Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3E7_LEIMA

TriTrypDb:

LmjF.34.0600 , LMJLV39_340012200 , LMJSD75_340011900

Length:

853

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3E7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3E7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.732
CLV_C14_Caspase3-7	774	778	PF00656	0.493
CLV_NRD_NRD_1	139	141	PF00675	0.563
CLV_NRD_NRD_1	142	144	PF00675	0.601
CLV_NRD_NRD_1	287	289	PF00675	0.474
CLV_NRD_NRD_1	372	374	PF00675	0.427
CLV_NRD_NRD_1	432	434	PF00675	0.437
CLV_NRD_NRD_1	438	440	PF00675	0.448
CLV_NRD_NRD_1	786	788	PF00675	0.531
CLV_NRD_NRD_1	92	94	PF00675	0.670
CLV_PCSK_FUR_1	140	144	PF00082	0.535
CLV_PCSK_KEX2_1	139	141	PF00082	0.563
CLV_PCSK_KEX2_1	142	144	PF00082	0.601
CLV_PCSK_KEX2_1	269	271	PF00082	0.515
CLV_PCSK_KEX2_1	287	289	PF00082	0.457
CLV_PCSK_KEX2_1	372	374	PF00082	0.427
CLV_PCSK_KEX2_1	432	434	PF00082	0.435
CLV_PCSK_KEX2_1	438	440	PF00082	0.438
CLV_PCSK_KEX2_1	536	538	PF00082	0.499
CLV_PCSK_KEX2_1	786	788	PF00082	0.472
CLV_PCSK_KEX2_1	795	797	PF00082	0.519
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.573
CLV_PCSK_PC1ET2_1	536	538	PF00082	0.499
CLV_PCSK_PC1ET2_1	795	797	PF00082	0.569
CLV_PCSK_SKI1_1	198	202	PF00082	0.531
CLV_PCSK_SKI1_1	260	264	PF00082	0.564
CLV_PCSK_SKI1_1	343	347	PF00082	0.422
CLV_PCSK_SKI1_1	52	56	PF00082	0.542
CLV_PCSK_SKI1_1	787	791	PF00082	0.532
DEG_APCC_DBOX_1	342	350	PF00400	0.409
DEG_APCC_DBOX_1	458	466	PF00400	0.487
DEG_SIAH_1	580	588	PF03145	0.613
DEG_SPOP_SBC_1	500	504	PF00917	0.623
DEG_SPOP_SBC_1	571	575	PF00917	0.546
DEG_SPOP_SBC_1	622	626	PF00917	0.603
DEG_SPOP_SBC_1	681	685	PF00917	0.621
DOC_ANK_TNKS_1	319	326	PF00023	0.473
DOC_CKS1_1	106	111	PF01111	0.632
DOC_CYCLIN_RxL_1	340	350	PF00134	0.426
DOC_CYCLIN_RxL_1	399	410	PF00134	0.348
DOC_MAPK_gen_1	139	149	PF00069	0.560
DOC_MAPK_gen_1	25	34	PF00069	0.509
DOC_MAPK_gen_1	399	407	PF00069	0.392
DOC_MAPK_gen_1	457	464	PF00069	0.426
DOC_MAPK_MEF2A_6	140	149	PF00069	0.564
DOC_MAPK_NFAT4_5	142	150	PF00069	0.501
DOC_PP2B_PxIxI_1	108	114	PF00149	0.661
DOC_USP7_MATH_1	112	116	PF00917	0.643
DOC_USP7_MATH_1	181	185	PF00917	0.572
DOC_USP7_MATH_1	194	198	PF00917	0.588
DOC_USP7_MATH_1	236	240	PF00917	0.568
DOC_USP7_MATH_1	24	28	PF00917	0.759
DOC_USP7_MATH_1	246	250	PF00917	0.515
DOC_USP7_MATH_1	480	484	PF00917	0.619
