Putative importin beta-1 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

importin beta-1 subunit, putative

Species:

Leishmania major

UniProt:

Q4Q3F9_LEIMA

TriTrypDb:

LmjF.34.0490 , LMJLV39_340010500 , LMJSD75_340010500

Length:

870

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005643	nuclear pore	3	2
GO:0005737	cytoplasm	2	12
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

Q4Q3F9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3F9

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	12
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0006913	nucleocytoplasmic transport	5	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0033365	protein localization to organelle	5	12
GO:0034504	protein localization to nucleus	6	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051169	nuclear transport	4	12
GO:0051170	import into nucleus	6	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0072594	establishment of protein localization to organelle	4	12

Molecular functions
Term	Name	Level	Count
GO:0005048	signal sequence binding	4	2
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0008139	nuclear localization sequence binding	5	2
GO:0019899	enzyme binding	3	11
GO:0031267	small GTPase binding	5	11
GO:0033218	amide binding	2	2
GO:0042277	peptide binding	3	2
GO:0051020	GTPase binding	4	11
GO:0061608	nuclear import signal receptor activity	3	2
GO:0140104	molecular carrier activity	1	2
GO:0140142	nucleocytoplasmic carrier activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	561	565	PF00656	0.596
CLV_C14_Caspase3-7	650	654	PF00656	0.529
CLV_C14_Caspase3-7	772	776	PF00656	0.451
CLV_NRD_NRD_1	376	378	PF00675	0.489
CLV_NRD_NRD_1	583	585	PF00675	0.438
CLV_PCSK_KEX2_1	378	380	PF00082	0.405
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.405
CLV_PCSK_SKI1_1	296	300	PF00082	0.457
CLV_PCSK_SKI1_1	323	327	PF00082	0.456
CLV_PCSK_SKI1_1	695	699	PF00082	0.344
CLV_PCSK_SKI1_1	76	80	PF00082	0.321
CLV_PCSK_SKI1_1	829	833	PF00082	0.428
CLV_PCSK_SKI1_1	855	859	PF00082	0.480
DEG_APCC_DBOX_1	860	868	PF00400	0.517
DEG_ODPH_VHL_1	777	789	PF01847	0.373
DOC_ANK_TNKS_1	741	748	PF00023	0.456
DOC_CKS1_1	443	448	PF01111	0.492
DOC_CYCLIN_RxL_1	320	330	PF00134	0.469
DOC_MAPK_gen_1	377	386	PF00069	0.335
DOC_MAPK_gen_1	731	741	PF00069	0.375
DOC_MAPK_MEF2A_6	495	504	PF00069	0.413
DOC_MIT_MIM_1	664	674	PF04212	0.357
DOC_PP1_RVXF_1	853	860	PF00149	0.421
DOC_PP4_FxxP_1	649	652	PF00568	0.537
DOC_USP7_MATH_1	14	18	PF00917	0.493
DOC_USP7_MATH_1	140	144	PF00917	0.460
DOC_USP7_MATH_1	243	247	PF00917	0.423
DOC_USP7_MATH_1	424	428	PF00917	0.370
DOC_USP7_MATH_1	619	623	PF00917	0.447
DOC_USP7_MATH_1	675	679	PF00917	0.376
