BRCT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q3F4_LEIMA

TriTrypDb:

LmjF.34.0530 , LMJLV39_340011400 , LMJSD75_340011100

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3F4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3F4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.614
CLV_C14_Caspase3-7	81	85	PF00656	0.657
CLV_NRD_NRD_1	410	412	PF00675	0.556
CLV_NRD_NRD_1	457	459	PF00675	0.577
CLV_NRD_NRD_1	59	61	PF00675	0.658
CLV_PCSK_KEX2_1	457	459	PF00082	0.577
DEG_APCC_DBOX_1	258	266	PF00400	0.486
DEG_SCF_FBW7_2	21	28	PF00400	0.613
DEG_SPOP_SBC_1	161	165	PF00917	0.651
DEG_SPOP_SBC_1	205	209	PF00917	0.570
DOC_CKS1_1	211	216	PF01111	0.398
DOC_CKS1_1	22	27	PF01111	0.613
DOC_CYCLIN_RxL_1	304	314	PF00134	0.452
DOC_CYCLIN_yCln2_LP_2	305	311	PF00134	0.331
DOC_MAPK_DCC_7	479	487	PF00069	0.504
DOC_MAPK_MEF2A_6	105	113	PF00069	0.504
DOC_MAPK_MEF2A_6	134	142	PF00069	0.566
DOC_MAPK_MEF2A_6	479	487	PF00069	0.504
DOC_PP1_RVXF_1	360	367	PF00149	0.582
DOC_PP2B_LxvP_1	486	489	PF13499	0.551
DOC_PP4_FxxP_1	487	490	PF00568	0.474
DOC_PP4_MxPP_1	459	462	PF00568	0.587
DOC_USP7_MATH_1	161	165	PF00917	0.622
DOC_USP7_MATH_1	205	209	PF00917	0.570
DOC_USP7_MATH_1	322	326	PF00917	0.554
DOC_USP7_MATH_1	379	383	PF00917	0.623
DOC_USP7_MATH_1	384	388	PF00917	0.555
DOC_USP7_MATH_1	410	414	PF00917	0.651
DOC_USP7_MATH_1	445	449	PF00917	0.754
DOC_USP7_MATH_1	475	479	PF00917	0.664
DOC_USP7_MATH_1	51	55	PF00917	0.630
DOC_WW_Pin1_4	144	149	PF00397	0.698
DOC_WW_Pin1_4	162	167	PF00397	0.704
DOC_WW_Pin1_4	21	26	PF00397	0.606
DOC_WW_Pin1_4	210	215	PF00397	0.455
DOC_WW_Pin1_4	260	265	PF00397	0.478
DOC_WW_Pin1_4	286	291	PF00397	0.482
DOC_WW_Pin1_4	299	304	PF00397	0.465
DOC_WW_Pin1_4	471	476	PF00397	0.666
LIG_14-3-3_CanoR_1	11	21	PF00244	0.596
LIG_14-3-3_CanoR_1	160	166	PF00244	0.542
LIG_14-3-3_CanoR_1	395	400	PF00244	0.624
LIG_14-3-3_CanoR_1	411	415	PF00244	0.567
LIG_BRCT_BRCA1_1	483	487	PF00533	0.497
LIG_EVH1_2	168	172	PF00568	0.537
LIG_FHA_1	13	19	PF00498	0.621
LIG_FHA_1	223	229	PF00498	0.482
LIG_FHA_1	311	317	PF00498	0.500
LIG_FHA_1	367	373	PF00498	0.585
LIG_FHA_1	53	59	PF00498	0.725
LIG_FHA_2	1	7	PF00498	0.552
LIG_FHA_2	22	28	PF00498	0.681
LIG_FHA_2	400	406	PF00498	0.656
LIG_FHA_2	449	455	PF00498	0.585
LIG_FHA_2	57	63	PF00498	0.716
LIG_LIR_Apic_2	208	214	PF02991	0.467
LIG_LIR_Apic_2	484	490	PF02991	0.486
LIG_LIR_Gen_1	170	179	PF02991	0.541
LIG_LIR_Gen_1	237	245	PF02991	0.443
LIG_LIR_Gen_1	439	445	PF02991	0.655
LIG_LIR_Nem_3	237	242	PF02991	0.436
LIG_LIR_Nem_3	439	443	PF02991	0.657
LIG_MAD2	39	47	PF02301	0.603
LIG_PROFILIN_1	45	51	PF00235	0.617
LIG_SH2_CRK	211	215	PF00017	0.525
LIG_SH2_CRK	306	310	PF00017	0.443
LIG_SH2_STAT5	397	400	PF00017	0.747
LIG_SH3_1	43	49	PF00018	0.586
LIG_SH3_1	457	463	PF00018	0.564
LIG_SH3_3	163	169	PF00018	0.828
LIG_SH3_3	186	192	PF00018	0.611
LIG_SH3_3	19	25	PF00018	0.610
LIG_SH3_3	199	205	PF00018	0.670
LIG_SH3_3	41	47	PF00018	0.597
LIG_SH3_3	417	423	PF00018	0.601
LIG_SH3_3	457	463	PF00018	0.564
LIG_SH3_4	244	251	PF00018	0.449
LIG_TRAF2_1	100	103	PF00917	0.571
LIG_TRAF2_1	116	119	PF00917	0.657
LIG_TRAF2_1	268	271	PF00917	0.442
LIG_TRAF2_1	341	344	PF00917	0.579
LIG_TRAF2_1	378	381	PF00917	0.594
LIG_WW_1	462	465	PF00397	0.601
MOD_CDK_SPK_2	21	26	PF00069	0.672
MOD_CDK_SPK_2	299	304	PF00069	0.397
MOD_CK1_1	281	287	PF00069	0.550
MOD_CK1_1	29	35	PF00069	0.629
MOD_CK1_1	387	393	PF00069	0.593
MOD_CK1_1	413	419	PF00069	0.614
MOD_CK1_1	448	454	PF00069	0.607
MOD_CK1_1	54	60	PF00069	0.645
MOD_CK2_1	113	119	PF00069	0.572
MOD_CK2_1	229	235	PF00069	0.574
MOD_CK2_1	270	276	PF00069	0.512
MOD_CK2_1	281	287	PF00069	0.497
MOD_CK2_1	367	373	PF00069	0.585
MOD_CK2_1	379	385	PF00069	0.607
MOD_CK2_1	399	405	PF00069	0.818
MOD_CK2_1	448	454	PF00069	0.587
MOD_CK2_1	56	62	PF00069	0.721
MOD_GlcNHglycan	148	151	PF01048	0.648
MOD_GlcNHglycan	186	189	PF01048	0.609
MOD_GlcNHglycan	232	235	PF01048	0.473
MOD_GlcNHglycan	27	31	PF01048	0.636
MOD_GlcNHglycan	446	450	PF01048	0.577
MOD_GlcNHglycan	479	482	PF01048	0.748
MOD_GSK3_1	206	213	PF00069	0.545
MOD_GSK3_1	335	342	PF00069	0.587
MOD_GSK3_1	395	402	PF00069	0.612
MOD_GSK3_1	410	417	PF00069	0.686
MOD_GSK3_1	441	448	PF00069	0.570
MOD_GSK3_1	471	478	PF00069	0.672
MOD_GSK3_1	52	59	PF00069	0.634
MOD_GSK3_1	7	14	PF00069	0.628
MOD_N-GLC_1	322	327	PF02516	0.496
MOD_NEK2_1	193	198	PF00069	0.688
MOD_PIKK_1	113	119	PF00454	0.518
MOD_PIKK_1	216	222	PF00454	0.459
MOD_PIKK_1	270	276	PF00454	0.490
MOD_PIKK_1	405	411	PF00454	0.637
MOD_PKA_2	410	416	PF00069	0.560
MOD_PKB_1	9	17	PF00069	0.567
MOD_Plk_1	270	276	PF00069	0.480
MOD_Plk_1	384	390	PF00069	0.577
MOD_Plk_1	414	420	PF00069	0.605
MOD_Plk_1	445	451	PF00069	0.736
MOD_Plk_2-3	339	345	PF00069	0.604
MOD_Plk_4	105	111	PF00069	0.587
MOD_Plk_4	206	212	PF00069	0.494
MOD_Plk_4	281	287	PF00069	0.708
MOD_Plk_4	481	487	PF00069	0.660
MOD_ProDKin_1	144	150	PF00069	0.699
MOD_ProDKin_1	162	168	PF00069	0.703
MOD_ProDKin_1	21	27	PF00069	0.611
MOD_ProDKin_1	210	216	PF00069	0.463
MOD_ProDKin_1	260	266	PF00069	0.467
MOD_ProDKin_1	286	292	PF00069	0.476
MOD_ProDKin_1	299	305	PF00069	0.456
MOD_ProDKin_1	471	477	PF00069	0.665
MOD_SUMO_for_1	243	246	PF00179	0.409
MOD_SUMO_for_1	25	28	PF00179	0.691
MOD_SUMO_for_1	65	68	PF00179	0.545
MOD_SUMO_rev_2	81	91	PF00179	0.743
MOD_SUMO_rev_2	97	107	PF00179	0.581
TRG_DiLeu_BaEn_1	106	111	PF01217	0.502
TRG_DiLeu_BaEn_2	234	240	PF01217	0.415
TRG_ENDOCYTIC_2	306	309	PF00928	0.509
TRG_ER_diArg_1	456	458	PF00400	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P589	Leptomonas seymouri	30%	68%
A0A3Q8IGZ7	Leishmania donovani	86%	100%
A4H7D5	Leishmania braziliensis	52%	71%
A4I9M3	Leishmania infantum	87%	100%
E9B4M2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%