DOC_USP7_MATH_1	500	504	PF00917	0.513
DOC_USP7_MATH_1	570	574	PF00917	0.728
DOC_USP7_MATH_1	587	591	PF00917	0.651
DOC_USP7_MATH_1	600	604	PF00917	0.642
DOC_USP7_MATH_1	611	615	PF00917	0.589
DOC_USP7_MATH_1	623	627	PF00917	0.596
DOC_USP7_MATH_1	630	634	PF00917	0.532
DOC_USP7_MATH_1	638	642	PF00917	0.531
DOC_USP7_MATH_1	655	659	PF00917	0.790
DOC_USP7_MATH_1	662	666	PF00917	0.684
DOC_USP7_MATH_1	682	686	PF00917	0.512
DOC_USP7_MATH_1	706	710	PF00917	0.822
DOC_USP7_MATH_1	724	728	PF00917	0.615
DOC_USP7_MATH_1	775	779	PF00917	0.520
DOC_USP7_MATH_1	791	795	PF00917	0.413
DOC_WW_Pin1_4	102	107	PF00397	0.646
DOC_WW_Pin1_4	17	22	PF00397	0.657
DOC_WW_Pin1_4	192	197	PF00397	0.662
DOC_WW_Pin1_4	549	554	PF00397	0.555
DOC_WW_Pin1_4	561	566	PF00397	0.706
DOC_WW_Pin1_4	572	577	PF00397	0.559
DOC_WW_Pin1_4	585	590	PF00397	0.579
DOC_WW_Pin1_4	596	601	PF00397	0.705
DOC_WW_Pin1_4	626	631	PF00397	0.747
DOC_WW_Pin1_4	634	639	PF00397	0.632
DOC_WW_Pin1_4	651	656	PF00397	0.563
DOC_WW_Pin1_4	689	694	PF00397	0.745
DOC_WW_Pin1_4	803	808	PF00397	0.601
LIG_14-3-3_CanoR_1	142	148	PF00244	0.531
LIG_14-3-3_CanoR_1	198	204	PF00244	0.509
LIG_14-3-3_CanoR_1	501	506	PF00244	0.615
LIG_14-3-3_CanoR_1	676	680	PF00244	0.677
LIG_14-3-3_CanoR_1	716	725	PF00244	0.666
LIG_14-3-3_CanoR_1	796	805	PF00244	0.571
LIG_Actin_WH2_2	126	141	PF00022	0.483
LIG_Actin_WH2_2	30	48	PF00022	0.540
LIG_Actin_WH2_2	342	359	PF00022	0.406
LIG_BIR_II_1	1	5	PF00653	0.660
LIG_CAP-Gly_1	847	853	PF01302	0.632
LIG_Clathr_ClatBox_1	346	350	PF01394	0.405
LIG_Clathr_ClatBox_1	420	424	PF01394	0.430
LIG_CtBP_PxDLS_1	85	89	PF00389	0.624
LIG_FHA_1	106	112	PF00498	0.633
LIG_FHA_1	29	35	PF00498	0.550
LIG_FHA_1	333	339	PF00498	0.472
LIG_FHA_1	4	10	PF00498	0.572
LIG_FHA_1	400	406	PF00498	0.470
LIG_FHA_1	46	52	PF00498	0.396
LIG_FHA_1	490	496	PF00498	0.614
LIG_FHA_1	502	508	PF00498	0.612
LIG_FHA_1	705	711	PF00498	0.583
LIG_FHA_1	749	755	PF00498	0.489
LIG_FHA_2	150	156	PF00498	0.602
LIG_FHA_2	230	236	PF00498	0.580
LIG_FHA_2	408	414	PF00498	0.346
LIG_LIR_Gen_1	305	316	PF02991	0.430
LIG_LIR_Gen_1	410	420	PF02991	0.347
LIG_LIR_Nem_3	264	268	PF02991	0.473
LIG_LIR_Nem_3	305	311	PF02991	0.430
LIG_LIR_Nem_3	324	330	PF02991	0.428
LIG_LIR_Nem_3	410	415	PF02991	0.346
LIG_LIR_Nem_3	806	811	PF02991	0.615
LIG_NRBOX	511	517	PF00104	0.472
LIG_NRBOX	62	68	PF00104	0.462
LIG_PCNA_yPIPBox_3	198	212	PF02747	0.523
