Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3G6_LEIMA

TriTrypDb:

LmjF.34.0420 , LMJLV39_340009600 , LMJSD75_340009600

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3G6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3G6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.557
CLV_C14_Caspase3-7	51	55	PF00656	0.731
CLV_MEL_PAP_1	194	200	PF00089	0.427
CLV_NRD_NRD_1	287	289	PF00675	0.457
CLV_NRD_NRD_1	405	407	PF00675	0.415
CLV_NRD_NRD_1	98	100	PF00675	0.618
CLV_PCSK_FUR_1	285	289	PF00082	0.438
CLV_PCSK_KEX2_1	285	287	PF00082	0.434
CLV_PCSK_KEX2_1	405	407	PF00082	0.415
CLV_PCSK_KEX2_1	98	100	PF00082	0.618
CLV_PCSK_SKI1_1	180	184	PF00082	0.487
CLV_PCSK_SKI1_1	224	228	PF00082	0.475
CLV_PCSK_SKI1_1	339	343	PF00082	0.382
CLV_Separin_Metazoa	365	369	PF03568	0.405
DEG_APCC_DBOX_1	196	204	PF00400	0.460
DOC_CKS1_1	68	73	PF01111	0.578
DOC_CKS1_1	85	90	PF01111	0.530
DOC_MAPK_gen_1	246	254	PF00069	0.470
DOC_MAPK_gen_1	388	395	PF00069	0.566
DOC_MAPK_MEF2A_6	192	200	PF00069	0.432
DOC_MAPK_MEF2A_6	248	256	PF00069	0.426
DOC_PP1_RVXF_1	366	372	PF00149	0.409
DOC_PP2B_LxvP_1	256	259	PF13499	0.450
DOC_USP7_MATH_1	117	121	PF00917	0.627
DOC_USP7_MATH_1	122	126	PF00917	0.450
DOC_USP7_MATH_1	141	145	PF00917	0.480
DOC_USP7_MATH_1	174	178	PF00917	0.553
DOC_USP7_MATH_1	196	200	PF00917	0.378
DOC_USP7_MATH_1	2	6	PF00917	0.560
DOC_USP7_MATH_1	210	214	PF00917	0.471
DOC_USP7_MATH_1	240	244	PF00917	0.475
DOC_USP7_MATH_1	321	325	PF00917	0.668
DOC_USP7_MATH_1	348	352	PF00917	0.425
DOC_USP7_MATH_1	386	390	PF00917	0.465
DOC_WW_Pin1_4	107	112	PF00397	0.717
DOC_WW_Pin1_4	113	118	PF00397	0.730
DOC_WW_Pin1_4	170	175	PF00397	0.621
DOC_WW_Pin1_4	271	276	PF00397	0.679
DOC_WW_Pin1_4	67	72	PF00397	0.557
DOC_WW_Pin1_4	84	89	PF00397	0.772
DOC_WW_Pin1_4	9	14	PF00397	0.545
LIG_14-3-3_CanoR_1	197	201	PF00244	0.531
LIG_14-3-3_CanoR_1	268	277	PF00244	0.561
LIG_14-3-3_CanoR_1	320	326	PF00244	0.560
LIG_14-3-3_CanoR_1	394	401	PF00244	0.528
LIG_14-3-3_CanoR_1	410	417	PF00244	0.432
LIG_Actin_WH2_2	187	203	PF00022	0.435
LIG_BIR_II_1	1	5	PF00653	0.540
LIG_BRCT_BRCA1_1	29	33	PF00533	0.531
LIG_Clathr_ClatBox_1	157	161	PF01394	0.457
LIG_FHA_1	144	150	PF00498	0.548
LIG_FHA_1	227	233	PF00498	0.384
LIG_FHA_1	358	364	PF00498	0.333
LIG_FHA_1	37	43	PF00498	0.490
LIG_FHA_2	167	173	PF00498	0.557
LIG_FHA_2	183	189	PF00498	0.307
LIG_FHA_2	373	379	PF00498	0.564
LIG_FHA_2	382	388	PF00498	0.515
LIG_FHA_2	68	74	PF00498	0.542
LIG_HP1_1	196	200	PF01393	0.440
LIG_LIR_Apic_2	12	17	PF02991	0.544
LIG_LIR_Gen_1	181	190	PF02991	0.441
LIG_LIR_Nem_3	181	186	PF02991	0.458
LIG_SH2_PTP2	14	17	PF00017	0.594
LIG_SH2_SRC	14	17	PF00017	0.599
LIG_SH2_STAT3	231	234	PF00017	0.438
LIG_SH2_STAT5	14	17	PF00017	0.678
LIG_SH2_STAT5	231	234	PF00017	0.438
LIG_SH2_STAT5	38	41	PF00017	0.441
LIG_SH3_1	10	16	PF00018	0.542
LIG_SH3_1	168	174	PF00018	0.585
LIG_SH3_3	10	16	PF00018	0.616
