Deoxyhypusine synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

deoxyhypusine synthase

Species:

Leishmania major

UniProt:

Q4Q3H5_LEIMA

TriTrypDb:

LmjF.34.0330 , LMJLV39_340008700 , LMJSD75_340008700

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q3H5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3H5

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008612	peptidyl-lysine modification to peptidyl-hypusine	3	11
GO:0009058	biosynthetic process	2	11
GO:0018193	peptidyl-amino acid modification	5	11
GO:0018205	peptidyl-lysine modification	6	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044238	primary metabolic process	2	11
GO:0051604	protein maturation	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016740	transferase activity	2	5
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	5
GO:0034038	deoxyhypusine synthase activity	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	395	399	PF00656	0.340
CLV_C14_Caspase3-7	519	523	PF00656	0.266
CLV_NRD_NRD_1	193	195	PF00675	0.341
CLV_NRD_NRD_1	417	419	PF00675	0.655
CLV_NRD_NRD_1	437	439	PF00675	0.598
CLV_NRD_NRD_1	568	570	PF00675	0.533
CLV_NRD_NRD_1	578	580	PF00675	0.566
CLV_NRD_NRD_1	64	66	PF00675	0.517
CLV_PCSK_FUR_1	152	156	PF00082	0.363
CLV_PCSK_FUR_1	566	570	PF00082	0.454
CLV_PCSK_KEX2_1	154	156	PF00082	0.368
CLV_PCSK_KEX2_1	193	195	PF00082	0.341
CLV_PCSK_KEX2_1	435	437	PF00082	0.601
CLV_PCSK_KEX2_1	568	570	PF00082	0.537
CLV_PCSK_KEX2_1	577	579	PF00082	0.580
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.368
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.601
CLV_PCSK_SKI1_1	432	436	PF00082	0.611
CLV_PCSK_SKI1_1	568	572	PF00082	0.414
CLV_PCSK_SKI1_1	79	83	PF00082	0.600
CLV_Separin_Metazoa	170	174	PF03568	0.424
DEG_SPOP_SBC_1	440	444	PF00917	0.605
DOC_CKS1_1	406	411	PF01111	0.515
DOC_CYCLIN_yCln2_LP_2	406	412	PF00134	0.564
DOC_CYCLIN_yCln2_LP_2	82	85	PF00134	0.468
DOC_MAPK_gen_1	480	486	PF00069	0.291
DOC_MAPK_RevD_3	555	569	PF00069	0.391
DOC_PP2B_LxvP_1	82	85	PF13499	0.468
DOC_SPAK_OSR1_1	121	125	PF12202	0.466
DOC_USP7_MATH_1	133	137	PF00917	0.575
DOC_USP7_MATH_1	327	331	PF00917	0.484
DOC_USP7_MATH_1	424	428	PF00917	0.595
DOC_USP7_MATH_1	440	444	PF00917	0.602
DOC_USP7_MATH_2	527	533	PF00917	0.266
DOC_USP7_UBL2_3	435	439	PF12436	0.619
DOC_WW_Pin1_4	129	134	PF00397	0.563
DOC_WW_Pin1_4	230	235	PF00397	0.525
DOC_WW_Pin1_4	256	261	PF00397	0.556
DOC_WW_Pin1_4	302	307	PF00397	0.331
DOC_WW_Pin1_4	390	395	PF00397	0.302
DOC_WW_Pin1_4	405	410	PF00397	0.462
DOC_WW_Pin1_4	441	446	PF00397	0.600
LIG_14-3-3_CanoR_1	173	178	PF00244	0.528
LIG_14-3-3_CanoR_1	193	203	PF00244	0.386
LIG_14-3-3_CanoR_1	267	273	PF00244	0.431
LIG_14-3-3_CanoR_1	326	332	PF00244	0.417
LIG_14-3-3_CanoR_1	375	381	PF00244	0.392
LIG_14-3-3_CanoR_1	437	445	PF00244	0.560
LIG_14-3-3_CanoR_1	568	576	PF00244	0.553
LIG_14-3-3_CanoR_1	577	587	PF00244	0.568
