Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3D4_LEIMA

TriTrypDb:

LmjF.34.0720 , LMJLV39_340013600 , LMJSD75_340013600

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3D4

PDB structure(s): 7ane_y

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004784	superoxide dismutase activity	2	4
GO:0005488	binding	1	4
GO:0016209	antioxidant activity	1	4
GO:0016491	oxidoreductase activity	2	4
GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	3	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.736
CLV_C14_Caspase3-7	464	468	PF00656	0.454
CLV_C14_Caspase3-7	473	477	PF00656	0.470
CLV_NRD_NRD_1	11	13	PF00675	0.527
CLV_NRD_NRD_1	22	24	PF00675	0.667
CLV_NRD_NRD_1	232	234	PF00675	0.518
CLV_NRD_NRD_1	300	302	PF00675	0.605
CLV_PCSK_KEX2_1	11	13	PF00082	0.577
CLV_PCSK_KEX2_1	201	203	PF00082	0.485
CLV_PCSK_KEX2_1	22	24	PF00082	0.568
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.485
CLV_PCSK_SKI1_1	11	15	PF00082	0.466
CLV_PCSK_SKI1_1	125	129	PF00082	0.439
CLV_PCSK_SKI1_1	46	50	PF00082	0.642
CLV_PCSK_SKI1_1	470	474	PF00082	0.346
DEG_APCC_DBOX_1	10	18	PF00400	0.529
DEG_APCC_DBOX_1	232	240	PF00400	0.668
DEG_APCC_DBOX_1	75	83	PF00400	0.504
DEG_SCF_FBW7_1	160	167	PF00400	0.497
DEG_SPOP_SBC_1	352	356	PF00917	0.764
DOC_CKS1_1	161	166	PF01111	0.487
DOC_CYCLIN_RxL_1	122	132	PF00134	0.439
DOC_CYCLIN_RxL_1	9	18	PF00134	0.490
DOC_MAPK_DCC_7	11	19	PF00069	0.582
DOC_MAPK_FxFP_2	454	457	PF00069	0.568
DOC_MAPK_gen_1	11	19	PF00069	0.505
DOC_MAPK_gen_1	60	66	PF00069	0.581
DOC_MAPK_MEF2A_6	11	19	PF00069	0.514
DOC_PP2B_LxvP_1	177	180	PF13499	0.507
DOC_PP2B_LxvP_1	62	65	PF13499	0.327
DOC_PP4_FxxP_1	454	457	PF00568	0.568
DOC_USP7_MATH_1	208	212	PF00917	0.570
DOC_USP7_MATH_1	27	31	PF00917	0.547
DOC_USP7_MATH_1	325	329	PF00917	0.656
DOC_USP7_MATH_1	352	356	PF00917	0.741
DOC_USP7_MATH_1	360	364	PF00917	0.719
DOC_USP7_MATH_1	376	380	PF00917	0.804
DOC_USP7_MATH_1	388	392	PF00917	0.654
DOC_USP7_MATH_1	44	48	PF00917	0.603
DOC_WW_Pin1_4	151	156	PF00397	0.557
DOC_WW_Pin1_4	160	165	PF00397	0.514
LIG_14-3-3_CanoR_1	109	118	PF00244	0.538
LIG_14-3-3_CanoR_1	231	237	PF00244	0.632
LIG_14-3-3_CanoR_1	470	475	PF00244	0.442
LIG_Actin_WH2_2	303	319	PF00022	0.621
LIG_AP2alpha_1	94	98	PF02296	0.327
LIG_BRCT_BRCA1_1	333	337	PF00533	0.751
LIG_BRCT_BRCA1_1	90	94	PF00533	0.364
LIG_EH1_1	28	36	PF00400	0.542
LIG_FHA_1	118	124	PF00498	0.568
LIG_FHA_1	161	167	PF00498	0.459
LIG_FHA_1	26	32	PF00498	0.616
LIG_FHA_1	280	286	PF00498	0.476
LIG_FHA_1	324	330	PF00498	0.609
LIG_FHA_1	370	376	PF00498	0.735
LIG_FHA_1	425	431	PF00498	0.512
LIG_FHA_1	437	443	PF00498	0.518
LIG_FHA_1	458	464	PF00498	0.427
LIG_FHA_2	239	245	PF00498	0.722
LIG_FHA_2	294	300	PF00498	0.540
LIG_FHA_2	450	456	PF00498	0.458
LIG_FHA_2	471	477	PF00498	0.456
LIG_LIR_Apic_2	451	457	PF02991	0.447
LIG_LIR_Nem_3	132	138	PF02991	0.436
LIG_LIR_Nem_3	91	97	PF02991	0.492
LIG_Pex14_1	417	421	PF04695	0.458
LIG_Pex14_2	94	98	PF04695	0.450
LIG_SH2_CRK	135	139	PF00017	0.527
LIG_SH2_CRK	162	166	PF00017	0.527
LIG_SH2_SRC	474	477	PF00017	0.593
LIG_SH2_STAP1	40	44	PF00017	0.590
LIG_SH2_STAT5	162	165	PF00017	0.552
LIG_SH2_STAT5	88	91	PF00017	0.478
LIG_SH2_STAT5	97	100	PF00017	0.511
LIG_SH3_3	158	164	PF00018	0.491
LIG_SH3_3	372	378	PF00018	0.792
LIG_TRAF2_1	241	244	PF00917	0.663
LIG_UBA3_1	176	183	PF00899	0.396