LIG_PDZ_Class_2	848	853	PF00595	0.565
LIG_Pex14_2	831	835	PF04695	0.586
LIG_REV1ctd_RIR_1	277	286	PF16727	0.495
LIG_SH2_CRK	327	331	PF00017	0.416
LIG_SH2_CRK	513	517	PF00017	0.477
LIG_SH2_STAP1	261	265	PF00017	0.454
LIG_SH2_STAP1	304	308	PF00017	0.439
LIG_SH2_STAP1	471	475	PF00017	0.531
LIG_SH2_STAT5	171	174	PF00017	0.540
LIG_SH2_STAT5	211	214	PF00017	0.516
LIG_SH3_2	496	501	PF14604	0.627
LIG_SH3_3	103	109	PF00018	0.625
LIG_SH3_3	493	499	PF00018	0.636
LIG_SH3_3	573	579	PF00018	0.536
LIG_SH3_3	632	638	PF00018	0.783
LIG_SH3_3	649	655	PF00018	0.549
LIG_SH3_3	676	682	PF00018	0.642
LIG_SH3_3	690	696	PF00018	0.573
LIG_SH3_3	729	735	PF00018	0.640
LIG_SH3_3	801	807	PF00018	0.593
LIG_SH3_CIN85_PxpxPR_1	496	501	PF14604	0.627
LIG_SUMO_SIM_par_1	30	36	PF11976	0.589
LIG_TRAF2_1	165	168	PF00917	0.547
LIG_TRAF2_1	428	431	PF00917	0.403
LIG_TRAF2_1	758	761	PF00917	0.553
LIG_WRC_WIRS_1	308	313	PF05994	0.417
LIG_WW_3	498	502	PF00397	0.629
MOD_CDC14_SPxK_1	195	198	PF00782	0.565
MOD_CDC14_SPxK_1	806	809	PF00782	0.612
MOD_CDK_SPK_2	634	639	PF00069	0.663
MOD_CDK_SPxK_1	192	198	PF00069	0.569
MOD_CDK_SPxK_1	561	567	PF00069	0.621
MOD_CDK_SPxK_1	689	695	PF00069	0.674
MOD_CDK_SPxK_1	803	809	PF00069	0.604
MOD_CK1_1	105	111	PF00069	0.690
MOD_CK1_1	115	121	PF00069	0.496
MOD_CK1_1	148	154	PF00069	0.542
MOD_CK1_1	19	25	PF00069	0.637
MOD_CK1_1	199	205	PF00069	0.521
MOD_CK1_1	229	235	PF00069	0.589
MOD_CK1_1	239	245	PF00069	0.545
MOD_CK1_1	3	9	PF00069	0.664
MOD_CK1_1	466	472	PF00069	0.487
MOD_CK1_1	588	594	PF00069	0.612
MOD_CK1_1	603	609	PF00069	0.685
MOD_CK1_1	626	632	PF00069	0.616
MOD_CK1_1	633	639	PF00069	0.630
MOD_CK1_1	665	671	PF00069	0.654
MOD_CK1_1	672	678	PF00069	0.583
MOD_CK1_1	684	690	PF00069	0.531
MOD_CK1_1	709	715	PF00069	0.619
MOD_CK1_1	718	724	PF00069	0.610
MOD_CK1_1	726	732	PF00069	0.615
MOD_CK1_1	748	754	PF00069	0.664
MOD_CK1_1	834	840	PF00069	0.583
MOD_CK1_1	98	104	PF00069	0.769
MOD_CK2_1	1	7	PF00069	0.662
MOD_CK2_1	149	155	PF00069	0.649
MOD_CK2_1	163	169	PF00069	0.479
MOD_CK2_1	216	222	PF00069	0.603
MOD_CK2_1	229	235	PF00069	0.516
MOD_CK2_1	280	286	PF00069	0.476
MOD_CK2_1	299	305	PF00069	0.448
MOD_CK2_1	30	36	PF00069	0.530
MOD_CK2_1	388	394	PF00069	0.489
MOD_CK2_1	407	413	PF00069	0.362
MOD_CK2_1	425	431	PF00069	0.371
MOD_CK2_1	84	90	PF00069	0.669
MOD_GlcNHglycan	100	103	PF01048	0.661
MOD_GlcNHglycan	114	117	PF01048	0.733
