Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania major

UniProt:

Q4Q3G1_LEIMA

TriTrypDb:

LmjF.34.0470 , LMJLV39_340010200 , LMJSD75_340010200

Length:

716

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0005840	ribosome	5	15
GO:0032991	protein-containing complex	1	15
GO:0036064	ciliary basal body	3	2
GO:0043226	organelle	2	15
GO:0043228	non-membrane-bounded organelle	3	15
GO:0043229	intracellular organelle	3	15
GO:0043232	intracellular non-membrane-bounded organelle	4	15
GO:0110165	cellular anatomical entity	1	15
GO:1990904	ribonucleoprotein complex	2	15
GO:0005730	nucleolus	5	5

Expansion

Sequence features

Q4Q3G1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3G1

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	1
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	608	612	PF00656	0.475
CLV_NRD_NRD_1	107	109	PF00675	0.562
CLV_NRD_NRD_1	294	296	PF00675	0.711
CLV_NRD_NRD_1	514	516	PF00675	0.772
CLV_PCSK_KEX2_1	107	109	PF00082	0.562
CLV_PCSK_KEX2_1	294	296	PF00082	0.711
CLV_PCSK_KEX2_1	696	698	PF00082	0.438
CLV_PCSK_PC1ET2_1	696	698	PF00082	0.486
CLV_PCSK_SKI1_1	155	159	PF00082	0.358
CLV_PCSK_SKI1_1	373	377	PF00082	0.341
CLV_PCSK_SKI1_1	385	389	PF00082	0.683
DEG_SPOP_SBC_1	185	189	PF00917	0.527
DEG_SPOP_SBC_1	208	212	PF00917	0.463
DOC_CYCLIN_yClb5_NLxxxL_5	648	656	PF00134	0.436
DOC_PP1_RVXF_1	134	141	PF00149	0.431
DOC_PP2B_LxvP_1	101	104	PF13499	0.530
DOC_PP4_FxxP_1	427	430	PF00568	0.573
DOC_PP4_MxPP_1	410	413	PF00568	0.520
DOC_USP7_MATH_1	165	169	PF00917	0.571
DOC_USP7_MATH_1	185	189	PF00917	0.523
DOC_USP7_MATH_1	204	208	PF00917	0.523
DOC_USP7_MATH_1	352	356	PF00917	0.547
DOC_USP7_MATH_1	414	418	PF00917	0.630
DOC_USP7_MATH_1	432	436	PF00917	0.568
DOC_USP7_MATH_1	455	459	PF00917	0.765
DOC_USP7_MATH_1	466	470	PF00917	0.673
DOC_USP7_MATH_1	482	486	PF00917	0.654
DOC_USP7_MATH_1	493	497	PF00917	0.594
DOC_USP7_MATH_1	501	505	PF00917	0.561
DOC_USP7_MATH_1	522	526	PF00917	0.676
DOC_USP7_MATH_1	544	548	PF00917	0.638
DOC_USP7_MATH_1	606	610	PF00917	0.547
DOC_USP7_MATH_1	655	659	PF00917	0.520
DOC_WW_Pin1_4	37	42	PF00397	0.561
DOC_WW_Pin1_4	408	413	PF00397	0.630
DOC_WW_Pin1_4	426	431	PF00397	0.625
DOC_WW_Pin1_4	509	514	PF00397	0.667
DOC_WW_Pin1_4	518	523	PF00397	0.659
DOC_WW_Pin1_4	596	601	PF00397	0.545
DOC_WW_Pin1_4	602	607	PF00397	0.594
DOC_WW_Pin1_4	81	86	PF00397	0.494
LIG_14-3-3_CanoR_1	107	115	PF00244	0.624
LIG_14-3-3_CanoR_1	275	281	PF00244	0.482
LIG_14-3-3_CanoR_1	294	300	PF00244	0.636
LIG_14-3-3_CanoR_1	389	397	PF00244	0.556
LIG_14-3-3_CanoR_1	426	430	PF00244	0.588
LIG_14-3-3_CanoR_1	476	482	PF00244	0.757
LIG_14-3-3_CanoR_1	507	513	PF00244	0.590
LIG_14-3-3_CanoR_1	643	649	PF00244	0.650
LIG_AP2alpha_2	13	15	PF02296	0.449
LIG_BIR_II_1	1	5	PF00653	0.536
LIG_BIR_III_4	264	268	PF00653	0.463
LIG_BRCT_BRCA1_1	210	214	PF00533	0.463
LIG_BRCT_BRCA1_1	249	253	PF00533	0.456
