Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3G7_LEIMA

TriTrypDb:

LmjF.34.0410 , LMJLV39_340009500 , LMJSD75_340009500

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3G7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3G7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	390	392	PF00675	0.614
CLV_NRD_NRD_1	84	86	PF00675	0.512
CLV_NRD_NRD_1	92	94	PF00675	0.499
CLV_PCSK_KEX2_1	92	94	PF00082	0.506
CLV_PCSK_SKI1_1	103	107	PF00082	0.515
CLV_PCSK_SKI1_1	244	248	PF00082	0.371
CLV_PCSK_SKI1_1	260	264	PF00082	0.482
CLV_PCSK_SKI1_1	63	67	PF00082	0.472
CLV_Separin_Metazoa	60	64	PF03568	0.447
DEG_APCC_KENBOX_2	310	314	PF00400	0.553
DOC_CDC14_PxL_1	245	253	PF14671	0.443
DOC_USP7_MATH_1	116	120	PF00917	0.518
DOC_USP7_MATH_1	185	189	PF00917	0.550
DOC_USP7_MATH_1	213	217	PF00917	0.502
DOC_USP7_MATH_1	3	7	PF00917	0.588
DOC_WW_Pin1_4	278	283	PF00397	0.592
DOC_WW_Pin1_4	398	403	PF00397	0.651
LIG_14-3-3_CanoR_1	63	68	PF00244	0.537
LIG_14-3-3_CanoR_1	92	100	PF00244	0.555
LIG_Actin_WH2_2	324	341	PF00022	0.501
LIG_Actin_WH2_2	33	49	PF00022	0.494
LIG_BIR_II_1	1	5	PF00653	0.619
LIG_eIF4E_1	240	246	PF01652	0.411
LIG_FHA_1	149	155	PF00498	0.443
LIG_FHA_1	192	198	PF00498	0.432
LIG_FHA_1	245	251	PF00498	0.434
LIG_FHA_1	316	322	PF00498	0.558
LIG_FHA_1	388	394	PF00498	0.582
LIG_FHA_2	184	190	PF00498	0.429
LIG_FHA_2	202	208	PF00498	0.422
LIG_FHA_2	271	277	PF00498	0.577
LIG_LIR_Apic_2	139	144	PF02991	0.479
LIG_LIR_Gen_1	178	185	PF02991	0.447
LIG_LIR_Nem_3	178	183	PF02991	0.468
LIG_MYND_1	57	61	PF01753	0.471
LIG_Pex14_2	180	184	PF04695	0.441
LIG_Pex14_2	78	82	PF04695	0.431
LIG_Rb_LxCxE_1	119	133	PF01857	0.464
LIG_REV1ctd_RIR_1	181	191	PF16727	0.454
LIG_SH2_NCK_1	124	128	PF00017	0.450
LIG_SH2_NCK_1	67	71	PF00017	0.518
LIG_SH2_PTP2	141	144	PF00017	0.479
LIG_SH2_SRC	124	127	PF00017	0.445
LIG_SH2_STAP1	367	371	PF00017	0.522
LIG_SH2_STAT5	141	144	PF00017	0.554
LIG_SH2_STAT5	179	182	PF00017	0.442
LIG_SH2_STAT5	39	42	PF00017	0.504
LIG_SH2_STAT5	44	47	PF00017	0.479
LIG_SH3_3	139	145	PF00018	0.506
LIG_SH3_3	243	249	PF00018	0.423
LIG_SH3_3	396	402	PF00018	0.671
LIG_SUMO_SIM_par_1	247	253	PF11976	0.517
LIG_SUMO_SIM_par_1	270	276	PF11976	0.544
LIG_SUMO_SIM_par_1	317	324	PF11976	0.500
LIG_TRAF2_1	144	147	PF00917	0.568
LIG_TRAF2_1	344	347	PF00917	0.466
LIG_UBA3_1	331	337	PF00899	0.352
MOD_CK1_1	255	261	PF00069	0.546
MOD_CK1_1	278	284	PF00069	0.663
MOD_CK1_1	401	407	PF00069	0.799
MOD_CK2_1	183	189	PF00069	0.443
MOD_CK2_1	201	207	PF00069	0.367
MOD_CK2_1	270	276	PF00069	0.553
MOD_GlcNHglycan	1	4	PF01048	0.627
MOD_GlcNHglycan	217	220	PF01048	0.438
MOD_GlcNHglycan	254	257	PF01048	0.561
MOD_GSK3_1	164	171	PF00069	0.587
MOD_GSK3_1	315	322	PF00069	0.583
MOD_GSK3_1	398	405	PF00069	0.681
MOD_GSK3_1	42	49	PF00069	0.592
MOD_N-GLC_1	278	283	PF02516	0.539
MOD_N-GLC_1	46	51	PF02516	0.554
MOD_NEK2_1	175	180	PF00069	0.480
MOD_NEK2_1	183	188	PF00069	0.406
MOD_NEK2_1	338	343	PF00069	0.500
MOD_NEK2_1	46	51	PF00069	0.488
MOD_NEK2_2	233	238	PF00069	0.404
MOD_PIKK_1	136	142	PF00454	0.475
MOD_PIKK_1	168	174	PF00454	0.520
MOD_PIKK_1	250	256	PF00454	0.501
MOD_PIKK_1	91	97	PF00454	0.570
MOD_PKA_2	221	227	PF00069	0.505
MOD_PKA_2	3	9	PF00069	0.602
MOD_PKA_2	338	344	PF00069	0.513
MOD_PKA_2	387	393	PF00069	0.568
MOD_PKA_2	91	97	PF00069	0.515
MOD_Plk_1	168	174	PF00069	0.449
MOD_Plk_1	367	373	PF00069	0.503
MOD_Plk_1	42	48	PF00069	0.488
MOD_Plk_2-3	164	170	PF00069	0.472
MOD_Plk_4	116	122	PF00069	0.525
MOD_Plk_4	175	181	PF00069	0.554
MOD_Plk_4	367	373	PF00069	0.466
MOD_Plk_4	71	77	PF00069	0.366
MOD_ProDKin_1	278	284	PF00069	0.597
MOD_ProDKin_1	398	404	PF00069	0.653
MOD_SUMO_rev_2	101	108	PF00179	0.300
MOD_SUMO_rev_2	14	23	PF00179	0.533
MOD_SUMO_rev_2	81	88	PF00179	0.515
TRG_DiLeu_BaEn_1	299	304	PF01217	0.626
TRG_ENDOCYTIC_2	124	127	PF00928	0.390
TRG_ENDOCYTIC_2	240	243	PF00928	0.409
TRG_NES_CRM1_1	147	161	PF08389	0.448
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK09	Leptomonas seymouri	59%	93%
A0A0S4KNI9	Bodo saltans	21%	100%
A0A3S7X7H5	Leishmania donovani	94%	100%
A4HAF5	Leishmania braziliensis	74%	99%
A4I9L1	Leishmania infantum	94%	100%
E9B4K9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%