Protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein phosphatase

Gene product:

Stage II sporulation protein E (SpoIIE), putative

Species:

Leishmania major

UniProt:

Q4Q3D3_LEIMA

TriTrypDb:

LmjF.34.0730 , LMJLV39_340013700 , LMJSD75_340013700

Length:

210

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3D3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3D3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004721	phosphoprotein phosphatase activity	3	11
GO:0004722	protein serine/threonine phosphatase activity	4	11
GO:0005488	binding	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0017018	myosin phosphatase activity	5	11
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	46	50	PF00656	0.381
CLV_NRD_NRD_1	155	157	PF00675	0.185
CLV_PCSK_FUR_1	14	18	PF00082	0.341
CLV_PCSK_KEX2_1	155	157	PF00082	0.185
CLV_PCSK_KEX2_1	16	18	PF00082	0.560
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.560
CLV_PCSK_SKI1_1	16	20	PF00082	0.293
CLV_PCSK_SKI1_1	2	6	PF00082	0.330
DEG_APCC_DBOX_1	1	9	PF00400	0.350
DEG_Nend_UBRbox_1	1	4	PF02207	0.295
DOC_MAPK_MEF2A_6	104	112	PF00069	0.385
DOC_PP4_FxxP_1	82	85	PF00568	0.372
DOC_USP7_MATH_1	12	16	PF00917	0.554
DOC_WW_Pin1_4	156	161	PF00397	0.372
LIG_14-3-3_CanoR_1	17	24	PF00244	0.305
LIG_Actin_WH2_2	51	69	PF00022	0.362
LIG_Clathr_ClatBox_1	205	209	PF01394	0.477
LIG_FAT_LD_1	122	130	PF03623	0.461
LIG_FHA_1	179	185	PF00498	0.372
LIG_FHA_1	201	207	PF00498	0.363
LIG_FHA_2	44	50	PF00498	0.372
LIG_LIR_Apic_2	154	160	PF02991	0.434
LIG_LIR_Apic_2	81	85	PF02991	0.486
LIG_LIR_Gen_1	107	117	PF02991	0.458
LIG_LIR_Nem_3	107	112	PF02991	0.358
LIG_NRBOX	121	127	PF00104	0.461
LIG_SH2_STAT5	157	160	PF00017	0.462
LIG_SH2_STAT5	172	175	PF00017	0.450
LIG_SH2_STAT5	7	10	PF00017	0.463
LIG_SH3_1	86	92	PF00018	0.396
LIG_SH3_3	86	92	PF00018	0.381
LIG_SUMO_SIM_par_1	40	46	PF11976	0.365
LIG_UBA3_1	201	210	PF00899	0.405
MOD_CDK_SPxxK_3	156	163	PF00069	0.372
MOD_CK2_1	91	97	PF00069	0.411
MOD_GlcNHglycan	93	96	PF01048	0.196
MOD_GSK3_1	12	19	PF00069	0.520
MOD_GSK3_1	188	195	PF00069	0.570
MOD_PKA_1	16	22	PF00069	0.307
MOD_PKA_2	16	22	PF00069	0.311
MOD_PKA_2	170	176	PF00069	0.394
MOD_Plk_1	178	184	PF00069	0.372
MOD_Plk_4	43	49	PF00069	0.380
MOD_Plk_4	51	57	PF00069	0.372
MOD_ProDKin_1	156	162	PF00069	0.372
MOD_SUMO_for_1	99	102	PF00179	0.461
TRG_DiLeu_BaEn_1	121	126	PF01217	0.461
TRG_DiLeu_BaLyEn_6	197	202	PF01217	0.507
TRG_DiLeu_LyEn_5	121	126	PF01217	0.461
TRG_ER_diArg_1	155	157	PF00400	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH92	Leptomonas seymouri	74%	75%
A0A0S4IN49	Bodo saltans	29%	66%
A0A1X0P973	Trypanosomatidae	55%	76%
A0A3Q8IUF7	Leishmania donovani	98%	100%
A0A3R7RFR7	Trypanosoma rangeli	55%	75%
A4HAI2	Leishmania braziliensis	92%	100%
B3P5D3	Drosophila erecta	34%	66%
B4HZE7	Drosophila sechellia	31%	67%
B4JYN1	Drosophila grimshawi	35%	68%
B4K616	Drosophila mojavensis	37%	67%
B4M5T5	Drosophila virilis	33%	67%
B4NBL6	Drosophila willistoni	28%	67%
B4R089	Drosophila simulans	31%	67%
C9ZN10	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	75%
E9AHS3	Leishmania infantum	98%	100%
E9B4P3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O64730	Arabidopsis thaliana	32%	70%
Q09189	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	70%
Q5U3N5	Danio rerio	37%	71%
Q6GR25	Xenopus laevis	35%	71%
Q6H7J3	Oryza sativa subsp. japonica	29%	67%
Q6NVE9	Mus musculus	34%	68%
Q8NI37	Homo sapiens	35%	69%
Q9VAH4	Drosophila melanogaster	33%	67%
V5AUW7	Trypanosoma cruzi	53%	75%