DOC_USP7_MATH_1	844	848	PF00917	0.491
DOC_USP7_UBL2_3	854	858	PF12436	0.561
DOC_WW_Pin1_4	101	106	PF00397	0.321
DOC_WW_Pin1_4	442	447	PF00397	0.427
LIG_14-3-3_CanoR_1	559	566	PF00244	0.563
LIG_14-3-3_CanoR_1	670	674	PF00244	0.466
LIG_14-3-3_CanoR_1	734	741	PF00244	0.529
LIG_Actin_WH2_2	402	419	PF00022	0.513
LIG_Actin_WH2_2	50	65	PF00022	0.321
LIG_Actin_WH2_2	544	561	PF00022	0.399
LIG_Actin_WH2_2	682	700	PF00022	0.517
LIG_Actin_WH2_2	802	819	PF00022	0.319
LIG_AP2alpha_1	438	442	PF02296	0.321
LIG_APCC_ABBA_1	590	595	PF00400	0.475
LIG_BIR_II_1	1	5	PF00653	0.455
LIG_BRCT_BRCA1_1	714	718	PF00533	0.426
LIG_Clathr_ClatBox_1	673	677	PF01394	0.357
LIG_FHA_1	175	181	PF00498	0.395
LIG_FHA_1	198	204	PF00498	0.349
LIG_FHA_1	268	274	PF00498	0.339
LIG_FHA_1	3	9	PF00498	0.428
LIG_FHA_1	314	320	PF00498	0.402
LIG_FHA_1	37	43	PF00498	0.430
LIG_FHA_1	443	449	PF00498	0.484
LIG_FHA_1	488	494	PF00498	0.411
LIG_FHA_1	607	613	PF00498	0.446
LIG_FHA_1	681	687	PF00498	0.415
LIG_FHA_2	189	195	PF00498	0.506
LIG_FHA_2	255	261	PF00498	0.492
LIG_FHA_2	332	338	PF00498	0.492
LIG_FHA_2	847	853	PF00498	0.525
LIG_GBD_Chelix_1	112	120	PF00786	0.372
LIG_GBD_Chelix_1	781	789	PF00786	0.458
LIG_Integrin_RGD_1	742	744	PF01839	0.600
LIG_LIR_Gen_1	252	263	PF02991	0.353
LIG_LIR_Gen_1	365	375	PF02991	0.444
LIG_LIR_Gen_1	436	446	PF02991	0.358
LIG_LIR_Gen_1	683	693	PF02991	0.432
LIG_LIR_Gen_1	703	713	PF02991	0.188
LIG_LIR_Gen_1	760	769	PF02991	0.369
LIG_LIR_LC3C_4	499	502	PF02991	0.419
LIG_LIR_Nem_3	127	133	PF02991	0.462
LIG_LIR_Nem_3	252	258	PF02991	0.342
LIG_LIR_Nem_3	365	371	PF02991	0.432
LIG_LIR_Nem_3	436	441	PF02991	0.333
LIG_LIR_Nem_3	494	500	PF02991	0.341
LIG_LIR_Nem_3	589	593	PF02991	0.459
LIG_LIR_Nem_3	653	659	PF02991	0.492
LIG_LIR_Nem_3	683	688	PF02991	0.400
LIG_LIR_Nem_3	69	73	PF02991	0.387
LIG_LIR_Nem_3	703	708	PF02991	0.187
LIG_LIR_Nem_3	715	721	PF02991	0.294
LIG_LIR_Nem_3	760	765	PF02991	0.362
LIG_LIR_Nem_3	80	86	PF02991	0.291
LIG_PCNA_yPIPBox_3	517	528	PF02747	0.399
LIG_Pex14_2	438	442	PF04695	0.321
LIG_Pex14_2	701	705	PF04695	0.453
LIG_PTB_Apo_2	679	686	PF02174	0.482
LIG_PTB_Phospho_1	679	685	PF10480	0.475
LIG_SH2_CRK	255	259	PF00017	0.343
LIG_SH2_CRK	368	372	PF00017	0.472
LIG_SH2_CRK	656	660	PF00017	0.490
LIG_SH2_CRK	762	766	PF00017	0.315
LIG_SH2_GRB2like	368	371	PF00017	0.513
LIG_SH2_GRB2like	685	688	PF00017	0.423
LIG_SH2_NCK_1	368	372	PF00017	0.413
LIG_SH2_NCK_1	762	766	PF00017	0.458
LIG_SH2_PTP2	685	688	PF00017	0.423
LIG_SH2_SRC	368	371	PF00017	0.446
LIG_SH2_STAT3	310	313	PF00017	0.440
LIG_SH2_STAT3	539	542	PF00017	0.433
LIG_SH2_STAT3	611	614	PF00017	0.408
LIG_SH2_STAT5	158	161	PF00017	0.387
LIG_SH2_STAT5	209	212	PF00017	0.489