LIG_WRC_WIRS_1	16	21	PF05994	0.555
MOD_CDC14_SPxK_1	154	157	PF00782	0.526
MOD_CDK_SPxK_1	151	157	PF00069	0.547
MOD_CK1_1	134	140	PF00069	0.556
MOD_CK1_1	259	265	PF00069	0.459
MOD_CK1_1	30	36	PF00069	0.475
MOD_CK1_1	333	339	PF00069	0.678
MOD_CK1_1	340	346	PF00069	0.655
MOD_CK1_1	441	447	PF00069	0.505
MOD_CK1_1	90	96	PF00069	0.473
MOD_CK2_1	164	170	PF00069	0.586
MOD_CK2_1	238	244	PF00069	0.745
MOD_CK2_1	286	292	PF00069	0.510
MOD_CK2_1	293	299	PF00069	0.514
MOD_CK2_1	338	344	PF00069	0.625
MOD_CK2_1	449	455	PF00069	0.462
MOD_CK2_1	475	481	PF00069	0.486
MOD_Cter_Amidation	20	23	PF01082	0.716
MOD_GlcNHglycan	166	169	PF01048	0.657
MOD_GlcNHglycan	210	213	PF01048	0.556
MOD_GlcNHglycan	261	264	PF01048	0.501
MOD_GlcNHglycan	282	285	PF01048	0.480
MOD_GlcNHglycan	318	321	PF01048	0.545
MOD_GlcNHglycan	340	343	PF01048	0.698
MOD_GlcNHglycan	347	350	PF01048	0.711
MOD_GlcNHglycan	356	359	PF01048	0.697
MOD_GlcNHglycan	361	365	PF01048	0.758
MOD_GlcNHglycan	378	381	PF01048	0.765
MOD_GlcNHglycan	390	393	PF01048	0.746
MOD_GlcNHglycan	40	43	PF01048	0.577
MOD_GSK3_1	147	154	PF00069	0.573
MOD_GSK3_1	160	167	PF00069	0.522
MOD_GSK3_1	21	28	PF00069	0.636
MOD_GSK3_1	255	262	PF00069	0.529
MOD_GSK3_1	276	283	PF00069	0.417
MOD_GSK3_1	287	294	PF00069	0.407
MOD_GSK3_1	30	37	PF00069	0.341
MOD_GSK3_1	323	330	PF00069	0.577
MOD_GSK3_1	333	340	PF00069	0.631
MOD_GSK3_1	376	383	PF00069	0.751
MOD_GSK3_1	384	391	PF00069	0.742
MOD_GSK3_1	40	47	PF00069	0.504
MOD_GSK3_1	436	443	PF00069	0.514
MOD_N-GLC_1	196	201	PF02516	0.408
MOD_N-GLC_1	345	350	PF02516	0.719
MOD_N-GLC_1	422	427	PF02516	0.602
MOD_N-GLC_1	457	462	PF02516	0.472
MOD_N-GLC_1	49	54	PF02516	0.582
MOD_NEK2_1	141	146	PF00069	0.503
MOD_NEK2_1	147	152	PF00069	0.479
MOD_NEK2_1	276	281	PF00069	0.461
MOD_NEK2_1	316	321	PF00069	0.535
MOD_NEK2_1	337	342	PF00069	0.734
MOD_NEK2_1	34	39	PF00069	0.482
MOD_NEK2_1	442	447	PF00069	0.388
MOD_PIKK_1	276	282	PF00454	0.380
MOD_PIKK_1	291	297	PF00454	0.628
MOD_PIKK_1	311	317	PF00454	0.334
MOD_PIKK_1	367	373	PF00454	0.768
MOD_PK_1	256	262	PF00069	0.456
MOD_PKA_2	21	27	PF00069	0.647
MOD_PKA_2	232	238	PF00069	0.604
MOD_Plk_1	131	137	PF00069	0.519
MOD_Plk_1	360	366	PF00069	0.747
MOD_Plk_1	457	463	PF00069	0.468
MOD_Plk_1	69	75	PF00069	0.489
MOD_Plk_4	141	147	PF00069	0.534
MOD_Plk_4	30	36	PF00069	0.527
MOD_Plk_4	333	339	PF00069	0.699
MOD_Plk_4	442	448	PF00069	0.452
MOD_Plk_4	449	455	PF00069	0.419
MOD_Plk_4	458	464	PF00069	0.385
MOD_ProDKin_1	151	157	PF00069	0.547
MOD_ProDKin_1	160	166	PF00069	0.525
MOD_SUMO_for_1	358	361	PF00179	0.746
MOD_SUMO_rev_2	93	103	PF00179	0.501
TRG_DiLeu_BaEn_1	9	14	PF01217	0.408
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.418
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.457
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.321
TRG_DiLeu_LyEn_5	9	14	PF01217	0.506
TRG_ENDOCYTIC_2	135	138	PF00928	0.523
TRG_ER_diArg_1	10	12	PF00400	0.497
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P312	Leptomonas seymouri	48%	95%
A0A1X0PA30	Trypanosomatidae	36%	100%
A0A3Q8IHA9	Leishmania donovani	92%	100%
A0A3R7K8T3	Trypanosoma rangeli	36%	100%
A4HAI1	Leishmania braziliensis	81%	100%
A4IAP2	Leishmania infantum	92%	100%
C9ZN11	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B4P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5DAY1	Trypanosoma cruzi	36%	100%