Leucine-rich repeat domain, L domain-like

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q3E3_LEIMA

TriTrypDb:

LmjF.34.0640 , LMJLV39_340012800 , LMJSD75_340012500

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	4
GO:0016020	membrane	2	4
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0110165	cellular anatomical entity	1	4
GO:0120025	plasma membrane bounded cell projection	3	4

Expansion

Sequence features

Q4Q3E3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3E3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.360
CLV_C14_Caspase3-7	221	225	PF00656	0.307
CLV_C14_Caspase3-7	335	339	PF00656	0.331
CLV_NRD_NRD_1	125	127	PF00675	0.609
CLV_NRD_NRD_1	143	145	PF00675	0.554
CLV_NRD_NRD_1	361	363	PF00675	0.593
CLV_NRD_NRD_1	435	437	PF00675	0.567
CLV_NRD_NRD_1	581	583	PF00675	0.594
CLV_PCSK_FUR_1	141	145	PF00082	0.556
CLV_PCSK_KEX2_1	143	145	PF00082	0.595
CLV_PCSK_KEX2_1	435	437	PF00082	0.567
CLV_PCSK_SKI1_1	19	23	PF00082	0.311
DEG_APCC_DBOX_1	125	133	PF00400	0.335
DEG_APCC_DBOX_1	143	151	PF00400	0.326
DEG_APCC_DBOX_1	373	381	PF00400	0.301
DEG_APCC_DBOX_1	487	495	PF00400	0.314
DEG_APCC_DBOX_1	83	91	PF00400	0.383
DEG_MDM2_SWIB_1	21	29	PF02201	0.279
DEG_SPOP_SBC_1	113	117	PF00917	0.423
DOC_CDC14_PxL_1	506	514	PF14671	0.311
DOC_CKS1_1	481	486	PF01111	0.330
DOC_CYCLIN_RxL_1	255	264	PF00134	0.326
DOC_CYCLIN_yCln2_LP_2	283	289	PF00134	0.306
DOC_MAPK_DCC_7	13	22	PF00069	0.422
DOC_MAPK_DCC_7	63	71	PF00069	0.408
DOC_MAPK_gen_1	126	134	PF00069	0.314
DOC_MAPK_gen_1	435	442	PF00069	0.327
DOC_MAPK_gen_1	531	541	PF00069	0.317
DOC_MAPK_MEF2A_6	13	22	PF00069	0.446
DOC_MAPK_MEF2A_6	435	444	PF00069	0.340
DOC_MAPK_MEF2A_6	534	543	PF00069	0.310
DOC_MAPK_MEF2A_6	63	71	PF00069	0.408
DOC_PP2B_LxvP_1	283	286	PF13499	0.295
DOC_USP7_MATH_1	114	118	PF00917	0.436
DOC_USP7_MATH_1	218	222	PF00917	0.315
DOC_USP7_MATH_1	329	333	PF00917	0.369
DOC_WW_Pin1_4	249	254	PF00397	0.465
DOC_WW_Pin1_4	434	439	PF00397	0.379
DOC_WW_Pin1_4	480	485	PF00397	0.339
DOC_WW_Pin1_4	520	525	PF00397	0.337
LIG_14-3-3_CanoR_1	531	537	PF00244	0.333
LIG_14-3-3_CanoR_1	542	550	PF00244	0.270
LIG_Actin_WH2_2	175	191	PF00022	0.330
LIG_APCC_ABBA_1	28	33	PF00400	0.295
LIG_APCC_ABBA_1	413	418	PF00400	0.301
LIG_APCC_ABBAyCdc20_2	412	418	PF00400	0.301
LIG_BRCT_BRCA1_1	539	543	PF00533	0.300
LIG_Clathr_ClatBox_1	343	347	PF01394	0.346
LIG_CSL_BTD_1	15	18	PF09270	0.422
LIG_FHA_1	174	180	PF00498	0.346
LIG_FHA_1	261	267	PF00498	0.325
LIG_FHA_1	313	319	PF00498	0.351
LIG_FHA_1	381	387	PF00498	0.307
LIG_FHA_1	435	441	PF00498	0.353
LIG_FHA_1	512	518	PF00498	0.309
LIG_FHA_1	536	542	PF00498	0.301
LIG_FHA_1	98	104	PF00498	0.409
LIG_FHA_2	113	119	PF00498	0.432
LIG_FHA_2	276	282	PF00498	0.301
LIG_FHA_2	286	292	PF00498	0.286
LIG_FHA_2	521	527	PF00498	0.369
LIG_GBD_Chelix_1	103	111	PF00786	0.519
LIG_LIR_Gen_1	545	554	PF02991	0.319
LIG_LIR_Gen_1	563	572	PF02991	0.249
LIG_LIR_Gen_1	73	82	PF02991	0.338
LIG_LIR_Nem_3	545	550	PF02991	0.315
LIG_LIR_Nem_3	563	567	PF02991	0.250
LIG_MYND_3	509	513	PF01753	0.309
LIG_NRBOX	279	285	PF00104	0.308
LIG_Pex14_2	21	25	PF04695	0.279
LIG_Pex14_2	543	547	PF04695	0.316
LIG_SH2_CRK	234	238	PF00017	0.305
LIG_SH2_STAP1	234	238	PF00017	0.305
LIG_SH2_STAP1	303	307	PF00017	0.317
LIG_SH2_STAP1	572	576	PF00017	0.353
LIG_SH2_STAT3	276	279	PF00017	0.311
LIG_SH2_STAT5	276	279	PF00017	0.451
LIG_SH2_STAT5	289	292	PF00017	0.328
LIG_SH2_STAT5	384	387	PF00017	0.316
