AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATPase family associated with various cellular activities (AAA), putative

Species:

Leishmania major

UniProt:

Q4Q3H4_LEIMA

TriTrypDb:

LmjF.34.0340 , LMJLV39_340008800 , LMJSD75_340008800

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4Q3H4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3H4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0016887	ATP hydrolysis activity	7	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	606	610	PF00656	0.709
CLV_C14_Caspase3-7	636	640	PF00656	0.713
CLV_C14_Caspase3-7	641	645	PF00656	0.710
CLV_C14_Caspase3-7	793	797	PF00656	0.631
CLV_NRD_NRD_1	215	217	PF00675	0.442
CLV_NRD_NRD_1	290	292	PF00675	0.447
CLV_NRD_NRD_1	341	343	PF00675	0.392
CLV_NRD_NRD_1	423	425	PF00675	0.430
CLV_NRD_NRD_1	509	511	PF00675	0.269
CLV_NRD_NRD_1	582	584	PF00675	0.433
CLV_NRD_NRD_1	742	744	PF00675	0.376
CLV_PCSK_FUR_1	189	193	PF00082	0.458
CLV_PCSK_KEX2_1	191	193	PF00082	0.536
CLV_PCSK_KEX2_1	215	217	PF00082	0.454
CLV_PCSK_KEX2_1	290	292	PF00082	0.447
CLV_PCSK_KEX2_1	343	345	PF00082	0.500
CLV_PCSK_KEX2_1	509	511	PF00082	0.269
CLV_PCSK_KEX2_1	742	744	PF00082	0.376
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.505
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.500
CLV_PCSK_SKI1_1	126	130	PF00082	0.391
CLV_PCSK_SKI1_1	28	32	PF00082	0.368
CLV_PCSK_SKI1_1	425	429	PF00082	0.465
CLV_PCSK_SKI1_1	43	47	PF00082	0.368
CLV_PCSK_SKI1_1	754	758	PF00082	0.366
DEG_APCC_DBOX_1	332	340	PF00400	0.619
DEG_APCC_DBOX_1	508	516	PF00400	0.469
DEG_Nend_UBRbox_2	1	3	PF02207	0.493
DOC_ANK_TNKS_1	474	481	PF00023	0.573
DOC_CDC14_PxL_1	348	356	PF14671	0.660
DOC_MAPK_gen_1	342	350	PF00069	0.642
DOC_MAPK_gen_1	447	456	PF00069	0.592
DOC_MAPK_gen_1	506	515	PF00069	0.479
DOC_MAPK_gen_1	544	553	PF00069	0.649
DOC_MAPK_MEF2A_6	509	517	PF00069	0.469
DOC_PP1_RVXF_1	482	488	PF00149	0.515
DOC_PP2B_LxvP_1	678	681	PF13499	0.586
DOC_PP4_FxxP_1	273	276	PF00568	0.717
DOC_PP4_FxxP_1	476	479	PF00568	0.595
DOC_SPAK_OSR1_1	475	479	PF12202	0.565
DOC_USP7_MATH_1	316	320	PF00917	0.661
DOC_USP7_MATH_1	389	393	PF00917	0.667
DOC_USP7_MATH_1	399	403	PF00917	0.660
DOC_USP7_MATH_1	414	418	PF00917	0.703
DOC_USP7_MATH_1	555	559	PF00917	0.535
DOC_USP7_MATH_1	616	620	PF00917	0.721
DOC_USP7_MATH_1	701	705	PF00917	0.600
DOC_USP7_UBL2_3	409	413	PF12436	0.642
DOC_WD40_RPTOR_TOS_1	533	539	PF00400	0.611
DOC_WW_Pin1_4	119	124	PF00397	0.585
DOC_WW_Pin1_4	3	8	PF00397	0.394
DOC_WW_Pin1_4	426	431	PF00397	0.619
DOC_WW_Pin1_4	614	619	PF00397	0.737
