Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3E4_LEIMA

TriTrypDb:

LmjF.34.0630 , LMJLV39_340012700 , LMJSD75_340012400

Length:

782

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3E4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3E4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	630	634	PF00656	0.490
CLV_NRD_NRD_1	191	193	PF00675	0.493
CLV_NRD_NRD_1	273	275	PF00675	0.668
CLV_NRD_NRD_1	285	287	PF00675	0.581
CLV_NRD_NRD_1	392	394	PF00675	0.574
CLV_NRD_NRD_1	463	465	PF00675	0.686
CLV_NRD_NRD_1	531	533	PF00675	0.478
CLV_NRD_NRD_1	585	587	PF00675	0.645
CLV_NRD_NRD_1	755	757	PF00675	0.538
CLV_NRD_NRD_1	83	85	PF00675	0.497
CLV_PCSK_FUR_1	364	368	PF00082	0.615
CLV_PCSK_FUR_1	529	533	PF00082	0.526
CLV_PCSK_KEX2_1	190	192	PF00082	0.484
CLV_PCSK_KEX2_1	273	275	PF00082	0.668
CLV_PCSK_KEX2_1	284	286	PF00082	0.583
CLV_PCSK_KEX2_1	366	368	PF00082	0.565
CLV_PCSK_KEX2_1	463	465	PF00082	0.682
CLV_PCSK_KEX2_1	531	533	PF00082	0.475
CLV_PCSK_KEX2_1	587	589	PF00082	0.599
CLV_PCSK_KEX2_1	755	757	PF00082	0.564
CLV_PCSK_KEX2_1	77	79	PF00082	0.548
CLV_PCSK_KEX2_1	83	85	PF00082	0.525
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.592
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.599
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.512
CLV_PCSK_SKI1_1	131	135	PF00082	0.485
CLV_PCSK_SKI1_1	201	205	PF00082	0.544
CLV_PCSK_SKI1_1	366	370	PF00082	0.594
CLV_PCSK_SKI1_1	387	391	PF00082	0.636
CLV_PCSK_SKI1_1	464	468	PF00082	0.697
CLV_PCSK_SKI1_1	60	64	PF00082	0.451
CLV_PCSK_SKI1_1	709	713	PF00082	0.599
CLV_PCSK_SKI1_1	756	760	PF00082	0.476
CLV_Separin_Metazoa	552	556	PF03568	0.529
CLV_Separin_Metazoa	563	567	PF03568	0.430
DEG_APCC_DBOX_1	366	374	PF00400	0.618
DEG_APCC_DBOX_1	613	621	PF00400	0.464
DEG_Nend_UBRbox_3	1	3	PF02207	0.649
DEG_SPOP_SBC_1	683	687	PF00917	0.587
DOC_CDC14_PxL_1	228	236	PF14671	0.508
DOC_CYCLIN_RxL_1	175	188	PF00134	0.524
DOC_CYCLIN_RxL_1	198	208	PF00134	0.534
DOC_CYCLIN_RxL_1	218	230	PF00134	0.321
DOC_CYCLIN_RxL_1	364	375	PF00134	0.592
DOC_CYCLIN_RxL_1	706	714	PF00134	0.472
DOC_MAPK_gen_1	364	373	PF00069	0.531
DOC_MAPK_gen_1	438	447	PF00069	0.550
DOC_MAPK_gen_1	529	538	PF00069	0.532
DOC_MAPK_gen_1	57	65	PF00069	0.490
DOC_MAPK_MEF2A_6	529	538	PF00069	0.562
DOC_MAPK_MEF2A_6	57	65	PF00069	0.510
DOC_MIT_MIM_1	702	711	PF04212	0.569
DOC_PP4_FxxP_1	298	301	PF00568	0.693
