CBF domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CBF/Mak21 family, putative

Species:

Leishmania major

UniProt:

Q4Q3D2_LEIMA

TriTrypDb:

LmjF.34.0740 , LMJLV39_340013800 , LMJSD75_340013800

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0030684	preribosome	3	2
GO:0030689	Noc complex	3	2
GO:0030692	Noc4p-Nop14p complex	4	2
GO:0032040	small-subunit processome	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	2
GO:0005634	nucleus	5	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10

Expansion

Sequence features

Q4Q3D2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3D2

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0022613	ribonucleoprotein complex biogenesis	4	12
GO:0042254	ribosome biogenesis	5	12
GO:0044085	cellular component biogenesis	3	12
GO:0071840	cellular component organization or biogenesis	2	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.362
CLV_MEL_PAP_1	202	208	PF00089	0.397
CLV_NRD_NRD_1	159	161	PF00675	0.495
CLV_NRD_NRD_1	321	323	PF00675	0.214
CLV_NRD_NRD_1	97	99	PF00675	0.394
CLV_PCSK_KEX2_1	159	161	PF00082	0.495
CLV_PCSK_KEX2_1	300	302	PF00082	0.270
CLV_PCSK_KEX2_1	99	101	PF00082	0.349
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.270
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.349
CLV_PCSK_PC7_1	95	101	PF00082	0.335
CLV_PCSK_SKI1_1	142	146	PF00082	0.509
CLV_PCSK_SKI1_1	322	326	PF00082	0.203
CLV_PCSK_SKI1_1	434	438	PF00082	0.292
CLV_PCSK_SKI1_1	62	66	PF00082	0.314
DEG_APCC_DBOX_1	273	281	PF00400	0.405
DEG_COP1_1	284	293	PF00400	0.427
DEG_MDM2_SWIB_1	182	190	PF02201	0.297
DEG_Nend_UBRbox_2	1	3	PF02207	0.546
DEG_SPOP_SBC_1	390	394	PF00917	0.418
DEG_SPOP_SBC_1	415	419	PF00917	0.564
DOC_CDC14_PxL_1	308	316	PF14671	0.414
DOC_CKS1_1	263	268	PF01111	0.414
DOC_CYCLIN_RxL_1	274	287	PF00134	0.414
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.247
DOC_MAPK_DCC_7	403	413	PF00069	0.414
DOC_MAPK_gen_1	300	307	PF00069	0.427
DOC_MAPK_MEF2A_6	403	411	PF00069	0.414
DOC_PP1_RVXF_1	130	136	PF00149	0.314
DOC_PP2B_LxvP_1	288	291	PF13499	0.414
DOC_PP2B_LxvP_1	307	310	PF13499	0.414
DOC_PP4_FxxP_1	316	319	PF00568	0.403
DOC_USP7_MATH_1	144	148	PF00917	0.301
DOC_USP7_MATH_1	303	307	PF00917	0.507
DOC_USP7_MATH_1	390	394	PF00917	0.442
DOC_USP7_MATH_1	415	419	PF00917	0.521
DOC_WW_Pin1_4	262	267	PF00397	0.414
DOC_WW_Pin1_4	27	32	PF00397	0.586
DOC_WW_Pin1_4	36	41	PF00397	0.531
DOC_WW_Pin1_4	421	426	PF00397	0.573
DOC_WW_Pin1_4	47	52	PF00397	0.429
DOC_WW_Pin1_4	72	77	PF00397	0.616
LIG_AP2alpha_2	377	379	PF02296	0.414
LIG_APCC_ABBA_1	170	175	PF00400	0.241
LIG_BRCT_BRCA1_1	180	184	PF00533	0.209
LIG_BRCT_BRCA1_1	316	320	PF00533	0.494