LIG_SH2_STAT5	222	225	PF00017	0.391
LIG_SH2_STAT5	261	264	PF00017	0.356
LIG_SH2_STAT5	415	418	PF00017	0.364
LIG_SH2_STAT5	539	542	PF00017	0.391
LIG_SH2_STAT5	611	614	PF00017	0.475
LIG_SH2_STAT5	625	628	PF00017	0.326
LIG_SH2_STAT5	634	637	PF00017	0.334
LIG_SH2_STAT5	645	648	PF00017	0.275
LIG_SH2_STAT5	685	688	PF00017	0.433
LIG_SH2_STAT5	750	753	PF00017	0.350
LIG_SH2_STAT5	780	783	PF00017	0.444
LIG_SH3_3	352	358	PF00018	0.480
LIG_SH3_3	816	822	PF00018	0.495
LIG_SUMO_SIM_anti_2	176	185	PF11976	0.387
LIG_SUMO_SIM_anti_2	499	505	PF11976	0.475
LIG_SUMO_SIM_par_1	603	610	PF11976	0.531
LIG_SUMO_SIM_par_1	615	622	PF11976	0.394
LIG_TRAF2_1	396	399	PF00917	0.508
LIG_TRAF2_1	481	484	PF00917	0.425
LIG_TRAF2_1	519	522	PF00917	0.437
LIG_TRAF2_1	78	81	PF00917	0.362
LIG_TYR_ITIM	253	258	PF00017	0.431
LIG_WRC_WIRS_1	34	39	PF05994	0.430
LIG_WRPW_2	718	721	PF00400	0.420
MOD_CDC14_SPxK_1	104	107	PF00782	0.434
MOD_CDK_SPxK_1	101	107	PF00069	0.321
MOD_CK1_1	233	239	PF00069	0.450
MOD_CK1_1	49	55	PF00069	0.337
MOD_CK1_1	700	706	PF00069	0.389
MOD_CK1_1	760	766	PF00069	0.345
MOD_CK1_1	847	853	PF00069	0.555
MOD_CK2_1	140	146	PF00069	0.459
MOD_CK2_1	187	193	PF00069	0.369
MOD_CK2_1	287	293	PF00069	0.316
MOD_CK2_1	347	353	PF00069	0.446
MOD_CK2_1	66	72	PF00069	0.403
MOD_CK2_1	750	756	PF00069	0.336
MOD_CK2_1	845	851	PF00069	0.508
MOD_GlcNHglycan	126	129	PF01048	0.529
MOD_GlcNHglycan	142	145	PF01048	0.486
MOD_GlcNHglycan	197	200	PF01048	0.466
MOD_GlcNHglycan	310	313	PF01048	0.436
MOD_GlcNHglycan	425	429	PF01048	0.374
MOD_GlcNHglycan	517	520	PF01048	0.475
MOD_GlcNHglycan	536	539	PF01048	0.574
MOD_GlcNHglycan	561	564	PF01048	0.544
MOD_GlcNHglycan	579	582	PF01048	0.421
MOD_GSK3_1	116	123	PF00069	0.573
MOD_GSK3_1	175	182	PF00069	0.493
MOD_GSK3_1	218	225	PF00069	0.452
MOD_GSK3_1	232	239	PF00069	0.278
MOD_GSK3_1	29	36	PF00069	0.489
MOD_GSK3_1	304	311	PF00069	0.488
MOD_GSK3_1	487	494	PF00069	0.403
MOD_GSK3_1	530	537	PF00069	0.415
MOD_GSK3_1	665	672	PF00069	0.428
MOD_GSK3_1	750	757	PF00069	0.341
MOD_GSK3_1	97	104	PF00069	0.383
MOD_N-GLC_1	2	7	PF02516	0.488
MOD_N-GLC_1	308	313	PF02516	0.501
MOD_N-GLC_1	338	343	PF02516	0.371
MOD_N-GLC_1	371	376	PF02516	0.448
MOD_NEK2_1	197	202	PF00069	0.482
MOD_NEK2_1	227	232	PF00069	0.347
MOD_NEK2_1	253	258	PF00069	0.353
MOD_NEK2_1	287	292	PF00069	0.314
MOD_NEK2_1	308	313	PF00069	0.499
MOD_NEK2_1	347	352	PF00069	0.311
MOD_NEK2_1	37	42	PF00069	0.380
MOD_NEK2_1	558	563	PF00069	0.551
MOD_NEK2_1	57	62	PF00069	0.157
MOD_NEK2_1	586	591	PF00069	0.427
MOD_NEK2_1	594	599	PF00069	0.433
MOD_NEK2_1	665	670	PF00069	0.370
MOD_NEK2_1	697	702	PF00069	0.348
MOD_NEK2_1	754	759	PF00069	0.320
MOD_NEK2_1	761	766	PF00069	0.312
MOD_NEK2_1	798	803	PF00069	0.429