DOC_USP7_MATH_1	301	305	PF00917	0.665
DOC_USP7_MATH_1	421	425	PF00917	0.552
DOC_USP7_MATH_1	462	466	PF00917	0.671
DOC_USP7_MATH_1	589	593	PF00917	0.601
DOC_USP7_MATH_1	601	605	PF00917	0.585
DOC_USP7_MATH_1	683	687	PF00917	0.587
DOC_USP7_MATH_1	734	738	PF00917	0.587
DOC_USP7_MATH_1	79	83	PF00917	0.636
DOC_USP7_MATH_2	506	512	PF00917	0.602
DOC_USP7_UBL2_3	159	163	PF12436	0.513
DOC_USP7_UBL2_3	411	415	PF12436	0.533
DOC_WW_Pin1_4	267	272	PF00397	0.675
DOC_WW_Pin1_4	278	283	PF00397	0.667
DOC_WW_Pin1_4	424	429	PF00397	0.556
LIG_14-3-3_CanoR_1	119	125	PF00244	0.557
LIG_14-3-3_CanoR_1	152	158	PF00244	0.544
LIG_14-3-3_CanoR_1	218	222	PF00244	0.516
LIG_14-3-3_CanoR_1	226	234	PF00244	0.546
LIG_14-3-3_CanoR_1	264	270	PF00244	0.696
LIG_14-3-3_CanoR_1	487	494	PF00244	0.664
LIG_14-3-3_CanoR_1	535	544	PF00244	0.532
LIG_14-3-3_CanoR_1	638	643	PF00244	0.463
LIG_14-3-3_CanoR_1	693	699	PF00244	0.584
LIG_Actin_WH2_2	751	768	PF00022	0.537
LIG_APCC_ABBA_1	547	552	PF00400	0.527
LIG_BRCT_BRCA1_1	243	247	PF00533	0.542
LIG_CaM_IQ_9	147	162	PF13499	0.528
LIG_CaM_IQ_9	701	717	PF13499	0.580
LIG_Clathr_ClatBox_1	370	374	PF01394	0.589
LIG_Clathr_ClatBox_1	62	66	PF01394	0.508
LIG_EH1_1	218	226	PF00400	0.355
LIG_FAT_LD_1	65	73	PF03623	0.508
LIG_FHA_1	264	270	PF00498	0.643
LIG_FHA_1	699	705	PF00498	0.722
LIG_FHA_1	760	766	PF00498	0.531
LIG_FHA_2	231	237	PF00498	0.464
LIG_FHA_2	322	328	PF00498	0.609
LIG_FHA_2	558	564	PF00498	0.548
LIG_HCF-1_HBM_1	396	399	PF13415	0.596
LIG_Integrin_isoDGR_2	345	347	PF01839	0.577
LIG_LIR_Apic_2	295	301	PF02991	0.690
LIG_LIR_Apic_2	396	402	PF02991	0.501
LIG_LIR_Gen_1	244	253	PF02991	0.539
LIG_LIR_Gen_1	359	370	PF02991	0.583
LIG_LIR_Gen_1	641	650	PF02991	0.522
LIG_LIR_LC3C_4	24	28	PF02991	0.547
LIG_LIR_Nem_3	244	250	PF02991	0.490
LIG_LIR_Nem_3	328	334	PF02991	0.639
LIG_LIR_Nem_3	359	365	PF02991	0.576
LIG_LIR_Nem_3	424	429	PF02991	0.487
LIG_LIR_Nem_3	641	646	PF02991	0.522
LIG_LYPXL_yS_3	417	420	PF13949	0.538
LIG_NRBOX	707	713	PF00104	0.574
LIG_PTB_Apo_2	411	418	PF02174	0.490
LIG_PTB_Phospho_1	411	417	PF10480	0.549
LIG_Rb_pABgroove_1	544	552	PF01858	0.532
LIG_SH2_CRK	331	335	PF00017	0.634
LIG_SH2_CRK	453	457	PF00017	0.617
LIG_SH2_NCK_1	453	457	PF00017	0.617
LIG_SH2_NCK_1	572	576	PF00017	0.479
LIG_SH2_STAP1	143	147	PF00017	0.491
LIG_SH2_STAP1	403	407	PF00017	0.578
LIG_SH2_STAP1	550	554	PF00017	0.431