LIG_Clathr_ClatBox_1	244	248	PF01394	0.252
LIG_eIF4E_1	213	219	PF01652	0.225
LIG_eIF4E_1	275	281	PF01652	0.403
LIG_FHA_1	120	126	PF00498	0.459
LIG_FHA_1	165	171	PF00498	0.309
LIG_FHA_1	213	219	PF00498	0.252
LIG_FHA_1	263	269	PF00498	0.418
LIG_FHA_1	351	357	PF00498	0.405
LIG_FHA_1	367	373	PF00498	0.496
LIG_FHA_1	386	392	PF00498	0.316
LIG_FHA_1	435	441	PF00498	0.503
LIG_FHA_1	461	467	PF00498	0.613
LIG_FHA_2	15	21	PF00498	0.467
LIG_FHA_2	392	398	PF00498	0.427
LIG_FHA_2	417	423	PF00498	0.548
LIG_FHA_2	47	53	PF00498	0.618
LIG_FHA_2	73	79	PF00498	0.569
LIG_LIR_Apic_2	313	319	PF02991	0.470
LIG_LIR_Apic_2	451	457	PF02991	0.544
LIG_LIR_Gen_1	114	125	PF02991	0.331
LIG_LIR_Gen_1	17	25	PF02991	0.497
LIG_LIR_Gen_1	181	190	PF02991	0.324
LIG_LIR_Gen_1	258	269	PF02991	0.470
LIG_LIR_Nem_3	114	120	PF02991	0.331
LIG_LIR_Nem_3	17	21	PF02991	0.484
LIG_LIR_Nem_3	181	185	PF02991	0.294
LIG_LIR_Nem_3	252	256	PF02991	0.406
LIG_LIR_Nem_3	258	264	PF02991	0.399
LIG_LIR_Nem_3	276	281	PF02991	0.403
LIG_LIR_Nem_3	313	318	PF02991	0.500
LIG_LIR_Nem_3	402	408	PF02991	0.492
LIG_LIR_Nem_3	429	435	PF02991	0.503
LIG_LIR_Nem_3	79	85	PF02991	0.460
LIG_NRBOX	259	265	PF00104	0.414
LIG_NRBOX	276	282	PF00104	0.414
LIG_PDZ_Class_2	463	468	PF00595	0.587
LIG_Pex14_1	82	86	PF04695	0.456
LIG_Pex14_2	182	186	PF04695	0.229
LIG_Pex14_2	316	320	PF04695	0.417
LIG_SH2_CRK	261	265	PF00017	0.470
LIG_SH2_CRK	432	436	PF00017	0.495
LIG_SH2_CRK	86	90	PF00017	0.477
LIG_SH2_NCK_1	454	458	PF00017	0.597
LIG_SH2_SRC	151	154	PF00017	0.270
LIG_SH2_STAP1	257	261	PF00017	0.470
LIG_SH2_STAP1	428	432	PF00017	0.518
LIG_SH2_STAT3	256	259	PF00017	0.414
LIG_SH2_STAT5	151	154	PF00017	0.309
LIG_SH2_STAT5	213	216	PF00017	0.247
LIG_SH2_STAT5	223	226	PF00017	0.265
LIG_SH2_STAT5	293	296	PF00017	0.407
LIG_SH2_STAT5	315	318	PF00017	0.432
LIG_SH3_3	206	212	PF00018	0.255
LIG_SH3_3	39	45	PF00018	0.649
LIG_SH3_3	404	410	PF00018	0.414
LIG_SUMO_SIM_par_1	167	175	PF11976	0.259
LIG_SUMO_SIM_par_1	215	222	PF11976	0.251
LIG_SUMO_SIM_par_1	232	238	PF11976	0.237
LIG_SUMO_SIM_par_1	243	248	PF11976	0.189
LIG_SUMO_SIM_par_1	279	284	PF11976	0.414
LIG_SUMO_SIM_par_1	409	414	PF11976	0.423
LIG_TYR_ITIM	84	89	PF00017	0.476
MOD_CDK_SPK_2	52	57	PF00069	0.597
MOD_CDK_SPxK_1	421	427	PF00069	0.594
MOD_CDK_SPxxK_3	36	43	PF00069	0.570
MOD_CK1_1	108	114	PF00069	0.352
MOD_CK1_1	154	160	PF00069	0.355
MOD_CK1_1	168	174	PF00069	0.185
MOD_CK1_1	235	241	PF00069	0.351
MOD_CK1_1	262	268	PF00069	0.452
MOD_CK1_1	284	290	PF00069	0.424
MOD_CK1_1	414	420	PF00069	0.540
MOD_CK2_1	335	341	PF00069	0.414
MOD_CK2_1	391	397	PF00069	0.423
MOD_CK2_1	415	421	PF00069	0.516
MOD_CK2_1	47	53	PF00069	0.560
