Putative leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cysteine leucine rich protein

Species:

Leishmania major

UniProt:

Q4Q3F2_LEIMA

TriTrypDb:

LmjF.34.0550 , LMJLV39_340011700 , LMJSD75_340011400

Length:

623

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	2
GO:0005634	nucleus	5	2
GO:0005886	plasma membrane	3	2
GO:0005929	cilium	4	8
GO:0016020	membrane	2	2
GO:0019005	SCF ubiquitin ligase complex	5	2
GO:0031461	cullin-RING ubiquitin ligase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

Q4Q3F2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3F2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0030163	protein catabolic process	4	2
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	571	573	PF00675	0.621
CLV_PCSK_KEX2_1	500	502	PF00082	0.414
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.474
CLV_PCSK_SKI1_1	285	289	PF00082	0.415
CLV_PCSK_SKI1_1	500	504	PF00082	0.510
CLV_PCSK_SKI1_1	551	555	PF00082	0.446
DOC_CDC14_PxL_1	543	551	PF14671	0.476
DOC_CYCLIN_RxL_1	432	440	PF00134	0.465
DOC_MAPK_gen_1	500	507	PF00069	0.408
DOC_MAPK_gen_1	572	580	PF00069	0.497
DOC_PP1_RVXF_1	458	465	PF00149	0.469
DOC_PP2B_LxvP_1	466	469	PF13499	0.515
DOC_PP4_FxxP_1	229	232	PF00568	0.634
DOC_PP4_FxxP_1	97	100	PF00568	0.661
DOC_USP7_MATH_1	139	143	PF00917	0.646
DOC_USP7_MATH_1	211	215	PF00917	0.626
DOC_USP7_MATH_1	244	248	PF00917	0.654
DOC_USP7_MATH_1	259	263	PF00917	0.491
DOC_USP7_MATH_1	378	382	PF00917	0.415
DOC_USP7_MATH_1	474	478	PF00917	0.427
DOC_USP7_MATH_1	488	492	PF00917	0.311
DOC_USP7_MATH_1	581	585	PF00917	0.561
DOC_USP7_MATH_1	76	80	PF00917	0.740
DOC_WW_Pin1_4	162	167	PF00397	0.679
DOC_WW_Pin1_4	209	214	PF00397	0.712
DOC_WW_Pin1_4	305	310	PF00397	0.483
DOC_WW_Pin1_4	596	601	PF00397	0.675
DOC_WW_Pin1_4	609	614	PF00397	0.647
DOC_WW_Pin1_4	72	77	PF00397	0.644
DOC_WW_Pin1_4	79	84	PF00397	0.631
LIG_14-3-3_CanoR_1	317	326	PF00244	0.594
LIG_14-3-3_CanoR_1	336	343	PF00244	0.357
LIG_14-3-3_CanoR_1	403	410	PF00244	0.418
LIG_14-3-3_CanoR_1	501	506	PF00244	0.494
LIG_14-3-3_CanoR_1	519	526	PF00244	0.326
LIG_BIR_II_1	1	5	PF00653	0.669
LIG_BIR_III_1	1	5	PF00653	0.686
LIG_BIR_III_2	339	343	PF00653	0.416
LIG_BIR_III_3	1	5	PF00653	0.686
LIG_BRCT_BRCA1_1	346	350	PF00533	0.448
LIG_FHA_1	152	158	PF00498	0.813
LIG_FHA_1	165	171	PF00498	0.569
LIG_FHA_1	20	26	PF00498	0.631
LIG_FHA_1	359	365	PF00498	0.457
LIG_FHA_1	424	430	PF00498	0.419
LIG_FHA_1	502	508	PF00498	0.456
LIG_FHA_1	548	554	PF00498	0.575
LIG_FHA_1	76	82	PF00498	0.691
LIG_FHA_2	142	148	PF00498	0.792
LIG_FHA_2	511	517	PF00498	0.438
LIG_FHA_2	536	542	PF00498	0.463
LIG_FHA_2	572	578	PF00498	0.529
LIG_FHA_2	613	619	PF00498	0.747
LIG_LIR_Gen_1	592	600	PF02991	0.691
LIG_LIR_Nem_3	172	176	PF02991	0.692
LIG_LIR_Nem_3	63	67	PF02991	0.668
LIG_LYPXL_yS_3	67	70	PF13949	0.658
LIG_NRBOX	461	467	PF00104	0.459
LIG_Pex14_2	223	227	PF04695	0.491
LIG_PTB_Apo_2	217	224	PF02174	0.494
LIG_Rb_pABgroove_1	344	352	PF01858	0.443
LIG_SH2_CRK	98	102	PF00017	0.645
LIG_SH2_SRC	98	101	PF00017	0.645
LIG_SH2_STAP1	404	408	PF00017	0.451
LIG_SH2_STAT3	96	99	PF00017	0.699
LIG_SH2_STAT5	401	404	PF00017	0.428
LIG_SH2_STAT5	96	99	PF00017	0.659
LIG_SH3_1	603	609	PF00018	0.659
LIG_SH3_1	98	104	PF00018	0.694
LIG_SH3_3	160	166	PF00018	0.742
LIG_SH3_3	168	174	PF00018	0.633
LIG_SH3_3	185	191	PF00018	0.709