LIG_14-3-3_CanoR_1	124	129	PF00244	0.645
LIG_14-3-3_CanoR_1	131	141	PF00244	0.600
LIG_14-3-3_CanoR_1	28	33	PF00244	0.265
LIG_14-3-3_CanoR_1	424	430	PF00244	0.648
LIG_14-3-3_CanoR_1	43	49	PF00244	0.605
LIG_14-3-3_CanoR_1	447	452	PF00244	0.612
LIG_14-3-3_CanoR_1	461	466	PF00244	0.475
LIG_14-3-3_CanoR_1	484	488	PF00244	0.552
LIG_14-3-3_CanoR_1	788	793	PF00244	0.610
LIG_Actin_WH2_2	522	540	PF00022	0.592
LIG_AP2alpha_1	671	675	PF02296	0.527
LIG_APCC_ABBA_1	372	377	PF00400	0.643
LIG_APCC_ABBA_1	559	564	PF00400	0.512
LIG_APCC_ABBAyCdc20_2	110	116	PF00400	0.654
LIG_BIR_III_4	566	570	PF00653	0.530
LIG_BRCT_BRCA1_1	104	108	PF00533	0.642
LIG_BRCT_BRCA1_1	110	114	PF00533	0.633
LIG_BRCT_BRCA1_1	121	125	PF00533	0.588
LIG_BRCT_BRCA1_1	269	273	PF00533	0.761
LIG_BRCT_BRCA1_1	402	406	PF00533	0.669
LIG_BRCT_BRCA1_1	452	456	PF00533	0.527
LIG_BRCT_BRCA1_2	104	110	PF00533	0.621
LIG_CaM_IQ_9	575	591	PF13499	0.609
LIG_CAP-Gly_1	793	801	PF01302	0.655
LIG_CtBP_PxDLS_1	658	662	PF00389	0.609
LIG_deltaCOP1_diTrp_1	115	125	PF00928	0.678
LIG_eIF4E_1	102	108	PF01652	0.659
LIG_FHA_1	458	464	PF00498	0.530
LIG_FHA_1	484	490	PF00498	0.563
LIG_FHA_1	496	502	PF00498	0.427
LIG_FHA_1	648	654	PF00498	0.672
LIG_FHA_1	719	725	PF00498	0.518
LIG_FHA_1	784	790	PF00498	0.531
LIG_FHA_2	264	270	PF00498	0.707
LIG_FHA_2	520	526	PF00498	0.469
LIG_FXI_DFP_1	562	566	PF00024	0.316
LIG_GBD_Chelix_1	504	512	PF00786	0.269
LIG_HCF-1_HBM_1	725	728	PF13415	0.584
LIG_LIR_Apic_2	270	276	PF02991	0.822
LIG_LIR_Apic_2	288	292	PF02991	0.593
LIG_LIR_Gen_1	101	108	PF02991	0.611
LIG_LIR_Gen_1	450	457	PF02991	0.577
LIG_LIR_Gen_1	563	571	PF02991	0.555
LIG_LIR_Gen_1	669	678	PF02991	0.541
LIG_LIR_Gen_1	682	688	PF02991	0.526
LIG_LIR_Nem_3	101	107	PF02991	0.611
LIG_LIR_Nem_3	115	121	PF02991	0.634
LIG_LIR_Nem_3	122	128	PF02991	0.598
LIG_LIR_Nem_3	379	385	PF02991	0.652
LIG_LIR_Nem_3	450	454	PF02991	0.535
LIG_LIR_Nem_3	486	490	PF02991	0.437
LIG_LIR_Nem_3	563	568	PF02991	0.545
LIG_LIR_Nem_3	570	575	PF02991	0.550
LIG_LIR_Nem_3	669	674	PF02991	0.534
LIG_LIR_Nem_3	682	687	PF02991	0.528
LIG_LYPXL_L_2	350	359	PF13949	0.592
LIG_LYPXL_S_1	350	354	PF13949	0.461
LIG_LYPXL_yS_3	351	354	PF13949	0.662
LIG_MLH1_MIPbox_1	269	273	PF16413	0.730
LIG_MLH1_MIPbox_1	452	456	PF16413	0.527
LIG_NRBOX	12	18	PF00104	0.325
LIG_PDZ_Class_3	796	801	PF00595	0.715
LIG_Pex14_1	37	41	PF04695	0.545
LIG_Pex14_1	44	48	PF04695	0.534
LIG_Pex14_2	114	118	PF04695	0.630
LIG_Pex14_2	125	129	PF04695	0.615
LIG_Pex14_2	30	34	PF04695	0.296
LIG_Pex14_2	40	44	PF04695	0.574
LIG_Pex14_2	451	455	PF04695	0.530
LIG_Pex14_2	671	675	PF04695	0.527