LIG_Actin_WH2_2	269	286	PF00022	0.474
LIG_Actin_WH2_2	311	328	PF00022	0.237
LIG_APCC_ABBA_1	543	548	PF00400	0.284
LIG_BIR_II_1	1	5	PF00653	0.406
LIG_BIR_III_2	573	577	PF00653	0.526
LIG_BRCT_BRCA1_1	261	265	PF00533	0.400
LIG_BRCT_BRCA1_1	392	396	PF00533	0.323
LIG_deltaCOP1_diTrp_1	308	316	PF00928	0.421
LIG_DLG_GKlike_1	173	181	PF00625	0.453
LIG_FHA_1	219	225	PF00498	0.509
LIG_FHA_1	362	368	PF00498	0.574
LIG_FHA_1	376	382	PF00498	0.420
LIG_FHA_1	400	406	PF00498	0.492
LIG_FHA_1	480	486	PF00498	0.338
LIG_FHA_1	507	513	PF00498	0.308
LIG_FHA_2	303	309	PF00498	0.374
LIG_FHA_2	447	453	PF00498	0.545
LIG_GBD_Chelix_1	317	325	PF00786	0.429
LIG_GBD_Chelix_1	457	465	PF00786	0.378
LIG_GBD_Chelix_1	55	63	PF00786	0.410
LIG_HCF-1_HBM_1	97	100	PF13415	0.510
LIG_LIR_Apic_2	159	164	PF02991	0.498
LIG_LIR_Apic_2	402	407	PF02991	0.513
LIG_LIR_Gen_1	262	273	PF02991	0.385
LIG_LIR_Gen_1	294	304	PF02991	0.432
LIG_LIR_Gen_1	42	50	PF02991	0.464
LIG_LIR_Gen_1	507	512	PF02991	0.303
LIG_LIR_Gen_1	539	549	PF02991	0.308
LIG_LIR_Gen_1	77	87	PF02991	0.596
LIG_LIR_Nem_3	262	268	PF02991	0.361
LIG_LIR_Nem_3	294	299	PF02991	0.444
LIG_LIR_Nem_3	507	511	PF02991	0.303
LIG_LIR_Nem_3	532	536	PF02991	0.275
LIG_LIR_Nem_3	539	545	PF02991	0.306
LIG_LIR_Nem_3	550	555	PF02991	0.434
LIG_LIR_Nem_3	77	83	PF02991	0.595
LIG_LIR_Nem_3	97	103	PF02991	0.405
LIG_LYPXL_S_1	99	103	PF13949	0.479
LIG_LYPXL_yS_3	100	103	PF13949	0.476
LIG_Pex14_2	392	396	PF04695	0.348
LIG_PTB_Apo_2	248	255	PF02174	0.381
LIG_PTB_Phospho_1	248	254	PF10480	0.383
LIG_SH2_CRK	161	165	PF00017	0.494
LIG_SH2_PTP2	80	83	PF00017	0.512
LIG_SH2_SRC	296	299	PF00017	0.443
LIG_SH2_STAP1	199	203	PF00017	0.481
LIG_SH2_STAP1	204	208	PF00017	0.568
LIG_SH2_STAT3	254	257	PF00017	0.510
LIG_SH2_STAT5	157	160	PF00017	0.468
LIG_SH2_STAT5	199	202	PF00017	0.451
LIG_SH2_STAT5	404	407	PF00017	0.529
LIG_SH2_STAT5	552	555	PF00017	0.374
LIG_SH2_STAT5	80	83	PF00017	0.580
LIG_SH3_1	161	167	PF00018	0.492
LIG_SH3_3	161	167	PF00018	0.553
LIG_SH3_3	23	29	PF00018	0.424
LIG_SH3_3	249	255	PF00018	0.399
LIG_SH3_3	557	563	PF00018	0.356
LIG_SH3_3	78	84	PF00018	0.560
LIG_SUMO_SIM_par_1	553	559	PF11976	0.399
LIG_TRAF2_1	167	170	PF00917	0.454
LIG_TRFH_1	80	84	PF08558	0.516
LIG_UBA3_1	149	154	PF00899	0.484
LIG_WRC_WIRS_1	269	274	PF05994	0.326
MOD_CK1_1	12	18	PF00069	0.486
MOD_CK1_1	214	220	PF00069	0.724
MOD_CK1_1	259	265	PF00069	0.517
MOD_CK1_1	330	336	PF00069	0.573
MOD_CK1_1	390	396	PF00069	0.414
MOD_CK1_1	42	48	PF00069	0.533
MOD_CK1_1	441	447	PF00069	0.652
MOD_CK1_1	479	485	PF00069	0.266
MOD_CK1_1	592	598	PF00069	0.661
MOD_CK2_1	302	308	PF00069	0.381
MOD_CK2_1	446	452	PF00069	0.607
MOD_DYRK1A_RPxSP_1	230	234	PF00069	0.498
MOD_GlcNHglycan	107	110	PF01048	0.259
MOD_GlcNHglycan	12	15	PF01048	0.471
MOD_GlcNHglycan	134	138	PF01048	0.690
MOD_GlcNHglycan	139	142	PF01048	0.620
MOD_GlcNHglycan	183	186	PF01048	0.308
MOD_GlcNHglycan	261	264	PF01048	0.375
