Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flagellar attachment zone protein, putative

Species:

Leishmania major

UniProt:

Q4Q3D9_LEIMA

TriTrypDb:

LmjF.34.0680 , LMJSD75_340013000 , LMJSD75_340013100 , LMJSD75_340013200 , LMJSD75_340013300

Length:

1277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	2
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q3D9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3D9

Function

Biological processes
Term	Name	Level	Count
GO:0000281	mitotic cytokinesis	4	2
GO:0000910	cytokinesis	3	2
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022402	cell cycle process	2	2
GO:0022607	cellular component assembly	4	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0044782	cilium organization	5	2
GO:0060271	cilium assembly	6	2
GO:0061640	cytoskeleton-dependent cytokinesis	4	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2
GO:1903047	mitotic cell cycle process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.639
CLV_NRD_NRD_1	1074	1076	PF00675	0.428
CLV_NRD_NRD_1	122	124	PF00675	0.661
CLV_NRD_NRD_1	165	167	PF00675	0.628
CLV_NRD_NRD_1	533	535	PF00675	0.489
CLV_NRD_NRD_1	755	757	PF00675	0.499
CLV_NRD_NRD_1	93	95	PF00675	0.674
CLV_NRD_NRD_1	977	979	PF00675	0.490
CLV_PCSK_FUR_1	397	401	PF00082	0.731
CLV_PCSK_FUR_1	533	537	PF00082	0.756
CLV_PCSK_FUR_1	619	623	PF00082	0.632
CLV_PCSK_FUR_1	755	759	PF00082	0.634
CLV_PCSK_FUR_1	841	845	PF00082	0.636
CLV_PCSK_FUR_1	977	981	PF00082	0.537
CLV_PCSK_KEX2_1	1074	1076	PF00082	0.428
CLV_PCSK_KEX2_1	236	238	PF00082	0.653
CLV_PCSK_KEX2_1	399	401	PF00082	0.738
CLV_PCSK_KEX2_1	533	535	PF00082	0.726
CLV_PCSK_KEX2_1	621	623	PF00082	0.638
CLV_PCSK_KEX2_1	755	757	PF00082	0.617
CLV_PCSK_KEX2_1	843	845	PF00082	0.642
CLV_PCSK_KEX2_1	93	95	PF00082	0.674
CLV_PCSK_KEX2_1	977	979	PF00082	0.529
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.653
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.738
CLV_PCSK_PC1ET2_1	535	537	PF00082	0.760
CLV_PCSK_PC1ET2_1	621	623	PF00082	0.638
CLV_PCSK_PC1ET2_1	757	759	PF00082	0.636
CLV_PCSK_PC1ET2_1	843	845	PF00082	0.642
CLV_PCSK_PC1ET2_1	979	981	PF00082	0.539
CLV_PCSK_SKI1_1	1196	1200	PF00082	0.568
CLV_PCSK_SKI1_1	123	127	PF00082	0.658
CLV_PCSK_SKI1_1	1251	1255	PF00082	0.693
CLV_PCSK_SKI1_1	258	262	PF00082	0.628