LIG_Pex14_2	684	688	PF04695	0.513
LIG_REV1ctd_RIR_1	38	47	PF16727	0.548
LIG_SH2_CRK	104	108	PF00017	0.618
LIG_SH2_CRK	289	293	PF00017	0.641
LIG_SH2_CRK	490	494	PF00017	0.516
LIG_SH2_PTP2	371	374	PF00017	0.613
LIG_SH2_SRC	102	105	PF00017	0.605
LIG_SH2_SRC	371	374	PF00017	0.598
LIG_SH2_STAP1	102	106	PF00017	0.608
LIG_SH2_STAP1	217	221	PF00017	0.646
LIG_SH2_STAP1	728	732	PF00017	0.593
LIG_SH2_STAT5	335	338	PF00017	0.614
LIG_SH2_STAT5	371	374	PF00017	0.674
LIG_SH2_STAT5	383	386	PF00017	0.594
LIG_SH2_STAT5	48	51	PF00017	0.575
LIG_SH2_STAT5	560	563	PF00017	0.521
LIG_SH2_STAT5	78	81	PF00017	0.592
LIG_SH3_3	1	7	PF00018	0.431
LIG_SH3_3	117	123	PF00018	0.584
LIG_SH3_3	239	245	PF00018	0.827
LIG_SH3_3	273	279	PF00018	0.710
LIG_SH3_3	346	352	PF00018	0.660
LIG_SH3_3	526	532	PF00018	0.566
LIG_SUMO_SIM_anti_2	281	288	PF11976	0.702
LIG_SUMO_SIM_par_1	281	288	PF11976	0.702
LIG_SUMO_SIM_par_1	511	516	PF11976	0.469
LIG_SUMO_SIM_par_1	518	525	PF11976	0.469
LIG_TRAF2_1	279	282	PF00917	0.654
LIG_TYR_ITIM	349	354	PF00017	0.662
LIG_UBA3_1	355	361	PF00899	0.593
MOD_CDK_SPK_2	119	124	PF00069	0.585
MOD_CDK_SPxxK_3	119	126	PF00069	0.583
MOD_CK1_1	177	183	PF00069	0.723
MOD_CK1_1	261	267	PF00069	0.728
MOD_CK1_1	268	274	PF00069	0.696
MOD_CK1_1	304	310	PF00069	0.719
MOD_CK1_1	392	398	PF00069	0.660
MOD_CK1_1	402	408	PF00069	0.684
MOD_CK1_1	443	449	PF00069	0.670
MOD_CK1_1	594	600	PF00069	0.655
MOD_CK1_1	6	12	PF00069	0.411
MOD_CK1_1	617	623	PF00069	0.768
MOD_CK1_1	626	632	PF00069	0.787
MOD_CK1_1	791	797	PF00069	0.626
MOD_CK2_1	263	269	PF00069	0.708
MOD_CK2_1	513	519	PF00069	0.469
MOD_CK2_1	653	659	PF00069	0.633
MOD_CK2_1	745	751	PF00069	0.495
MOD_Cter_Amidation	189	192	PF01082	0.537
MOD_Cter_Amidation	740	743	PF01082	0.387
MOD_GlcNHglycan	318	321	PF01048	0.472
MOD_GlcNHglycan	377	381	PF01048	0.418
MOD_GlcNHglycan	386	389	PF01048	0.433
MOD_GlcNHglycan	402	405	PF01048	0.411
MOD_GlcNHglycan	597	600	PF01048	0.511
MOD_GlcNHglycan	620	623	PF01048	0.623
MOD_GlcNHglycan	625	628	PF01048	0.625
MOD_GlcNHglycan	767	770	PF01048	0.312
MOD_GlcNHglycan	8	11	PF01048	0.611
MOD_GSK3_1	137	144	PF00069	0.702
MOD_GSK3_1	177	184	PF00069	0.697
MOD_GSK3_1	258	265	PF00069	0.725
MOD_GSK3_1	400	407	PF00069	0.675
MOD_GSK3_1	414	421	PF00069	0.692
MOD_GSK3_1	443	450	PF00069	0.602
MOD_GSK3_1	457	464	PF00069	0.477
MOD_GSK3_1	492	499	PF00069	0.469
MOD_GSK3_1	515	522	PF00069	0.516
MOD_GSK3_1	591	598	PF00069	0.613
MOD_GSK3_1	610	617	PF00069	0.712
MOD_GSK3_1	761	768	PF00069	0.572
MOD_GSK3_1	788	795	PF00069	0.601
MOD_N-GLC_1	262	267	PF02516	0.480