LIG_SH2_STAT5	237	240	PF00017	0.483
LIG_SH2_STAT5	256	259	PF00017	0.535
LIG_SH3_1	415	421	PF00018	0.569
LIG_SH3_3	415	421	PF00018	0.594
LIG_SUMO_SIM_anti_2	351	357	PF11976	0.599
LIG_SUMO_SIM_par_1	351	357	PF11976	0.690
LIG_SUMO_SIM_par_1	369	375	PF11976	0.494
LIG_TRAF2_1	124	127	PF00917	0.582
LIG_TRAF2_1	514	517	PF00917	0.578
LIG_TRAF2_1	700	703	PF00917	0.590
LIG_TRAF2_1	85	88	PF00917	0.527
LIG_UBA3_1	114	123	PF00899	0.494
LIG_UBA3_1	32	37	PF00899	0.524
LIG_UBA3_1	430	435	PF00899	0.555
LIG_UBA3_1	68	77	PF00899	0.464
MOD_CDC14_SPxK_1	270	273	PF00782	0.663
MOD_CDC14_SPxK_1	281	284	PF00782	0.670
MOD_CDK_SPxK_1	267	273	PF00069	0.656
MOD_CDK_SPxK_1	278	284	PF00069	0.679
MOD_CDK_SPxxK_3	267	274	PF00069	0.679
MOD_CDK_SPxxK_3	278	285	PF00069	0.669
MOD_CK1_1	267	273	PF00069	0.765
MOD_CK1_1	304	310	PF00069	0.697
MOD_CK1_1	317	323	PF00069	0.546
MOD_CK1_1	354	360	PF00069	0.688
MOD_CK1_1	424	430	PF00069	0.476
MOD_CK1_1	489	495	PF00069	0.787
MOD_CK1_1	496	502	PF00069	0.664
MOD_CK1_1	634	640	PF00069	0.516
MOD_CK1_1	641	647	PF00069	0.523
MOD_CK1_1	674	680	PF00069	0.682
MOD_CK1_1	681	687	PF00069	0.681
MOD_CK2_1	163	169	PF00069	0.464
MOD_CK2_1	321	327	PF00069	0.675
MOD_CK2_1	557	563	PF00069	0.542
MOD_CK2_1	578	584	PF00069	0.656
MOD_CK2_1	697	703	PF00069	0.640
MOD_Cter_Amidation	188	191	PF01082	0.484
MOD_GlcNHglycan	187	190	PF01048	0.511
MOD_GlcNHglycan	307	310	PF01048	0.703
MOD_GlcNHglycan	316	319	PF01048	0.739
MOD_GlcNHglycan	356	359	PF01048	0.545
MOD_GlcNHglycan	384	387	PF01048	0.640
MOD_GlcNHglycan	464	467	PF01048	0.722
MOD_GlcNHglycan	488	491	PF01048	0.698
MOD_GlcNHglycan	573	576	PF01048	0.554
MOD_GlcNHglycan	591	594	PF01048	0.635
MOD_GlcNHglycan	603	606	PF01048	0.702
MOD_GlcNHglycan	678	681	PF01048	0.681
MOD_GlcNHglycan	690	693	PF01048	0.668
MOD_GSK3_1	226	233	PF00069	0.459
MOD_GSK3_1	263	270	PF00069	0.683
MOD_GSK3_1	274	281	PF00069	0.700
MOD_GSK3_1	301	308	PF00069	0.767
MOD_GSK3_1	317	324	PF00069	0.678
MOD_GSK3_1	467	474	PF00069	0.808
MOD_GSK3_1	489	496	PF00069	0.601
MOD_GSK3_1	634	641	PF00069	0.517
MOD_GSK3_1	661	668	PF00069	0.607
MOD_GSK3_1	670	677	PF00069	0.685
MOD_GSK3_1	678	685	PF00069	0.781
MOD_GSK3_1	688	695	PF00069	0.712
MOD_N-GLC_1	314	319	PF02516	0.664
MOD_NEK2_1	136	141	PF00069	0.492
MOD_NEK2_1	150	155	PF00069	0.495
MOD_NEK2_1	185	190	PF00069	0.520
MOD_NEK2_1	257	262	PF00069	0.704
