Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q3H0_LEIMA

TriTrypDb:

LmjF.34.0380 , LMJLV39_340009200 , LMJSD75_340009200

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 4
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3H0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3H0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	407	411	PF00656	0.500
CLV_NRD_NRD_1	106	108	PF00675	0.535
CLV_NRD_NRD_1	138	140	PF00675	0.607
CLV_NRD_NRD_1	317	319	PF00675	0.604
CLV_NRD_NRD_1	508	510	PF00675	0.682
CLV_PCSK_KEX2_1	106	108	PF00082	0.535
CLV_PCSK_KEX2_1	138	140	PF00082	0.607
CLV_PCSK_SKI1_1	132	136	PF00082	0.677
CLV_PCSK_SKI1_1	308	312	PF00082	0.563
CLV_PCSK_SKI1_1	476	480	PF00082	0.629
DEG_APCC_DBOX_1	299	307	PF00400	0.468
DEG_COP1_1	250	259	PF00400	0.506
DEG_Nend_UBRbox_4	1	3	PF02207	0.720
DEG_ODPH_VHL_1	11	22	PF01847	0.361
DEG_SCF_TRCP1_1	69	74	PF00400	0.357
DOC_MAPK_DCC_7	255	265	PF00069	0.462
DOC_MAPK_DCC_7	7	16	PF00069	0.547
DOC_MAPK_gen_1	337	343	PF00069	0.434
DOC_MAPK_gen_1	7	16	PF00069	0.520
DOC_MAPK_MEF2A_6	10	18	PF00069	0.518
DOC_PP1_RVXF_1	306	312	PF00149	0.436
DOC_USP7_MATH_1	112	116	PF00917	0.360
DOC_USP7_MATH_1	23	27	PF00917	0.395
DOC_USP7_MATH_1	362	366	PF00917	0.463
DOC_USP7_MATH_1	430	434	PF00917	0.461
DOC_USP7_MATH_1	441	445	PF00917	0.371
DOC_USP7_MATH_1	52	56	PF00917	0.454
DOC_USP7_MATH_1	560	564	PF00917	0.453
DOC_WW_Pin1_4	1	6	PF00397	0.680
DOC_WW_Pin1_4	154	159	PF00397	0.406
DOC_WW_Pin1_4	250	255	PF00397	0.494
DOC_WW_Pin1_4	258	263	PF00397	0.397
DOC_WW_Pin1_4	484	489	PF00397	0.427
LIG_14-3-3_CanoR_1	285	294	PF00244	0.480
LIG_14-3-3_CanoR_1	455	464	PF00244	0.323
LIG_14-3-3_CanoR_1	509	516	PF00244	0.390
LIG_14-3-3_CterR_2	569	572	PF00244	0.525
LIG_BIR_III_4	44	48	PF00653	0.487
LIG_BRCT_BRCA1_1	432	436	PF00533	0.400
LIG_BRCT_BRCA1_1	549	553	PF00533	0.320
LIG_BRCT_BRCA1_1	69	73	PF00533	0.411
LIG_CtBP_PxDLS_1	262	266	PF00389	0.406
LIG_EH1_1	110	118	PF00400	0.361
LIG_FHA_1	117	123	PF00498	0.377
LIG_FHA_1	129	135	PF00498	0.382
LIG_FHA_1	187	193	PF00498	0.560
LIG_FHA_1	271	277	PF00498	0.401
LIG_FHA_1	281	287	PF00498	0.431
LIG_FHA_1	393	399	PF00498	0.408
LIG_FHA_1	420	426	PF00498	0.459
LIG_FHA_1	544	550	PF00498	0.353
LIG_FHA_1	87	93	PF00498	0.367
LIG_FHA_1	97	103	PF00498	0.349
LIG_FHA_2	369	375	PF00498	0.377
LIG_FHA_2	380	386	PF00498	0.433
LIG_FHA_2	443	449	PF00498	0.424
LIG_Integrin_isoDGR_2	46	48	PF01839	0.703
LIG_LIR_LC3C_4	115	118	PF02991	0.342
LIG_LIR_Nem_3	458	463	PF02991	0.365
LIG_MLH1_MIPbox_1	549	553	PF16413	0.320
LIG_NBox_RRM_1	538	548	PF00076	0.334
LIG_PTB_Apo_2	532	539	PF02174	0.440
LIG_PTB_Apo_2	548	555	PF02174	0.283
LIG_REV1ctd_RIR_1	551	561	PF16727	0.360
LIG_SH2_PTP2	469	472	PF00017	0.399
LIG_SH2_SRC	469	472	PF00017	0.436
LIG_SH2_STAP1	143	147	PF00017	0.384
LIG_SH2_STAT5	104	107	PF00017	0.328
LIG_SH2_STAT5	124	127	PF00017	0.398
LIG_SH2_STAT5	275	278	PF00017	0.440
LIG_SH2_STAT5	388	391	PF00017	0.435
LIG_SH2_STAT5	469	472	PF00017	0.392
LIG_SH2_STAT5	516	519	PF00017	0.441
LIG_SH2_STAT5	552	555	PF00017	0.334
LIG_SH2_STAT5	96	99	PF00017	0.409
LIG_SH3_1	327	333	PF00018	0.401
LIG_SH3_1	361	367	PF00018	0.449
LIG_SH3_1	412	418	PF00018	0.511
LIG_SH3_2	5	10	PF14604	0.670
LIG_SH3_3	2	8	PF00018	0.677
LIG_SH3_3	251	257	PF00018	0.500
LIG_SH3_3	327	333	PF00018	0.401
LIG_SH3_3	33	39	PF00018	0.458