MOD_CK2_1	72	78	PF00069	0.583
MOD_GlcNHglycan	229	232	PF01048	0.280
MOD_GlcNHglycan	359	362	PF01048	0.294
MOD_GlcNHglycan	413	416	PF01048	0.287
MOD_GlcNHglycan	6	9	PF01048	0.366
MOD_GSK3_1	104	111	PF00069	0.557
MOD_GSK3_1	164	171	PF00069	0.296
MOD_GSK3_1	222	229	PF00069	0.272
MOD_GSK3_1	310	317	PF00069	0.516
MOD_GSK3_1	350	357	PF00069	0.419
MOD_GSK3_1	385	392	PF00069	0.422
MOD_GSK3_1	4	11	PF00069	0.424
MOD_GSK3_1	411	418	PF00069	0.487
MOD_GSK3_1	434	441	PF00069	0.495
MOD_GSK3_1	460	467	PF00069	0.617
MOD_N-GLC_1	154	159	PF02516	0.568
MOD_N-GLC_1	164	169	PF02516	0.572
MOD_NEK2_1	119	124	PF00069	0.454
MOD_NEK2_1	164	169	PF00069	0.295
MOD_NEK2_1	281	286	PF00069	0.428
MOD_NEK2_1	314	319	PF00069	0.507
MOD_NEK2_1	366	371	PF00069	0.479
MOD_NEK2_1	385	390	PF00069	0.411
MOD_NEK2_1	391	396	PF00069	0.414
MOD_NEK2_1	411	416	PF00069	0.380
MOD_PK_1	205	211	PF00069	0.344
MOD_PKA_1	98	104	PF00069	0.627
MOD_PKA_2	336	342	PF00069	0.403
MOD_PKA_2	366	372	PF00069	0.428
MOD_Plk_1	164	170	PF00069	0.420
MOD_Plk_1	281	287	PF00069	0.427
MOD_Plk_1	396	402	PF00069	0.462
MOD_Plk_1	428	434	PF00069	0.509
MOD_Plk_2-3	455	461	PF00069	0.602
MOD_Plk_4	108	114	PF00069	0.399
MOD_Plk_4	165	171	PF00069	0.326
MOD_Plk_4	205	211	PF00069	0.344
MOD_Plk_4	259	265	PF00069	0.403
MOD_Plk_4	289	295	PF00069	0.441
MOD_Plk_4	303	309	PF00069	0.467
MOD_Plk_4	310	316	PF00069	0.468
MOD_Plk_4	391	397	PF00069	0.414
MOD_ProDKin_1	262	268	PF00069	0.414
MOD_ProDKin_1	27	33	PF00069	0.584
MOD_ProDKin_1	36	42	PF00069	0.537
MOD_ProDKin_1	421	427	PF00069	0.575
MOD_ProDKin_1	47	53	PF00069	0.428
MOD_ProDKin_1	72	78	PF00069	0.607
MOD_SUMO_for_1	138	141	PF00179	0.335
MOD_SUMO_rev_2	20	30	PF00179	0.556
MOD_SUMO_rev_2	417	425	PF00179	0.629
TRG_DiLeu_BaEn_1	276	281	PF01217	0.470
TRG_DiLeu_LyEn_5	276	281	PF01217	0.507
TRG_ENDOCYTIC_2	18	21	PF00928	0.494
TRG_ENDOCYTIC_2	257	260	PF00928	0.403
TRG_ENDOCYTIC_2	261	264	PF00928	0.403
TRG_ENDOCYTIC_2	275	278	PF00928	0.403
TRG_ENDOCYTIC_2	315	318	PF00928	0.432
TRG_ENDOCYTIC_2	432	435	PF00928	0.493
TRG_ENDOCYTIC_2	86	89	PF00928	0.578
TRG_NLS_MonoExtC_3	97	102	PF00514	0.544
TRG_NLS_MonoExtN_4	95	102	PF00514	0.542
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSH0	Leptomonas seymouri	81%	100%
A0A0S4JK57	Bodo saltans	48%	100%
A0A1X0P9H6	Trypanosomatidae	59%	100%
A0A3S7X7L0	Leishmania donovani	96%	100%
A0A422N8P2	Trypanosoma rangeli	59%	100%
A4HAI3	Leishmania braziliensis	91%	100%
C9ZN09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AHS4	Leishmania infantum	96%	100%
E9B4P4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
F4IMH3	Arabidopsis thaliana	29%	81%
Q8BHY2	Mus musculus	30%	91%
V5BAB5	Trypanosoma cruzi	61%	100%