MOD_NEK2_1	536	541	PF00069	0.560
MOD_NEK2_1	571	576	PF00069	0.631
MOD_NEK2_1	594	599	PF00069	0.428
MOD_NEK2_1	743	748	PF00069	0.537
MOD_OFUCOSY	619	625	PF10250	0.482
MOD_PIKK_1	161	167	PF00454	0.544
MOD_PIKK_1	457	463	PF00454	0.668
MOD_PIKK_1	537	543	PF00454	0.529
MOD_PKA_2	118	124	PF00069	0.555
MOD_PKA_2	217	223	PF00069	0.544
MOD_PKA_2	263	269	PF00069	0.644
MOD_PKA_2	272	278	PF00069	0.612
MOD_PKA_2	462	468	PF00069	0.686
MOD_PKA_2	486	492	PF00069	0.756
MOD_PKA_2	496	502	PF00069	0.651
MOD_PKA_2	578	584	PF00069	0.656
MOD_PKA_2	692	698	PF00069	0.591
MOD_PKA_2	93	99	PF00069	0.492
MOD_PKB_1	190	198	PF00069	0.531
MOD_PKB_1	262	270	PF00069	0.690
MOD_PKB_1	586	594	PF00069	0.599
MOD_Plk_1	257	263	PF00069	0.491
MOD_Plk_1	294	300	PF00069	0.691
MOD_Plk_1	360	366	PF00069	0.577
MOD_Plk_2-3	230	236	PF00069	0.460
MOD_Plk_2-3	294	300	PF00069	0.691
MOD_Plk_4	638	644	PF00069	0.525
MOD_Plk_4	694	700	PF00069	0.658
MOD_Plk_4	743	749	PF00069	0.513
MOD_ProDKin_1	267	273	PF00069	0.677
MOD_ProDKin_1	278	284	PF00069	0.667
MOD_ProDKin_1	424	430	PF00069	0.550
MOD_SUMO_for_1	36	39	PF00179	0.529
MOD_SUMO_rev_2	138	147	PF00179	0.493
MOD_SUMO_rev_2	5	12	PF00179	0.515
MOD_SUMO_rev_2	53	62	PF00179	0.507
MOD_SUMO_rev_2	581	589	PF00179	0.627
MOD_SUMO_rev_2	71	79	PF00179	0.532
TRG_DiLeu_BaEn_1	58	63	PF01217	0.510
TRG_DiLeu_BaEn_4	374	380	PF01217	0.605
TRG_DiLeu_BaEn_4	38	44	PF01217	0.533
TRG_DiLeu_BaEn_4	58	64	PF01217	0.511
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.455
TRG_DiLeu_BaLyEn_6	613	618	PF01217	0.491
TRG_ENDOCYTIC_2	331	334	PF00928	0.637
TRG_ENDOCYTIC_2	403	406	PF00928	0.526
TRG_ENDOCYTIC_2	417	420	PF00928	0.541
TRG_ENDOCYTIC_2	550	553	PF00928	0.440
TRG_ENDOCYTIC_2	643	646	PF00928	0.526
TRG_ER_diArg_1	190	192	PF00400	0.511
TRG_ER_diArg_1	261	264	PF00400	0.490
TRG_ER_diArg_1	284	286	PF00400	0.579
TRG_ER_diArg_1	444	447	PF00400	0.508
TRG_ER_diArg_1	529	532	PF00400	0.476
TRG_ER_diArg_1	754	756	PF00400	0.566
TRG_NLS_MonoExtN_4	364	370	PF00514	0.594
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	709	714	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3M8	Leptomonas seymouri	56%	76%
A0A3Q8IHX7	Leishmania donovani	93%	99%
A0A422N4B9	Trypanosoma rangeli	28%	88%
A4HAH3	Leishmania braziliensis	83%	99%
A4I9N3	Leishmania infantum	93%	99%
E9B4N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%