV_PCSK_SKI1_1	96	100	PF00082	0.299
DEG_Nend_Nbox_1	1	3	PF02207	0.579
DOC_PIKK_1	161	169	PF02985	0.577
DOC_PP1_RVXF_1	120	127	PF00149	0.540
DOC_PP1_RVXF_1	351	358	PF00149	0.736
DOC_PP1_RVXF_1	82	89	PF00149	0.571
DOC_PP4_FxxP_1	98	101	PF00568	0.417
DOC_USP7_MATH_1	22	26	PF00917	0.684
DOC_USP7_MATH_1	297	301	PF00917	0.658
DOC_USP7_MATH_1	314	318	PF00917	0.754
DOC_USP7_UBL2_3	14	18	PF12436	0.689
DOC_WW_Pin1_4	116	121	PF00397	0.407
DOC_WW_Pin1_4	256	261	PF00397	0.418
LIG_14-3-3_CanoR_1	110	116	PF00244	0.505
LIG_14-3-3_CanoR_1	135	145	PF00244	0.350
LIG_14-3-3_CanoR_1	183	187	PF00244	0.535
LIG_14-3-3_CanoR_1	248	252	PF00244	0.439
LIG_APCC_ABBAyCdc20_2	284	290	PF00400	0.440
LIG_BRCT_BRCA1_1	104	108	PF00533	0.499
LIG_FHA_1	110	116	PF00498	0.470
LIG_FHA_1	220	226	PF00498	0.550
LIG_FHA_1	264	270	PF00498	0.497
LIG_FHA_1	46	52	PF00498	0.488
LIG_FHA_2	189	195	PF00498	0.312
LIG_FHA_2	213	219	PF00498	0.472
LIG_FHA_2	71	77	PF00498	0.669
LIG_FHA_2	87	93	PF00498	0.564
LIG_LIR_Gen_1	105	115	PF02991	0.453
LIG_LIR_Gen_1	194	203	PF02991	0.363
LIG_LIR_Gen_1	54	63	PF02991	0.514
LIG_LIR_Nem_3	105	111	PF02991	0.433
LIG_LIR_Nem_3	180	184	PF02991	0.503
LIG_LIR_Nem_3	194	198	PF02991	0.365
LIG_LIR_Nem_3	250	254	PF02991	0.469
LIG_LIR_Nem_3	54	59	PF02991	0.518
LIG_Pex14_1	177	181	PF04695	0.481
LIG_Pex14_1	263	267	PF04695	0.457
LIG_Pex14_2	239	243	PF04695	0.465
LIG_Pex14_2	267	271	PF04695	0.446
LIG_PTB_Apo_2	50	57	PF02174	0.496
LIG_PTB_Phospho_1	50	56	PF10480	0.530
LIG_SH2_CRK	145	149	PF00017	0.514
LIG_SH2_CRK	184	188	PF00017	0.553
LIG_SH2_CRK	311	315	PF00017	0.618
LIG_SH2_CRK	56	60	PF00017	0.496
LIG_SH2_NCK_1	145	149	PF00017	0.514
LIG_SH2_NCK_1	184	188	PF00017	0.553
LIG_SH2_SRC	211	214	PF00017	0.354
LIG_SH2_SRC	288	291	PF00017	0.577
LIG_SH2_STAP1	138	142	PF00017	0.415
LIG_SH2_STAP1	145	149	PF00017	0.409
LIG_SH2_STAT5	158	161	PF00017	0.612
LIG_SH2_STAT5	197	200	PF00017	0.378
LIG_SH2_STAT5	211	214	PF00017	0.312
LIG_SH2_STAT5	251	254	PF00017	0.378
LIG_SH3_3	149	155	PF00018	0.524
LIG_SH3_3	25	31	PF00018	0.458
LIG_SUMO_SIM_par_1	111	116	PF11976	0.454
LIG_TYR_ITIM	286	291	PF00017	0.579
LIG_WRC_WIRS_1	123	128	PF05994	0.559
MOD_CDC14_SPxK_1	119	122	PF00782	0.538
MOD_CDK_SPxK_1	116	122	PF00069	0.516
MOD_CK1_1	256	262	PF00069	0.503
MOD_CK1_1	329	335	PF00069	0.743
MOD_CK1_1	72	78	PF00069	0.618
MOD_CK2_1	86	92	PF00069	0.522
MOD_Cter_Amidation	246	249	PF01082	0.452
MOD_GlcNHglycan	184	187	PF01048	0.494
MOD_GlcNHglycan	332	335	PF01048	0.788
MOD_GSK3_1	321	328	PF00069	0.744
MOD_N-GLC_1	116	121	PF02516	0.422
MOD_N-GLC_1	52	57	PF02516	0.531
MOD_N-GLC_2	141	143	PF02516	0.555
MOD_NEK2_1	4	9	PF00069	0.622
MOD_NEK2_1	52	57	PF00069	0.492
MOD_NEK2_1	69	74	PF00069	0.565
MOD_NEK2_2	314	319	PF00069	0.639
MOD_OFUCOSY	252	257	PF10250	0.480
MOD_PKA_2	109	115	PF00069	0.499
MOD_PKA_2	136	142	PF00069	0.464
MOD_PKA_2	182	188	PF00069	0.539
MOD_PKA_2	219	225	PF00069	0.506
MOD_PKA_2	247	253	PF00069	0.458
MOD_PKB_1	135	143	PF00069	0.321
MOD_Plk_1	52	58	PF00069	0.504
MOD_Plk_2-3	61	67	PF00069	0.561
MOD_Plk_4	122	128	PF00069	0.468
MOD_Plk_4	250	256	PF00069	0.369
MOD_Plk_4	263	269	PF00069	0.398
MOD_ProDKin_1	116	122	PF00069	0.411
MOD_ProDKin_1	256	262	PF00069	0.430
MOD_SUMO_rev_2	345	355	PF00179	0.662
TRG_DiLeu_BaEn_1	344	349	PF01217	0.694
TRG_DiLeu_BaEn_4	344	350	PF01217	0.740
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.645
TRG_DiLeu_LyEn_5	344	349	PF01217	0.694
TRG_ENDOCYTIC_2	145	148	PF00928	0.518
TRG_ENDOCYTIC_2	288	291	PF00928	0.577
TRG_ENDOCYTIC_2	56	59	PF00928	0.511
TRG_ER_diArg_1	135	138	PF00400	0.522
TRG_ER_diArg_1	284	286	PF00400	0.418
TRG_ER_diArg_1	346	348	PF00400	0.655
TRG_NES_CRM1_1	164	176	PF08389	0.527
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.709
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	60	65	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4J3	Leptomonas seymouri	70%	100%
A0A0S4KHG7	Bodo saltans	38%	100%
A0A1X0P8H6	Trypanosomatidae	42%	100%
A0A3R7MF23	Trypanosoma rangeli	40%	100%
A0A3S7X7C6	Leishmania donovani	95%	100%
A4H7D8	Leishmania braziliensis	76%	100%
A4I9K2	Leishmania infantum	95%	100%
D0A1W1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B4K0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DIM4	Trypanosoma cruzi	42%	100%