MOD_N-GLC_1	302	307	PF02516	0.459
MOD_NEK2_1	137	142	PF00069	0.636
MOD_NEK2_1	210	215	PF00069	0.672
MOD_NEK2_1	591	596	PF00069	0.620
MOD_NEK2_1	653	658	PF00069	0.655
MOD_NEK2_1	699	704	PF00069	0.733
MOD_NEK2_1	706	711	PF00069	0.548
MOD_NEK2_1	71	76	PF00069	0.603
MOD_NEK2_1	745	750	PF00069	0.527
MOD_NEK2_2	404	409	PF00069	0.642
MOD_NEK2_2	483	488	PF00069	0.555
MOD_NEK2_2	555	560	PF00069	0.527
MOD_PIKK_1	177	183	PF00454	0.723
MOD_PIKK_1	263	269	PF00454	0.829
MOD_PIKK_1	295	301	PF00454	0.645
MOD_PIKK_1	314	320	PF00454	0.570
MOD_PIKK_1	610	616	PF00454	0.734
MOD_PIKK_1	718	724	PF00454	0.571
MOD_PIKK_1	745	751	PF00454	0.525
MOD_PK_1	743	749	PF00069	0.601
MOD_PK_1	788	794	PF00069	0.618
MOD_PKA_2	174	180	PF00069	0.723
MOD_PKA_2	483	489	PF00069	0.553
MOD_PKA_2	602	608	PF00069	0.815
MOD_PKA_2	647	653	PF00069	0.673
MOD_Plk_1	102	108	PF00069	0.598
MOD_Plk_1	268	274	PF00069	0.706
MOD_Plk_1	392	398	PF00069	0.624
MOD_Plk_1	415	421	PF00069	0.674
MOD_Plk_1	706	712	PF00069	0.539
MOD_Plk_1	733	739	PF00069	0.698
MOD_Plk_2-3	519	525	PF00069	0.455
MOD_Plk_2-3	635	641	PF00069	0.692
MOD_Plk_2-3	664	670	PF00069	0.599
MOD_Plk_2-3	733	739	PF00069	0.569
MOD_Plk_4	102	108	PF00069	0.598
MOD_Plk_4	137	143	PF00069	0.692
MOD_Plk_4	268	274	PF00069	0.698
MOD_Plk_4	350	356	PF00069	0.612
MOD_Plk_4	415	421	PF00069	0.654
MOD_Plk_4	44	50	PF00069	0.623
MOD_Plk_4	450	456	PF00069	0.528
MOD_Plk_4	461	467	PF00069	0.525
MOD_Plk_4	483	489	PF00069	0.584
MOD_Plk_4	496	502	PF00069	0.476
MOD_Plk_4	555	561	PF00069	0.525
MOD_Plk_4	647	653	PF00069	0.673
MOD_Plk_4	680	686	PF00069	0.533
MOD_Plk_4	701	707	PF00069	0.618
MOD_Plk_4	9	15	PF00069	0.263
MOD_ProDKin_1	119	125	PF00069	0.583
MOD_ProDKin_1	3	9	PF00069	0.394
MOD_ProDKin_1	426	432	PF00069	0.619
MOD_ProDKin_1	614	620	PF00069	0.735
MOD_SUMO_rev_2	269	279	PF00179	0.701
TRG_DiLeu_BaEn_2	151	157	PF01217	0.628
TRG_DiLeu_BaLyEn_6	695	700	PF01217	0.558
TRG_ENDOCYTIC_2	104	107	PF00928	0.620
TRG_ENDOCYTIC_2	351	354	PF00928	0.662
TRG_ENDOCYTIC_2	382	385	PF00928	0.647
TRG_ENDOCYTIC_2	42	45	PF00928	0.594
TRG_ER_diArg_1	214	216	PF00400	0.652
TRG_ER_diArg_1	289	291	PF00400	0.645
TRG_ER_diArg_1	473	476	PF00400	0.562
TRG_ER_diArg_1	508	510	PF00400	0.469
TRG_Pf-PMV_PEXEL_1	291	296	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	583	587	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDZ4	Leptomonas seymouri	50%	97%
A0A3Q8IUC9	Leishmania donovani	91%	100%
A4HAE8	Leishmania braziliensis	67%	100%
A4I9K4	Leishmania infantum	91%	100%
E9B4K2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%