LIG_SH3_3	168	174	PF00018	0.627
LIG_SH3_3	230	236	PF00018	0.384
LIG_SH3_3	82	88	PF00018	0.675
LIG_SH3_3	91	97	PF00018	0.662
LIG_SUMO_SIM_anti_2	249	255	PF11976	0.422
LIG_SUMO_SIM_par_1	156	161	PF11976	0.450
LIG_SUMO_SIM_par_1	249	255	PF11976	0.403
LIG_SUMO_SIM_par_1	351	358	PF11976	0.400
LIG_TRAF2_1	112	115	PF00917	0.597
LIG_TRAF2_1	61	64	PF00917	0.527
LIG_WRC_WIRS_1	4	9	PF05994	0.527
MOD_CK1_1	144	150	PF00069	0.450
MOD_CK1_1	163	169	PF00069	0.517
MOD_CK1_1	269	275	PF00069	0.613
MOD_CK1_1	276	282	PF00069	0.523
MOD_CK1_1	355	361	PF00069	0.492
MOD_CK1_1	36	42	PF00069	0.480
MOD_CK1_1	389	395	PF00069	0.606
MOD_CK2_1	2	8	PF00069	0.593
MOD_CK2_1	372	378	PF00069	0.549
MOD_CK2_1	381	387	PF00069	0.516
MOD_CK2_1	67	73	PF00069	0.567
MOD_GlcNHglycan	124	127	PF01048	0.475
MOD_GlcNHglycan	143	146	PF01048	0.424
MOD_GlcNHglycan	242	245	PF01048	0.480
MOD_GlcNHglycan	323	326	PF01048	0.726
MOD_GlcNHglycan	412	415	PF01048	0.536
MOD_GlcNHglycan	88	91	PF01048	0.651
MOD_GSK3_1	113	120	PF00069	0.595
MOD_GSK3_1	141	148	PF00069	0.552
MOD_GSK3_1	166	173	PF00069	0.577
MOD_GSK3_1	262	269	PF00069	0.434
MOD_GSK3_1	276	283	PF00069	0.452
MOD_GSK3_1	328	335	PF00069	0.572
MOD_GSK3_1	342	349	PF00069	0.360
MOD_GSK3_1	377	384	PF00069	0.607
MOD_GSK3_1	389	396	PF00069	0.496
MOD_NEK2_1	160	165	PF00069	0.483
MOD_NEK2_1	182	187	PF00069	0.579
MOD_NEK2_1	227	232	PF00069	0.361
MOD_NEK2_1	254	259	PF00069	0.425
MOD_NEK2_1	263	268	PF00069	0.419
MOD_NEK2_1	33	38	PF00069	0.424
MOD_NEK2_1	342	347	PF00069	0.371
MOD_NEK2_1	393	398	PF00069	0.543
MOD_NEK2_2	196	201	PF00069	0.454
MOD_OFUCOSY	35	40	PF10250	0.463
MOD_PIKK_1	303	309	PF00454	0.357
MOD_PIKK_1	348	354	PF00454	0.424
MOD_PIKK_1	393	399	PF00454	0.497
MOD_PK_1	246	252	PF00069	0.425
MOD_PKA_2	196	202	PF00069	0.532
MOD_PKA_2	270	276	PF00069	0.591
MOD_PKA_2	319	325	PF00069	0.551
MOD_PKA_2	389	395	PF00069	0.564
MOD_PKA_2	64	70	PF00069	0.592
MOD_Plk_1	254	260	PF00069	0.406
MOD_Plk_4	160	166	PF00069	0.524
MOD_Plk_4	227	233	PF00069	0.384
MOD_ProDKin_1	107	113	PF00069	0.714
MOD_ProDKin_1	170	176	PF00069	0.618
MOD_ProDKin_1	271	277	PF00069	0.680
MOD_ProDKin_1	67	73	PF00069	0.565
MOD_ProDKin_1	84	90	PF00069	0.772
MOD_ProDKin_1	9	15	PF00069	0.549
MOD_SUMO_for_1	281	284	PF00179	0.500
MOD_SUMO_rev_2	274	283	PF00179	0.589
TRG_DiLeu_BaEn_1	365	370	PF01217	0.402
TRG_DiLeu_BaEn_4	63	69	PF01217	0.521
TRG_DiLeu_BaLyEn_6	198	203	PF01217	0.453
TRG_DiLeu_LyEn_5	365	370	PF01217	0.402
TRG_ER_diArg_1	285	288	PF00400	0.475
TRG_ER_diArg_1	405	407	PF00400	0.415
TRG_ER_diArg_1	97	99	PF00400	0.624
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	287	292	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDW8	Leptomonas seymouri	37%	72%
A0A3S7X7D6	Leishmania donovani	91%	100%
A4HAF6	Leishmania braziliensis	71%	100%
A4I9L2	Leishmania infantum	91%	100%
E9B4L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%