CLV_PCSK_SKI1_1	360	364	PF00082	0.670
CLV_PCSK_SKI1_1	38	42	PF00082	0.574
CLV_PCSK_SKI1_1	61	65	PF00082	0.576
DEG_APCC_DBOX_1	1073	1081	PF00400	0.469
DEG_APCC_DBOX_1	85	93	PF00400	0.640
DEG_APCC_KENBOX_2	1189	1193	PF00400	0.693
DEG_MDM2_SWIB_1	1235	1242	PF02201	0.725
DEG_Nend_Nbox_1	1	3	PF02207	0.682
DEG_SPOP_SBC_1	346	350	PF00917	0.535
DOC_MAPK_gen_1	109	116	PF00069	0.517
DOC_MAPK_gen_1	1106	1114	PF00069	0.684
DOC_MAPK_MEF2A_6	1190	1199	PF00069	0.435
DOC_MAPK_MEF2A_6	283	292	PF00069	0.645
DOC_PP1_RVXF_1	358	364	PF00149	0.537
DOC_USP7_MATH_1	206	210	PF00917	0.400
DOC_USP7_MATH_1	346	350	PF00917	0.492
DOC_USP7_MATH_1	425	429	PF00917	0.664
DOC_USP7_MATH_1	458	462	PF00917	0.717
DOC_USP7_MATH_1	647	651	PF00917	0.754
DOC_USP7_MATH_1	680	684	PF00917	0.631
DOC_USP7_MATH_1	869	873	PF00917	0.752
DOC_USP7_MATH_1	902	906	PF00917	0.630
DOC_USP7_UBL2_3	109	113	PF12436	0.516
DOC_USP7_UBL2_3	199	203	PF12436	0.681
DOC_WW_Pin1_4	129	134	PF00397	0.661
DOC_WW_Pin1_4	427	432	PF00397	0.769
DOC_WW_Pin1_4	433	438	PF00397	0.744
DOC_WW_Pin1_4	649	654	PF00397	0.756
DOC_WW_Pin1_4	655	660	PF00397	0.688
DOC_WW_Pin1_4	871	876	PF00397	0.755
DOC_WW_Pin1_4	877	882	PF00397	0.691
LIG_14-3-3_CanoR_1	123	131	PF00244	0.668
LIG_14-3-3_CanoR_1	166	174	PF00244	0.473
LIG_14-3-3_CanoR_1	283	287	PF00244	0.658
LIG_14-3-3_CanoR_1	385	391	PF00244	0.692
LIG_14-3-3_CanoR_1	445	455	PF00244	0.743
LIG_14-3-3_CanoR_1	543	547	PF00244	0.779
LIG_14-3-3_CanoR_1	667	677	PF00244	0.724
LIG_14-3-3_CanoR_1	765	769	PF00244	0.658
LIG_14-3-3_CanoR_1	889	899	PF00244	0.736
LIG_14-3-3_CanoR_1	987	991	PF00244	0.549
LIG_14-3-3_CanoR_1	99	107	PF00244	0.529
LIG_Actin_WH2_2	110	125	PF00022	0.653
LIG_Actin_WH2_2	53	68	PF00022	0.457
LIG_BIR_III_4	484	488	PF00653	0.609
LIG_BIR_III_4	706	710	PF00653	0.632
LIG_BIR_III_4	928	932	PF00653	0.618
LIG_CSK_EPIYA_1	470	474	PF00017	0.723
LIG_CSK_EPIYA_1	692	696	PF00017	0.601
LIG_CSK_EPIYA_1	914	918	PF00017	0.607
LIG_FHA_1	1022	1028	PF00498	0.610
LIG_FHA_1	1215	1221	PF00498	0.777
LIG_FHA_1	1226	1232	PF00498	0.581
LIG_FHA_1	166	172	PF00498	0.504
LIG_FHA_1	175	181	PF00498	0.427
LIG_FHA_1	218	224	PF00498	0.535
LIG_FHA_1	269	275	PF00498	0.715
LIG_FHA_1	282	288	PF00498	0.480
LIG_FHA_1	296	302	PF00498	0.408
LIG_FHA_1	42	48	PF00498	0.551
LIG_FHA_1	52	58	PF00498	0.481
LIG_FHA_1	578	584	PF00498	0.721
LIG_FHA_1	800	806	PF00498	0.834