LIG_SH2_STAT5	496	499	PF00017	0.333
LIG_SH2_STAT5	570	573	PF00017	0.314
LIG_SH3_1	320	326	PF00018	0.385
LIG_SH3_3	107	113	PF00018	0.346
LIG_SH3_3	12	18	PF00018	0.559
LIG_SH3_3	244	250	PF00018	0.547
LIG_SH3_3	320	326	PF00018	0.385
LIG_SH3_3	62	68	PF00018	0.437
LIG_SUMO_SIM_par_1	174	181	PF11976	0.314
LIG_SUMO_SIM_par_1	182	187	PF11976	0.297
LIG_SUMO_SIM_par_1	308	315	PF11976	0.337
LIG_SUMO_SIM_par_1	342	349	PF11976	0.367
LIG_SUMO_SIM_par_1	401	406	PF11976	0.399
LIG_SUMO_SIM_par_1	513	521	PF11976	0.320
LIG_SUMO_SIM_par_1	67	73	PF11976	0.392
LIG_WRC_WIRS_1	561	566	PF05994	0.320
MOD_CDK_SPxxK_3	434	441	PF00069	0.366
MOD_CK1_1	332	338	PF00069	0.350
MOD_CK1_1	421	427	PF00069	0.472
MOD_CK1_1	452	458	PF00069	0.311
MOD_CK1_1	532	538	PF00069	0.325
MOD_CK1_1	8	14	PF00069	0.641
MOD_CK2_1	112	118	PF00069	0.436
MOD_CK2_1	166	172	PF00069	0.401
MOD_CK2_1	224	230	PF00069	0.277
MOD_CK2_1	275	281	PF00069	0.285
MOD_CK2_1	458	464	PF00069	0.314
MOD_CK2_1	520	526	PF00069	0.369
MOD_CK2_1	90	96	PF00069	0.290
MOD_GlcNHglycan	172	176	PF01048	0.561
MOD_GlcNHglycan	224	227	PF01048	0.508
MOD_GlcNHglycan	263	266	PF01048	0.526
MOD_GlcNHglycan	306	310	PF01048	0.523
MOD_GlcNHglycan	347	353	PF01048	0.594
MOD_GlcNHglycan	423	427	PF01048	0.686
MOD_GlcNHglycan	429	432	PF01048	0.678
MOD_GlcNHglycan	453	457	PF01048	0.507
MOD_GlcNHglycan	469	472	PF01048	0.462
MOD_GlcNHglycan	53	56	PF01048	0.772
MOD_GlcNHglycan	72	75	PF01048	0.487
MOD_GSK3_1	156	163	PF00069	0.399
MOD_GSK3_1	189	196	PF00069	0.394
MOD_GSK3_1	218	225	PF00069	0.311
MOD_GSK3_1	249	256	PF00069	0.407
MOD_GSK3_1	329	336	PF00069	0.365
MOD_GSK3_1	401	408	PF00069	0.251
MOD_GSK3_1	418	425	PF00069	0.432
MOD_GSK3_1	516	523	PF00069	0.325
MOD_GSK3_1	53	60	PF00069	0.476
MOD_LATS_1	370	376	PF00433	0.317
MOD_N-GLC_1	57	62	PF02516	0.673
MOD_NEK2_1	182	187	PF00069	0.320
MOD_NEK2_1	260	265	PF00069	0.313
MOD_NEK2_1	31	36	PF00069	0.311
MOD_NEK2_1	380	385	PF00069	0.295
MOD_NEK2_1	386	391	PF00069	0.287
MOD_NEK2_1	403	408	PF00069	0.303
MOD_NEK2_1	492	497	PF00069	0.304
MOD_NEK2_1	530	535	PF00069	0.462
MOD_NEK2_1	90	95	PF00069	0.343
MOD_NEK2_2	166	171	PF00069	0.400
MOD_NEK2_2	253	258	PF00069	0.507
MOD_NEK2_2	387	392	PF00069	0.310
MOD_PIKK_1	135	141	PF00454	0.327
MOD_PIKK_1	189	195	PF00454	0.341
MOD_PIKK_1	275	281	PF00454	0.285
MOD_PIKK_1	403	409	PF00454	0.390
MOD_PIKK_1	5	11	PF00454	0.609
MOD_PKA_2	5	11	PF00069	0.654
MOD_PKA_2	530	536	PF00069	0.330
MOD_PKA_2	97	103	PF00069	0.346
MOD_Plk_1	166	172	PF00069	0.497
MOD_Plk_1	305	311	PF00069	0.326
MOD_Plk_1	380	386	PF00069	0.301
MOD_Plk_1	492	498	PF00069	0.310
MOD_Plk_2-3	224	230	PF00069	0.277
MOD_Plk_4	106	112	PF00069	0.331
MOD_Plk_4	211	217	PF00069	0.319
MOD_Plk_4	31	37	PF00069	0.280
MOD_Plk_4	511	517	PF00069	0.309
MOD_ProDKin_1	249	255	PF00069	0.452
MOD_ProDKin_1	434	440	PF00069	0.369
MOD_ProDKin_1	480	486	PF00069	0.333
MOD_ProDKin_1	520	526	PF00069	0.337
MOD_SUMO_rev_2	521	530	PF00179	0.340
TRG_ENDOCYTIC_2	234	237	PF00928	0.451
TRG_ENDOCYTIC_2	572	575	PF00928	0.339
TRG_ER_diArg_1	140	143	PF00400	0.327
TRG_ER_diArg_1	434	436	PF00400	0.400
TRG_ER_diLys_1	583	586	PF00400	0.432
TRG_NES_CRM1_1	485	498	PF08389	0.319
TRG_NES_CRM1_1	508	521	PF08389	0.318
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	569	573	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X7I2	Leishmania donovani	93%	100%
E9B4N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%