Stc1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterized conserved protein (DUF2039), putative

Species:

Leishmania major

UniProt:

Q4Q3D7_LEIMA

TriTrypDb:

LmjF.34.0700 , LMJLV39_340013400 , LMJSD75_340013400

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q3D7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3D7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.551
CLV_NRD_NRD_1	189	191	PF00675	0.481
CLV_NRD_NRD_1	192	194	PF00675	0.478
CLV_NRD_NRD_1	209	211	PF00675	0.297
CLV_NRD_NRD_1	213	215	PF00675	0.458
CLV_NRD_NRD_1	68	70	PF00675	0.293
CLV_NRD_NRD_1	90	92	PF00675	0.281
CLV_PCSK_FUR_1	190	194	PF00082	0.529
CLV_PCSK_FUR_1	20	24	PF00082	0.463
CLV_PCSK_FUR_1	207	211	PF00082	0.333
CLV_PCSK_KEX2_1	191	193	PF00082	0.554
CLV_PCSK_KEX2_1	209	211	PF00082	0.325
CLV_PCSK_KEX2_1	22	24	PF00082	0.486
CLV_PCSK_KEX2_1	68	70	PF00082	0.278
CLV_PCSK_KEX2_1	90	92	PF00082	0.315
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.523
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.505
CLV_PCSK_PC7_1	205	211	PF00082	0.400
CLV_PCSK_SKI1_1	161	165	PF00082	0.416
CLV_PCSK_SKI1_1	210	214	PF00082	0.451
CLV_PCSK_SKI1_1	23	27	PF00082	0.537
DEG_APCC_DBOX_1	197	205	PF00400	0.556
DEG_Nend_Nbox_1	1	3	PF02207	0.454
DOC_USP7_MATH_1	125	129	PF00917	0.615
DOC_USP7_MATH_1	222	226	PF00917	0.599
DOC_USP7_UBL2_3	22	26	PF12436	0.570
DOC_WW_Pin1_4	26	31	PF00397	0.508
LIG_14-3-3_CanoR_1	56	62	PF00244	0.425
LIG_BRCT_BRCA1_1	12	16	PF00533	0.549
LIG_FHA_1	180	186	PF00498	0.512
LIG_FHA_1	2	8	PF00498	0.491
LIG_FHA_1	56	62	PF00498	0.395
LIG_FHA_2	130	136	PF00498	0.597
LIG_FHA_2	137	143	PF00498	0.623
LIG_FHA_2	216	222	PF00498	0.499
LIG_FHA_2	82	88	PF00498	0.389
LIG_LIR_Gen_1	13	21	PF02991	0.481
LIG_LIR_Gen_1	151	159	PF02991	0.571
LIG_LIR_Gen_1	160	169	PF02991	0.421
LIG_LIR_Nem_3	13	19	PF02991	0.644
LIG_LIR_Nem_3	151	156	PF02991	0.588
LIG_LIR_Nem_3	160	165	PF02991	0.387
LIG_LIR_Nem_3	79	83	PF02991	0.284
LIG_PDZ_Class_3	224	229	PF00595	0.601
LIG_Pex14_1	5	9	PF04695	0.487
LIG_Pex14_1	76	80	PF04695	0.278
LIG_Pex14_2	10	14	PF04695	0.484
LIG_REV1ctd_RIR_1	14	24	PF16727	0.598
LIG_SH2_CRK	104	108	PF00017	0.420
LIG_SH2_GRB2like	36	39	PF00017	0.338
LIG_SH2_STAT3	83	86	PF00017	0.420
LIG_SH2_STAT5	83	86	PF00017	0.279
LIG_TRAF2_1	141	144	PF00917	0.798
LIG_TRAF2_1	169	172	PF00917	0.448
LIG_TRAF2_1	84	87	PF00917	0.420
LIG_UBA3_1	15	22	PF00899	0.466
MOD_CDK_SPxxK_3	26	33	PF00069	0.508
MOD_CK1_1	128	134	PF00069	0.692
MOD_CK1_1	200	206	PF00069	0.509
MOD_CK1_1	55	61	PF00069	0.336
MOD_CK2_1	138	144	PF00069	0.636
MOD_CK2_1	200	206	PF00069	0.509
MOD_CK2_1	81	87	PF00069	0.389
MOD_CMANNOS	2	5	PF00535	0.492
MOD_GlcNHglycan	127	130	PF01048	0.675
MOD_GSK3_1	1	8	PF00069	0.639
MOD_GSK3_1	125	132	PF00069	0.568
MOD_GSK3_1	138	145	PF00069	0.619
MOD_GSK3_1	175	182	PF00069	0.465
MOD_GSK3_1	82	89	PF00069	0.437
MOD_N-GLC_1	26	31	PF02516	0.574
MOD_N-GLC_1	37	42	PF02516	0.361
MOD_N-GLC_2	93	95	PF02516	0.278
MOD_NEK2_1	1	6	PF00069	0.582
MOD_NEK2_1	15	20	PF00069	0.628
MOD_NEK2_1	37	42	PF00069	0.382
MOD_NEK2_2	5	10	PF00069	0.489
MOD_PIKK_1	215	221	PF00454	0.485
MOD_PIKK_1	82	88	PF00454	0.427
MOD_PKA_1	214	220	PF00069	0.509
MOD_PKA_2	175	181	PF00069	0.431
MOD_PKA_2	197	203	PF00069	0.504
MOD_PKA_2	208	214	PF00069	0.381
MOD_PKA_2	55	61	PF00069	0.365
MOD_Plk_4	5	11	PF00069	0.487
MOD_ProDKin_1	26	32	PF00069	0.510
TRG_DiLeu_BaEn_4	172	178	PF01217	0.470
TRG_ENDOCYTIC_2	104	107	PF00928	0.278
TRG_ENDOCYTIC_2	162	165	PF00928	0.387
TRG_ER_diArg_1	189	192	PF00400	0.562
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAJ2	Leptomonas seymouri	63%	100%
A0A0S4KI64	Bodo saltans	42%	100%
A0A1X0PAK0	Trypanosomatidae	39%	95%
A0A3S7X7J4	Leishmania donovani	91%	81%
A0A422MR74	Trypanosoma rangeli	40%	100%
A4HAH9	Leishmania braziliensis	79%	100%
A4IAN9	Leishmania infantum	91%	81%
C9ZN14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	80%
E9B4N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BJE2	Trypanosoma cruzi	38%	78%