MOD_GlcNHglycan	161	164	PF01048	0.719
MOD_GlcNHglycan	183	186	PF01048	0.635
MOD_GlcNHglycan	238	241	PF01048	0.634
MOD_GlcNHglycan	273	276	PF01048	0.602
MOD_GlcNHglycan	473	476	PF01048	0.630
MOD_GlcNHglycan	486	489	PF01048	0.564
MOD_GlcNHglycan	613	616	PF01048	0.647
MOD_GlcNHglycan	625	628	PF01048	0.602
MOD_GlcNHglycan	640	643	PF01048	0.549
MOD_GlcNHglycan	657	660	PF01048	0.613
MOD_GlcNHglycan	664	668	PF01048	0.700
MOD_GlcNHglycan	722	725	PF01048	0.586
MOD_GlcNHglycan	726	729	PF01048	0.675
MOD_GlcNHglycan	747	750	PF01048	0.535
MOD_GlcNHglycan	759	765	PF01048	0.546
MOD_GlcNHglycan	771	776	PF01048	0.493
MOD_GlcNHglycan	815	818	PF01048	0.635
MOD_GSK3_1	145	152	PF00069	0.599
MOD_GSK3_1	159	166	PF00069	0.704
MOD_GSK3_1	19	26	PF00069	0.685
MOD_GSK3_1	192	199	PF00069	0.587
MOD_GSK3_1	28	35	PF00069	0.602
MOD_GSK3_1	480	487	PF00069	0.566
MOD_GSK3_1	596	603	PF00069	0.632
MOD_GSK3_1	622	629	PF00069	0.628
MOD_GSK3_1	630	637	PF00069	0.589
MOD_GSK3_1	643	650	PF00069	0.562
MOD_GSK3_1	651	658	PF00069	0.740
MOD_GSK3_1	662	669	PF00069	0.577
MOD_GSK3_1	671	678	PF00069	0.564
MOD_GSK3_1	680	687	PF00069	0.539
MOD_GSK3_1	704	711	PF00069	0.651
MOD_GSK3_1	712	719	PF00069	0.784
MOD_GSK3_1	720	727	PF00069	0.543
MOD_GSK3_1	741	748	PF00069	0.557
MOD_GSK3_1	767	774	PF00069	0.506
MOD_GSK3_1	80	87	PF00069	0.598
MOD_GSK3_1	98	105	PF00069	0.631
MOD_N-GLC_1	332	337	PF02516	0.419
MOD_N-GLC_1	484	489	PF02516	0.551
MOD_N-GLC_1	745	750	PF02516	0.544
MOD_N-GLC_1	831	836	PF02516	0.577
MOD_NEK2_1	1	6	PF00069	0.659
MOD_NEK2_1	138	143	PF00069	0.513
MOD_NEK2_1	145	150	PF00069	0.509
MOD_NEK2_1	159	164	PF00069	0.749
MOD_NEK2_1	16	21	PF00069	0.512
MOD_NEK2_1	268	273	PF00069	0.512
MOD_NEK2_1	341	346	PF00069	0.416
MOD_NEK2_1	407	412	PF00069	0.419
MOD_NEK2_1	415	420	PF00069	0.444
MOD_NEK2_1	45	50	PF00069	0.581
MOD_NEK2_1	490	495	PF00069	0.580
MOD_NEK2_1	710	715	PF00069	0.635
MOD_NEK2_1	717	722	PF00069	0.588
MOD_NEK2_1	831	836	PF00069	0.581
MOD_NEK2_1	95	100	PF00069	0.635
MOD_NEK2_2	196	201	PF00069	0.538
MOD_PIKK_1	10	16	PF00454	0.618
MOD_PIKK_1	229	235	PF00454	0.580
MOD_PIKK_1	506	512	PF00454	0.472
MOD_PIKK_1	78	84	PF00454	0.640
MOD_PK_1	695	701	PF00069	0.635
MOD_PKA_2	138	144	PF00069	0.519
MOD_PKA_2	24	30	PF00069	0.537
MOD_PKA_2	374	380	PF00069	0.486
MOD_PKA_2	45	51	PF00069	0.542
MOD_PKA_2	466	472	PF00069	0.487
MOD_PKA_2	500	506	PF00069	0.588