MOD_NEK2_1	845	850	PF00069	0.574
MOD_OFUCOSY	228	234	PF10250	0.388
MOD_OFUCOSY	699	704	PF10250	0.459
MOD_PIKK_1	763	769	PF00454	0.415
MOD_PIKK_1	798	804	PF00454	0.475
MOD_PK_1	379	385	PF00069	0.389
MOD_PKA_2	416	422	PF00069	0.469
MOD_PKA_2	558	564	PF00069	0.559
MOD_PKA_2	669	675	PF00069	0.466
MOD_PKA_2	733	739	PF00069	0.509
MOD_PKB_1	377	385	PF00069	0.397
MOD_Plk_1	338	344	PF00069	0.365
MOD_Plk_1	379	385	PF00069	0.389
MOD_Plk_1	424	430	PF00069	0.456
MOD_Plk_1	491	497	PF00069	0.378
MOD_Plk_1	594	600	PF00069	0.519
MOD_Plk_1	663	669	PF00069	0.335
MOD_Plk_1	798	804	PF00069	0.468
MOD_Plk_2-3	331	337	PF00069	0.527
MOD_Plk_4	179	185	PF00069	0.381
MOD_Plk_4	243	249	PF00069	0.324
MOD_Plk_4	313	319	PF00069	0.348
MOD_Plk_4	33	39	PF00069	0.389
MOD_Plk_4	379	385	PF00069	0.389
MOD_Plk_4	57	63	PF00069	0.346
MOD_Plk_4	586	592	PF00069	0.542
MOD_Plk_4	651	657	PF00069	0.502
MOD_Plk_4	669	675	PF00069	0.300
MOD_Plk_4	680	686	PF00069	0.344
MOD_Plk_4	697	703	PF00069	0.237
MOD_Plk_4	750	756	PF00069	0.352
MOD_Plk_4	757	763	PF00069	0.340
MOD_Plk_4	811	817	PF00069	0.353
MOD_ProDKin_1	101	107	PF00069	0.321
MOD_ProDKin_1	442	448	PF00069	0.423
MOD_SUMO_for_1	94	97	PF00179	0.380
MOD_SUMO_rev_2	190	198	PF00179	0.505
MOD_SUMO_rev_2	44	52	PF00179	0.303
MOD_SUMO_rev_2	509	519	PF00179	0.515
MOD_SUMO_rev_2	692	700	PF00179	0.416
TRG_DiLeu_BaEn_1	129	134	PF01217	0.400
TRG_DiLeu_BaEn_4	277	283	PF01217	0.350
TRG_ENDOCYTIC_2	255	258	PF00928	0.335
TRG_ENDOCYTIC_2	368	371	PF00928	0.385
TRG_ENDOCYTIC_2	497	500	PF00928	0.392
TRG_ENDOCYTIC_2	656	659	PF00928	0.482
TRG_ENDOCYTIC_2	685	688	PF00928	0.440
TRG_ENDOCYTIC_2	762	765	PF00928	0.314
TRG_ER_diArg_1	376	379	PF00400	0.416
TRG_Pf-PMV_PEXEL_1	584	588	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	84	89	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB22	Leptomonas seymouri	80%	100%
A0A0S4J2L0	Bodo saltans	48%	100%
A0A1X0P8K4	Trypanosomatidae	55%	100%
A0A3Q8IUD8	Leishmania donovani	99%	100%
A0A3R7LLX8	Trypanosoma rangeli	53%	100%
A4HAG4	Leishmania braziliensis	88%	100%
A4I9L9	Leishmania infantum	99%	100%
D0A1Y4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B4L7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O00410	Homo sapiens	21%	79%
O13864	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
O18388	Drosophila melanogaster	27%	98%
P52296	Rattus norvegicus	28%	99%
P52297	Xenopus laevis	29%	99%
P70168	Mus musculus	29%	99%
Q06142	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q14974	Homo sapiens	29%	99%
Q3SYU7	Bos taurus	21%	97%
Q8BFY9	Mus musculus	21%	97%
Q8BKC5	Mus musculus	21%	79%
Q92973	Homo sapiens	21%	97%
Q9FJD4	Arabidopsis thaliana	30%	100%
V5BHR5	Trypanosoma cruzi	49%	100%