LeishMANIAdb
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Phosphoglycan beta 1,2 arabinosyltransferase,(SCA like)

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphoglycan beta 1,2 arabinosyltransferase,(SCA like)
Gene product:
phosphoglycan beta 1,2 arabinosyltransferase, (SCA like)
Species:
Leishmania major
UniProt:
Q4Q3F6_LEIMA
TriTrypDb:
LmjF.34.0510 , LMJLV39_340011200 * , LMJSD75_340010900
Length:
901

Annotations

LeishMANIAdb annotations

A signal-anchored enzyme family expanded in Leishmaniids. Any identification as glycosyltransferase is highly tentative.. Localization: Golgi (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8
GO:0005796 Golgi lumen 5 2
GO:0031974 membrane-enclosed lumen 2 2
GO:0043233 organelle lumen 3 2
GO:0070013 intracellular organelle lumen 4 2

Expansion

Sequence features

Q4Q3F6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3F6

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 2
GO:0005996 monosaccharide metabolic process 3 2
GO:0006012 galactose metabolic process 5 2
GO:0008152 metabolic process 1 2
GO:0019318 hexose metabolic process 4 2
GO:0044238 primary metabolic process 2 2
GO:0044281 small molecule metabolic process 2 2
GO:0071704 organic substance metabolic process 2 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0016740 transferase activity 2 10
GO:0008378 galactosyltransferase activity 5 2
GO:0016757 glycosyltransferase activity 3 2
GO:0016758 hexosyltransferase activity 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 270 274 PF00656 0.474
CLV_C14_Caspase3-7 317 321 PF00656 0.457
CLV_C14_Caspase3-7 551 555 PF00656 0.399
CLV_NRD_NRD_1 376 378 PF00675 0.547
CLV_NRD_NRD_1 410 412 PF00675 0.579
CLV_NRD_NRD_1 492 494 PF00675 0.686
CLV_NRD_NRD_1 558 560 PF00675 0.803
CLV_NRD_NRD_1 566 568 PF00675 0.600
CLV_NRD_NRD_1 648 650 PF00675 0.652
CLV_NRD_NRD_1 720 722 PF00675 0.592
CLV_NRD_NRD_1 726 728 PF00675 0.609
CLV_NRD_NRD_1 789 791 PF00675 0.558
CLV_NRD_NRD_1 877 879 PF00675 0.515
CLV_PCSK_FUR_1 718 722 PF00082 0.540
CLV_PCSK_KEX2_1 376 378 PF00082 0.557
CLV_PCSK_KEX2_1 410 412 PF00082 0.579
CLV_PCSK_KEX2_1 47 49 PF00082 0.616
CLV_PCSK_KEX2_1 492 494 PF00082 0.654
CLV_PCSK_KEX2_1 558 560 PF00082 0.722
CLV_PCSK_KEX2_1 566 568 PF00082 0.748
CLV_PCSK_KEX2_1 626 628 PF00082 0.662
CLV_PCSK_KEX2_1 647 649 PF00082 0.623
CLV_PCSK_KEX2_1 720 722 PF00082 0.592
CLV_PCSK_KEX2_1 726 728 PF00082 0.609
CLV_PCSK_KEX2_1 789 791 PF00082 0.523
CLV_PCSK_KEX2_1 877 879 PF00082 0.515
CLV_PCSK_PC1ET2_1 47 49 PF00082 0.484
CLV_PCSK_PC1ET2_1 626 628 PF00082 0.651