MOD_PKA_2	662	668	PF00069	0.643
MOD_PKA_2	675	681	PF00069	0.599
MOD_PKA_2	715	721	PF00069	0.605
MOD_PKA_2	775	781	PF00069	0.676
MOD_PKB_1	461	469	PF00069	0.441
MOD_Plk_1	118	124	PF00069	0.519
MOD_Plk_1	341	347	PF00069	0.414
MOD_Plk_1	490	496	PF00069	0.671
MOD_Plk_1	831	837	PF00069	0.549
MOD_Plk_2-3	394	400	PF00069	0.485
MOD_Plk_2-3	767	773	PF00069	0.509
MOD_Plk_4	145	151	PF00069	0.512
MOD_Plk_4	199	205	PF00069	0.521
MOD_ProDKin_1	102	108	PF00069	0.648
MOD_ProDKin_1	17	23	PF00069	0.656
MOD_ProDKin_1	192	198	PF00069	0.661
MOD_ProDKin_1	549	555	PF00069	0.559
MOD_ProDKin_1	561	567	PF00069	0.708
MOD_ProDKin_1	572	578	PF00069	0.558
MOD_ProDKin_1	585	591	PF00069	0.577
MOD_ProDKin_1	596	602	PF00069	0.706
MOD_ProDKin_1	626	632	PF00069	0.747
MOD_ProDKin_1	634	640	PF00069	0.634
MOD_ProDKin_1	651	657	PF00069	0.565
MOD_ProDKin_1	689	695	PF00069	0.746
MOD_ProDKin_1	803	809	PF00069	0.604
MOD_SUMO_for_1	347	350	PF00179	0.403
MOD_SUMO_for_1	450	453	PF00179	0.423
MOD_SUMO_rev_2	47	56	PF00179	0.542
MOD_SUMO_rev_2	788	797	PF00179	0.554
MOD_SUMO_rev_2	96	101	PF00179	0.685
TRG_DiLeu_BaEn_1	342	347	PF01217	0.412
TRG_DiLeu_BaEn_2	275	281	PF01217	0.529
TRG_DiLeu_BaEn_4	167	173	PF01217	0.539
TRG_DiLeu_BaEn_4	453	459	PF01217	0.412
TRG_DiLeu_BaLyEn_6	325	330	PF01217	0.447
TRG_ENDOCYTIC_2	308	311	PF00928	0.424
TRG_ENDOCYTIC_2	327	330	PF00928	0.439
TRG_ENDOCYTIC_2	513	516	PF00928	0.480
TRG_ER_diArg_1	138	140	PF00400	0.551
TRG_ER_diArg_1	287	289	PF00400	0.474
TRG_ER_diArg_1	353	356	PF00400	0.608
TRG_ER_diArg_1	372	375	PF00400	0.320
TRG_ER_diArg_1	432	434	PF00400	0.445
TRG_ER_diArg_1	437	439	PF00400	0.466
TRG_ER_diArg_1	457	460	PF00400	0.369
TRG_ER_diArg_1	461	464	PF00400	0.454
TRG_NES_CRM1_1	336	350	PF08389	0.470
TRG_NES_CRM1_1	453	468	PF08389	0.485
TRG_NES_CRM1_1	53	65	PF08389	0.481
TRG_NLS_MonoExtC_3	794	800	PF00514	0.589
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	403	408	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	438	443	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	52	57	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	787	792	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5X2	Leptomonas seymouri	61%	98%
A0A3S7X7I5	Leishmania donovani	91%	100%
A4HAH0	Leishmania braziliensis	72%	99%
A4I9N0	Leishmania infantum	91%	100%
E9B4M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%