MOD_GlcNHglycan	30	33	PF01048	0.427
MOD_GlcNHglycan	336	339	PF01048	0.741
MOD_GlcNHglycan	364	367	PF01048	0.483
MOD_GlcNHglycan	425	429	PF01048	0.522
MOD_GlcNHglycan	590	594	PF01048	0.645
MOD_GlcNHglycan	6	9	PF01048	0.469
MOD_GSK3_1	129	136	PF00069	0.648
MOD_GSK3_1	137	144	PF00069	0.675
MOD_GSK3_1	210	217	PF00069	0.666
MOD_GSK3_1	230	237	PF00069	0.538
MOD_GSK3_1	298	305	PF00069	0.372
MOD_GSK3_1	330	337	PF00069	0.630
MOD_GSK3_1	424	431	PF00069	0.564
MOD_GSK3_1	439	446	PF00069	0.660
MOD_GSK3_1	9	16	PF00069	0.475
MOD_LATS_1	417	423	PF00433	0.610
MOD_NEK2_1	10	15	PF00069	0.434
MOD_NEK2_1	105	110	PF00069	0.328
MOD_NEK2_1	111	116	PF00069	0.302
MOD_NEK2_1	268	273	PF00069	0.438
MOD_NEK2_1	48	53	PF00069	0.378
MOD_NEK2_1	55	60	PF00069	0.429
MOD_PIKK_1	21	27	PF00454	0.446
MOD_PK_1	419	425	PF00069	0.608
MOD_PKA_1	438	444	PF00069	0.588
MOD_PKA_1	568	574	PF00069	0.450
MOD_PKA_1	578	584	PF00069	0.591
MOD_PKA_2	376	382	PF00069	0.418
MOD_PKA_2	568	574	PF00069	0.450
MOD_PKA_2	578	584	PF00069	0.588
MOD_PKB_1	436	444	PF00069	0.590
MOD_PKB_1	566	574	PF00069	0.432
MOD_PKB_1	577	585	PF00069	0.514
MOD_Plk_1	399	405	PF00069	0.361
MOD_Plk_1	506	512	PF00069	0.308
MOD_Plk_1	547	553	PF00069	0.273
MOD_Plk_4	173	179	PF00069	0.469
MOD_Plk_4	376	382	PF00069	0.318
MOD_Plk_4	387	393	PF00069	0.371
MOD_Plk_4	400	406	PF00069	0.476
MOD_Plk_4	548	554	PF00069	0.317
MOD_ProDKin_1	129	135	PF00069	0.575
MOD_ProDKin_1	230	236	PF00069	0.522
MOD_ProDKin_1	256	262	PF00069	0.547
MOD_ProDKin_1	302	308	PF00069	0.330
MOD_ProDKin_1	390	396	PF00069	0.301
MOD_ProDKin_1	405	411	PF00069	0.473
MOD_ProDKin_1	441	447	PF00069	0.600
MOD_SUMO_for_1	153	156	PF00179	0.491
MOD_SUMO_for_1	525	528	PF00179	0.399
TRG_DiLeu_BaEn_1	6	11	PF01217	0.525
TRG_DiLeu_BaEn_2	117	123	PF01217	0.342
TRG_DiLeu_BaLyEn_6	551	556	PF01217	0.266
TRG_ENDOCYTIC_2	100	103	PF00928	0.476
TRG_ENDOCYTIC_2	296	299	PF00928	0.442
TRG_ENDOCYTIC_2	43	46	PF00928	0.370
TRG_ENDOCYTIC_2	546	549	PF00928	0.307
TRG_ENDOCYTIC_2	552	555	PF00928	0.336
TRG_ENDOCYTIC_2	80	83	PF00928	0.580
TRG_ER_diArg_1	192	194	PF00400	0.360
TRG_ER_diArg_1	436	438	PF00400	0.533
TRG_ER_diArg_1	565	568	PF00400	0.499
TRG_ER_diArg_1	576	579	PF00400	0.739
TRG_NLS_Bipartite_1	418	439	PF00514	0.586
TRG_NLS_MonoCore_2	434	439	PF00514	0.530
TRG_NLS_MonoExtC_3	434	439	PF00514	0.596
TRG_NLS_MonoExtN_4	432	439	PF00514	0.592
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXU4	Leptomonas seymouri	55%	100%
A0A1X0P8R7	Trypanosomatidae	37%	100%
A0A3Q8IH77	Leishmania donovani	93%	100%
A0A422NFI0	Trypanosoma rangeli	37%	100%
A4HAE7	Leishmania braziliensis	75%	100%
A4I9K3	Leishmania infantum	93%	100%
B5APK2	Leishmania donovani	93%	100%
D0A1W5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B4K1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q38BX0	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	38%	100%
V5BRS6	Trypanosoma cruzi	37%	100%