CLV_PCSK_SKI1_1 424 428 PF00082 0.542
CLV_PCSK_SKI1_1 493 497 PF00082 0.768
CLV_PCSK_SKI1_1 54 58 PF00082 0.505
CLV_PCSK_SKI1_1 627 631 PF00082 0.595
CLV_PCSK_SKI1_1 649 653 PF00082 0.604
CLV_PCSK_SKI1_1 687 691 PF00082 0.705
CLV_PCSK_SKI1_1 739 743 PF00082 0.576
CLV_PCSK_SKI1_1 793 797 PF00082 0.615
CLV_PCSK_SKI1_1 800 804 PF00082 0.549
DEG_APCC_DBOX_1 423 431 PF00400 0.307
DEG_APCC_DBOX_1 582 590 PF00400 0.346
DEG_APCC_DBOX_1 626 634 PF00400 0.386
DEG_APCC_DBOX_1 791 799 PF00400 0.294
DEG_COP1_1 501 509 PF00400 0.467
DEG_Nend_UBRbox_3 1 3 PF02207 0.698
DOC_ANK_TNKS_1 549 556 PF00023 0.405
DOC_MAPK_gen_1 566 574 PF00069 0.369
DOC_MAPK_gen_1 626 632 PF00069 0.503
DOC_MAPK_gen_1 637 646 PF00069 0.311
DOC_MAPK_MEF2A_6 566 573 PF00069 0.374
DOC_MAPK_MEF2A_6 597 606 PF00069 0.345
DOC_MAPK_MEF2A_6 637 646 PF00069 0.350
DOC_PP1_RVXF_1 439 445 PF00149 0.354
DOC_PP2B_LxvP_1 197 200 PF13499 0.376
DOC_PP4_FxxP_1 104 107 PF00568 0.424
DOC_PP4_FxxP_1 382 385 PF00568 0.310
DOC_PP4_FxxP_1 526 529 PF00568 0.553
DOC_USP7_MATH_1 148 152 PF00917 0.539
DOC_USP7_MATH_1 175 179 PF00917 0.413
DOC_USP7_MATH_1 228 232 PF00917 0.372
DOC_USP7_MATH_1 265 269 PF00917 0.411
DOC_USP7_MATH_1 339 343 PF00917 0.363
DOC_USP7_MATH_1 375 379 PF00917 0.470
DOC_USP7_MATH_1 464 468 PF00917 0.396
DOC_USP7_MATH_1 625 629 PF00917 0.434
DOC_USP7_MATH_1 754 758 PF00917 0.371
DOC_WW_Pin1_4 10 15 PF00397 0.668
DOC_WW_Pin1_4 505 510 PF00397 0.491
DOC_WW_Pin1_4 596 601 PF00397 0.349
LIG_14-3-3_CanoR_1 106 115 PF00244 0.418
LIG_14-3-3_CanoR_1 144 152 PF00244 0.395
LIG_14-3-3_CanoR_1 215 221 PF00244 0.358
LIG_14-3-3_CanoR_1 230 238 PF00244 0.412
LIG_14-3-3_CanoR_1 377 383 PF00244 0.327
LIG_14-3-3_CanoR_1 441 445 PF00244 0.352
LIG_14-3-3_CanoR_1 470 480 PF00244 0.342
LIG_14-3-3_CanoR_1 540 549 PF00244 0.358
LIG_14-3-3_CanoR_1 558 564 PF00244 0.396
LIG_14-3-3_CanoR_1 583 593 PF00244 0.366
LIG_14-3-3_CanoR_1 611 620 PF00244 0.384
LIG_14-3-3_CanoR_1 637 646 PF00244 0.342
LIG_14-3-3_CanoR_1 687 693 PF00244 0.435
LIG_14-3-3_CanoR_1 694 701 PF00244 0.346
LIG_14-3-3_CanoR_1 829 837 PF00244 0.423
LIG_Actin_WH2_1 570 585 PF00022 0.345
LIG_Actin_WH2_2 582 599 PF00022 0.385
LIG_APCC_ABBA_1 796 801 PF00400 0.289
LIG_BRCT_BRCA1_1 233 237 PF00533 0.365
LIG_BRCT_BRCA1_1 727 731 PF00533 0.463
LIG_CtBP_PxDLS_1 371 377 PF00389 0.329
LIG_FHA_1 135 141 PF00498 0.428
LIG_FHA_1 157 163 PF00498 0.426
LIG_FHA_1 215 221 PF00498 0.382
LIG_FHA_1 293 299 PF00498 0.430
LIG_FHA_1 339 345 PF00498 0.465
LIG_FHA_1 346 352 PF00498 0.318
LIG_FHA_1 379 385 PF00498 0.362
LIG_FHA_1 445 451 PF00498 0.511