LIG_FHA_2	1039	1045	PF00498	0.535
LIG_FHA_2	1161	1167	PF00498	0.553
LIG_FHA_2	149	155	PF00498	0.650
LIG_FHA_2	309	315	PF00498	0.661
LIG_FHA_2	34	40	PF00498	0.528
LIG_FHA_2	353	359	PF00498	0.652
LIG_FHA_2	474	480	PF00498	0.768
LIG_FHA_2	595	601	PF00498	0.641
LIG_FHA_2	696	702	PF00498	0.646
LIG_FHA_2	817	823	PF00498	0.775
LIG_FHA_2	918	924	PF00498	0.645
LIG_Integrin_isoDGR_2	72	74	PF01839	0.560
LIG_LIR_Apic_2	4	8	PF02991	0.466
LIG_LIR_Gen_1	1138	1147	PF02991	0.682
LIG_LIR_Gen_1	1211	1220	PF02991	0.653
LIG_LIR_Gen_1	1236	1247	PF02991	0.673
LIG_LIR_Gen_1	157	165	PF02991	0.630
LIG_LIR_Gen_1	42	47	PF02991	0.548
LIG_LIR_Gen_1	456	467	PF02991	0.567
LIG_LIR_Gen_1	678	689	PF02991	0.571
LIG_LIR_Gen_1	900	911	PF02991	0.573
LIG_LIR_Nem_3	1102	1108	PF02991	0.536
LIG_LIR_Nem_3	1138	1143	PF02991	0.688
LIG_LIR_Nem_3	1211	1215	PF02991	0.638
LIG_LIR_Nem_3	1236	1242	PF02991	0.677
LIG_LIR_Nem_3	157	161	PF02991	0.483
LIG_LIR_Nem_3	42	46	PF02991	0.558
LIG_LIR_Nem_3	456	462	PF02991	0.789
LIG_LIR_Nem_3	678	684	PF02991	0.666
LIG_LIR_Nem_3	900	906	PF02991	0.672
LIG_LYPXL_SIV_4	224	232	PF13949	0.617
LIG_NRBOX	1194	1200	PF00104	0.568
LIG_Pex14_2	1235	1239	PF04695	0.705
LIG_SH2_CRK	1105	1109	PF00017	0.555
LIG_SH2_CRK	21	25	PF00017	0.541
LIG_SH2_CRK	229	233	PF00017	0.650
LIG_SH2_CRK	43	47	PF00017	0.543
LIG_SH2_NCK_1	344	348	PF00017	0.533
LIG_SH2_PTP2	5	8	PF00017	0.594
LIG_SH2_SRC	23	26	PF00017	0.334
LIG_SH2_SRC	5	8	PF00017	0.637
LIG_SH2_STAP1	1140	1144	PF00017	0.688
LIG_SH2_STAP1	353	357	PF00017	0.544
LIG_SH2_STAP1	43	47	PF00017	0.543
LIG_SH2_STAP1	473	477	PF00017	0.780
LIG_SH2_STAP1	695	699	PF00017	0.661
LIG_SH2_STAP1	917	921	PF00017	0.659
LIG_SH2_STAT5	1038	1041	PF00017	0.558
LIG_SH2_STAT5	23	26	PF00017	0.334
LIG_SH2_STAT5	43	46	PF00017	0.289
LIG_SH2_STAT5	5	8	PF00017	0.637
LIG_SH2_STAT5	594	597	PF00017	0.661
LIG_SH2_STAT5	816	819	PF00017	0.660
LIG_SH3_3	1023	1029	PF00018	0.607
LIG_SH3_3	285	291	PF00018	0.648
LIG_SH3_3	579	585	PF00018	0.719
LIG_SH3_3	801	807	PF00018	0.839
LIG_SUMO_SIM_anti_2	112	119	PF11976	0.526
LIG_TRAF2_1	1041	1044	PF00917	0.529
LIG_TRAF2_1	389	392	PF00917	0.569
LIG_TRAF2_1	476	479	PF00917	0.555
LIG_TRAF2_1	597	600	PF00917	0.636
LIG_TRAF2_1	698	701	PF00917	0.634
LIG_TRAF2_1	819	822	PF00917	0.766
LIG_TRAF2_1	920	923	PF00917	0.636
LIG_TYR_ITIM	19	24	PF00017	0.523