LIG_SH3_3	361	367	PF00018	0.447
LIG_SH3_3	412	418	PF00018	0.485
LIG_SH3_3	465	471	PF00018	0.423
LIG_SUMO_SIM_par_1	261	267	PF11976	0.369
LIG_TRAF2_1	177	180	PF00917	0.523
LIG_TRAF2_1	414	417	PF00917	0.506
LIG_TRAF2_1	85	88	PF00917	0.350
MOD_CDC14_SPxK_1	4	7	PF00782	0.531
MOD_CDK_SPK_2	250	255	PF00069	0.626
MOD_CDK_SPK_2	484	489	PF00069	0.562
MOD_CDK_SPxK_1	1	7	PF00069	0.541
MOD_CK1_1	154	160	PF00069	0.469
MOD_CK1_1	174	180	PF00069	0.611
MOD_CK1_1	231	237	PF00069	0.495
MOD_CK1_1	264	270	PF00069	0.410
MOD_CK1_1	289	295	PF00069	0.740
MOD_CK1_1	298	304	PF00069	0.630
MOD_CK1_1	365	371	PF00069	0.478
MOD_CK1_1	558	564	PF00069	0.605
MOD_CK2_1	174	180	PF00069	0.648
MOD_CK2_1	278	284	PF00069	0.490
MOD_CK2_1	368	374	PF00069	0.444
MOD_CK2_1	379	385	PF00069	0.524
MOD_CK2_1	436	442	PF00069	0.455
MOD_CK2_1	523	529	PF00069	0.507
MOD_GlcNHglycan	364	367	PF01048	0.519
MOD_GlcNHglycan	476	479	PF01048	0.540
MOD_GlcNHglycan	510	513	PF01048	0.567
MOD_GlcNHglycan	52	55	PF01048	0.701
MOD_GlcNHglycan	560	563	PF01048	0.569
MOD_GlcNHglycan	69	72	PF01048	0.459
MOD_GlcNHglycan	73	76	PF01048	0.529
MOD_GSK3_1	112	119	PF00069	0.397
MOD_GSK3_1	124	131	PF00069	0.498
MOD_GSK3_1	150	157	PF00069	0.439
MOD_GSK3_1	163	170	PF00069	0.569
MOD_GSK3_1	264	271	PF00069	0.433
MOD_GSK3_1	276	283	PF00069	0.562
MOD_GSK3_1	294	301	PF00069	0.702
MOD_GSK3_1	419	426	PF00069	0.469
MOD_GSK3_1	543	550	PF00069	0.444
MOD_GSK3_1	67	74	PF00069	0.461
MOD_GSK3_1	86	93	PF00069	0.423
MOD_N-GLC_1	166	171	PF02516	0.570
MOD_N-GLC_1	423	428	PF02516	0.397
MOD_N-GLC_1	534	539	PF02516	0.460
MOD_NEK2_1	116	121	PF00069	0.424
MOD_NEK2_1	150	155	PF00069	0.426
MOD_NEK2_1	200	205	PF00069	0.520
MOD_NEK2_1	228	233	PF00069	0.549
MOD_NEK2_1	276	281	PF00069	0.511
MOD_NEK2_1	436	441	PF00069	0.424
MOD_NEK2_1	508	513	PF00069	0.574
MOD_NEK2_1	547	552	PF00069	0.394
MOD_NEK2_1	86	91	PF00069	0.558
MOD_PIKK_1	231	237	PF00454	0.541
MOD_PIKK_1	286	292	PF00454	0.570
MOD_PIKK_1	392	398	PF00454	0.467
MOD_PIKK_1	419	425	PF00454	0.574
MOD_PIKK_1	86	92	PF00454	0.484
MOD_PKA_2	286	292	PF00069	0.570
MOD_PKA_2	508	514	PF00069	0.573
MOD_Plk_1	166	172	PF00069	0.573
MOD_Plk_1	423	429	PF00069	0.539
MOD_Plk_1	534	540	PF00069	0.453
MOD_Plk_1	86	92	PF00069	0.440
MOD_Plk_4	12	18	PF00069	0.341
MOD_Plk_4	23	29	PF00069	0.307
MOD_Plk_4	32	38	PF00069	0.535
MOD_Plk_4	365	371	PF00069	0.462
MOD_Plk_4	543	549	PF00069	0.476
MOD_Plk_4	60	66	PF00069	0.553
MOD_Plk_4	78	84	PF00069	0.334
MOD_ProDKin_1	1	7	PF00069	0.585
MOD_ProDKin_1	154	160	PF00069	0.490
MOD_ProDKin_1	250	256	PF00069	0.596
MOD_ProDKin_1	258	264	PF00069	0.453
MOD_ProDKin_1	484	490	PF00069	0.503
MOD_SUMO_for_1	183	186	PF00179	0.675
MOD_SUMO_for_1	494	497	PF00179	0.548
MOD_SUMO_rev_2	407	414	PF00179	0.619
TRG_DiLeu_BaEn_1	78	83	PF01217	0.432
TRG_DiLeu_BaEn_2	431	437	PF01217	0.414
TRG_DiLeu_BaEn_2	528	534	PF01217	0.449
TRG_DiLeu_BaEn_2	542	548	PF01217	0.290
TRG_DiLeu_BaEn_4	87	93	PF01217	0.406
TRG_ENDOCYTIC_2	145	148	PF00928	0.380
TRG_ER_diArg_1	105	107	PF00400	0.343
TRG_ER_diArg_1	137	139	PF00400	0.461
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P8	Leptomonas seymouri	54%	100%
A0A3Q8IF83	Leishmania donovani	91%	100%
A4HAF2	Leishmania braziliensis	76%	100%
A4I9K8	Leishmania infantum	92%	100%
A4I9K9	Leishmania infantum	25%	99%
E9B4K6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%