LIG_FHA_1 501 507 PF00498 0.487
LIG_FHA_1 544 550 PF00498 0.378
LIG_FHA_1 588 594 PF00498 0.410
LIG_FHA_1 599 605 PF00498 0.346
LIG_FHA_1 639 645 PF00498 0.384
LIG_FHA_1 829 835 PF00498 0.392
LIG_FHA_2 111 117 PF00498 0.406
LIG_FHA_2 165 171 PF00498 0.464
LIG_FHA_2 181 187 PF00498 0.387
LIG_FHA_2 244 250 PF00498 0.390
LIG_FHA_2 299 305 PF00498 0.412
LIG_FHA_2 313 319 PF00498 0.394
LIG_FHA_2 454 460 PF00498 0.441
LIG_FHA_2 509 515 PF00498 0.444
LIG_FHA_2 534 540 PF00498 0.431
LIG_FHA_2 549 555 PF00498 0.403
LIG_FHA_2 583 589 PF00498 0.338
LIG_FHA_2 650 656 PF00498 0.427
LIG_FHA_2 688 694 PF00498 0.312
LIG_GBD_Chelix_1 73 81 PF00786 0.235
LIG_GBD_Chelix_1 847 855 PF00786 0.444
LIG_Integrin_isoDGR_2 27 29 PF01839 0.470
LIG_Integrin_isoDGR_2 412 414 PF01839 0.488
LIG_LIR_Apic_2 284 290 PF02991 0.363
LIG_LIR_Apic_2 381 385 PF02991 0.350
LIG_LIR_Apic_2 524 529 PF02991 0.542
LIG_LIR_Gen_1 348 358 PF02991 0.402
LIG_LIR_Gen_1 394 403 PF02991 0.345
LIG_LIR_Gen_1 483 490 PF02991 0.313
LIG_LIR_Gen_1 628 635 PF02991 0.388
LIG_LIR_Gen_1 69 78 PF02991 0.488
LIG_LIR_Gen_1 744 752 PF02991 0.345
LIG_LIR_Gen_1 79 87 PF02991 0.394
LIG_LIR_Gen_1 99 108 PF02991 0.478
LIG_LIR_LC3C_4 137 142 PF02991 0.323
LIG_LIR_Nem_3 348 353 PF02991 0.380
LIG_LIR_Nem_3 394 398 PF02991 0.333
LIG_LIR_Nem_3 536 541 PF02991 0.429
LIG_LIR_Nem_3 628 632 PF02991 0.433
LIG_LIR_Nem_3 69 74 PF02991 0.481
LIG_LIR_Nem_3 728 734 PF02991 0.430
LIG_LIR_Nem_3 744 748 PF02991 0.382
LIG_LIR_Nem_3 79 83 PF02991 0.367
LIG_LIR_Nem_3 794 799 PF02991 0.379
LIG_LIR_Nem_3 852 856 PF02991 0.335
LIG_LIR_Nem_3 894 900 PF02991 0.376
LIG_LIR_Nem_3 99 104 PF02991 0.480
LIG_LYPXL_yS_3 779 782 PF13949 0.356
LIG_NRBOX 591 597 PF00104 0.385
LIG_NRBOX 82 88 PF00104 0.305
LIG_OCRL_FandH_1 83 95 PF00620 0.305
LIG_Pex14_2 80 84 PF04695 0.384
LIG_SH2_CRK 415 419 PF00017 0.316
LIG_SH2_CRK 767 771 PF00017 0.403
LIG_SH2_PTP2 287 290 PF00017 0.404
LIG_SH2_SRC 420 423 PF00017 0.344
LIG_SH2_STAP1 613 617 PF00017 0.414
LIG_SH2_STAP1 710 714 PF00017 0.387
LIG_SH2_STAP1 783 787 PF00017 0.376
LIG_SH2_STAP1 893 897 PF00017 0.295
LIG_SH2_STAT3 613 616 PF00017 0.365
LIG_SH2_STAT5 287 290 PF00017 0.420
LIG_SH2_STAT5 292 295 PF00017 0.352
LIG_SH2_STAT5 349 352 PF00017 0.313
LIG_SH2_STAT5 395 398 PF00017 0.371
LIG_SH2_STAT5 415 418 PF00017 0.215
LIG_SH2_STAT5 745 748 PF00017 0.391
LIG_SH3_3 121 127 PF00018 0.410
LIG_SH3_3 139 145 PF00018 0.215
LIG_SH3_3 256 262 PF00018 0.491
LIG_SH3_3 304 310 PF00018 0.425
LIG_SH3_3 466 472 PF00018 0.405
LIG_SH3_3 503 509 PF00018 0.461
LIG_SH3_3 629 635 PF00018 0.383
