Transmembrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Predicted membrane protein, putative

Species:

Leishmania major

UniProt:

Q4Q3D6_LEIMA

TriTrypDb:

LmjF.34.0705

Length:

160

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0035869	ciliary transition zone	2	2
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q3D6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3D6

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0044782	cilium organization	5	2
GO:0060271	cilium assembly	6	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2
GO:1905515	non-motile cilium assembly	7	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_CYCLIN_yCln2_LP_2	42	48	PF00134	0.260
DOC_PP2B_LxvP_1	42	45	PF13499	0.260
DOC_USP7_MATH_1	133	137	PF00917	0.373
LIG_BRCT_BRCA1_1	11	15	PF00533	0.505
LIG_EVH1_1	44	48	PF00568	0.309
LIG_FHA_1	104	110	PF00498	0.260
LIG_FHA_1	132	138	PF00498	0.456
LIG_FHA_1	31	37	PF00498	0.256
LIG_FHA_1	79	85	PF00498	0.453
LIG_LIR_Gen_1	106	115	PF02991	0.259
LIG_LIR_Gen_1	22	32	PF02991	0.271
LIG_LIR_Gen_1	58	67	PF02991	0.275
LIG_LIR_Nem_3	116	122	PF02991	0.353
LIG_LIR_Nem_3	22	28	PF02991	0.271
LIG_LIR_Nem_3	58	62	PF02991	0.305
LIG_PCNA_PIPBox_1	53	62	PF02747	0.313
LIG_Pex14_1	103	107	PF04695	0.226
LIG_SH2_STAT5	107	110	PF00017	0.231
LIG_SH2_STAT5	119	122	PF00017	0.276
LIG_SH3_3	42	48	PF00018	0.271
LIG_SUMO_SIM_anti_2	58	64	PF11976	0.421
LIG_TYR_ITIM	99	104	PF00017	0.372
LIG_UBA3_1	70	77	PF00899	0.219
LIG_WRC_WIRS_1	56	61	PF05994	0.360
MOD_CK1_1	4	10	PF00069	0.590
MOD_GlcNHglycan	115	118	PF01048	0.306
MOD_GlcNHglycan	3	6	PF01048	0.438
MOD_GlcNHglycan	81	84	PF01048	0.314
MOD_GlcNHglycan	86	89	PF01048	0.355
MOD_GSK3_1	1	8	PF00069	0.711
MOD_NEK2_1	113	118	PF00069	0.256
MOD_NEK2_1	131	136	PF00069	0.421
MOD_NEK2_1	19	24	PF00069	0.330
MOD_NEK2_1	78	83	PF00069	0.503
MOD_PIKK_1	131	137	PF00454	0.382
MOD_Plk_4	103	109	PF00069	0.229
MOD_Plk_4	115	121	PF00069	0.292
MOD_Plk_4	55	61	PF00069	0.313
MOD_SUMO_for_1	146	149	PF00179	0.585
TRG_ENDOCYTIC_2	101	104	PF00928	0.299
TRG_ENDOCYTIC_2	107	110	PF00928	0.264
TRG_ENDOCYTIC_2	119	122	PF00928	0.287
TRG_ER_diLys_1	157	160	PF00400	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KJD7	Bodo saltans	42%	100%
A0A1X0P9G7	Trypanosomatidae	46%	89%
A0A3Q8IH07	Leishmania donovani	94%	100%
A0A3R7JUI1	Trypanosoma rangeli	54%	95%
A4IAP0	Leishmania infantum	94%	100%
C9ZN13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	95%
E9B4P0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%