LIG_UBA3_1	81	88	PF00899	0.551
LIG_WRC_WIRS_1	1212	1217	PF05994	0.629
LIG_WRC_WIRS_1	278	283	PF05994	0.647
MOD_CDK_SPK_2	433	438	PF00069	0.619
MOD_CDK_SPK_2	655	660	PF00069	0.623
MOD_CDK_SPK_2	877	882	PF00069	0.625
MOD_CDK_SPxxK_3	427	434	PF00069	0.753
MOD_CDK_SPxxK_3	649	656	PF00069	0.757
MOD_CDK_SPxxK_3	871	878	PF00069	0.758
MOD_CK1_1	1214	1220	PF00069	0.643
MOD_CK1_1	186	192	PF00069	0.661
MOD_CK1_1	268	274	PF00069	0.672
MOD_CK1_1	423	429	PF00069	0.684
MOD_CK1_1	545	551	PF00069	0.517
MOD_CK1_1	645	651	PF00069	0.747
MOD_CK1_1	767	773	PF00069	0.521
MOD_CK1_1	867	873	PF00069	0.752
MOD_CK1_1	989	995	PF00069	0.503
MOD_CK2_1	1038	1044	PF00069	0.547
MOD_CK2_1	1160	1166	PF00069	0.550
MOD_CK2_1	148	154	PF00069	0.560
MOD_CK2_1	308	314	PF00069	0.659
MOD_CK2_1	33	39	PF00069	0.521
MOD_CK2_1	352	358	PF00069	0.651
MOD_CK2_1	386	392	PF00069	0.694
MOD_CK2_1	473	479	PF00069	0.614
MOD_CK2_1	594	600	PF00069	0.652
MOD_CK2_1	695	701	PF00069	0.651
MOD_CK2_1	816	822	PF00069	0.784
MOD_CK2_1	917	923	PF00069	0.652
MOD_GlcNHglycan	1002	1005	PF01048	0.636
MOD_GlcNHglycan	185	188	PF01048	0.675
MOD_GlcNHglycan	292	295	PF01048	0.642
MOD_GlcNHglycan	369	372	PF01048	0.659
MOD_GlcNHglycan	422	425	PF01048	0.733
MOD_GlcNHglycan	440	443	PF01048	0.557
MOD_GlcNHglycan	558	561	PF01048	0.726
MOD_GlcNHglycan	644	647	PF01048	0.728
MOD_GlcNHglycan	662	665	PF01048	0.533
MOD_GlcNHglycan	780	783	PF01048	0.730
MOD_GlcNHglycan	866	869	PF01048	0.744
MOD_GlcNHglycan	884	887	PF01048	0.562
MOD_GSK3_1	1225	1232	PF00069	0.750
MOD_GSK3_1	186	193	PF00069	0.663
MOD_GSK3_1	207	214	PF00069	0.364
MOD_GSK3_1	26	33	PF00069	0.576
MOD_GSK3_1	264	271	PF00069	0.657
MOD_GSK3_1	277	284	PF00069	0.484
MOD_GSK3_1	286	293	PF00069	0.488
MOD_GSK3_1	419	426	PF00069	0.675
MOD_GSK3_1	641	648	PF00069	0.737
MOD_GSK3_1	863	870	PF00069	0.744
MOD_GSK3_1	88	95	PF00069	0.650
MOD_N-GLC_2	1260	1262	PF02516	0.707
MOD_NEK2_1	1	6	PF00069	0.483
MOD_NEK2_1	281	286	PF00069	0.647
MOD_NEK2_1	333	338	PF00069	0.667
MOD_NEK2_1	386	391	PF00069	0.691
MOD_PIKK_1	446	452	PF00454	0.875
MOD_PIKK_1	668	674	PF00454	0.725
MOD_PIKK_1	890	896	PF00454	0.734
MOD_PK_1	88	94	PF00069	0.648
MOD_PKA_1	123	129	PF00069	0.669
MOD_PKA_2	1229	1235	PF00069	0.751
MOD_PKA_2	165	171	PF00069	0.470
MOD_PKA_2	206	212	PF00069	0.378
MOD_PKA_2	282	288	PF00069	0.650