LIG_BRCT_BRCA1_1	31	35	PF00533	0.522
LIG_BRCT_BRCA1_1	354	358	PF00533	0.522
LIG_CSL_BTD_1	101	104	PF09270	0.542
LIG_FHA_1	110	116	PF00498	0.676
LIG_FHA_1	133	139	PF00498	0.459
LIG_FHA_1	200	206	PF00498	0.449
LIG_FHA_1	329	335	PF00498	0.506
LIG_FHA_1	372	378	PF00498	0.558
LIG_FHA_1	663	669	PF00498	0.468
LIG_FHA_2	512	518	PF00498	0.607
LIG_FHA_2	597	603	PF00498	0.601
LIG_LIR_Gen_1	212	219	PF02991	0.589
LIG_LIR_Gen_1	633	644	PF02991	0.450
LIG_LIR_Gen_1	96	104	PF02991	0.484
LIG_LIR_Nem_3	182	186	PF02991	0.482
LIG_LIR_Nem_3	2	6	PF02991	0.531
LIG_LIR_Nem_3	211	217	PF02991	0.583
LIG_LIR_Nem_3	633	639	PF02991	0.452
LIG_LIR_Nem_3	96	101	PF02991	0.492
LIG_MLH1_MIPbox_1	211	215	PF16413	0.463
LIG_MYND_1	37	41	PF01753	0.463
LIG_Pex14_1	160	164	PF04695	0.435
LIG_Pex14_2	179	183	PF04695	0.375
LIG_Rb_pABgroove_1	236	244	PF01858	0.379
LIG_SH2_CRK	343	347	PF00017	0.287
LIG_SH2_CRK	636	640	PF00017	0.450
LIG_SH2_PTP2	98	101	PF00017	0.522
LIG_SH2_STAP1	688	692	PF00017	0.431
LIG_SH2_STAT3	667	670	PF00017	0.402
LIG_SH2_STAT5	147	150	PF00017	0.356
LIG_SH2_STAT5	209	212	PF00017	0.566
LIG_SH2_STAT5	217	220	PF00017	0.482
LIG_SH2_STAT5	258	261	PF00017	0.549
LIG_SH2_STAT5	303	306	PF00017	0.413
LIG_SH2_STAT5	341	344	PF00017	0.376
LIG_SH2_STAT5	532	535	PF00017	0.618
LIG_SH2_STAT5	565	568	PF00017	0.674
LIG_SH2_STAT5	667	670	PF00017	0.610
LIG_SH2_STAT5	98	101	PF00017	0.543
LIG_SH3_2	11	16	PF14604	0.453
LIG_SH3_3	40	46	PF00018	0.463
LIG_SH3_3	5	11	PF00018	0.535
LIG_SUMO_SIM_par_1	201	207	PF11976	0.479
LIG_TRAF2_1	620	623	PF00917	0.461
LIG_WRC_WIRS_1	180	185	PF05994	0.415
MOD_CDC14_SPxK_1	512	515	PF00782	0.601
MOD_CDK_SPK_2	81	86	PF00069	0.297
MOD_CDK_SPxK_1	509	515	PF00069	0.596
MOD_CDK_SPxxK_3	408	415	PF00069	0.567
MOD_CDK_SPxxK_3	509	516	PF00069	0.701
MOD_CK1_1	207	213	PF00069	0.380
MOD_CK1_1	247	253	PF00069	0.369
MOD_CK1_1	279	285	PF00069	0.564
MOD_CK1_1	458	464	PF00069	0.715
MOD_CK1_1	468	474	PF00069	0.749
MOD_CK1_1	511	517	PF00069	0.672
MOD_CK1_1	523	529	PF00069	0.582
MOD_CK1_1	609	615	PF00069	0.532
MOD_CK2_1	388	394	PF00069	0.708
MOD_CK2_1	511	517	PF00069	0.621
MOD_CK2_1	570	576	PF00069	0.803
MOD_CK2_1	596	602	PF00069	0.601
MOD_GlcNHglycan	206	209	PF01048	0.332
MOD_GlcNHglycan	219	222	PF01048	0.331
MOD_GlcNHglycan	243	247	PF01048	0.340
MOD_GlcNHglycan	261	264	PF01048	0.365
MOD_GlcNHglycan	265	268	PF01048	0.345
MOD_GlcNHglycan	281	284	PF01048	0.439
MOD_GlcNHglycan	3	6	PF01048	0.663
MOD_GlcNHglycan	324	327	PF01048	0.351
MOD_GlcNHglycan	379	382	PF01048	0.467
MOD_GlcNHglycan	418	421	PF01048	0.671
MOD_GlcNHglycan	461	464	PF01048	0.671
MOD_GlcNHglycan	468	471	PF01048	0.634
MOD_GlcNHglycan	49	52	PF01048	0.325
MOD_GlcNHglycan	495	498	PF01048	0.543
MOD_GlcNHglycan	522	525	PF01048	0.612
MOD_GlcNHglycan	611	615	PF01048	0.530
MOD_GlcNHglycan	710	713	PF01048	0.773
MOD_GlcNHglycan	91	94	PF01048	0.344
MOD_GSK3_1	103	110	PF00069	0.477
MOD_GSK3_1	204	211	PF00069	0.314
