19S proteasome regulatory subunit,Metallo-peptidase, Clan MP, Family M67

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATPase subunit 11, putative

Species:

Leishmania major

UniProt:

Q4Q3E2_LEIMA

TriTrypDb:

LmjF.34.0650 , LMJLV39_340012900 , LMJSD75_340012600

Length:

309

Annotations

Annotations by Jardim et al.

Proteasome, proteasome regulatory non-ATP-ase subunit 11

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 6
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	yes	yes: 6
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 15

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 15

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005838	proteasome regulatory particle	2	2
GO:0008541	proteasome regulatory particle, lid subcomplex	2	2
GO:0032991	protein-containing complex	1	11
GO:0110165	cellular anatomical entity	1	2
GO:0000502	proteasome complex	3	9
GO:0140535	intracellular protein-containing complex	2	9
GO:1902494	catalytic complex	2	9
GO:1905368	peptidase complex	3	9
GO:1905369	endopeptidase complex	4	9

Expansion

Sequence features

Q4Q3E2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3E2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0016579	protein deubiquitination	6	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0030163	protein catabolic process	4	2
GO:0036211	protein modification process	4	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0070646	protein modification by small protein removal	5	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	2
GO:0008233	peptidase activity	3	11
GO:0008237	metallopeptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0019783	ubiquitin-like protein peptidase activity	4	11
GO:0044877	protein-containing complex binding	2	2
GO:0061578	K63-linked deubiquitinase activity	6	11
GO:0070628	proteasome binding	3	2
GO:0101005	deubiquitinase activity	5	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.774
CLV_NRD_NRD_1	211	213	PF00675	0.513
CLV_NRD_NRD_1	225	227	PF00675	0.634
CLV_PCSK_SKI1_1	179	183	PF00082	0.594
CLV_PCSK_SKI1_1	219	223	PF00082	0.619
CLV_PCSK_SKI1_1	261	265	PF00082	0.639
DEG_Nend_UBRbox_2	1	3	PF02207	0.826
DOC_MAPK_gen_1	212	220	PF00069	0.511
DOC_MAPK_MEF2A_6	202	211	PF00069	0.488
DOC_MAPK_MEF2A_6	213	222	PF00069	0.506
DOC_MAPK_MEF2A_6	45	52	PF00069	0.412
DOC_PP4_FxxP_1	72	75	PF00568	0.412
DOC_USP7_MATH_1	146	150	PF00917	0.490
DOC_USP7_UBL2_3	257	261	PF12436	0.640
DOC_WW_Pin1_4	133	138	PF00397	0.412
LIG_14-3-3_CanoR_1	138	143	PF00244	0.459
LIG_14-3-3_CanoR_1	179	188	PF00244	0.546
LIG_FHA_1	180	186	PF00498	0.534
LIG_FHA_1	27	33	PF00498	0.425
LIG_FHA_1	63	69	PF00498	0.412
LIG_LIR_Apic_2	174	178	PF02991	0.640
LIG_LIR_Apic_2	70	75	PF02991	0.416
LIG_LIR_Nem_3	157	162	PF02991	0.565
LIG_NRBOX	217	223	PF00104	0.512
LIG_PCNA_yPIPBox_3	294	304	PF02747	0.617
LIG_PDZ_Class_2	304	309	PF00595	0.517
LIG_Pex14_1	229	233	PF04695	0.533
LIG_RPA_C_Fungi	19	31	PF08784	0.671
LIG_SH2_CRK	205	209	PF00017	0.493
LIG_SH2_GRB2like	132	135	PF00017	0.524
LIG_SH2_GRB2like	204	207	PF00017	0.576
LIG_SH2_PTP2	175	178	PF00017	0.673
LIG_SH2_SRC	175	178	PF00017	0.581
LIG_SH2_STAP1	64	68	PF00017	0.412
LIG_SH2_STAT3	262	265	PF00017	0.671
LIG_SH2_STAT5	175	178	PF00017	0.656
LIG_SH2_STAT5	262	265	PF00017	0.671