MOD_PKA_2	444	450	PF00069	0.745
MOD_PKA_2	542	548	PF00069	0.778
MOD_PKA_2	666	672	PF00069	0.732
MOD_PKA_2	764	770	PF00069	0.656
MOD_PKA_2	888	894	PF00069	0.740
MOD_PKA_2	92	98	PF00069	0.661
MOD_PKA_2	986	992	PF00069	0.550
MOD_Plk_1	1237	1243	PF00069	0.592
MOD_Plk_1	207	213	PF00069	0.368
MOD_Plk_1	41	47	PF00069	0.557
MOD_Plk_4	1	7	PF00069	0.483
MOD_Plk_4	1066	1072	PF00069	0.431
MOD_Plk_4	1211	1217	PF00069	0.625
MOD_Plk_4	207	213	PF00069	0.368
MOD_Plk_4	282	288	PF00069	0.650
MOD_ProDKin_1	129	135	PF00069	0.652
MOD_ProDKin_1	427	433	PF00069	0.771
MOD_ProDKin_1	649	655	PF00069	0.755
MOD_ProDKin_1	871	877	PF00069	0.756
MOD_SUMO_for_1	262	265	PF00179	0.659
MOD_SUMO_for_1	511	514	PF00179	0.600
MOD_SUMO_for_1	733	736	PF00179	0.562
MOD_SUMO_for_1	955	958	PF00179	0.554
MOD_SUMO_rev_2	193	200	PF00179	0.554
MOD_SUMO_rev_2	316	325	PF00179	0.661
MOD_SUMO_rev_2	478	482	PF00179	0.756
MOD_SUMO_rev_2	507	513	PF00179	0.630
MOD_SUMO_rev_2	700	704	PF00179	0.632
MOD_SUMO_rev_2	729	735	PF00179	0.507
MOD_SUMO_rev_2	922	926	PF00179	0.633
MOD_SUMO_rev_2	951	957	PF00179	0.499
TRG_DiLeu_BaEn_1	112	117	PF01217	0.518
TRG_DiLeu_BaEn_1	1139	1144	PF01217	0.688
TRG_DiLeu_BaEn_1	1149	1154	PF01217	0.500
TRG_ENDOCYTIC_2	1105	1108	PF00928	0.555
TRG_ENDOCYTIC_2	1140	1143	PF00928	0.690
TRG_ENDOCYTIC_2	1212	1215	PF00928	0.535
TRG_ENDOCYTIC_2	21	24	PF00928	0.532
TRG_ENDOCYTIC_2	229	232	PF00928	0.643
TRG_ENDOCYTIC_2	43	46	PF00928	0.552
TRG_ENDOCYTIC_2	459	462	PF00928	0.654
TRG_ENDOCYTIC_2	681	684	PF00928	0.713
TRG_ENDOCYTIC_2	78	81	PF00928	0.657
TRG_ENDOCYTIC_2	903	906	PF00928	0.720
TRG_ER_diArg_1	1073	1075	PF00400	0.513
TRG_ER_diArg_1	1243	1246	PF00400	0.726
TRG_ER_diArg_1	533	536	PF00400	0.491
TRG_ER_diArg_1	755	758	PF00400	0.503
TRG_ER_diArg_1	92	94	PF00400	0.659
TRG_ER_diArg_1	977	980	PF00400	0.492
TRG_NES_CRM1_1	495	510	PF08389	0.595
TRG_NES_CRM1_1	717	732	PF08389	0.608
TRG_NES_CRM1_1	939	954	PF08389	0.599
TRG_NLS_MonoExtN_4	533	538	PF00514	0.492
TRG_NLS_MonoExtN_4	755	760	PF00514	0.501
TRG_NLS_MonoExtN_4	977	982	PF00514	0.490
TRG_Pf-PMV_PEXEL_1	1075	1079	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	1196	1200	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HAH8	Leishmania braziliensis	77%	100%
A4I9N8	Leishmania infantum	93%	100%
E9B4N7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%