LIG_SH3_3 730 736 PF00018 0.482
LIG_SUMO_SIM_anti_2 830 839 PF11976 0.365
LIG_SUMO_SIM_par_1 570 576 PF11976 0.344
LIG_SUMO_SIM_par_1 599 605 PF11976 0.351
LIG_TRAF2_1 167 170 PF00917 0.461
LIG_TRAF2_1 456 459 PF00917 0.409
LIG_TRAF2_1 519 522 PF00917 0.453
LIG_TRAF2_1 842 845 PF00917 0.319
LIG_TRFH_1 580 584 PF08558 0.383
LIG_WRC_WIRS_1 384 389 PF05994 0.354
LIG_WRC_WIRS_1 77 82 PF05994 0.282
LIG_WW_1 780 783 PF00397 0.342
LIG_WW_3 198 202 PF00397 0.377
MOD_CDK_SPxK_1 10 16 PF00069 0.626
MOD_CK1_1 147 153 PF00069 0.444
MOD_CK1_1 231 237 PF00069 0.486
MOD_CK1_1 378 384 PF00069 0.431
MOD_CK1_1 501 507 PF00069 0.578
MOD_CK1_1 508 514 PF00069 0.406
MOD_CK1_1 543 549 PF00069 0.353
MOD_CK1_1 562 568 PF00069 0.533
MOD_CK1_1 575 581 PF00069 0.318
MOD_CK1_1 76 82 PF00069 0.373
MOD_CK1_1 868 874 PF00069 0.332
MOD_CK1_1 94 100 PF00069 0.391
MOD_CK2_1 110 116 PF00069 0.410
MOD_CK2_1 164 170 PF00069 0.485
MOD_CK2_1 173 179 PF00069 0.418
MOD_CK2_1 241 247 PF00069 0.373
MOD_CK2_1 416 422 PF00069 0.331
MOD_CK2_1 453 459 PF00069 0.451
MOD_CK2_1 508 514 PF00069 0.501
MOD_CK2_1 516 522 PF00069 0.491
MOD_CK2_1 533 539 PF00069 0.367
MOD_CK2_1 582 588 PF00069 0.348
MOD_CK2_1 649 655 PF00069 0.428
MOD_CK2_1 687 693 PF00069 0.412
MOD_CK2_1 830 836 PF00069 0.392
MOD_Cter_Amidation 556 559 PF01082 0.670
MOD_GlcNHglycan 146 149 PF01048 0.612
MOD_GlcNHglycan 221 224 PF01048 0.695
MOD_GlcNHglycan 234 237 PF01048 0.577
MOD_GlcNHglycan 280 284 PF01048 0.613
MOD_GlcNHglycan 30 33 PF01048 0.503
MOD_GlcNHglycan 38 41 PF01048 0.520
MOD_GlcNHglycan 518 521 PF01048 0.680
MOD_GlcNHglycan 522 526 PF01048 0.651
MOD_GlcNHglycan 660 663 PF01048 0.617
MOD_GlcNHglycan 93 96 PF01048 0.654
MOD_GSK3_1 102 109 PF00069 0.491
MOD_GSK3_1 144 151 PF00069 0.404
MOD_GSK3_1 175 182 PF00069 0.407
MOD_GSK3_1 228 235 PF00069 0.346
MOD_GSK3_1 330 337 PF00069 0.488
MOD_GSK3_1 345 352 PF00069 0.349
MOD_GSK3_1 440 447 PF00069 0.361
MOD_GSK3_1 496 503 PF00069 0.603
MOD_GSK3_1 558 565 PF00069 0.493
MOD_GSK3_1 584 591 PF00069 0.364
MOD_GSK3_1 596 603 PF00069 0.345
MOD_N-GLC_1 207 212 PF02516 0.673
MOD_N-GLC_1 378 383 PF02516 0.518
MOD_N-GLC_1 454 459 PF02516 0.605
MOD_N-GLC_1 501 506 PF02516 0.683
MOD_N-GLC_1 533 538 PF02516 0.614
MOD_N-GLC_1 822 827 PF02516 0.619
MOD_N-GLC_2 873 875 PF02516 0.506
MOD_NEK2_1 173 178 PF00069 0.367
MOD_NEK2_1 241 246 PF00069 0.391
MOD_NEK2_1 35 40 PF00069 0.725
MOD_NEK2_1 391 396 PF00069 0.437
MOD_NEK2_1 548 553 PF00069 0.440
MOD_NEK2_1 612 617 PF00069 0.350
MOD_NEK2_1 725 730 PF00069 0.529
MOD_NEK2_1 856 861 PF00069 0.304