MOD_GSK3_1	259	266	PF00069	0.384
MOD_GSK3_1	275	282	PF00069	0.578
MOD_GSK3_1	35	42	PF00069	0.328
MOD_GSK3_1	352	359	PF00069	0.281
MOD_GSK3_1	364	371	PF00069	0.456
MOD_GSK3_1	385	392	PF00069	0.648
MOD_GSK3_1	455	462	PF00069	0.638
MOD_GSK3_1	465	472	PF00069	0.603
MOD_GSK3_1	518	525	PF00069	0.711
MOD_GSK3_1	552	559	PF00069	0.761
MOD_GSK3_1	566	573	PF00069	0.618
MOD_GSK3_1	602	609	PF00069	0.603
MOD_GSK3_1	674	681	PF00069	0.454
MOD_N-GLC_1	327	332	PF02516	0.487
MOD_N-GLC_1	356	361	PF02516	0.213
MOD_N-GLC_1	493	498	PF02516	0.715
MOD_N-GLC_2	124	126	PF02516	0.599
MOD_N-GLC_2	473	475	PF02516	0.595
MOD_NEK2_1	1	6	PF00069	0.633
MOD_NEK2_1	179	184	PF00069	0.472
MOD_NEK2_1	186	191	PF00069	0.628
MOD_NEK2_1	242	247	PF00069	0.495
MOD_NEK2_1	274	279	PF00069	0.469
MOD_NEK2_1	342	347	PF00069	0.363
MOD_NEK2_1	566	571	PF00069	0.588
MOD_NEK2_1	674	679	PF00069	0.415
MOD_NEK2_1	89	94	PF00069	0.315
MOD_NEK2_2	244	249	PF00069	0.322
MOD_PIKK_1	165	171	PF00454	0.542
MOD_PIKK_1	461	467	PF00454	0.713
MOD_PIKK_1	642	648	PF00454	0.421
MOD_PIKK_1	662	668	PF00454	0.352
MOD_PKA_1	107	113	PF00069	0.620
MOD_PKA_1	294	300	PF00069	0.683
MOD_PKA_2	106	112	PF00069	0.525
MOD_PKA_2	122	128	PF00069	0.488
MOD_PKA_2	15	21	PF00069	0.499
MOD_PKA_2	274	280	PF00069	0.503
MOD_PKA_2	294	300	PF00069	0.688
MOD_PKA_2	388	394	PF00069	0.536
MOD_PKA_2	425	431	PF00069	0.575
MOD_PKA_2	475	481	PF00069	0.632
MOD_PKA_2	642	648	PF00069	0.649
MOD_PKA_2	674	680	PF00069	0.471
MOD_Plk_1	153	159	PF00069	0.427
MOD_Plk_1	371	377	PF00069	0.380
MOD_Plk_1	393	399	PF00069	0.529
MOD_Plk_1	445	451	PF00069	0.641
MOD_Plk_1	552	558	PF00069	0.606
MOD_Plk_4	210	216	PF00069	0.380
MOD_Plk_4	295	301	PF00069	0.562
MOD_Plk_4	371	377	PF00069	0.360
MOD_ProDKin_1	37	43	PF00069	0.434
MOD_ProDKin_1	408	414	PF00069	0.630
MOD_ProDKin_1	426	432	PF00069	0.621
MOD_ProDKin_1	509	515	PF00069	0.669
MOD_ProDKin_1	518	524	PF00069	0.658
MOD_ProDKin_1	596	602	PF00069	0.545
MOD_ProDKin_1	81	87	PF00069	0.340
MOD_SUMO_rev_2	330	340	PF00179	0.312
MOD_SUMO_rev_2	529	538	PF00179	0.554
MOD_SUMO_rev_2	689	698	PF00179	0.433
TRG_DiLeu_BaEn_1	625	630	PF01217	0.455
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.297
TRG_ENDOCYTIC_2	343	346	PF00928	0.352
TRG_ENDOCYTIC_2	636	639	PF00928	0.451
TRG_ENDOCYTIC_2	98	101	PF00928	0.413
TRG_ER_diArg_1	293	295	PF00400	0.734

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY0	Leptomonas seymouri	42%	100%
A0A3Q8IGC4	Leishmania donovani	24%	100%
A0A3Q8IKN8	Leishmania donovani	93%	100%
A0A3R7NL29	Trypanosoma rangeli	33%	97%
A4HAG2	Leishmania braziliensis	76%	99%
A4HDT7	Leishmania braziliensis	24%	100%
A4I135	Leishmania infantum	24%	100%
A4I9L7	Leishmania infantum	93%	100%
D0A1X8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	92%
E9ATR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B4L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QAA4	Leishmania major	24%	100%