Amastin-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like protein

Species:

Leishmania major

UniProt:

Q4Q3F7_LEIMA

TriTrypDb:

LmjF.34.0500 , LMJLV39_340011100 , LMJSD75_340010700

Length:

212

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 12, no: 201
NetGPI	no	yes: 0, no: 213

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	191
GO:0110165	cellular anatomical entity	1	191

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Expansion

Sequence features

Q4Q3F7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3F7

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	72	74	PF00675	0.495
CLV_PCSK_FUR_1	72	76	PF00082	0.407
CLV_PCSK_KEX2_1	72	74	PF00082	0.506
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.403
CLV_PCSK_SKI1_1	145	149	PF00082	0.402
DEG_MDM2_SWIB_1	157	165	PF02201	0.492
DOC_CKS1_1	23	28	PF01111	0.364
DOC_MAPK_gen_1	72	84	PF00069	0.284
DOC_MAPK_MEF2A_6	108	116	PF00069	0.558
DOC_MAPK_MEF2A_6	4	13	PF00069	0.541

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	33%	100%
A0A0N0P547	Leptomonas seymouri	41%	100%
A0A0N0P6P9	Leptomonas seymouri	26%	92%
A0A0N0P993	Leptomonas seymouri	28%	95%
A0A0N1HWY5	Leptomonas seymouri	33%	100%
A0A0N1I295	Leptomonas seymouri	28%	100%
A0A0N1PAD5	Leptomonas seymouri	25%	84%
A0A0N1PDH0	Leptomonas seymouri	39%	100%
A0A0N1PFN2	Leptomonas seymouri	26%	100%
A0A0S4J784	Bodo saltans	24%	95%

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