MOD_NEK2_1 91 96 PF00069 0.565
MOD_NEK2_2 180 185 PF00069 0.343
MOD_NEK2_2 405 410 PF00069 0.243
MOD_PIKK_1 252 258 PF00454 0.342
MOD_PIKK_1 533 539 PF00454 0.498
MOD_PIKK_1 612 618 PF00454 0.360
MOD_PIKK_1 66 72 PF00454 0.607
MOD_PIKK_1 754 760 PF00454 0.363
MOD_PIKK_1 94 100 PF00454 0.477
MOD_PKA_1 558 564 PF00069 0.489
MOD_PKA_2 110 116 PF00069 0.349
MOD_PKA_2 200 206 PF00069 0.368
MOD_PKA_2 214 220 PF00069 0.360
MOD_PKA_2 28 34 PF00069 0.672
MOD_PKA_2 298 304 PF00069 0.455
MOD_PKA_2 375 381 PF00069 0.413
MOD_PKA_2 440 446 PF00069 0.357
MOD_PKA_2 558 564 PF00069 0.483
MOD_PKA_2 582 588 PF00069 0.436
MOD_PKA_2 725 731 PF00069 0.458
MOD_PKA_2 828 834 PF00069 0.369
MOD_PKB_1 540 548 PF00069 0.364
MOD_PKB_1 647 655 PF00069 0.461
MOD_Plk_1 334 340 PF00069 0.544
MOD_Plk_1 378 384 PF00069 0.320
MOD_Plk_1 501 507 PF00069 0.578
MOD_Plk_1 533 539 PF00069 0.382
MOD_Plk_1 587 593 PF00069 0.342
MOD_Plk_2-3 110 116 PF00069 0.335
MOD_Plk_4 110 116 PF00069 0.415
MOD_Plk_4 345 351 PF00069 0.337
MOD_Plk_4 383 389 PF00069 0.344
MOD_Plk_4 391 397 PF00069 0.380
MOD_Plk_4 588 594 PF00069 0.292
MOD_Plk_4 660 666 PF00069 0.407
MOD_Plk_4 702 708 PF00069 0.359
MOD_Plk_4 73 79 PF00069 0.283
MOD_Plk_4 830 836 PF00069 0.412
MOD_Plk_4 96 102 PF00069 0.418
MOD_ProDKin_1 10 16 PF00069 0.670
MOD_ProDKin_1 505 511 PF00069 0.482
MOD_ProDKin_1 596 602 PF00069 0.346
MOD_SUMO_for_1 804 807 PF00179 0.352
TRG_DiLeu_BaEn_1 110 115 PF01217 0.332
TRG_DiLeu_BaEn_1 588 593 PF01217 0.343
TRG_DiLeu_BaLyEn_6 31 36 PF01217 0.674
TRG_ENDOCYTIC_2 101 104 PF00928 0.447
TRG_ENDOCYTIC_2 395 398 PF00928 0.346
TRG_ENDOCYTIC_2 415 418 PF00928 0.272
TRG_ENDOCYTIC_2 609 612 PF00928 0.354
TRG_ENDOCYTIC_2 745 748 PF00928 0.338
TRG_ENDOCYTIC_2 767 770 PF00928 0.397
TRG_ENDOCYTIC_2 779 782 PF00928 0.373
TRG_ENDOCYTIC_2 783 786 PF00928 0.318
TRG_ENDOCYTIC_2 799 802 PF00928 0.349
TRG_ENDOCYTIC_2 892 895 PF00928 0.325
TRG_ER_diArg_1 409 411 PF00400 0.367
TRG_ER_diArg_1 646 649 PF00400 0.408
TRG_ER_diArg_1 718 721 PF00400 0.393
TRG_ER_diArg_1 725 727 PF00400 0.385
TRG_ER_diArg_1 789 792 PF00400 0.380
TRG_ER_diArg_1 876 878 PF00400 0.312
TRG_NLS_MonoExtN_4 769 775 PF00514 0.404
TRG_Pf-PMV_PEXEL_1 424 428 PF00026 0.548

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HW42 Leptomonas seymouri 40% 100%
A0A0N1P9X3 Leptomonas seymouri 35% 100%
A0A3Q8IMZ0 Leishmania donovani 88% 100%
A4HRS2 Leishmania infantum 34% 100%
A4I9M1 Leishmania infantum 88% 100%
E9AC93 Leishmania major 33% 100%
E9AC97 Leishmania major 33% 100%
E9B4M0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS