Putative Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide-sensitive factor attachment protein, gamma)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide-sensitive factor attachment protein, gamma), putative

Species:

Leishmania major

UniProt:

Q4Q3F3_LEIMA

TriTrypDb:

LmjF.34.0540 , LMJLV39_340011600 , LMJSD75_340011300

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031201	SNARE complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0098796	membrane protein complex	2	2

Expansion

Sequence features

Q4Q3F3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3F3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005483	soluble NSF attachment protein activity	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019905	syntaxin binding	4	2
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	381	385	PF00656	0.682
CLV_NRD_NRD_1	159	161	PF00675	0.562
CLV_PCSK_KEX2_1	159	161	PF00082	0.562
CLV_PCSK_KEX2_1	179	181	PF00082	0.367
CLV_PCSK_KEX2_1	228	230	PF00082	0.402
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.367
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.402
CLV_PCSK_SKI1_1	24	28	PF00082	0.438
CLV_PCSK_SKI1_1	247	251	PF00082	0.356
CLV_PCSK_SKI1_1	338	342	PF00082	0.373
DEG_SCF_FBW7_2	1	8	PF00400	0.460
DEG_SPOP_SBC_1	370	374	PF00917	0.739
DOC_CYCLIN_RxL_1	338	347	PF00134	0.455
DOC_CYCLIN_yClb5_NLxxxL_5	247	253	PF00134	0.470
DOC_MAPK_MEF2A_6	208	215	PF00069	0.363
DOC_MAPK_MEF2A_6	261	268	PF00069	0.288
DOC_PP1_RVXF_1	23	30	PF00149	0.371
DOC_PP4_FxxP_1	201	204	PF00568	0.466
DOC_USP7_MATH_1	161	165	PF00917	0.624
DOC_USP7_MATH_1	195	199	PF00917	0.476
DOC_USP7_MATH_1	334	338	PF00917	0.497
DOC_USP7_MATH_1	364	368	PF00917	0.672
DOC_USP7_MATH_1	371	375	PF00917	0.692
DOC_USP7_MATH_1	76	80	PF00917	0.417
DOC_USP7_UBL2_3	20	24	PF12436	0.404
DOC_USP7_UBL2_3	348	352	PF12436	0.616
DOC_WW_Pin1_4	1	6	PF00397	0.493
DOC_WW_Pin1_4	234	239	PF00397	0.596
LIG_14-3-3_CanoR_1	151	157	PF00244	0.540
LIG_BRCT_BRCA1_1	197	201	PF00533	0.510
LIG_eIF4E_1	207	213	PF01652	0.379
LIG_FHA_1	105	111	PF00498	0.622
LIG_FHA_1	169	175	PF00498	0.439
LIG_FHA_2	165	171	PF00498	0.624
LIG_FHA_2	240	246	PF00498	0.530
LIG_FHA_2	271	277	PF00498	0.510
LIG_FHA_2	381	387	PF00498	0.706
LIG_LIR_Apic_2	155	161	PF02991	0.491
LIG_LIR_Apic_2	198	204	PF02991	0.496
LIG_LIR_Gen_1	280	289	PF02991	0.475
LIG_LIR_Gen_1	327	336	PF02991	0.390
LIG_LIR_Nem_3	177	181	PF02991	0.471
LIG_LIR_Nem_3	280	284	PF02991	0.469
LIG_LIR_Nem_3	327	332	PF02991	0.395
LIG_SH2_CRK	158	162	PF00017	0.517
LIG_SH2_CRK	178	182	PF00017	0.433
LIG_SH2_CRK	47	51	PF00017	0.508
LIG_SH2_GRB2like	47	50	PF00017	0.500
LIG_SH2_NCK_1	122	126	PF00017	0.453
LIG_SH2_SRC	122	125	PF00017	0.454
LIG_SH2_SRC	243	246	PF00017	0.517
LIG_SH2_STAT5	173	176	PF00017	0.416
LIG_SH2_STAT5	279	282	PF00017	0.480
LIG_SH2_STAT5	47	50	PF00017	0.368
LIG_SUMO_SIM_anti_2	184	190	PF11976	0.455
LIG_SUMO_SIM_anti_2	265	270	PF11976	0.276
LIG_SUMO_SIM_par_1	184	190	PF11976	0.382
LIG_TRAF2_1	121	124	PF00917	0.453
LIG_TRAF2_1	298	301	PF00917	0.379
LIG_TRAF2_1	318	321	PF00917	0.229
MOD_CDK_SPxK_1	1	7	PF00069	0.471
MOD_CK1_1	152	158	PF00069	0.550
MOD_CK1_1	164	170	PF00069	0.506
MOD_CK1_1	351	357	PF00069	0.698
MOD_CK1_1	94	100	PF00069	0.576
MOD_CK2_1	295	301	PF00069	0.342
MOD_CK2_1	380	386	PF00069	0.653
MOD_Cter_Amidation	17	20	PF01082	0.498
MOD_GlcNHglycan	16	19	PF01048	0.547
MOD_GlcNHglycan	163	166	PF01048	0.580
MOD_GlcNHglycan	216	219	PF01048	0.431
MOD_GlcNHglycan	365	369	PF01048	0.668
MOD_GlcNHglycan	99	102	PF01048	0.593
MOD_GSK3_1	104	111	PF00069	0.512
MOD_GSK3_1	160	167	PF00069	0.584
MOD_GSK3_1	239	246	PF00069	0.498
MOD_GSK3_1	344	351	PF00069	0.533
MOD_GSK3_1	378	385	PF00069	0.781
MOD_GSK3_1	93	100	PF00069	0.580
MOD_N-GLC_1	133	138	PF02516	0.542
MOD_N-GLC_2	326	328	PF02516	0.401
MOD_NEK2_1	269	274	PF00069	0.336
MOD_PIKK_1	371	377	PF00454	0.589
MOD_PIKK_1	58	64	PF00454	0.408
MOD_PIKK_1	85	91	PF00454	0.481
MOD_PKA_1	341	347	PF00069	0.493
MOD_Plk_1	334	340	PF00069	0.355
MOD_Plk_2-3	382	388	PF00069	0.695
MOD_ProDKin_1	1	7	PF00069	0.482
MOD_ProDKin_1	234	240	PF00069	0.594
MOD_SUMO_rev_2	240	249	PF00179	0.505
TRG_DiLeu_BaEn_1	184	189	PF01217	0.345
TRG_DiLeu_BaEn_4	123	129	PF01217	0.467
TRG_ENDOCYTIC_2	178	181	PF00928	0.470
TRG_ENDOCYTIC_2	47	50	PF00928	0.414
TRG_ER_diArg_1	158	160	PF00400	0.556
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.323
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I337	Leptomonas seymouri	66%	99%
A0A0S4J5L6	Bodo saltans	30%	100%
A0A1X0P9K4	Trypanosomatidae	37%	100%
A0A3Q8IKP9	Leishmania donovani	92%	100%
A0A422MZB1	Trypanosoma rangeli	37%	100%
A4H7D4	Leishmania braziliensis	76%	93%
A4I9M4	Leishmania infantum	92%	100%
D0A1Z0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B4M3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BRU6	Trypanosoma cruzi	36%	100%