LIG_SH2_STAT5	64	67	PF00017	0.412
LIG_SH3_3	140	146	PF00018	0.442
LIG_SUMO_SIM_anti_2	139	145	PF11976	0.454
LIG_SUMO_SIM_anti_2	33	39	PF11976	0.412
LIG_SUMO_SIM_par_1	251	256	PF11976	0.657
LIG_UBA3_1	252	257	PF00899	0.625
LIG_UBA3_1	94	99	PF00899	0.524
MOD_CDK_SPK_2	133	138	PF00069	0.412
MOD_CK1_1	189	195	PF00069	0.644
MOD_CK2_1	245	251	PF00069	0.530
MOD_GlcNHglycan	191	194	PF01048	0.645
MOD_GlcNHglycan	2	6	PF01048	0.769
MOD_GSK3_1	26	33	PF00069	0.410
MOD_GSK3_1	70	77	PF00069	0.425
MOD_N-GLC_1	133	138	PF02516	0.524
MOD_N-GLC_1	296	301	PF02516	0.524
MOD_NEK2_1	296	301	PF00069	0.504
MOD_NEK2_2	146	151	PF00069	0.498
MOD_PIKK_1	261	267	PF00454	0.656
MOD_PK_1	138	144	PF00069	0.458
MOD_PKA_2	15	21	PF00069	0.773
MOD_PKA_2	23	29	PF00069	0.452
MOD_PKA_2	242	248	PF00069	0.517
MOD_Plk_1	296	302	PF00069	0.523
MOD_Plk_1	62	68	PF00069	0.412
MOD_Plk_4	138	144	PF00069	0.458
MOD_ProDKin_1	133	139	PF00069	0.412
MOD_SUMO_for_1	233	236	PF00179	0.607
TRG_DiLeu_BaEn_1	217	222	PF01217	0.511
TRG_DiLeu_BaEn_1	51	56	PF01217	0.412
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.603
TRG_ENDOCYTIC_2	132	135	PF00928	0.412
TRG_ENDOCYTIC_2	204	207	PF00928	0.464
TRG_NES_CRM1_1	145	157	PF08389	0.497
TRG_NES_CRM1_1	277	289	PF08389	0.631
TRG_NLS_MonoExtC_3	211	217	PF00514	0.507
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II09	Leptomonas seymouri	95%	100%
A0A0N1PD30	Leptomonas seymouri	32%	69%
A0A0S4KHQ1	Bodo saltans	29%	76%
A0A151EH88	Theionarchaea archaeon (strain DG-70-1)	23%	94%
A0A1X0P9L3	Trypanosomatidae	72%	100%
A0A3Q8IFA3	Leishmania donovani	100%	100%
A0A3R7M5F1	Trypanosoma rangeli	27%	80%
A0A422N4D2	Trypanosoma rangeli	71%	100%
A4HAH5	Leishmania braziliensis	98%	100%
A4I9N5	Leishmania infantum	100%	100%
C9ZW23	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	78%
D0A1Z5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9B4N4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
O00487	Homo sapiens	51%	100%
O35593	Mus musculus	51%	100%
O76577	Caenorhabditis elegans	50%	99%
O94454	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
P41878	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	100%
P41883	Caenorhabditis elegans	49%	97%
P43588	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	100%
P91001	Caenorhabditis elegans	36%	84%
Q4IJM4	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	38%	91%
Q4P804	Ustilago maydis (strain 521 / FGSC 9021)	37%	76%
Q4WZP2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	39%	93%
Q54PF3	Dictyostelium discoideum	38%	93%
Q5BBF1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	38%	92%
Q5PPY6	Xenopus laevis	28%	93%
Q6C1I3	Yarrowia lipolytica (strain CLIB 122 / E 150)	29%	89%
Q6C703	Yarrowia lipolytica (strain CLIB 122 / E 150)	36%	87%
Q6FKS1	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	48%	100%
Q6P381	Xenopus tropicalis	26%	92%
Q750E9	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	49%	99%
Q7RXX8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	39%	92%
Q86IJ1	Dictyostelium discoideum	49%	100%
Q8SQY3	Encephalitozoon cuniculi (strain GB-M1)	48%	100%
Q9FVU9	Arabidopsis thaliana	37%	86%
Q9LT08	Arabidopsis thaliana	51%	100%
Q9V3H2	Drosophila melanogaster	51%	100%
Q9XZ58	Drosophila melanogaster	36%	94%
V5BMB2	Trypanosoma cruzi	71%	100%