LIG_SH3_3	204	210	PF00018	0.719
LIG_SH3_3	603	609	PF00018	0.659
LIG_SH3_3	98	104	PF00018	0.735
LIG_SUMO_SIM_par_1	479	484	PF11976	0.360
LIG_TRAF2_1	513	516	PF00917	0.448
LIG_WRC_WIRS_1	489	494	PF05994	0.441
MOD_CDK_SPxxK_3	596	603	PF00069	0.691
MOD_CK1_1	165	171	PF00069	0.684
MOD_CK1_1	212	218	PF00069	0.679
MOD_CK1_1	372	378	PF00069	0.376
MOD_CK1_1	518	524	PF00069	0.457
MOD_CK1_1	607	613	PF00069	0.721
MOD_CK1_1	75	81	PF00069	0.823
MOD_CK2_1	141	147	PF00069	0.789
MOD_CK2_1	259	265	PF00069	0.513
MOD_CK2_1	510	516	PF00069	0.464
MOD_CK2_1	535	541	PF00069	0.415
MOD_CK2_1	571	577	PF00069	0.467
MOD_CK2_1	612	618	PF00069	0.744
MOD_GlcNHglycan	141	144	PF01048	0.679
MOD_GlcNHglycan	167	170	PF01048	0.764
MOD_GlcNHglycan	354	357	PF01048	0.378
MOD_GlcNHglycan	51	54	PF01048	0.569
MOD_GlcNHglycan	520	523	PF01048	0.463
MOD_GlcNHglycan	591	594	PF01048	0.710
MOD_GlcNHglycan	84	87	PF01048	0.815
MOD_GSK3_1	15	22	PF00069	0.574
MOD_GSK3_1	158	165	PF00069	0.762
MOD_GSK3_1	197	204	PF00069	0.687
MOD_GSK3_1	209	216	PF00069	0.640
MOD_GSK3_1	245	252	PF00069	0.613
MOD_GSK3_1	354	361	PF00069	0.454
MOD_GSK3_1	365	372	PF00069	0.383
MOD_GSK3_1	383	390	PF00069	0.450
MOD_GSK3_1	501	508	PF00069	0.467
MOD_GSK3_1	594	601	PF00069	0.646
MOD_GSK3_1	604	611	PF00069	0.660
MOD_GSK3_1	68	75	PF00069	0.700
MOD_GSK3_1	82	89	PF00069	0.655
MOD_N-GLC_1	244	249	PF02516	0.663
MOD_N-GLC_1	30	35	PF02516	0.569
MOD_N-GLC_1	352	357	PF02516	0.416
MOD_N-GLC_1	392	397	PF02516	0.469
MOD_N-GLC_1	535	540	PF02516	0.392
MOD_N-GLC_1	79	84	PF02516	0.704
MOD_N-GLC_2	330	332	PF02516	0.440
MOD_N-GLC_2	380	382	PF02516	0.421
MOD_NEK2_1	158	163	PF00069	0.814
MOD_NEK2_1	201	206	PF00069	0.661
MOD_NEK2_1	249	254	PF00069	0.570
MOD_NEK2_1	318	323	PF00069	0.390
MOD_NEK2_1	352	357	PF00069	0.352
MOD_NEK2_1	358	363	PF00069	0.457
MOD_NEK2_1	437	442	PF00069	0.497
MOD_NEK2_1	494	499	PF00069	0.514
MOD_NEK2_1	505	510	PF00069	0.405
MOD_NEK2_1	571	576	PF00069	0.526
MOD_PIKK_1	19	25	PF00454	0.489
MOD_PIKK_1	369	375	PF00454	0.388
MOD_PIKK_1	454	460	PF00454	0.470
MOD_PIKK_1	86	92	PF00454	0.640
MOD_PKA_2	324	330	PF00069	0.443
MOD_PKA_2	335	341	PF00069	0.447
MOD_PKA_2	402	408	PF00069	0.457
MOD_PKA_2	505	511	PF00069	0.481
MOD_PKA_2	518	524	PF00069	0.489
MOD_PKA_2	571	577	PF00069	0.500
MOD_Plk_1	197	203	PF00069	0.665
MOD_Plk_1	244	250	PF00069	0.639
MOD_Plk_1	30	36	PF00069	0.570
MOD_Plk_1	386	392	PF00069	0.443
MOD_Plk_1	454	460	PF00069	0.392
MOD_Plk_1	515	521	PF00069	0.473
MOD_Plk_4	153	159	PF00069	0.771
MOD_Plk_4	201	207	PF00069	0.805
MOD_Plk_4	344	350	PF00069	0.451
MOD_Plk_4	354	360	PF00069	0.421
MOD_ProDKin_1	162	168	PF00069	0.679
MOD_ProDKin_1	209	215	PF00069	0.709
MOD_ProDKin_1	305	311	PF00069	0.478
MOD_ProDKin_1	596	602	PF00069	0.675
MOD_ProDKin_1	609	615	PF00069	0.653
MOD_ProDKin_1	72	78	PF00069	0.646
MOD_ProDKin_1	79	85	PF00069	0.631
MOD_SUMO_rev_2	115	120	PF00179	0.693
MOD_SUMO_rev_2	390	400	PF00179	0.441
MOD_SUMO_rev_2	561	565	PF00179	0.550
TRG_ENDOCYTIC_2	595	598	PF00928	0.693
TRG_ENDOCYTIC_2	67	70	PF00928	0.658
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N0	Leptomonas seymouri	64%	99%
A0A3S5ISR4	Trypanosoma rangeli	24%	75%
A0A3S7X7J0	Leishmania donovani	95%	100%
A4H7D3	Leishmania braziliensis	82%	100%
A4I9M5	Leishmania infantum	95%	100%
E9B4M4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%